Article
Cell Biology
Fan Zhang, Junyu Lin, Dechao Feng, Jiayu Liang, Yiping Lu, Zhihong Liu, Xianding Wang
Summary: This study explored the correlation between cuprotosis and clear cell renal cell carcinoma (ccRCC) and developed a cuprotosis-related signature to predict the prognosis of patients with ccRCC. The signature risk score was significantly associated with tumor stage, histological grade, and immune cell infiltrates in ccRCC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Genetics & Heredity
You Zuo, Shuai Fu, Zhongwei Zhao, Zeyan Li, Yijian Wu, Tienan Qi, Jianguo Zheng, Qinglong Du, Zhonghua Xu, Nengwang Yu
Summary: This study constructed a sarcomatoid-associated gene risk index (SAGRI) to predict the prognosis of renal cell carcinoma and found that SAGRI has a high predictive power. The study also suggested that the SAGRI-HIGH subgroup may benefit from immunotherapy.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Kun Meng, Yuyu Hu, Dingkang Wang, Yuying Li, Fujin Shi, Jiangli Lu, Yang Wang, Yun Cao, Chris Zhiyi Zhang, Qing-Yu He
Summary: A seven-mitochondrial-gene signature was generated to predict prognosis of ccRCC patients, with EFHD1 being less studied but found to be correlated with unfavorable outcome. Overexpression of EFHD1 reduced mitochondrial Ca2+ and inhibited cell migration and tumor metastasis by binding to mitochondrial calcium uniporter (MCU) and deactivating the Hippo/YAP pathway. Upregulation of STARD13 induced by EFHD1 enhanced the phosphorylation of YAP at Ser-127. The EFHD1-MCU-STARD13 axis serves as a novel regulator in ccRCC progression.
Article
Oncology
Shiqi Miao, Jing Song, Qingyuan Liu, Jiayi Lai, Huirui Wang, Longke Ran
Summary: This study investigates the key gene in ccRCC tumor metastasis using gene expression profiling and clinical data. The results identify HSD11B2 as a potential biomarker and therapeutic target for ccRCC metastasis.
Article
Biotechnology & Applied Microbiology
Zuhu Yu, Chong Lu, Bin Lu, Hong Gao, Rongfang Liang, Wuxing Xiang
Summary: This study identified necroptosis-related microRNAs (miRNAs) associated with the prognosis of clear cell renal cell carcinoma (ccRCC), and developed a prognostic signature to predict overall survival in ccRCC patients. The targeted genes of these miRNAs were predicted using miRNA databases, and their functional and pathway associations with ccRCC prognosis were investigated. The differential expression of the three miRNAs in the signature was validated in ccRCC tissues.
Article
Cell Biology
Zonglong Wu, Yimeng Song, Yaqian Wu, Liyuan Ge, Zhuo Liu, Tan Du, Shudong Zhang, Lulin Ma
Summary: This study identified metastasis-related genes in clear cell renal cell carcinoma (ccRCC) and constructed a metastasis-associated prognostic gene signature. Kinesin family member 23 (KIF23) was identified as a prognostic marker in ccRCC patients, and inhibition of KIF23 expression reduced ccRCC cell proliferation, migration, and invasion.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biology
Maeva Dufies, Annelies Verbiest, Lindsay S. Cooley, Papa Diogop Ndiaye, Xingkang He, Nicolas Nottet, Wilfried Souleyreau, Anais Hagege, Stephanie Torrino, Julien Parola, Sandy Giuliano, Delphine Borchiellini, Renaud Schiappa, Baharia Mograbi, Jessica Zucman-Rossi, Karim Bensalah, Alain Ravaud, Patrick Auberger, Andreas Bikfalvi, Emmanuel Chamorey, Nathalie Rioux-Leclercq, Nathalie M. Mazure, Benoit Beuselinck, Yihai Cao, Jean Christophe Bernhard, Damien Ambrosetti, Gilles Pages
Summary: Dufies et al. found high Plk1 expression levels in aggressive clear cell renal cell carcinoma and discovered that Plk1 is transcriptionally upregulated in a manner dependent on HIF-2. They also found that high Plk1 expression is correlated to a poor prognosis and resistance to tyrosine kinase inhibitor against VEGF receptor, suggesting a critical role for hypoxia/HIF-2-induced Plk1 in disease progression.
COMMUNICATIONS BIOLOGY
(2021)
Article
Oncology
Jianxin Xue, Wensun Chen, Wenbo Xu, Zicheng Xu, Xiao Li, Feng Qi, Zengjun Wang
Summary: This study aimed to describe distant metastasis patterns in ccRCC patients, with the lung being the most common metastatic site. Different survival outcomes and prognostic factors were identified for different metastatic patterns. This research would be valuable for future clinical practice.
Article
Oncology
Xianhui Liu, Weiyu Zhang, Huanrui Wang, Lin Zhu, Kexin Xu
Summary: ACADSB plays an important role in the diagnosis and prognosis of ccRCC. Its downregulation may promote tumorigenesis and tumor progression. The expression level of ACADSB can serve as a significant parameter to discriminate between normal and tumor tissues.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Yue Wu, Xi Zhang, Xian Wei, Huan Feng, Bintao Hu, Zhiyao Deng, Bo Liu, Yang Luan, Yajun Ruan, Xiaming Liu, Zhuo Liu, Jihong Liu, Tao Wang
Summary: By analyzing differentially expressed ubiquitin-related genes in ccRCC, seven prognostic-related genes were identified and used to construct a predictive signature, which showed good prediction accuracy for evaluating tumor progression in ccRCC patients. The signature was confirmed to be an independent prognostic factor related to the prognosis of ccRCC patients, potentially providing diagnostic and prognostic markers for ccRCC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Yingqiang Lu, Haixiang Qin, Bo Jiang, Wenfeng Lu, Jiange Hao, Wenmin Cao, Lin Du, Wei Chen, Xiaozhi Zhao, Hongqian Guo
Summary: The study identified the essential role of KLF2 in suppressing the metastasis of ccRCC and its close correlation with GPX4. KLF2 deficiency is sufficient to inhibit ferroptosis and promote the migration and invasion of RCC cells. Reverting KLF2 expression decreased pulmonary metastatic lesions and prolonged life span of mice, while GPX4 overexpression reversed these properties, establishing a novel critical pathway for human ccRCC invasion and metastasis.
Article
Biochemical Research Methods
Malena Manzi, Nicolas Zabalegui, Maria Eugenia Monge
Summary: The study evaluated a lipid panel that differentiated healthy individuals from clear cell renal cell carcinoma patients, and found that it could serve as an indicator for metabolic restoration after surgery. Specific lipids were able to distinguish patients with poor prognosis and could be used as prognostic tools during patient follow-up care.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Multidisciplinary Sciences
Xiu-wu Pan, Wen-jin Chen, Da Xu, Wen-bin Guan, Lin Li, Jia-xin Chen, Wei-jie Chen, Ke-qin Dong, Jian-qing Ye, Si-shun Gan, Wang Zhou, Xin-gang Cui
Summary: Based on scRNA-seq data, clear cell renal cell carcinoma (ccRCC) can be classified into three subgroups with diverse molecular features. These subtypes have different treatment outcomes and potential targets, providing useful information for personalized therapy.
Article
Biochemistry & Molecular Biology
Jing Zhang, Yun Deng, Hui Zhang, Zhiyuan Zhang, Xin Jin, Yan Xuan, Zhen Zhang, Xuejun Ma
Summary: In this study, the role of ferroptosis in the tumor microenvironment of ccRCC was investigated, and 16 immune-related ferroptosis genes (IRFGs) were identified. An IRFG score model was constructed to evaluate its prognostic value in ccRCC patients, and it showed excellent performance in predicting patient survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Yixiao Zhang, Xudong Zhu, Xinbo Qiao, Lisha Sun, Tianhui Xia, Caigang Liu
Summary: The study revealed that HSC70 expression was associated with poor prognosis in ccRCC patients, with those expressing HSC70 having significantly shorter overall survival and higher rates of distant organ metastasis and death. HSC70 may serve as a potential therapeutic target for ccRCC.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)