Article
Pharmacology & Pharmacy
Xuan Zhai, Lu-sheng Li, Yu-dong Zhou, Wen-yuan Ji, Hui Chen, Han Xiao, Ping Liang
Summary: The study revealed that EZH2 expression is increased in glioblastoma multiforme (GBM) cells, and knockdown of EZH2 can suppress cell proliferation and migration while enhancing sensitivity to TMZ. Additionally, EZH2 positively regulates mRNA stability of Twist1, contributing to the malignancy of GBM cells.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Immunology
Zehua Ye, Yuqi Xia, Xiangjun Zhou, Bojun Li, Weimin Yu, Yuan Ruan, Haoyong Li, JinZhuo Ning, Lijia Chen, Ting Rao, Fan Cheng
Summary: This study aimed to investigate the role and mechanism of CXCR4 in calcium oxalate (CaOx) crystal deposition-induced renal fibrosis. The results showed that inhibition of CXCR4 could attenuate CaOx crystal-induced renal fibrosis and suppress autophagy and EMT pathways. Therefore, CXCR4 may be a potential target for preventing renal fibrosis in patients with nephrolithiasis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Oncology
Zhaotao Wang, Yongping Li, Minyi Liu, Danmin Chen, Jiajie Lu, Yunxiang Ji, Zhou Xing, Yezhong Wang
Summary: The study demonstrates that 3BDO can suppress the progression and growth of GBM both in vitro and in vivo by downregulating survivin-mediated stemness and EMT.
Article
Medicine, Research & Experimental
Na Young Kim, In Jin Ha, Jae-Young Um, Alan Prem Kumar, Gautam Sethi, Kwang Seok Ahn
Summary: This study found that LGA can effectively inhibit the proliferation, invasive ability, and migration of hepatocellular carcinoma cells, and reduce the occurrence of EMT by suppressing MnSOD expression. This has important implications for the development of novel anti-metastatic agents.
Article
Cell Biology
Min Hee Yang, In Jin Ha, Jeongjun Ahn, Chang-Kwon Kim, Mina Lee, Kwang Seok Ahn
Summary: Loliolide (LL), a natural compound isolated from Vicia tenuifolia Roth, exhibits various pharmacological effects and can suppress the expression of CXCR4 and CXCR7, the stimulation of CXCL12, the expression of MnSOD and mesenchymal markers, while inducing the expression of epithelial markers. LL also significantly inhibits cellular invasion, migration, and metastasis in colon and breast cancer cells.
CELLULAR SIGNALLING
(2023)
Article
Oncology
Tiantian Yin, Jing Wu, Yuchen Hu, Min Zhang, Jie He
Summary: This study revealed that lncRNA HULC stimulates the EMT process and VM in human GBM, suggesting it may be a potential therapeutic target for intervention in GBM.
Article
Oncology
Zhi Liu, Zhaotao Wang, Danmin Chen, Xiaorui Liu, Guoyong Yu, Yan Zhang, Chen Chen, Ruxiang Xu, Yezhong Wang, Ru-en Liu
Summary: This study investigated the mechanisms of paeoniflorin in inhibiting epithelial-to-mesenchymal transition (EMT) and angiogenesis in glioblastoma. The research found that paeoniflorin inhibited EMT by downregulating c-Met signaling in glioblastoma cells and displayed anti-angiogenic effects by suppressing cell proliferation, migration, invasion, and tube formation through downregulating c-Met in human umbilical vein endothelial cells (HUVECs). Furthermore, paeoniflorin induced autophagy activation and promoted c-Met autophagic degradation via K63-linked c-Met polyubiquitination. These findings suggest that paeoniflorin inhibits EMT and angiogenesis through K63-linked c-Met polyubiquitination-dependent autophagic degradation in human glioblastoma.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Omaima A. Ahmedy, Marwa W. Kamel, Dalia M. Abouelfadl, Marwa E. Shabana, Rabab H. Sayed
Summary: This study discovered the protective effects of berberine in bleomycin-induced pulmonary fibrosis in mice, and its mechanism involved the activation of adenosine A2a receptor and suppression of SDF-1/CXCR4 signaling pathway. Berberine improved lung fibrosis by modulating the purinergic system, inhibiting epithelial mesenchymal transition, and effectively suppressing inflammation and oxidative stress.
Article
Immunology
Hong Chen, Bo Liang, Xiaolin Luo, Wenyu Zhang, Xiong Song, Hailin Lan, Qiuyuan Yue, Jingdun Xie, Mingwei Zhang
Summary: This study comprehensively analyzed the potential function of IKBIP in glioblastoma multiforme (GBM) and found that high IKBIP levels were associated with poor patient survival. Three prognostic models were established and validated, and IKBIP was identified as an independent prognostic factor. Further analysis revealed the involvement of immune cells and related pathways in the high-risk group. Molecular biology experiments validated the inhibitory effect of IKBIP knockdown on cell invasion and proliferation, and its promotion of cell senescence.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Xu Xu, Yunan Hou, Niya Long, Lishi Jiang, Zhangwei Yan, Yuan Xu, Ying Lv, Xin Xiang, Hua Yang, Jian Liu, Xiaolan Qi, Liangzhao Chu
Summary: This study found that the expression of TPPP3 is higher in glioma compared to normal brain tissue, and increases with the grade of glioma. Up-regulation of TPPP3 enhances migration, invasion, and proliferation abilities, while reducing apoptosis in glioblastoma cells. TPPP3 also affects the process of EMT by regulating the expression of Snail1 protein. Low TPPP3 expression is associated with better survival expectations in glioblastoma patients. This study provides new insights and directions for further research on the role of TPPP3 in glioblastoma.
SCIENTIFIC REPORTS
(2023)
Review
Genetics & Heredity
Botle Precious Setlai, Rodney Hull, Rui Manuel Reis, Cyril Agbor, Melvin Anyasi Ambele, Thanyani Victor Mulaudzi, Zodwa Dlamini
Summary: MicroRNAs (miRNA) are small non-coding RNAs that regulate oncogenes or tumor suppressor genes by suppressing gene translation or promoting mRNA translation into proteins. Circulating miRNAs can serve as prognostic markers for cancer, aiding in early detection. miRNA-related EMT can be targeted for therapeutic purposes in glioblastomas.
Article
Oncology
Alja Zottel, Metka Novak, Neja Samec, Bernarda Majc, Sara Colja, Mojca Katrasnik, Milos Vittori, Barbara Hrastar, Ana Rotter, Andrej Porcnik, Tamara Lah Turnsek, Radovan Komel, Barbara Breznik, Ivana Jovcevska
Summary: This study investigated the effect of anti-vimentin nanobody Nb79 on glioblastoma cell invasion. The results showed that vimentin is upregulated in glioblastoma tissue and Nb79 can reduce glioblastoma cell invasion. In addition, Nb79 treatment increases the expression of tight junction protein ZO-1 on the cell membrane.
Article
Medicine, Research & Experimental
Yi-Pin Lin, You-Cheng Hseu, Varadharajan Thiyagarajan, Chithravel Vadivalagan, Sudhir Pandey, Kai-Yuan Lin, Yuan-Tai Hsu, Jiunn-Wang Liao, Chuan-Chen Lee, Hsin-Ling Yang
Summary: This study investigated the anticancer activities of Antrodia salmonea (AS) on human glioblastoma cells and discovered that AS can retard growth, suppress colony formation, attenuate epithelial-mesenchymal transition (EMT), induce apoptosis and autophagy, and inhibit the PI3K/AKT/mTOR signaling pathway. AS also reduced tumor burden in xenografted nude mice. These findings suggest that AS has the potential to be an effective antitumor agent in human glioblastoma treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Na Young Kim, Young Yun Jung, Min Hee Yang, Jae-Young Um, Gautam Sethi, Kwang Seok Ahn
Summary: This study found that IIPT derived from Angelica dahurica can potentially function as a novel anti-metastatic agent by inhibiting EMT and metastasis process via inhibition of NF-kappa B activation and CXCR4 expression.
CELLULAR SIGNALLING
(2022)
Article
Chemistry, Multidisciplinary
Hsin-Tzu Hsieh, Hsi-Chien Huang, Chieh-Wei Chung, Cheng-Chin Chiang, Tiffaney Hsia, Hsin-Fang Wu, Rui-Lin Huang, Chi-Shiun Chiang, Jane Wang, Tsai-Te Lu, Yunching Chen
Summary: The study presents an immunotherapeutic approach using CXCR4-targeted lipid-calcium-phosphate nanoparticles for the treatment of glioblastoma multiforme (GBM). By delivering nitric oxide (NO), the approach enhances blood-brain barrier permeability and improves the delivery of siRNA against the immune checkpoint ligand PD-L1 to GBM tumors. This results in increased infiltration and activation of cytotoxic T cells, suppressing GBM progression.
JOURNAL OF CONTROLLED RELEASE
(2022)