Article
Multidisciplinary Sciences
Leonid Kharin, Igor Bychkov, Nikolay Karnaukhov, Mark Voloshin, Rushaniya Fazliyeva, Alexander Deneka, Elena Frantsiyants, Oleg Kit, Erica Golemis, Yanis Boumber
Summary: The study found that MSI2 is significantly elevated in early-stage tumors and metastases of colorectal cancer, and is associated with poor prognosis. Depletion of MSI2 suppresses the growth and survival of CRC cells, and reduces the expression of specific proteins.
Review
Biology
Nadine Bley, Ali Hmedat, Simon Mueller, Robin Rolnik, Alexander Rausch, Marcell Lederer, Stefan Huettelmaier
Summary: The RNA-binding protein Musashi-1 (MSI1) plays a crucial role in promoting stemness properties during development and in cancer, contributing to cancer growth and therapy resistance. MSI1's specific expression pattern and diverse functions make it an interesting target for future cancer therapy, with current research focusing on MSI1-directed inhibitors with anti-tumor activity.
Article
Pharmacology & Pharmacy
Xue Zhang, Kaiyan Su, Yifan Liu, Darong Zhu, Yuting Pan, Xisong Ke, Yi Qu
Summary: This study demonstrates the essential role of MSI2 in the survival of colorectal cancer cells and identifies palmatine as a functional antagonist for MSI2-dependent growth in cancer cells.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Tiffany S. Haiduk, Mark Sicking, Kathrin A. Bruecksken, Nancy A. Espinoza-Sanchez, Kai Moritz Eder, Bjoern Kemper, Hans Theodor Eich, Martin Goette, Burkhard Greve, Fabian M. Troschel
Summary: This study reveals the crucial role of Musashi RNA-binding proteins in inflammatory breast cancer, as they are associated with tumor proliferation, cancer stem cell characteristics, and therapy resistance. Inhibiting the expression of MSI genes can alleviate drug resistance and tumor growth.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Review
Biotechnology & Applied Microbiology
Jian Sun, Weiwei Sheng, Yuteng Ma, Ming Dong
Summary: In the aggressive progression of malignant tumors, MSI2 plays a crucial role in regulating EMT and is closely associated with the EGF, TGF-beta, Notch, and Wnt pathways.
ONCOTARGETS AND THERAPY
(2021)
Article
Cell Biology
Youwei Chen, Ying Chen, Qianyan Li, Huahua Liu, Jiazhen Han, Hailin Zhang, Liming Cheng, Gufa Lin
Summary: This study identifies the presence of short C-terminal MSI1 (MSI1-C) proteins in early mouse embryos and mouse ESCs, but not in human ESCs. MSI1-C plays an essential role in regulating pluripotency states and early embryonic development by binding to RNAs involved in DNA-damage repair, enhancing the survival and blastoid formation ability of hESCs.
Article
Biochemistry & Molecular Biology
Theresa Strauss, Burkhard Greve, Michael Gabriel, Nurjannah Achmad, Dhanusha Schwan, Nancy Adriana Espinoza-Sanchez, Antonio Simone Lagana, Ludwig Kiesel, Matti Poutanen, Martin Goette, Sebastian Daniel Schaefer
Summary: This study found that the silencing of Musashi-1 and Musashi-2 increased cell apoptosis and necrosis, and reduced the expression of stem cell genes and cell proliferation in endometriosis. Additionally, the Musashi genes had an impact on the expression of the cell cycle regulator p21. These findings suggest the therapeutic potential of targeting the Musashi-Notch axis in the treatment of endometriosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Jiong Yang, Shigang Ding
Summary: The challenge in colorectal cancer treatment is the lack of specific-targeting therapy to precisely kill malignant cells. A study designed an RNA-only delivery kill switch to eliminate CMS2 type CRC cells, showing a proof-of-principle approach for targeted therapy.
ACS SYNTHETIC BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yasuro Furuichi, Ayana Furutani, Kotaro Tamura, Yasuko Manabe, Nobuharu L. Fujii
Summary: Skeletal muscle undergoes structural and metabolic changes in response to various conditions. The RNA-binding protein Musashi-2 (Msi2) is dominantly expressed in slow-type muscle fibers, and its knockout leads to a decrease in both fiber size and number, as well as a reduction in fast-type fibers and metabolic protein expression. These findings demonstrate the critical role of Msi2 in maintaining fiber type composition and metabolism.
Article
Biochemistry & Molecular Biology
Ravi Gor, Shruthi Sanjitha Sampath, Lizha Mary Lazer, Satish Ramalingam
Summary: This study is the first to demonstrate the role of PUM1 in colon cancer development, showing its high expression in colon cancer cells and its promotion of proliferation, migration, and colony formation. PUM1 overexpression also leads to an increase in spheroid size and number, indicating its involvement in maintaining cancer stem cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Medicine, General & Internal
Zhangfu Li, Jiangbei Yuan, Qingen Da, Zilong Yan, Jianhua Qu, Dan Li, Xu Liu, Qimin Zhan, Jikui Liu
Summary: This study identified proteome-wide CCAT1 partners using RAP-MS method, revealing Vimentin as one of the CCAT1 binding proteins involved in the tumor metastasis pathway. Knockdown of Vimentin and rescue of downregulation by overexpressing CCAT1 indicated that CCAT1 could enhance tumor migration and invasion abilities by stabilizing Vimentin protein.
CHINESE MEDICAL JOURNAL
(2023)
Article
Cell Biology
Yeongji Yu, Hyejin Kim, SeokGyeong Choi, JinSuh Yu, Joo Yeon Lee, Hani Lee, Sukjoon Yoon, Woo-Young Kim
Summary: The study suggests that targeting stearoyl-CoA desaturase 1 (SCD1) may selectively eliminate cancer stem cells (CSCs) in colon cancer by inducing apoptosis and affecting the survival ability of CSCs through specific signaling pathways. The suppression effect of SCD1 inhibition on CSCs is primarily mediated by the downregulation of Notch and Wnt signaling genes, indicating the potential of targeting SCD1 in clinical settings for colon cancer treatment.
Article
Oncology
Fabian M. Troschel, Heike Palenta, Katrin Borrmann, Kristin Heshe, San Hue Hua, George W. Yip, Ludwig Kiesel, Hans Theodor Eich, Martin Gotte, Burkhard Greve
Summary: MSI-1 is a negative prognostic marker for disease-free and distant metastasis-free survival in breast cancer. Silencing MSI-1 downregulates proliferation while increasing apoptosis, and upregulates the anti-proliferation mediator p21, especially after irradiation. Combining MSI-1 silencing and irradiation reduces cancer cell survival, indicating potential synergistic effects.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Review
Oncology
Debashri Manna, Devanand Sarkar
Summary: Chemotherapy is a major treatment for cancers, but cancer cells often develop resistance through genetic and epigenetic alterations, allowing them to adapt to environmental stresses and treatment pressures. The oncogene AEG-1 plays a significant role in promoting tumorigenesis and chemoresistance in various cancers. Understanding the molecular mechanisms of AEG-1 could provide insights into overcoming chemoresistance in aggressive cancers.
Article
Cardiac & Cardiovascular Systems
Sandhya Singh, Aakash Gaur, Rakesh Kumar Sharma, Renu Kumari, Shakti Prakash, Sunaina Kumari, Ayushi Devendrasingh Chaudhary, Pankaj Prasun, Priyanka Pant, Hannah Hunkler, Thomas Thum, Kumaravelu Jagavelu, Pragya Bharati, Kashif Hanif, Pragya Chitkara, Shailesh Kumar, Kalyan Mitra, Shashi Kumar Gupta
Summary: This study confirmed the presence of Msi2 in the heart and found that it can induce cardiomyocyte hypertrophy and heart failure. It was also discovered that Msi2 causes mitochondrial dysfunction in the heart and identified Cluh and Smyd1 as its downstream targets.
BASIC RESEARCH IN CARDIOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Hao Liu, Ruirui Zhang, Dan Zhang, Chun Zhang, Zhuo Zhang, Xiujuan Fu, Yu Luo, Siwei Chen, Ailing Wu, Weiling Zeng, Kunyan Qu, Hao Zhang, Sijiao Wang, Houyin Shi
Summary: This study developed a RGD-decorated liposome for targeted delivery of (-)-Gosspol, which has inhibitory effects on various types of cancers. The liposome exhibited high drug loading efficiency, controlled particle size, sustained drug release, enhanced tumor targeting, and significant antitumor activity.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Multidisciplinary Sciences
Daichao Wu, Alexander Kolesnikov, Rui Yin, Johnathan D. Guest, Ragul Gowthaman, Anton Shmelev, Yana Serdyuk, Dmitry V. Dianov, Grigory A. Efimov, Brian G. Pierce, Roy A. Mariuzza
Summary: This study reveals the structural information of SARS-CoV-2-specific T-cell receptors (TCRs) bound to their peptide-MHC targets and explains the mechanisms behind their selection of specific germline genes and recognition of different variants. This has important implications for designing vaccines to elicit pan-coronavirus immunity.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Huiyong Ma, Tarsis Brust, Kevin J. Frankowski, Kimberly M. Lovell, Michael D. Cameron, Laura M. Bohn, Jeffrey Aube
Summary: This study focused on the modification of a sulfonamide-based KOR antagonist series, resulting in a 4-fold increase in potency compared to the lead compound. The improved analogue exhibited suitable brain levels and a shorter clearance time.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Khushboo Kapadia, Ashley E. Trojniak, Kenneth B. Guzman Rodriguez, Nicholas J. Klus, Coral Huntley, Peter McDonald, Anuradha Roy, Kevin J. Frankowski, Jeffrey Aube, Nancy A. Muma
Summary: By disrupting the binding of mutant huntingtin protein to calmodulin, small-molecule compounds have shown protective effects against cytotoxicity and normalized receptor-stimulated calcium release in cell and mouse models of Huntington's disease.
ACS CHEMICAL NEUROSCIENCE
(2022)
Review
Chemistry, Multidisciplinary
Hashim F. Motiwala, Ahlam M. Armaly, Jackson G. Cacioppo, Thomas C. Coombs, Kimberly R. K. Koehn, Verrill M. Norwood IV, Jeffrey Aube
Summary: HFIP is a polar solvent that is widely used in organic synthesis for stabilizing ionic species, transferring protons, and engaging in various intermolecular interactions.
Review
Pharmacology & Pharmacy
Ruirui Zhang, Hao Zhang, Houyin Shi, Dan Zhang, Zhuo Zhang, Hao Liu
Summary: Dihydromyricetin (DHM) is a natural flavonoid with various functions, and its development potential in pharmacy is great. However, it faces challenges such as low solubility, permeability, and stability. Although extensive research has been conducted, the transformation of DHM research results into market products is still insufficient.
Editorial Material
Gastroenterology & Hepatology
Kristi L. Neufeld
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ruirui Zhang, Houyin Shi, Sifang Li, Hao Zhang, Dan Zhang, Ailing Wu, Chun Zhang, Chunhong Li, Xiujuan Fu, Siwei Chen, Jiaoyue Shi, Yang Tian, Sihan Wang, Yu Wang, Hao Liu
Summary: This study developed a gastric floating tablet with a double-layered structure for controlled release of dihydromyricetin (DHM). The tablet showed high drug release rate, good floating ability, and prolonged retention time in the stomach. It also enhanced the bioavailability of DHM and exhibited potent and long-term therapeutic effects on systemic inflammation in rabbits.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Editorial Material
Chemistry, Medicinal
Jeffrey Aube, Craig W. Lindsley, Christa E. Mueller
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Medicine, Research & Experimental
Fei Du, Lu-han Yang, Jiao Liu, Jian Wang, Lianpeng Fan, Suwit Duangmano, Hao Liu, Minghua Liu, Jun Wang, Xiaolin Zhong, Zhuo Zhang, Fang Wang
Summary: Malignant melanoma is a common tumor with high mortality rate. Immunotherapy combined with other treatment strategies is currently the mainstay of treatment for melanoma, but immune checkpoint inhibitors may not be effective in clinical treatment. This review comprehensively summarizes the role of mitochondria in melanoma, including its function in tumor cells and changes in mitochondrial function in melanoma resistant to PD-1 inhibitors, aiming to develop therapeutic strategies for improving the clinical response rate and patient survival.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Plant Sciences
Qian Zhang, Xiujuan Fu, Hao Liu, Yangxi Chen, Siwei Chen, Hong Niu, Yu Luo, Hui Lei, Dan Zhang
Summary: This paper provides a systematic summary of the research on Dendrobium nobile Lindl (DNL) from 1935 to 2022, including its botanical characteristics, chemical composition, pharmacological activity, and toxicology. The stems of DNL contain alkaloids, polysaccharides, sesquiterpenes, Phenanthrenes, benzenes and other chemical components, with alkaloids and polysaccharides identified as the main active constituents. Extracts from DNL have shown various pharmacological activities, such as anti-tumor, blood sugar reduction, nerve protection, immune enhancement, anti-inflammation, and anti-aging.
PHYTOCHEMISTRY REVIEWS
(2023)
Editorial Material
Chemistry, Medicinal
Jeffrey Aube, Craig W. Lindsley, Christa E. Mueller
ACS MEDICINAL CHEMISTRY LETTERS
(2023)
Editorial Material
Chemistry, Medicinal
Jeffrey Aube, Craig W. Lindsley, Christa E. Mueller
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2023)
Article
Immunology
Juan Carlos Lopez-Rodriguez, Steven J. Hancock, Kelin Li, Stefania Crotta, Christopher Barrington, Alejandro Suarez-Bonnet, Simon L. Priestnall, Jeffrey Aube, Andreas Wack, Paul Klenerman, Jose A. Bengoechea, Patricia Barral
Summary: Mucosal-associated invariant T (MAIT) cells in the lungs are important for host defense against infections. This study demonstrates that MAIT cell activation during bacterial pneumonia caused by Klebsiella pneumoniae is independent of MR1 and driven by type I interferons (IFNs). Type I IFNs stimulate the activation and effector functions of MAIT cells and play a central role in their response to Klebsiella infection. This finding suggests that targeting type I IFNs could be a strategy to manipulate MAIT cell functions during bacterial infections.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Oncology
Lanjing Wei, Qi Zhang, Cuncong Zhong, Lily He, Yuxia Zhang, Ahlam M. M. Armaly, Jeffrey Aube, Danny R. R. Welch, Liang Xu, Xiaoqing Wu
Summary: Chemotherapy is the standard treatment for TNBC, but chemoresistance limits its efficacy. The RNA-binding protein HuR could be targeted to enhance chemotherapy efficacy. In this study, a docetaxel-resistant TNBC cell subline was established, and the HuR inhibitor KH-3 synergistically inhibited cell proliferation and tumor growth in combination with docetaxel, downregulated HuR targets, restored docetaxel's effects, induced apoptotic cell death and caused cell cycle arrest.
MOLECULAR ONCOLOGY
(2023)
Article
Oncology
Andra S. Martinikova, Miroslav Stoyanov, Anna Oravetzova, Yannick P. Kok, Shibo Yu, Jana Dobrovolna, Pavel Janscak, Marcel van Vugt, Libor Macurek
Summary: Oncogene-induced replication stress is a major cause of genome instability in cancer cells. This study reveals that increased activity of PPM1D exacerbates replication stress caused by cyclin E1 overexpression, leading to abnormal cell cycle progression and accumulation of DNA copy number alterations. Pharmacological inhibition of PPM1D can alleviate replication stress-induced genome instability.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Alamelu G. Bharadwaj, Meghan E. McLean, Margaret L. Dahn, Hannah F. Cahill, Marie-Claire D. Wasson, Raj Pranap Arun, Olivia L. Walker, Brianne M. Cruickshank, Wasundara Fernando, Jaganathan Venkatesh, Penelope J. Barnes, Gillian Bethune, Gregory Knapp, Lucy K. Helyer, Carman A. Giacomantonio, David M. Waisman, Paola Marcato
Summary: ALDH1A3 regulates the plasminogen activation pathway to promote breast cancer metastasis. Co-expression of ALDH1A3 and tPA is associated with TNBC subtype, high tumor grade, and recurrent metastatic disease.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Nayela N. Chowdhury, Yi Yang, Ananya Dutta, Michelle Luo, Zimu Wei, Sara R. Abrahams, Alexey S. Revenko, Fenil Shah, Lindsey A. Miles, Robert J. Parmer, Bas de Laat, Alisa S. Wolberg, James P. Luyendyk, Melissa L. Fishel, Matthew J. Flick
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal metastatic disease associated with robust activation of the coagulation and fibrinolytic systems. Primary fibrinolytic protease plasminogen promotes PDAC tumor growth and metastatic potential through engaging plasminogen receptors on tumor cells.
MOLECULAR ONCOLOGY
(2024)
Article
Oncology
Nuria Gendrau-Sanclemente, Agnes Figueras, Kristina Gracova, Alvaro Lahiguera, Elisenda Alsina-Sanchis, Juan A. Marin-Jimenez, August Vidal, Xavier Matias-Guiu, Sergi Fernandez-Gonzalez, Marc Barahona, Lola Marti, Jordi Ponce, Francesc Vinals
Summary: High-grade serous ovarian cancer (HGSOC), the deadliest gynecological malignancy, spreads through transcoelomic dissemination. This study reveals that platelet-derived growth factor receptor beta (PDGFRβ) is essential for the formation of tumorspheres in HGSOC. Inhibition of PDGFRβ blocks the clustering of ovarian cancer cells and prevents peritoneal dissemination.
MOLECULAR ONCOLOGY
(2024)