Article
Andrology
Jih Hoon Park, Kyoungjune Pak, Nam Cheol Park, Hyun Jun Park
Summary: This study found that patients complaining of dull pain preoperatively had a higher likelihood of postoperative pain resolution. Subinguinal ligation was more effective for pain resolution than high ligation, and microsurgical varicocelectomy showed better surgical outcomes than laparoscopic varicocelectomy.
WORLD JOURNAL OF MENS HEALTH
(2021)
Review
Andrology
Daoxian Qiu, Qingjing Shi, Lianjun Pan
Summary: The meta-analysis evaluated the efficacy of varicocelectomy for sperm DNA integrity, with results showing a significant improvement in sperm DNA integrity among clinical varicocele patients following the surgery.
Article
Andrology
Mohamed A. El-Dighidy, Mahmoud H. Sherief, Mostafa A. Shamaa, Ahmed I. El-Sakka
Summary: The study found that smoking and/or obesity have a negative impact on semen parameters and hormonal levels in sub-fertile men undergoing sub-inguinal varicocelectomy.
Review
Obstetrics & Gynecology
Filipe Tenorio Lira Neto, Matheus Roque, Sandro C. Esteves
Summary: This study found that varicocelectomy can reduce sperm deoxyribonucleic acid fragmentation rates in infertile men with clinical varicocele. Men with elevated preoperative SDF levels showed a more significant treatment effect after the surgery.
FERTILITY AND STERILITY
(2021)
Article
Biochemistry & Molecular Biology
Sha Han, Jiaqiang Luo, Shuai Xu, Liangyu Zhao, Chencheng Yao, Junwei Xu, Ruhui Tian, Erlei Zhi, Yuhua Huang, Shujie Xia, Zheng Li, Peng Li
Summary: Aging negatively affects human testicular function, leading to impaired steroidogenesis and decreased testosterone levels. Low-intensity pulsed ultrasound (LIPUS) has been shown to increase testosterone levels in animal models and is a non-invasive treatment option for male erectile dysfunction. This study investigates the effect of LIPUS on human senescent Leydig cells (LCs) and finds that stimulation with LIPUS improves the senescence phenotype and enhances LCs' secretory function, increasing the expression of key pathways in testosterone synthesis. These findings suggest that LIPUS may be a novel treatment for human senescent LCs with decreased testosterone secretion levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Huitao Li, Zina Wen, Chaobo Ni, Xianwu Chen, Yong Cheng, Yuxin Liu, Xiaoheng Li, Qiqi Zhu, Ren-Shan Ge
Summary: Short-term exposure to PFDoA in adulthood delayed Leydig cell regeneration by preventing Leydig cells from stem cells through multiple mechanisms.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Review
Endocrinology & Metabolism
Indrashis Bhattacharya, Souvik Dey
Summary: Leydig cells (Lc) in the testis play a critical role in male fertility by producing testosterone in response to luteinizing hormone (LH). Recent studies have identified the diverse origins of these cells and their differential transcriptomic and steroidogenic outputs. Fetal Lc (FLc) originate from coelomic epithelium and perivascular cells, and gradually give way to adult Lc (ALc), which are considered to be derived from FLc and perivascular cells. This article summarizes the current understanding of Lc development, their cellular origins, and their functional significance in rodent and primate testes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Andrology
Mohamed Mahdi, Ahmad Majzoub, Kareim Khalafalla, Jason To, Maria Aviles-Sandoval, Haitham Elbardisi, Sami AlSaid, Ashok Agarwal, Ralf Henkel, Mohamed Arafa
Summary: This study evaluated the efficacy of redo varicocelectomy on male fertility potential and pregnancy outcome through a systematic review and meta-analysis. The results showed significant improvements in semen parameters following the surgery, with overall pregnancy outcome reported in seven studies. No significant changes were noted in hormone levels.
Article
Environmental Sciences
Xinrui Hao, Xiaoju Guan, Xingxing Zhao, Minpeng Ji, Xin Wen, Panpan Chen, Fenfen Chen, Jianying Yang, Qingquan Lian, Leping Ye, Haolin Chen
Summary: Studies have shown that phthalates, such as MEHP, can significantly inhibit the proliferation and differentiation of stem Leydig cells (SLCs). It also affects the differentiation of SLCs into Leydig cells and adipocytes.
Article
Endocrinology & Metabolism
Dandan Luo, Xiangyu Qi, Xiaoqin Xu, Leilei Yang, Chunxiao Yu, Qingbo Guan
Summary: Age-related decline in testosterone is associated with Leydig cell aging, and obesity accelerates this process. The study found that p38 MAPK is involved in Leydig cell aging induced by age and obesity. Inhibition of p38 MAPK can delay Leydig cell aging and alleviate the decline in testosterone.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Environmental Sciences
Shijun Li, Yun Wang, Cheng Zou, Qiqi Zhu, Yiyan Wang, Haiqiong Chen, Wenjing Yang, Yuhan Tu, Haoni Yan, Xiaoheng Li, Ren-Shan Ge
Summary: This study investigated the effects of cypermethrin exposure on the development and function of Leydig cells in male rats during late puberty. The results showed that cypermethrin reduced testosterone levels and increased luteinizing hormone levels, while decreasing the number of Leydig cells. Furthermore, cypermethrin induced oxidative stress and mitochondrial damage.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jinlian Liang, Hanhao Li, Jiaxin Mei, Zhen Cao, Yan Tang, Rufei Huang, Huan Xia, Qihao Zhang, Qi Xiang, Yan Yang, Yadong Huang
Summary: The study revealed that SC-derived miR-145-5p plays a significant role in regulating the functions of Leydig cells and may serve as a diagnostic biomarker for male hypogonadism developmental abnormalities during puberty.
Article
Multidisciplinary Sciences
Xinzong Zhang, Cuncan Deng, Wujiang Liu, Huang Liu, Yu Zhou, Qianyi Li, Houbin Zheng, Qiling Wang, Min Jiang, Tao Pang, Chunjie Ma, Cheng Huang, Qingguo Zhao, Yunge Tang
Summary: The influence of varicocele and microsurgical varicocelectomy on semen quality remains unclear. This study investigated the changes in semen metabolism after microsurgical varicocelectomy and found that varicocele significantly affects semen metabolism and microsurgical varicocelectomy can reverse this metabolic abnormality. Additionally, three dipeptides were identified in the seminal plasma of varicocele patients, which decreased after varicocelectomy coincident with an improvement in semen quality. Furthermore, eight metabolites may be helpful to distinguish varicocele patients from normal subjects.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Lipeng Li, Zijie Pei, Ruiting Wu, Yaling Zhang, Yaxian Pang, Huaifang Hu, Wentao Hu, Zihan Geng, Tengfei Feng, Yujie Niu, Guimin Hao, Rong Zhang
Summary: Epidemiological studies have revealed an association between chronic exposure to PM2.5 and male infertility, but the underlying mechanisms were unclear. In this study, mice models exposed to PM2.5 showed decreased sperm quality and increased testosterone levels. Ferrostatin-1 treatment effectively mitigated PM2.5-induced testicular dysfunction. Further investigations showed that PM2.5 exposure led to ferroptosis in Leydig cells, which was partially rescued by Fer-1 intervention. The upregulation of FDX1, a mediator involved in steroidogenesis, caused cellular ROS elevation and ferrous iron overload, leading to ferroptotic cell death and increased testosterone levels.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Reproductive Biology
Banu Orta Yilmaz, Yasemin Aydin
Summary: Arsenite and fluoride, commonly found in underground drinking water, have negative impacts on testicular function and fertility. In mouse Leydig cells, exposure to individual or combined arsenite and fluoride induces oxidative stress, cell apoptosis, alters antioxidant balance, and suppresses steroidogenic enzyme expression. This study highlights the detrimental effects of environmentally relevant concentrations of arsenite and fluoride on testosterone production in Leydig cells and male infertility.
Article
Andrology
N. Enatsu, K. Chiba, K. Sumii, T. Fukuda, K. Okada, K. Matsushita, M. Fujisawa
Article
Endocrinology & Metabolism
Keisuke Okada, Kohei Yamaguchi, Koji Chiba, Hideaki Miyake, Masato Fujisawa
Article
Andrology
K. Matsushita, K. Yamaguchi, F. Li, K. Okada, M. Ando, K. Chiba, M. Koshida, H. Miyake, M. Fujisawa
Article
Biochemistry & Molecular Biology
Keisuke Okada, Hideaki Miyake, Kohei Yamaguchi, Koji Chiba, Kazuhiro Maeta, Shymaa E. Bilasy, Hironori Edamatsu, Tohru Kataoka, Masato Fujisawa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2014)
Article
Reproductive Biology
Fuping Li, Kohei Yamaguchi, Keisuke Okada, Kei Matsushita, Noritoshi Enatsu, Koji Chiba, Huanxun Yue, Masato Fujisawa
BIOLOGY OF REPRODUCTION
(2013)
Article
Andrology
Fuping Li, Kohei Yamaguchi, Keisuke Okada, Kei Matsushita, Makoto Ando, Koji Chiba, Huanxun Yue, Masato Fujisawa
SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE
(2012)
Article
Urology & Nephrology
Fuping Li, Koji Chiba, Kohei Yamaguchi, Keisuke Okada, Kei Matsushita, Makoto Ando, Huanxun Yue, Masato Fujisawa
Article
Andrology
Mikito Tanaka, Koji Chiba, Keisuke Okada, Masato Fujisawa
Article
Andrology
Noritoshi Enatsu, Yihsien Enatsu, Keisuke Okada, Koji Chiba, Yukiko Matsumoto, Shoji Kokeguchi, Masahide Shiotani
Article
Biochemistry & Molecular Biology
Yasuhiro Kaku, Koji Chiba, Katsuya Sato, Atsushi Onishi, Takaki Ishida, Keisuke Okada, Masato Fujisawa
Summary: The study found that tadalafil (a commonly used medication) has a protective effect against the testicular toxicity caused by CDDP (an anticancer drug) in mice, improving adverse effects such as testicular atrophy and decreased sperm concentration. The results suggest that the antioxidant effect of tadalafil may contribute to its protective effect, and ROCK2 and oxidative stress may be involved in the antioxidant effects of tadalafil.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Surgery
Shin Ueda, Keisuke Okada, Maki Kanzawa, Teruo Fukuda, Junya Furukawa, Masato Fujisawa
JOURNAL OF SURGICAL CASE REPORTS
(2020)
Review
Andrology
Keisuke Okada, Masato Fujisawa
WORLD JOURNAL OF MENS HEALTH
(2019)
Article
Public, Environmental & Occupational Health
Keisuke Okada, Hideaki Miyake, Takaki Ishida, Kenta Sumii, Noritoshi Enatsu, Koji Chiba, Kei Matsushita, Masato Fujisawa
AMERICAN JOURNAL OF MENS HEALTH
(2018)
