Combination of PKCε Activation and PTP1B Inhibition Effectively Suppresses Aβ-Induced GSK-3β Activation and Tau Phosphorylation

α, β-DCP-LA Selectively Activates PKC-ε and Stimulates Neurotransmitter Release with the Highest Potency among 4 Diastereomers

(2017) Tadashi Shimizu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

p70 S6 Kinase and Tau in Alzheimer's Disease

(2017) Jin-Jing Pei et al.   JOURNAL OF ALZHEIMERS DISEASE

PTP1B Inhibition Causes Rac1 Activation by Enhancing Receptor Tyrosine Kinase Signaling

(2014) Ayako Tsuchiya et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Tauopathy contributes to synaptic and cognitive deficits in a murine model for Alzheimer's disease

(2014) Ilie-Cosmin Stancu et al.   FASEB JOURNAL

The linoleic acid derivative DCP-LA increases membrane surface localization of the α7 ACh receptor in a protein 4.1N-dependent manner

(2013) Takeshi Kanno et al.   BIOCHEMICAL JOURNAL

Tau-aggregation inhibitor therapy for Alzheimer's disease

(2013) Claude M. Wischik et al.   BIOCHEMICAL PHARMACOLOGY

Platelet-derived growth factor-induced Akt phosphorylation requires mTOR/Rictor and phospholipase C-γ1, whereas S6 phosphorylation depends on mTOR/Raptor and phospholipase D

(2013) Masoud Razmara et al.   Cell Communication and Signaling

Effects of Newly Synthesized DCP-LA-Phospholipids on Protein Kinase C and Protein Phosphatases

(2013) Takeshi Kanno et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Diacylglycerol promotes GLUT4 translocation to the cell surface in a PKCε-dependent and PKCλ/ι and -ζ-independent manner

(2013) Ayako Tsuchiya et al.   LIFE SCIENCES

Increased misfolding and truncation of tau in APP/PS1/tau transgenic mice compared to mutant tau mice

(2013) Céline Héraud et al.   NEUROBIOLOGY OF DISEASE

Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy

(2013) Danielle L. Graham et al.   NEUROPHARMACOLOGY

Alzheimer disease

(2013) Justin M. Nussbaum et al.   Prion

Brain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathies: Figure 1

(2012) Kurt R. Brunden et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Linoleic Acid Derivative DCP-LA Stimulates Vesicular Transport of a7 ACh Receptors towards Surface Membrane

(2012) Takeshi Kanno et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Tau pathology in children and young adults: can you still be unconditionally baptist?

(2011) Charles Duyckaerts   ACTA NEUROPATHOLOGICA

Aβ Accelerates the Spatiotemporal Progression of Tau Pathology and Augments Tau Amyloidosis in an Alzheimer Mouse Model

(2010) David E. Hurtado et al.   AMERICAN JOURNAL OF PATHOLOGY

Discovery of Brain-Penetrant, Orally Bioavailable Aminothienopyridazine Inhibitors of Tau Aggregation

(2010) Carlo Ballatore et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease

(2010) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

DCP-LA neutralizes mutant amyloid β peptide-induced impairment of long-term potentiation and spatial learning

(2009) Tetsu Nagata et al.   BEHAVIOURAL BRAIN RESEARCH

DCP-LA stimulates AMPA receptor exocytosis through CaMKII activation due to PP-1 inhibition

(2009) Takeshi Kanno et al.   JOURNAL OF CELLULAR PHYSIOLOGY

 -Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

(2009) Q.-L. Ma et al.   JOURNAL OF NEUROSCIENCE

Lithium and Neuropsychiatric Therapeutics: Neuroplasticity via Glycogen Synthase Kinase-3β, β-Catenin, and Neurotrophin Cascades

(2009) Akihiko Wada   JOURNAL OF PHARMACOLOGICAL SCIENCES

Diffusion-weighted brain imaging study of patients with clinical diagnosis of corticobasal degeneration, progressive supranuclear palsy and Parkinson's disease

(2008) Giovanni Rizzo et al.   BRAIN

Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin

(2008) Inmaculada Cuchillo-Ibanez et al.   FASEB JOURNAL

Proline-directed Pseudo-phosphorylation at AT8 and PHF1 Epitopes Induces a Compaction of the Paperclip Folding of Tau and Generates a Pathological (MC-1) Conformation

(2008) Sadasivam Jeganathan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY