Article
Neurosciences
Kelsey Barcomb, Christopher P. Ford
Summary: This review summarizes the previous work on the changes in neurotransmitter co-release and circuit dysfunction associated with the degeneration of midbrain dopamine neurons in Parkinson's disease.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Cell Biology
Jie Zhao, Manish Kumar, Jeevan Sharma, Zhihai Yuan
Summary: Arbutin may improve the performance of PD mouse models by inhibiting the function of the A(2A)R and enhancing the effects of cyclic adenosine monophosphate.
NEURAL REGENERATION RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Wen Jiang, Yu Jiang, Xinghai Zhang, Hongli Mu, Yuanming Song, Hengli Zhao
Summary: This study characterized the function of HMBOX1 in cell proliferation by comparing the metabolic profiles of HMBOX1-overexpressed RAW264.7 cells to those of the controls. The results showed that HMBOX1 inhibited macrophage proliferation through regulation of glutamine transportation. These findings provide a new direction for therapeutic interventions in macrophage-related inflammatory diseases.
Article
Neurosciences
Peter A. LeWitt, Jia Li, Kuan-Han Wu, Mei Lu
Summary: Comprehensive metabolomic profiling of biochemicals in CSF and serum identified diagnostic biomarkers for Parkinson's disease. Twenty-one CSF compounds showed significantly different concentrations between PD and healthy controls. Logistic LASSO regression selected 23 biochemicals that accurately distinguished PD from controls with high sensitivity and specificity. This study provides further evidence for the involvement of polyamine pathways in the neurodegeneration of PD.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Nicola D'Ascenzo, Emanuele Antonecchia, Antonella Angiolillo, Victor Bender, Marco Camerlenghi, Qingguo Xie, Alfonso Di Costanzo
Summary: This study identified PD blood metabolites and metabolic pathways significantly correlated with age, and proposed a personalized age-dependent approach to early PD diagnosis.
CELL AND BIOSCIENCE
(2022)
Article
Plant Sciences
Chengyan Long, Yang Yang, Yunhong Wang, Xiaomei Zhang, Li Zhang, Sixing Huang, Dajian Yang, Xingfang Qiao, Yong Yang, Yanlei Guo
Summary: The study demonstrated that THH extract showed beneficial effects on rheumatoid arthritis in a rat model, improving body weight, reducing joint damage, and modulating immune responses. Metabolomics analysis identified important metabolic pathways affected by THHE administration, suggesting potential targets for therapy development.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Neurosciences
F. Campanelli, G. Natale, G. Marino, V. Ghiglieri, P. Calabresi
Summary: This paper provides an overview of the critical mechanism of glutamatergic hyperactivity in the early and advanced stages of Parkinson's disease. Synaptic dysfunction is the primary target in the early stages of the disease, leading to alterations in other neurotransmitter systems and persistent modifications that generate movement disorders.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Cell Biology
Yang Liu, Lei Cao, Yuting Song, Zhengwei Kang, Ting Liu, Jianhua Ding, Gang Hu, Ming Lu
Summary: SLC1A5_var plays a positive regulatory role in Parkinson's disease, improving PD-like motor symptoms and protecting dopaminergic neurons through maintaining mitochondrial energy metabolism. Additionally, SLC1A5_var inhibits astrocyte reactivity and the secretion of inflammatory cytokines to suppress neuroinflammation.
CELL DEATH & DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Min-Ho Nam, Moonsun Sa, Yeon Ha Ju, Mingu Gordon Park, C. Justin Lee
Summary: This study shows that in Parkinson's disease, MAOB is involved in the aberrant synthesis of GABA and H2O2 in reactive astrocytes, leading to gradual damage and death of dopaminergic neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Bradley M. Roberts, Emanuel F. Lopes, Stephanie J. Cragg
Summary: Striatal dopamine release is inhibited by striatal gamma-aminobutyric acid (GABA) acting via GABA(A) and GABA(B) receptors, which is regulated by plasma membrane GABA uptake transporters on striatal astrocytes. The regulation of striatal GABA-DA interactions serves as a potential therapeutic target for psychomotor disorders associated with dysregulated DA signaling.
Review
Clinical Neurology
Paolo Calabresi, Giulia Di Lazzaro, Gioia Marino, Federica Campanelli, Veronica Ghiglieri
Summary: The critical role of alpha-synuclein in Parkinson's disease has been discovered, but current treatments still face challenges. Developing cellular and animal models helps understand the physiological and pathological functions of alpha-synuclein, as well as the pathogenesis of Parkinson's disease.
Article
Clinical Neurology
Andrea Guerra, Donato Colella, Margherita Giangrosso, Antonio Cannavacciuolo, Giulia Paparella, Giovanni Fabbrini, Antonio Suppa, Alfredo Berardelli, Matteo Bologna
Summary: In this study, the authors found that abnormal beta and gamma oscillations in the basal ganglia are related to bradykinesia in patients with Parkinson's disease. Transcranial alternating current stimulation (tACS) can modulate cortical rhythms and was found to affect movement speed and amplitude in this study. Changes in inhibitory interneuronal activity may reflect compensatory mechanisms in the primary motor cortex (M1) to counteract bradykinesia.
Article
Neurosciences
Chao Wang, Cheng Zhou, Tao Guo, Yeerfan Jiaerken, Siyu Yang, Peiyu Huang, Xiaojun Xu, Minming Zhang
Summary: This study found that chronic coffee consumption is associated with a decrease in striatal volume in patients with Parkinson's disease, but the effects may diminish or compensate after quitting coffee.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Andreas-Antonios Roussakis, Zhou Zeng, Nicholas P. Lao-Kaim, Antonio Martin-Bastida, Paola Piccini
Summary: The study found that in moderate-stage Parkinson's disease, asymmetry in striatal dopaminergic degeneration becomes less prominent over time, while the asymmetry of motor symptoms remains consistent between the clinically most and least affected body sides.
JOURNAL OF NEUROLOGY
(2021)
Article
Medicine, General & Internal
Chao Wang, Cheng Zhou, Tao Guo, Yeerfan Jiaerken, Siyu Yang, Xiaopei Xu, Ling Hu, Peiyu Huang, Xiaojun Xu, Minming Zhang
Summary: This study found that current coffee consumption is associated with decreased striatal dopamine transporter availability in the caudate. However, the effects of caffeine on dopamine transporter may fade and disappear after quitting coffee consumption.
Article
Food Science & Technology
Lingling Jiang, Linlin Pan, Hongchang Gao, Hong Zheng
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2020)
Article
Food Science & Technology
Jie Feng, Lingling Jiang, Jialei Zhang, Hong Zheng, Yanfang Sun, Shaoning Chen, Meilan Yu, Wei Hu, Defa Shi, Xiaohong Sun, Hongfei Lu
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2020)
Article
Biochemistry & Molecular Biology
Pengtao Xu, Jie Ning, Qiaoying Jiang, Chen Li, Junjie Yan, Liangcai Zhao, Hongchang Gao, Hong Zheng
Summary: Metabolic alterations in specific brain regions of T1D mice may serve as potential biomarkers for early diagnosis and monitoring of diabetic cognitive decline.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Biochemical Research Methods
Yi Zhou, Chen Li, Xinyi Wang, Pengxi Deng, Wenting He, Hong Zheng, Liangcai Zhao, Hongchang Gao
Summary: This study found that female mice upregulated levels of FGFR1, FGFR2, and beta-klotho to alleviate FGF21 resistance induced by a high-fat diet. The metabolic patterns of male mice fed a high-fat diet were significantly different from those of female mice on a high-fat diet and the normal diet group. Low-density lipoprotein/very low density lipoprotein and betaine levels were associated with the resistance of female mice to the high-fat diet. These findings suggest that sex-based metabolic differences and susceptibility to obesity may be mediated by the FGF21 signaling pathway.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Biochemical Research Methods
Pengxi Deng, Yi Zhou, Xinyi Wang, Kaifan Tang, Haowei Jiang, Wenting He, Hong Zheng, Liangcai Zhao, Hongchang Gao, Chen Li
Summary: The study showed that bFGF treatment significantly restored intestinal barrier function and reduced inflammatory infiltration in the cecum. Metabolomic results indicated that bFGF remodeled metabolic patterns in the colon, cecum, and small intestine of db/db mice, including energy metabolism, short chain fatty acid metabolism, amino acid metabolism, and choline metabolism.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yafei Zheng, Qingqing Xu, Qihao Jin, Yao Du, Junjie Yan, Hongchang Gao, Hong Zheng
Summary: In this study, the urinary and faecal metabolic profiles in APP/PS1 mice were investigated, revealing disrupted metabolic phenotypes and potential biomarkers at earlier stage of AD.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Yinli Huang, Wei Dong, Minjie Lin, Hongchang Gao, Hong Zheng
Summary: This study investigated the impact of bFGF on heart metabolism in streptozotocin-induced diabetic rats and found that bFGF can effectively attenuate myocardial fibrosis and metabolic disorders, mainly involving amino acid metabolism and energy metabolism.
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
(2023)
Review
Biochemistry & Molecular Biology
Yinli Huang, Jiahui Lu, Qihui Zhao, Junli Chen, Wei Dong, Minjie Lin, Hong Zheng
Summary: This review discusses the application of NMR-based metabolomics in diabetic therapy using traditional Chinese medicine (TCM), providing insights into the metabolic mechanisms affected by TCM treatment.
Article
Biochemical Research Methods
Na Ying, Hanqi Luo, Baixia Li, Kaiyan Gong, Fei Liang, Hongchang Gao, Tao Huang, Hong Zheng
Summary: Exercise, including high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT), can improve behavioral and cognitive impairments in Alzheimer's disease (AD) mice. Metabolomics analysis reveals significant changes in energy metabolism, neurotransmitter metabolism, and membrane metabolism in multiple brain regions after both types of exercises. HIIT also alters astrocyte-neuron metabolism in the hippocampus and hypothalamus of AD mice. These findings suggest that exercise can modulate brain metabolism in a region- and exercise-specific manner, potentially providing a novel approach for the prevention and treatment of AD.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yinli Huang, Na Ying, Qihui Zhao, Junli Chen, Sin-Yeang Teow, Wei Dong, Minjie Lin, Lingling Jiang, Hong Zheng
Summary: The study investigates the causal relationship between gut microbiota and the beneficial effect of inulin on obesity-related disorders. Inulin supplementation can reduce body weight, fat accumulation, inflammation, and improve glucose metabolism in obese mice. The effects of inulin can be partially transferred by fecal microbiota transplantation, suggesting that Bifidobacterium and Muribaculum may play a key role.
Article
Biochemistry & Molecular Biology
Qihui Zhao, Junli Chen, Mengjun Wu, Xiaoli Yin, Qiaoying Jiang, Hongchang Gao, Hong Zheng
Summary: Diabetic cognitive decline is closely related to gut microbial disorders. This study transplanted gut microbiota from healthy mice into type 1 diabetic mice and found that fecal microbiota transplantation effectively improved cognitive function and reduced neuroinflammation and neuronal injury. The study also showed that glutamate metabolism played a key role in the gut-brain axis and cognitive functions.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Chen Li, Yi Zhou, Yan Niu, Wenting He, Xinyi Wang, Xi Zhang, Yali Wu, Wenli Zhang, Liangcai Zhao, Hong Zheng, Weihong Song, Hongchang Gao
Summary: 3-Phosphoinositide-dependent protein kinase-1 (Pdk1) plays a critical role in multiple signaling pathways. The expression of Pdk1 is downregulated in patients with heart diseases. Deficiency of Pdk1 leads to apoptosis, oxidative damage, and disturbed metabolism.
Correction
Endocrinology & Metabolism
Yinli Huang, Wei Dong, Minjie Lin, Hongchang Gao, Hong Zheng
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
(2023)
Article
Endocrinology & Metabolism
Yinli Huang, Junli Chen, Jiahui Lu, Hanqi Luo, Na Ying, Wei Dong, Minjie Lin, Hong Zheng
Summary: High blood sugar has long-term effects on hippocampal metabolic changes in rats, mainly involving neurotransmitter metabolism and choline metabolism.
METABOLIC BRAIN DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Kaiyan Gong, Junli Chen, Xiaoli Yin, Mengjun Wu, Hong Zheng, Lingling Jiang
Summary: This study analyzed the metabolic changes in different intestinal segments of type 1 diabetic mice using metabolomics. The findings revealed segment-specific metabolic disorders, with disrupted amino acid metabolism in the jejunum and disrupted fatty acid metabolism in the ileum, cecum, and colon.