Article
Reproductive Biology
Bin Liu, Yongjie Liu, Shuman Li, Pingping Chen, Jun Zhang, Liping Feng
Summary: This study investigated the reproductive outcomes of BDNF treatment and potential mechanisms in aged mice. The results showed that BDNF treatment could improve ovarian function and fertility in aged mice by promoting ovarian cell proliferation and activating the TrkB and cyclin D1-creb signaling pathways. Therefore, targeting the BDNF-TrkB signaling pathway may be a potential novel therapeutic strategy to reverse ovarian aging.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Food Science & Technology
Lan Tang, Shengnan Li, Jie Yu, Yujie Zhang, Lilin Yang, Dayan Tong, Jie Xu
Summary: This study found that chronic exposure to nonylphenol (NP) can increase anxiety behavior in rats and reduce the expression of key proteins/genes in the BDNF/TrkB/CREB signaling network.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Saima Khatoon, Mohammed Samim, Mansi Dahalia, Nidhi
Summary: Fisetin has been found to improve cognitive function in mice with PTZ-induced kindling through modulation of oxidative stress markers, gene expressions, and neurotransmitter levels. These findings suggest a therapeutic potential of fisetin against cognitive dysfunction associated with PTZ-induced kindling.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Clinical Neurology
Samira S. Valvassori, Gustavo C. Dal-Pont, Roger B. Varela, Wilson R. Resende, Fernanda F. Gava, Franciele G. Mina, Josiane Budni, Joao Quevedo
Summary: The study demonstrated that ouabain affects the behavior and memory of rats, including increasing locomotion and exploration behavior, as well as reducing memory index and aversive memory. Moreover, ouabain induced alterations in the BDNF signaling pathway, which may be associated with memory impairment.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Environmental Sciences
Yi-Zhou Li, Zi-Yao Wu, Bi-Qi Zhu, Yu-Xiao Wang, Ya-Qi Kan, Huai-Cai Zeng
Summary: In this study, the role of the BDNF-TrkB-CREB signaling pathway in bisphenol S (BPS)-induced neurotoxicity was investigated. The results showed that BPS damaged the hippocampal ultrastructure and reduced the number of synapses in male mice. Additionally, BPS increased the methylation rate of BDNF promoter IV and altered the expression of various proteins involved in the pathway. These findings suggest that the BDNF-TrkB-CREB pathway may play a role in BPS-induced neurotoxicity through methylation regulation.
Article
Neurosciences
Jung-Eun Lee, So-Young Park, Pyung-Lim Han
Summary: Aging leads to alterations in gene expression in the hippocampus, affecting the ability to cope with stress in mice. Downregulation of SUV39H1 and subsequent changes in its signaling pathways may increase susceptibility to stress in aging individuals. Additionally, the phenolic compound rosmarinic acid shows promise in reversing stress-induced changes and producing antidepressant effects via a distinct mechanism from traditional antidepressants.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biology
Guillermo Moya-Alvarado, Reynaldo Tiburcio-Felix, Maria Raquel Ibanez, Alejandro A. Aguirre-Soto, Miguel Guerra, Chengbiao Wu, William C. Mobley, Eran Perlson, Francisca C. Bronfman
Summary: Brain-derived neurotrophic factor (BDNF) and its receptors, tropomyosin kinase receptor B (TrkB) and the p75 neurotrophin receptor (p75), play a crucial role in regulating dendritic growth in the central nervous system (CNS). Through axonal signaling, BDNF enhances dendritic growth from the neuronal cell body, mediated by cAMP response element-binding protein (CREB) and axonal TrkB activity. Dynein-dependent transport of BDNF-TrkB-containing endosomes is necessary for long-distance induction of dendritic growth. These axonal signaling endosomes coordinate the transcription and translation of genes involved in learning and memory regulation.
Article
Environmental Sciences
Rundong Liu, Lin Bai, Mengchen Liu, Ruike Wang, Yingying Wu, Qiong Li, Yue Ba, Huizhen Zhang, Guoyu Zhou, Fangfang Yu, Hui Huang
Summary: Lead and high-fat diets are co-occurring risk factors for cognitive impairment. This study found that combined exposure to lead and high-fat diets exacerbates cognitive deficits and affects synaptic plasticity through multiple signaling pathways. The study highlights the importance of evaluating the effects of mixed exposures on brain function in realistic environments and the need to modulate central pathways to prevent neurological disorders.
ENVIRONMENTAL POLLUTION
(2022)
Article
Plant Sciences
Wen-Kai Wang, Yuan Zhou, Lu Fan, Yue Sun, Fan Ge, Mei Xue
Summary: The study demonstrates that the TCM formula DBD effectively improves glucose tolerance in DD rats and alleviates depression-like behavior. DBD exerts antidepressant-like effects by regulating the CREB/BDNF/TrkB pathway to protect and remodel hippocampal neurons. Additionally, the main active component, ferulic acid (FA), significantly contributes to the treatment effects of DBD.
Article
Behavioral Sciences
Tao Tong, Yiping Chen, Chonyao Hao, Junliang Shen, Wenjie Chen, Wenjing Cheng, Simin Yan, Jianguo Li, Yuhan Li, Tuergong Gulizhaerkezi, Jingyu Zeng, Xianjun Meng
Summary: This study aimed to explore the potential mechanism of the antidepressant effect of acupuncture. The results showed that acupuncture therapy can improve behavioral deficits, increase serum levels of 5-hydroxytryptamine and FNDC5/IRISIN, and reduce the impact of CUMS on pro-BDNF. Both acupuncture and fluoxetine can improve the %area of IBA-1, GFAP, BrdU, and DCX in LHb, as well as increase the expression of BDNF/TrkB/CREB. These findings suggest that acupuncture therapy may relieve depression-related manifestations through the BDNF/TrkB/CREB pathway in LHb.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Jing Wang, Yichen Cai, Jingyi Sun, Hua Feng, Xiaoyu Zhu, Qian Chen, Feng Gao, Qingbin Ni, Leilei Mao, Mingfeng Yang, Baoliang Sun
Summary: In this study, non-invasive treatment methods using AAV vectors carrying BDNF or TrkB genes were performed on stroke-injured rats. The combination therapy significantly improved upper limb motor functional recovery and neurotransmission efficiency, promoting axonal remodeling and restoration of synaptic structures.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mostafa A. Rabie, Heba I. Ibrahim, Noha N. Nassar, Reham M. Atef
Summary: Huntington's disease (HD) is a neurodegenerative disease characterized by progressive impairment in motor, behavioral, and cognitive functions. This study investigated the protective effects of the adenosine A1 receptor agonist CHA in an HD-like rat model induced by 3-nitropropionic acid (3NP). The results showed that CHA attenuated neuronal death, improved cognitive and motor deficits, and reduced inflammatory and oxidative stress markers. These effects were associated with the activation of the PI3K/Akt/CREB/BDNF pathway and a decrease in astrocyte and microglia activation. Overall, CHA may have a protective effect against HD by modulating oxidative stress, excitotoxicity, and inflammatory pathways.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Xulan Zhang, Lu Ni, Shanshan Hu, Bowen Yue, Xiaochun Chen, Ding Yuan, Ting Wang, Zhiyong Zhou
Summary: This study found that administration of polygonatum sibiricum (PS) effectively improves cognitive function and enhances synaptic plasticity in aging rats by regulating the BDNF-TrkB signaling pathway. PS has the potential to be developed as a functional food for improving neurological function and anti-aging.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Neurosciences
Pingping Tan, Ting Xue, Yue Wang, Zhichao Hu, Jianbin Su, Rongrong Yang, Jianlin Ji, Minxiu Ye, Zhuo Chen, Chao Huang, Xu Lu
Summary: The abnormal increase of NR6A1 in the hippocampus impairs the CREB-BDNF signaling cascade, leading to the development of depression-like behaviors. Genetic knockdown of NR6A1 can prevent stress-induced depression-like behaviors.
Article
Multidisciplinary Sciences
Laddawan Lalert, Supang Maneesri le-Grand, Tachpon Techarang, Soontaraporn Huntula, Chuchard Punsawad
Summary: Low-dose APAP treatment improves cognitive dysfunction in the D-gal aging model by activating the BDNF/TrkB signaling pathway.
Article
Nutrition & Dietetics
Peiyun Li, Chunrong Zhong, Shuzhen Li, Taoping Sun, Hao Huang, Xi Chen, Yalun Zhu, Xiaoli Hu, Xiaobo Peng, Xu Zhang, Wei Bao, Zhilei Shan, Jinquan Cheng, Frank B. Hu, Nianhong Yang, Liegang Liu
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2018)
Article
Nutrition & Dietetics
Peiyun Li, Jiawei Yin, Yalun Zhu, Shuzhen Li, Sijing Chen, Taoping Sun, Zhilei Shan, Jiawei Wang, Qianqian Shang, Xiaoqin Li, Wei Yang, Liegang Liu
CLINICAL NUTRITION
(2019)
Article
Cell Biology
Hao Huang, Peipei Yan, Taoping Sun, Xiaoxing Mo, Jiawei Yin, Peiyun Li, Yalun Zhu, Shuang Rong, Wei Yang, Xiaoyi Chen, Liegang Liu
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2018)
Article
Nutrition & Dietetics
Taoping Sun, Yanwei Zhang, Hao Huang, Xiaoqian Wang, Li Zhou, Shuzhen Li, Suli Huang, Changhui Xie, Ying Wen, Yalun Zhu, Xiaoli Hu, Liangkai Chen, Peiyun Li, Sijing Chen, Wei Yang, Wei Bao, Frank B. Hu, Jinquan Cheng, Liegang Liu
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2019)
Letter
Nutrition & Dietetics
Taoping Sun, Hao Huang, Wei Bao, Liegang Liu
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2019)
Article
Endocrinology & Metabolism
Xiaobo Peng, Zihui Xu, Xiaoxing Mo, Qianqian Guo, Jiawei Yin, Mengdai Xu, Zhao Peng, Taoping Sun, Li Zhou, Xiaolin Peng, Shufang Xu, Wei Yang, Wei Bao, Zhilei Shan, Xiaoqin Li, Liegang Liu
Article
Cell Biology
Li Zhou, Cheng Luo, Jiawei Yin, Yalun Zhu, Peiyun Li, Sijing Chen, Taoping Sun, Manling Xie, Zhilei Shan, Benfeng Cao, Xueting Hu, Ying Rong, Wei Yang, Xiaoqin Li, Aijun Tan, Liegang Liu
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Endocrinology & Metabolism
Xueting Hu, Shuang Rong, Qiang Wang, Taoping Sun, Wei Bao, Liangkai Chen, Liegang Liu
Summary: Elevated plasma uric acid levels are associated with higher risk of insulin resistance, with a more pronounced association observed among women. However, the study does not support a causal role of plasma uric acid on insulin resistance in newly diagnosed T2D patients.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Environmental Sciences
Benfeng Cao, Can Fang, Xiaolin Peng, Xiaoqin Li, Xueting Hu, Pan Xiang, Li Zhou, Hongjie Liu, Yue Huang, Qin Zhang, Shan Lin, Mengke Wang, Yang Liu, Taoping Sun, Sijing Chen, Zhilei Shan, Jiawei Yin, Liegang Liu
Summary: This study aimed to investigate the association of plasma cobalt with newly diagnosed type 2 diabetes (T2D) and explore potential interaction effects between cobalt and other redox metals. The results indicated a U-shaped relationship between T2D and plasma cobalt levels, with significant interaction effects observed with copper. Higher or lower concentrations of plasma cobalt were associated with increased odds of T2D, highlighting the importance of studying the inter-relationships among redox metals in the context of T2D.
Article
Peripheral Vascular Disease
Taoping Sun, Yanwei Zhang, Jiawei Yin, Xiaobo Peng, Li Zhou, Suli Huang, Ying Wen, Benfeng Cao, Liangkai Chen, Xiaoqin Li, Wei Yang, Aijun Tan, Jinquan Cheng, Liegang Liu
Summary: This study found a positive association between plasma TMAO concentrations and ischemic stroke risk, with higher TMAO levels linked to increased odds of stroke. This association was consistent across different subgroups. Further research is needed to explore the predictive role of plasma TMAO concentrations in stroke risk.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2021)
Article
Nutrition & Dietetics
Taoping Sun, Yao Deng, Xuyang Geng, Qin Fang, Xiaoqin Li, Liangkai Chen, Meixiao Zhan, Deyun Li, Kejing Zhu, Huawen Li, Liegang Liu
Summary: The study found that increased plasma DHPPA concentration is associated with a lower risk of NAFLD in Chinese adults, independently of well-known risk factors.
JOURNAL OF NUTRITION
(2022)
Article
Nutrition & Dietetics
Li Zhou, Shan Hu, Shuang Rong, Xiaoxing Mo, Qiang Wang, Jiawei Yin, Xiaobo Peng, Xiaoqin Li, Liangkai Chen, Zhilei Shan, Guohong Liu, Taoping Sun, Liegang Liu
Summary: This study examined the association between plasma DHPPA, a biomarker of whole-grain wheat and rye intake, and MetS risk in a Chinese population. The findings revealed that individuals with higher DHPPA concentrations had lower odds of MetS, providing further evidence for the health benefits of whole grain consumption.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Nutrition & Dietetics
Peiyun Li, Shan Hu, Yalun Zhu, Taoping Sun, Yue Huang, Zihui Xu, Hongjie Liu, Cheng Luo, Shiqiong Zhou, Aijun Tan, Liegang Liu
Summary: This study identified two novel fatty acid patterns that were inversely associated with the odds of gestational diabetes mellitus (GDM). The combination of circulating fatty acids may be a more significant marker for GDM development than individual fatty acids or their subgroups.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Xiaoli Hu, Qianqian Guo, Xiaoqian Wang, Qiang Wang, Liangkai Chen, Taoping Sun, Peiyun Li, Zhilei Shan, Liegang Liu, Chao Gao, Ying Rong
Summary: This study found an association between plasma transthyretin levels and the risk of newly diagnosed type 2 diabetes mellitus (T2DM) and impaired glucose regulation (IGR) in a Chinese population. Higher plasma transthyretin concentrations were associated with an increased risk of T2DM and IGR.
Article
Endocrinology & Metabolism
Taoping Sun, Ying Rong, Xiaoli Hu, Yalun Zhu, Hao Huang, Liangkai Chen, Peiyun Li, Shuzhen Li, Wei Yang, Jinquan Cheng, Xuefeng Yang, Ping Yao, Frank B. Hu, Liegang Liu