Protein aggregation as an antibiotic design strategy

Antimicrobial Peptides (AMPs) with Dual Mechanisms: Membrane Disruption and Apoptosis

(2015) Juneyoung Lee et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Selectivity of Aggregation-Determining Interactions

(2015) Ashok Ganesan et al.   JOURNAL OF MOLECULAR BIOLOGY

A sensor for quantification of macromolecular crowding in living cells

(2015) Arnold J Boersma et al.   NATURE METHODS

The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex

(2015) A Carolin Seefeldt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The mechanism of inhibition of protein synthesis by the proline-rich peptide oncocin

(2015) Raktim N Roy et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex

(2015) A Carolin Seefeldt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The mechanism of inhibition of protein synthesis by the proline-rich peptide oncocin

(2015) Raktim N Roy et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Predicting aggregation-prone sequences in proteins

(2014) Greet De Baets et al.   Essays in Biochemistry

Hp1404, a New Antimicrobial Peptide from the Scorpion Heterometrus petersii

(2014) Zhongjie Li et al.   PLoS One

How crowded is the prokaryotic cytoplasm?

(2013) Jan Spitzer et al.   FEBS LETTERS

Protein aggregation in bacteria: the thin boundary between functionality and toxicity

(2013) N. G. Bednarska et al.   MICROBIOLOGY-SGM

CAMP: Collection of sequences and structures of antimicrobial peptides

(2013) Faiza Hanif Waghu et al.   NUCLEIC ACIDS RESEARCH

Common mechanism unites membrane poration by amyloid and antimicrobial peptides

(2013) N. B. Last et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-Seeding of Misfolded Proteins: Implications for Etiology and Pathogenesis of Protein Misfolding Diseases

(2013) Rodrigo Morales et al.   PLoS Pathogens

Amyloid Fibrils Trigger the Release of Neutrophil Extracellular Traps (NETs), Causing Fibril Fragmentation by NET-associated Elastase

(2012) Estefania P. C. Azevedo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomers

(2012) E. Evangelisti et al.   JOURNAL OF CELL SCIENCE

Cross-seeding effects of amyloid β-protein and α-synuclein

(2012) Kenjiro Ono et al.   JOURNAL OF NEUROCHEMISTRY

Turning a new phage

(2012) Lauren Gravitz   NATURE MEDICINE

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

Atomic View of a Toxic Amyloid Small Oligomer

(2012) Arthur Laganowsky et al.   SCIENCE

Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions

(2011) Heidi Olzscha et al.   CELL

Rational Design of Oncocin Derivatives with Superior Protease Stabilities and Antibacterial Activities Based on the High-Resolution Structure of the Oncocin-DnaK Complex

(2011) Daniel Knappe et al.   CHEMBIOCHEM

Discovery research: the scientific challenge of finding new antibiotics

(2011) D. M. Livermore et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Antimicrobial Peptides: Old Molecules with New Ideas

(2011) Teruaki Nakatsuji et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

(2011) Jie Xu et al.   Nature Chemical Biology

Ensembl Genomes: an integrative resource for genome-scale data from non-vertebrate species

(2011) Paul J. Kersey et al.   NUCLEIC ACIDS RESEARCH

Synthesis of a library of oligothiophenes and their utilization as fluorescent ligands for spectral assignment of protein aggregates

(2011) Therése Klingstedt et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells

(2011) Christian Münch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The expanding scope of antimicrobial peptide structures and their modes of action

(2011) Leonard T. Nguyen et al.   TRENDS IN BIOTECHNOLOGY

Damage of the Bacterial Cell Envelope by Antimicrobial Peptides Gramicidin S and PGLa as Revealed by Transmission and Scanning Electron Microscopy

(2010) M. Hartmann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Fluorescent Pentameric Thiophene Derivative Detects in Vitro-Formed Prefibrillar Protein Aggregates

(2010) Per Hammarström et al.   BIOCHEMISTRY

Bacterial membrane lipids in the action of antimicrobial agents

(2010) Richard M. Epand et al.   JOURNAL OF PEPTIDE SCIENCE

A causative link between the structure of aberrant protein oligomers and their toxicity

(2010) Silvia Campioni et al.   Nature Chemical Biology

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

(2010) Stephanie J. Soscia et al.   PLoS One

ms_lims, a simple yet powerful open source laboratory information management system for MS-driven proteomics

(2010) Kenny Helsens et al.   PROTEOMICS

Novel Pentameric Thiophene Derivatives forin Vitroandin VivoOptical Imaging of a Plethora of Protein Aggregates in Cerebral Amyloidoses

(2009) Andreas Åslund et al.   ACS Chemical Biology

Preventing Carryover of Peptides and Proteins in Nano LC-MS Separations

(2009) Goran Mitulović et al.   ANALYTICAL CHEMISTRY

Activation of phospholipase A2 by temporin B: Formation of antimicrobial peptide-enzyme amyloid-type cofibrils

(2009) Christian Code et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Binding of amphipathic α-helical antimicrobial peptides to lipid membranes: Lessons from temporins B and L

(2009) Ajay K. Mahalka et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Comprehensive identification of essential Staphylococcus aureus genes using Transposon-Mediated Differential Hybridisation (TMDH)

(2009) Roy R Chaudhuri et al.   BMC GENOMICS

E. coli Transports Aggregated Proteins to the Poles by a Specific and Energy-Dependent Process

(2009) Assaf Rokney et al.   JOURNAL OF MOLECULAR BIOLOGY

Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates

(2009) Pei-Hsien Ren et al.   NATURE CELL BIOLOGY

The Transcellular Spread of Cytosolic Amyloids, Prions, and Prionoids

(2009) Adriano Aguzzi et al.   NEURON

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

APD2: the updated antimicrobial peptide database and its application in peptide design

(2008) Guangshun Wang et al.   NUCLEIC ACIDS RESEARCH

Asymmetric segregation of protein aggregates is associated with cellular aging and rejuvenation

(2008) A. B. Lindner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE

Posterior Error Probabilities and False Discovery Rates: Two Sides of the Same Coin

(2007) Lukas Käll et al.   JOURNAL OF PROTEOME RESEARCH