Article
Geriatrics & Gerontology
Mark Sanderson-Cimino, Jeremy A. Elman, Xin M. Tu, Alden L. Gross, Matthew S. Panizzon, Daniel E. Gustavson, Mark W. Bondi, Emily C. Edmonds, Joel S. Eppig, Carol E. Franz, Amy J. Jak, Michael J. Lyons, Kelsey R. Thomas, McKenna E. Williams, William S. Kremen
Summary: Cognitive practice effects (PEs) can impact the diagnosis and progression prediction of MCI, increasing prevalence, reducing reversion rates, and increasing the risk of dementia. Accounting for PEs can improve diagnostic accuracy and the prediction ability of dementia in MCI diagnoses.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Lauren K. S. Lei, Bess Y. H. Lam, Daniel W. L. Lai, Xue Bai, Jessica Li, Zhi Zou, Chetwyn C. H. Chan
Summary: This study explored the two-year changes in MoCA scores in older adults and identified three MCI subgroups based on the differential changes in MoCA scores. These findings are contrary to significant deteriorations in executive function and finger dexterity across all subgroups. Repeated exposure to MoCA tests during the follow-up period was found to be a plausible indicator of the MCI subgroup categorization.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Psychology, Clinical
Kevin Duff, Dustin B. Hammers
Summary: This study used a method developed by Calamia et al. to predict follow-up scores in a sample of older adults with amnestic mild cognitive impairment. The results showed that some observed scores were lower than the predicted scores, especially on cognitive tests that were not included in the original meta-analysis. Therefore, caution is warranted when using this method in the context of mild cognitive impairment.
CLINICAL NEUROPSYCHOLOGIST
(2022)
Article
Clinical Neurology
Binyin Li, Huidong Tang, Guiying He, Zhijia Jin, Yixi He, Pei Huang, Naying He, Shengdi Chen
Summary: Cognitive training combined with Tai Chi has positive effects on delaying mild cognitive impairment (MCI) progression to dementia. Prolonged mixed training further delays decline in global cognition and memory. Functional magnetic resonance imaging shows increased regional activity in both cognitive training and Tai Chi group.
ALZHEIMERS & DEMENTIA
(2023)
Review
Geriatrics & Gerontology
Xin Wang, Keyi Si, Wei Gu, Xueqiang Wang
Summary: Mild cognitive impairment (MCI) is a global concern among the elderly that affects their health and quality of life. Tai Chi, a form of mind-body exercise, has been recommended as a part of management for MCI patients. This review summarizes epidemiological studies on the effects of Tai Chi on symptom remission in older adults with MCI and explores the potential mechanisms. Evidence suggests that Tai Chi improves cognitive functions and alleviates symptoms of MCI by activating brain signals, altering connectivity, increasing brain volume, and modulating neurotropic and inflammation factors. Studies comparing different types and frequencies of Tai Chi can help identify effective paradigms for MCI in older people.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Tommy Kwan Hin Fong, Teris Cheung, Sze Ting Joanna Ngan, Kelvin Tong, Wai Yan Vivian Lui, Wai Chi Chan, Corine Sau Man Wong, Calvin Pak Wing Cheng
Summary: This study aimed to assess the effectiveness and tolerability of transcranial pulse stimulation (TPS) with neuro-navigation in older adults with mild neurocognitive disorder (NCD). The results showed a significant improvement in cognition of elderly with mild NCD after receiving TPS intervention. This study provides valuable information for the long-term effect of TPS in cognition in older adults.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Review
Clinical Neurology
Ya-Xin Chen, Ning Liang, Xiao-Ling Li, Si-Hong Yang, Yan-Ping Wang, Nan-Nan Shi
Summary: This study compared and harmonized recommendations for the diagnosis and treatment of Mild Cognitive Impairment (MCI) based on current clinical practice guidelines. Neuropsychological testing and biomarker assessments were common recommendations for MCI diagnosis, while there were differing opinions on pharmacological interventions. Non-pharmacological interventions like physical activity and cognitive interventions were widely recommended. More research is needed on the diagnosis and treatment of MCI.
FRONTIERS IN NEUROLOGY
(2021)
Article
Nursing
Qiao-hong Yang, Xia Lyu, Qing-ran Lin, Zi-wen Wang, Li Tang, Yu Zhao, Qi-yuan Lyu
Summary: The study evaluated the effects of a multicomponent intervention on Chinese patients with mild cognitive impairment. The results showed that the intervention had beneficial effects on cognitive function, physical function, depression symptoms, and quality of life, slowing the progression of the disease.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2022)
Article
Neurosciences
Xiaocao Liu, Qingze Zeng, Xiao Luo, Kaicheng Li, Xiaopei Xu, Luwei Hong, Jixuan Li, Xiaojun Guan, Xiaojun Xu, Peiyu Huang, Min-Ming Zhang
Summary: This study investigated the effect of the APOE epsilon 2 allele on basal forebrain cholinergic system functional connectivity in cognitively normal and mild cognitive impairment patients. The results showed an interaction effect between APOE epsilon 2 genotype and functional connectivity, and the functional connectivity was associated with cognitive performance. Therefore, the APOE epsilon 2 genotype may have a protective role in mild cognitive impairment.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Biochemistry & Molecular Biology
Kyoungjoo Cho
Summary: Cognitive impairment is a serious condition associated with aging and disruption of inflammation and innate immunity. Recent studies have shown that the innate immune system is prevalent in patients with Alzheimer's disease, and peripheral neutrophil markers can predict a decline in cognitive function in patients with mild cognitive impairment. Furthermore, altered levels of pro-inflammatory interleukins have been reported in patients with mild cognitive impairment, potentially playing a role in the progression from early cognitive impairment to dementia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychology, Clinical
Kevin Duff, Ava Dixon, Lindsay Embree
Summary: Practice effects play a potentially important role in the diagnosis, prognosis, and treatment recommendations of mild cognitive impairment (MCI) and Alzheimer's disease (AD), but the understanding of these short-term changes in test scores is still unclear. In an observational study, researchers examined the variables that influence the magnitude of practice effects in MCI and AD patients. The study found that practice effects were minimally related to demographic variables and medical comorbidities, but significantly related to cognitive variables, depressive symptoms, and daily functioning.
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2023)
Review
Medicine, General & Internal
Ilaria Corbo, Giulia Marselli, Valerio Di Ciero, Maria Casagrande
Summary: Cognitive reserve (CR) is the ability to adapt and compensate for brain damage or disease. This systematic literature review examined the role of CR in preventing Mild Cognitive Impairment (MCI) and found that high CR is significantly associated with a reduced risk of MCI. The review also confirmed a positive relationship between CR and cognitive functioning in both MCI and healthy individuals.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Giovanni Cirillo, Roberta Pepe, Mattia Siciliano, Domenico Ippolito, Dario Ricciardi, Manuela de Stefano, Daniela Buonanno, Danilo Atripaldi, Salvatore Abbadessa, Brunella Perfetto, Minoo Sharbafshaaer, Giovanna Sepe, Simona Bonavita, Alessandro Iavarone, Vincenzo Todisco, Michele Papa, Gioacchino Tedeschi, Sabrina Esposito, Francesca Trojsi
Summary: This study evaluated the effects of bilateral rTMS on plasmatic levels of MMPs and TIMPs, as well as cognitive performances, in MCI patients. The results showed that rTMS treatment reduced MMP1, -9, and -10 levels, increased TIMP1 and TIMP2 levels, and improved visuospatial performances in MCI patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
J. Thaiyanto, C. Sittichoke, K. Phirom, S. Sungkarat
Summary: The study revealed that a 12-week multicomponent exercise program can significantly improve cognitive performance and reduce fall risk in older women with mild cognitive impairment, particularly in enhancing attention and dual-task ability.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Rheumatology
Wuriliga, Dong Xu, Yang He, Dan Xu, Beidi Chen, Xue Li, Xiaoying Zhang, Jun Zhang, Ming Shen, Rong Mu
Summary: This study explored mild cognitive impairment (MCI) in patients with SSc and its characteristics. The results showed that MCI is common in SSc patients, who also exhibited impaired memory, attention, and executive ability. SSc patients with MCI had lower education level, malnutrition, and higher ANA positivity compared to those without MCI.
Article
Neurosciences
Kathleen E. Langbehn, Ellen van der Plas, David J. Moser, Jeffrey D. Long, Laurie Gutmann, Peggy C. Nopoulos
Summary: The study found that adult-onset myotonic dystrophy type 1 (DM1) patients have lower intellectual functioning compared to unaffected adults, with a negative correlation between hippocampal volume and cognitive scores, suggesting that increased hippocampal volume may be pathological.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Substance Abuse
Ethan Sahker, Soeun Park, Yunkyoung Loh Garrison, Chi W. Yeung, Yan Luo, Stephan Arndt, Toshi A. Furukawa
Summary: This study investigated the impact of Asian American and Pacific Islander (AAPI) population metrics on completion of substance use disorder treatment. The findings showed that AAPI Percentage and AAPI Percent Change were positively associated with treatment completion, while AAPI Population was negatively associated with treatment completion. The results suggest that improving outcomes in areas with low AAPI densities can be achieved by supporting AAPI communities and cultural social networks.
JOURNAL OF ETHNICITY IN SUBSTANCE ABUSE
(2022)
Article
Health Care Sciences & Services
J. Priyanka Vakkalanka, Brian C. Lund, Marcia M. Ward, Stephan Arndt, R. William Field, Mary Charlton, Ryan M. Carnahan
Summary: Compared to traditional in-person visits, telehealth showed lower rates of treatment discontinuation for substance use disorder and mental health. Patients receiving treatment through telehealth had higher treatment retention rates, making it a suitable option for individuals managing opioid use disorder.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Clinical Neurology
Jacob N. Miller, Alison Kruger, David J. Moser, Laurie Gutmann, Ellen van der Plas, Timothy R. Koscik, Sarah A. Cumming, Darren G. Monckton, Peggy C. Nopoulos
Summary: The study found that intelligence quotient was associated with depression and anxiety, while cerebral white matter fractional anisotropy was linked to apathy and hypersomnolence. Disease duration was significantly related to apathy, hypersomnolence, intelligence quotient, and cerebral white matter fractional anisotropy, but not depression or anxiety. These results suggest that cognitive deficits, hypersomnolence, and apathy in myotonic dystrophy type 1 are influenced by the underlying neuropathology, while depression and anxiety are more related to coping with the physical and emotional burden of the chronic disease.
FRONTIERS IN NEUROLOGY
(2021)
Article
Health Care Sciences & Services
Jayamalathi Priyanka Vakkalanka, Brian C. Lund, Stephan Arndt, William Field, Mary Charlton, Marcia M. Ward, Ryan M. Carnahan
Summary: The study found that Veterans initiating buprenorphine treatment often did not have a therapeutic history with their initial provider, but this did not impact treatment retention. Future research should focus on how treatment quality and provider influence patient outcomes.
HEALTH SERVICES RESEARCH
(2022)
Article
Geriatrics & Gerontology
Andrea Weber, Alison Lynch, Benjamin Miskle, Stephan Arndt, Laura Acion
Summary: The percentage of older adults entering substance use treatment for the first time continues to increase, particularly in the use of illicit drugs. Opioid and methamphetamine use has also increased among older adults entering treatment. As the population ages and substance use trends change, treatment programs must adapt to meet the needs of older adults.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Editorial Material
Geriatrics & Gerontology
Stephan Arndt
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Medicine, Research & Experimental
Lisa S. Segre, Rebecca Chuffo Davila, Cheryl Carter, Stephan Arndt
Summary: This study found that race/ethnicity matching between recruiters and participants can significantly increase the enrollment of racial/ethnic minority groups in clinical trials.
CONTEMPORARY CLINICAL TRIALS
(2022)
Article
Substance Abuse
Andrea Weber, Benjamin Miskle, Alison Lynch, Stephan Arndt, Laura Acion
Summary: The study found that 65% of SUD treatment facilities provided at least one pharmacotherapy, while 35% did not. Facilities offering pharmacotherapy also provided, on average, 6 additional treatment options. The most commonly available pharmacotherapy was psychiatric medications, followed by buprenorphine/naloxone and naltrexone.
SUBSTANCE ABUSE AND REHABILITATION
(2022)
Article
Psychiatry
Lisa S. Segre, Jennifer E. McCabe, Rebecca Chuffo Davila, Stephan Arndt
Summary: This study aimed to assess the feasibility and effectiveness of nurse-delivered Listening Visits over Zoom for NICU mothers. The results showed significant improvement in IDAS-GD scores and high satisfaction rates among participants.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Nursing
Lisa S. Segre, Jennifer E. McCabe, Rebecca Chuffo Davila, Cheryl Carter, Michael W. O'Hara, Stephan Arndt
Summary: In this trial, NICU nurses successfully delivered Listening Visits (LVs) to emotionally distressed mothers of hospitalized newborns. Although depression symptoms did not significantly differ between the LVs group and the usual care (UC) group posttreatment or at follow-up, post hoc analyses showed comparatively higher rates of clinical improvement immediately after LVs, suggesting early intervention can reduce maternal depression when women are most distressed.
Article
Psychiatry
Nicholas L. Bormann, Andrea N. Weber, Benjamin Miskle, Nicole Woodson-DeFauw, Stephan Arndt, Alison C. Lynch
Summary: Research reveals that minority populations are more worried about the risks of using psychedelic substances compared to White individuals, possibly due to societal stigma and racial disparities. As further research into the potential therapeutic benefits of psychedelics continues, perceptions of their risks may change.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Substance Abuse
Nicholas L. Bormann, Andrea N. Weber, Stephan Arndt, Alison Lynch
Summary: This study examines the impact of OUD treatment on patients' recovery capital (RC) and co-occurring alcohol use. The findings suggest that as RC improves, there is a significant increase in past 30-day abstinence.
AMERICAN JOURNAL ON ADDICTIONS
(2023)
Article
Substance Abuse
Nicholas L. Bormann, Benjamin Miskle, Paul Holdefer, Stephan Arndt, Alison C. Lynch, Andrea N. Weber
Summary: This study identified sex differences in injection drug use in the United States. Females had a higher prevalence among people who inject drugs and started using substances later in life and for a shorter duration compared to males.
DRUG AND ALCOHOL DEPENDENCE REPORTS
(2023)
Article
Substance Abuse
Yen-Han Lee, Yi-Ting Hana Lee, Yen-Chang Chang, Ching-Ti Liu, Stephan Arndt
Summary: The study found that in states with medical marijuana legalization, participants were more likely to report past use of marijuana, buying marijuana, receiving it for free or sharing, and growing it themselves. However, nonwhite participants residing in these states were less likely to report past use or receiving marijuana for free or sharing.
JOURNAL OF SUBSTANCE USE
(2022)