期刊
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
卷 16, 期 11, 页码 1424-1432出版社
INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)
DOI: 10.5588/ijtld.12.0479
关键词
Mycobacterium tuberculosis; immunopathogenic mechanisms; immunopathology
资金
- Bill & Melinda Gates Foundation Grand Challenges in Global Health [74, 82]
- European and Developing Countries Clinical Trials Partnership (AE-TBC Project)
- the Netherlands Leprosy Relief Foundation
- Turing Foundation
- Q M Gastmann Wichers Foundation
- European Union [280873]
In this review, we discuss the 'knowns' and 'unknowns' of host defence towards Mycobacterium tuberculosis. With regard to the 'knowns', both protective and immunopathogenic mechanisms are discussed, including recently discovered new pathways of host defence and inflammatory immunopathology. With regard to the 'unknowns', there will be emphasis on unanswered key questions, accompanied by a perspective on needs and priorities for future research. The role of the inflammatory response and its dysregulation in tuberculosis-related immune reconstitution inflammatory syndrome will also be discussed.
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