Review
Oncology
Minhong Wu, Yan Zhou, Qingsheng Chen, Zhiling Yu, Hongyong Gu, Pengxiu Lin, Yanling Li, Cailing Liu
Summary: This study suggests that C-reactive protein to albumin ratio (CAR) has a potential prognostic role in patients with urinary cancers. High pretreated CAR is associated with inferior overall survival and progression-free survival. CAR can act as a predictor in renal cell carcinoma, bladder cancer, and prostate cancer subgroups. The results of this study are reliable and robust.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Xinpan Chen, Wang Guo, Zongli Diao, Hongdong Huang, Wenhu Liu
Summary: The lymphocyte-to-C reactive protein ratio (LCR) is a novel marker of inflammation that has been shown to predict mortality in patients with malignant cancer. This study evaluated the utility of LCR in patients undergoing hemodialysis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Jiahui Zhou, Wene Wei, Hu Hou, Shufang Ning, Jilin Li, Baoyue Huang, Kaisheng Liu, Litu Zhang
Summary: The study found that CRP, GPS, and CAR have independent prognostic values in patients with CRC. Survival nomograms based on these markers can provide more valuable clinical significance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Endocrinology & Metabolism
Kechong Zhou, Chao Li, Tao Chen, Xuejun Zhang, Baoluo Ma
Summary: In this meta-analysis of 16 studies, elevated levels of C-reactive protein (CRP) were found to be associated with worse overall survival, cancer-specific survival, and progression-free survival in patients with prostate cancer. Subgroup analysis based on disease staging yielded consistent results. However, further studies are needed to confirm these findings.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Yaoting Zhang, Dongsheng Gu
Summary: This study found that pretreatment serum CRP level is associated with prognosis in patients with head and neck squamous cell carcinoma. Patients with high CRP level had worse survival outcomes, and CRP level is correlated with N1-3 stage and prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Yaohua Yu, Weiwei Wu, Yanyan Dong, Jiliang Li
Summary: The study found that the C-reactive protein-to-albumin ratio (CAR) can predict sepsis and prognosis in severe burns, with higher CAR levels associated with lower 30-day postburn survival rates.
MEDIATORS OF INFLAMMATION
(2021)
Article
Otorhinolaryngology
Chien-An Ko, Ku-Hao Fang, Cheng-Ming Hsu, Yi-Chan Lee, Geng-He Chang, Ethan Huang, Ming-Shao Tsai, Yao-Te Tsai
Summary: This study aimed to investigate the preoperative C-reactive protein (CRP)-lymphocyte ratio (CLR) as a prognostic biomarker in oral cavity squamous cell carcinoma (OSCC). The results showed that a higher preoperative CLR was significantly associated with clinicopathological aggressiveness and predicted unfavorable overall survival and disease-free survival. The CLR-based nomogram provided accurate survival prediction in OSCC patients.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Immunology
Niyati Mehta, Nijee S. S. Luthra, Daniel M. M. Corcos, Giamila Fantuzzi
Summary: Parkinson's disease (PD) is the fastest growing neurological disease worldwide, with no disease-modifying treatments available. Physical exercise is currently the most promising treatment to slow disease progression. Chronic inflammation is associated with the onset, progression, and symptom severity of PD, and C-reactive protein (CRP) should be used as the primary biomarker for monitoring inflammation and disease progression and severity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Cheng-Yu Tang, Jen-Fan Hang, Yi-Ping Hung, Nai-Chi Chiu, Jiun- Lai, Ming-Huang Chen, Chun-Yu Liu, Muh-Hwa Yang, Yee Chao, Peter Mu-Hsin Chang
Summary: This study compared the treatment results and examined prognostic factors of unfavorable cancer of unknown primary (CUP). The results showed that the prognosis of unfavorable CUP has not changed much over the past 20 years. A new prognostic stratification model was proposed to further stratify unfavorable CUP based on Eastern Cooperative Oncology Group score and C-reactive protein values.
Review
Medical Laboratory Technology
Marta Kramer Mikkelsen, Nana Aviaja Frederikke Lindblom, Anne Dyhl-Polk, Carsten Bogh Juhl, Julia Sidenius Johansen, Dorte Nielsen
Summary: Inflammation is an important characteristic of cancer, and circulating inflammatory biomarkers, such as C-reactive protein (CRP), have been explored for their clinical value in prognosis, prediction, and monitoring of therapeutic response in breast cancer patients. However, the results regarding the use of serum CRP as a biomarker in breast cancer appear inconsistent, particularly in non-metastatic and general breast cancer populations. Meta-analyses suggest limited value in these settings, but consistent findings support an association between high serum CRP and poor prognosis in metastatic breast cancer patients. Further research is needed to assess the role of serum CRP in prediction and monitoring of treatment response.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ivan Melnikov, Sergey Kozlov, Olga Saburova, Yuliya Avtaeva, Konstantin Guria, Zufar Gabbasov
Summary: This review aimed to trace the inflammatory pathway from the NLRP3 inflammasome to monomeric C-reactive protein (mCRP) in atherosclerotic cardiovascular disease. mCRP has a distinct proinflammatory profile and has been shown to deposit in atherosclerotic plaques and damaged tissues. Recent advances in detection techniques and the introduction of mCRP assays have made it more accessible and widely used. However, studies on compounds targeting CRP are limited to animal models or small clinical trials. Overall, the importance of this research is rated as 8 out of 10.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Blanca Molins, Marc Figueras-Roca, Oliver Valero, Victor Llorenc, Sara Romero-Vazquez, Oriol Sibila, Alfredo Adan, Carolina Garcia-Vidal, Alex Soriano
Summary: In COVID-19 patients, monomeric CRP levels are associated with disease severity, and levels higher than 4000 ng/mL independently predict disease severity.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Clinical Neurology
Chae Gyu Park, Sue Hyun Lee, Min Kyung Chu
Summary: This study evaluated the levels of C-reactive protein (CRP) in participants with chronic migraine (CM) and episodic migraine (EM) compared to healthy controls. The results showed no significant difference in CRP levels among the groups.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, General & Internal
Anna Baritussio, Chun-yan Cheng, Giulia Lorenzoni, Cristina Basso, Stefania Rizzo, Monica De Gaspari, Francesco Fachin, Andrea Silvio Giordani, Honoria Ocagli, Elena Pontara, Maria Grazia Peloso Cattini, Elisa Bison, Nicoletta Gallo, Mario Plebani, Giuseppe Tarantini, Sabino Iliceto, Dario Gregori, Renzo Marcolongo, Alida Linda Patrizia Caforio
Summary: The role of inflammation markers in myocarditis is unclear. This study found that elevated CRP at diagnosis can identify patients with clinically suspected myocarditis and less severe clinical features, but does not contribute to predicting survival. The strongest predictors of death/heart transplant are reduced LVEF, biopsy-proven diagnosis, and positive ANA.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Alina Frey, Daniel Martin, Louisa D'Cruz, Emmanouil Fokas, Claus Rodel, Maximilian Fleischmann
Summary: The study assessed the C-reactive protein (CRP) to albumin ratio (CAR) as a prognostic score in locally advanced non-small-cell lung cancer (NSCLC) patients treated with CRT. The findings showed that elevated CAR was associated with worse outcomes, including poorer local control and shorter survival.
Article
Urology & Nephrology
Naoko Kawamura, Minato Yokoyama, Hajime Tanaka, Takayuki Nakayama, Yosuke Yasuda, Toshiki Kijima, Soichiro Yoshida, Junichiro Ishioka, Yoh Matsuoka, Kazutaka Saito, Kazunori Kihara, Yasuhisa Fujii
INTERNATIONAL JOURNAL OF UROLOGY
(2019)
Article
Urology & Nephrology
Toshiki Kijima, Hajime Tanaka, Fumitaka Koga, Hitoshi Masuda, Soichiro Yoshida, Minato Yokoyama, Junichiro Ishioka, Yoh Matsuoka, Kazutaka Saito, Kazunori Kihara, Yasuhisa Fujii
Article
Radiology, Nuclear Medicine & Medical Imaging
Shugo Yajima, Soichiro Yoshida, Taro Takahara, Yuki Arita, Hiroshi Tanaka, Yuma Waseda, Minato Yokoyama, Junichiro Ishioka, Yoh Matsuoka, Kazutaka Saito, Kazunori Kihara, Yasuhisa Fujii
EUROPEAN RADIOLOGY
(2019)
Article
Urology & Nephrology
Masaki Kobayashi, Hajime Tanaka, Ukihide Tateishi, Noboru Numao, Junji Yonese, Masaya Ito, Fumitaka Koga, Hiroshi Fukushima, Sho Uehara, Soichiro Yoshida, Minato Yokoyama, Junichiro Ishioka, Yoh Matsuoka, Kazutaka Saito, Kazunori Kihara, Yasuhisa Fujii
INTERNATIONAL JOURNAL OF UROLOGY
(2019)
Article
Oncology
Soichiro Yoshida, Taro Takahara, Yuki Arita, Chikako Ishii, Yusuke Uchida, Keiko Nakagawa, Kazuma Toda, Tsuyoshi Sakamoto, Toshiki Kijima, Minato Yokoyama, Junichiro Ishioka, Yoh Matsuoka, Kazutaka Saito, Ryoichi Yoshimura, Yasuhisa Fujii
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2019)
Article
Urology & Nephrology
Masahiro Toide, Minato Yokoyama, Motohiro Fujiwara, Toshiki Kijima, Kazutaka Saito, Yasuhisa Fujii
INTERNATIONAL JOURNAL OF UROLOGY
(2019)
Article
Oncology
Yuma Waseda, Shuichiro Kobayashi, Eiichiro Kanda, Minato Yokoyama, Junichiro Ishioka, Yoh Matsuoka, Kazutaka Saito, Yasuhisa Fujii
CLINICAL GENITOURINARY CANCER
(2020)
Article
Oncology
Hiroshi Fukushima, Kazutaka Saito, Yosuke Yasuda, Hajime Tanaka, Dattatraya Patil, Brittney H. Cotta, Sunil H. Patel, Viraj A. Master, Ithaar H. Derweesh, Yasuhisa Fujii
CLINICAL GENITOURINARY CANCER
(2020)
Article
Oncology
Toshiki Kijima, Hajime Tanaka, Sho Uehara, Soichiro Yoshida, Minato Yokoyama, Junichiro Ishioka, Yoh Matsuoka, Kazutaka Saito, Kazunori Kihara, Yasuhisa Fujii
CLINICAL GENITOURINARY CANCER
(2020)
Article
Oncology
Soichiro Yoshida, Taro Takahara, Chikako Ishii, Yuki Arita, Yuma Waseda, Toshiki Kijima, Minato Yokoyama, Junichiro Ishioka, Yoh Matsuoka, Kazutaka Saito, Yasuhisa Fujii
CLINICAL GENITOURINARY CANCER
(2020)
Article
Oncology
Hiroshi Fukushima, Masaharu Inoue, Toshiki Kijima, Soichiro Yoshida, Minato Yokoyama, Junichiro Ishioka, Yoh Matsuoka, Kazutaka Saito, Yasuhisa Fujii
CLINICAL GENITOURINARY CANCER
(2020)
Article
Urology & Nephrology
Hajime Tanaka, Hiroshi Fukushima, Toshiki Kijima, Yuki Nakamura, Shugo Yajima, Sho Uehara, Soichiro Yoshida, Minato Yokoyama, Junichiro Ishioka, Yoh Matsuoka, Kazutaka Saito, Yasuhisa Fujii
INTERNATIONAL JOURNAL OF UROLOGY
(2020)
Editorial Material
Urology & Nephrology
Toshiki Kijima, Masaya Ito, Junichiro Ishioka, Yoh Matsuoka, Kazutaka Saito, Yasuhisa Fujii
INTERNATIONAL JOURNAL OF UROLOGY
(2020)
Article
Urology & Nephrology
Yuki Nakamura, Minato Yokoyama, Soichiro Yoshida, Hajime Tanaka, Toshiki Kijima, Junichiro Ishioka, Yoh Matsuoka, Kazutaka Saito, Isao Minami, Takanobu Yoshimoto, Shotaro Naito, Yoshihiro Ogawa, Tetsuya Yamada, Shinichi Uchida, Yasuhisa Fujii
INTERNATIONAL JOURNAL OF UROLOGY
(2020)
Article
Urology & Nephrology
Hiroshi Fukushima, Shingo Moriyama, Yuma Waseda, Shohei Fukuda, Sho Uehara, Hajime Tanaka, Toshiki Kijima, Soichiro Yoshida, Minato Yokoyama, Junichiro Ishioka, Yoh Matsuoka, Kazutaka Saito, Yasuhisa Fujii
Summary: This study investigated the role of bladder neck involvement (BNI) in risk substratification of intermediate-risk NMIBC patients and found that BNI can effectively sub-stratify patients based on their risks of progression and recurrence, assisting in determining follow-up and therapeutic strategies for these patients.
EUROPEAN UROLOGY FOCUS
(2021)