Loss of Presenilin 2 Function Is Associated with Defective LPS-Mediated Innate Immune Responsiveness

Increased Inflammatory Response Both in Brain and in Periphery in Presenilin 1 and Presenilin 2 Conditional Double Knock-Out Mice

(2017) Xu Jiang et al.   JOURNAL OF ALZHEIMERS DISEASE

A fast growing spectrum of biological functions of γ-secretase in development and disease

(2013) Nathalie Jurisch-Yaksi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Presenilins are novel substrates for TRAF6-mediated ubiquitination

(2013) Run Yan et al.   CELLULAR SIGNALLING

Processive proteolysis by γ-secretase and the mechanism of Alzheimer’s disease

(2012) Michael S. Wolfe   BIOLOGICAL CHEMISTRY

Intraperitoneal injection of JNK-specific inhibitor SP600125 inhibits the expression of presenilin-1 and Notch signaling in mouse brain without induction of apoptosis

(2012) Moshiur Rahman et al.   BRAIN RESEARCH

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

(2012) Lucía Chávez-Gutiérrez et al.   EMBO JOURNAL

Nuclear Factor-κB Regulates βAPP and β- and γ-Secretases Differently at Physiological and Supraphysiological Aβ Concentrations

(2012) Linda Chami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer's Disease: Presenilin 2-Sparing  -Secretase Inhibition Is a Tolerable A  Peptide-Lowering Strategy

(2012) T. Borgegard et al.   JOURNAL OF NEUROSCIENCE

Therapeutic approaches to modulating Notch signaling: Current challenges and future prospects

(2012) Casper Groth et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

γ-Secretase inhibitors and modulators for Alzheimer’s disease

(2011) Michael S. Wolfe   JOURNAL OF NEUROCHEMISTRY

A Presenilin-1 Mutation Identified in Familial Alzheimer Disease with Cotton Wool Plaques Causes a Nearly Complete Loss of γ-Secretase Activity

(2010) Elizabeth A. Heilig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Presenilin 2 Is the Predominant γ-Secretase in Microglia and Modulates Cytokine Release

(2010) Suman Jayadev et al.   PLoS One

 -Secretase and Human Disease

(2010) R. J. Kelleher et al.   SCIENCE

ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by γ-secretase

(2009) Athena Chalaris et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Presenilin-dependent regulated intramembrane proteolysis and γ-secretase activity

(2009) J. V. McCarthy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Recent Advances in the Identification of γ-Secretase Inhibitors To Clinically Test the Aβ Oligomer Hypothesis of Alzheimer’s Disease

(2009) Anthony F. Kreft et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of basal activity of c-jun-NH2-terminal kinase (JNK) represses the expression of presenilin-1 by a p53-dependent mechanism

(2008) Sebum Lee et al.   BRAIN RESEARCH

Interleukin-1 Receptor Type 1 Is a Substrate for γ-Secretase-dependent Regulated Intramembrane Proteolysis

(2008) Baukje M. Elzinga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor Necrosis Factor-α–elicited Stimulation of γ-Secretase Is Mediated by c-Jun N-terminal Kinase-dependent Phosphorylation of Presenilin and Nicastrin

(2008) Lan-Hsin Kuo et al.   MOLECULAR BIOLOGY OF THE CELL

Presenilins: Members of the γ-Secretase Quartets, But Part-Time Soloists Too

(2008) Tomoko Wakabayashi et al.   PHYSIOLOGY

Defective signal transduction in B lymphocytes lacking presenilin proteins

(2008) T. Yagi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Secretase Limits the Inflammatory Response Through the Processing of LRP1

(2008) K. Zurhove et al.   Science Signaling

Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein

(2008) Ting Yang et al.   Molecular Brain

Proteomic Profiling of γ-Secretase Substrates and Mapping of Substrate Requirements

(2008) Matthew L Hemming et al.   PLOS BIOLOGY

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

(2003) H. F. Dovey et al.   JOURNAL OF NEUROCHEMISTRY