期刊
INTERNATIONAL JOURNAL OF UROLOGY
卷 19, 期 6, 页码 512-522出版社
WILEY
DOI: 10.1111/j.1442-2042.2012.02987.x
关键词
benign prostatic hyperplasia; estrogen receptors alpha and ss; pathogenesis; prostate cancer; therapeutic target
Accumulating evidence shows that estrogens participate in the pathogenesis and development of benign prostatic hyperplasia and prostate cancer by activating estrogen receptor a. In contrast, estrogen receptor beta is involved in the differentiation and maturation of prostatic epithelial cells, and thus possesses antitumor effects in prostate cancer. However, the natural ligands of estrogen receptor beta are not fully understood, and its mode of action according to its ligands and the binding sites located in the promoter regions of downstream genes remains to be elucidated. Here, we review recent experimental investigations of estrogen receptors and their urological relevance. Estrogen receptor-mediated signaling in the prostate is essential together with the androgen receptor-mediated pathway, providing a new therapeutic target for prostatic diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据