Article
Biology
Daniel C. Cook, Timothy A. Ryan
Summary: Control of neurotransmission efficacy is crucial for understanding brain's information processing. Presynaptic GPCRs, which can locally affect synaptic strength, have been found to inhibit voltage-gated calcium influx, contributing to complete silencing of nerve terminals. These findings suggest that neural circuits can modulate information throughput at the single synapse level by leveraging the non-linear relationship between action potential driven calcium influx and external calcium concentration.
Article
Biochemistry & Molecular Biology
Nicoletta Plotegher
Summary: Mitochondria, endoplasmic reticulum, and lysosomes play important roles in regulating pre-synaptic function. They can modulate ATP availability, control synaptic protein levels, and regulate Ca2+ signaling, which ultimately impact neuronal activity. The interplay between these organelles, either through signaling pathways or physical membrane contacts, needs to be considered when studying their impact on neurotransmission. This review discusses the physiological role of pre-synaptic organelles in neuronal function.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2023)
Review
Chemistry, Medicinal
Mingming Zhao, Ziyan Zhang, Zhiyu Pan, Sijia Ma, Meiying Chang, Jiao Fan, Shunxuan Xue, Yuejun Wang, Hua Qu, Yu Zhang
Summary: This meta-analysis of 12 randomized controlled trials demonstrates that N-/T-type calcium channel blockers are more effective than L-type calcium channel blockers in reducing urine albumin/protein excretion in patients with chronic kidney disease treated with renin-angiotensin system inhibitors, without affecting serum creatinine, glomerular filtration rate, and adverse effects.
Article
Physiology
Jussep Salgado-Almario, Yillcer Molina, Manuel Vicente, Antonio Martinez-Sielva, Raul Rodriguez-Garcia, Pierre Vincent, Beatriz Domingo, Juan Llopis
Summary: This study investigates the contributions of ERG channels and TTCCs to the pacemaker and atrioventricular conduction in zebrafish larvae and explores the mechanisms causing atrioventricular block. The zebrafish lines expressing Ca2+ biosensors in the heart provide a valuable model for studying physiological feedback mechanisms and complex arrhythmias.
Review
Biochemistry & Molecular Biology
Dario Melgari, Anthony Frosio, Serena Calamaio, Gaia A. Marzi, Carlo Pappone, Ilaria Rivolta
Summary: T-type calcium channels play important roles in cancer and may serve as prognostic factors. However, the use of drugs to reduce their expression may lead to complications due to lack of selectivity. Moreover, T-type calcium channels are involved in side effects of certain anticancer agents, making patients more sensitive to pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Cell Biology
Katarzyna M. Grochowska, Michael R. Kreutz
Summary: The neuronal metastable proteome includes aggregation-prone proteins related to neurodegeneration. Recent work has revealed that chaperone-mediated autophagy (CMA) helps in the rapid removal of disease-relevant proteins through dendritic exocytic lysosomes. This lysosomal exocytosis also plays a role in synaptic modulation.
Article
Biochemistry & Molecular Biology
Ozge D. Ozcete, Tobias Moser
Summary: This study investigated the transfer function of synapses in inner hair cells, finding that differences in voltage dependence and release site coupling can affect synaptic transmission, contributing to the functional diversity of spiral ganglion neurons. The reported mechanism may help sensory cells and neurons in general to diversify signaling, even in nearby synapses.
Article
Biochemistry & Molecular Biology
Linlin Tian, Xiaodong Li, Yi Ding, Minli Li, Yunzhao Tang, Daiqing Li
Summary: The study showed that CLOCK is abundantly expressed in rat pancreatic beta cells, and its knockdown significantly affects insulin secretion. The potential pathway of CLOCK mediating Cav1.2 expression may play a crucial role in regulating insulin secretion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Neurosciences
Adam Davison, Uwe Thorsten Lux, Johann Helmut Brandstaetter, Norbert Babai
Summary: It has been found that the Ca2+ currents in cone photoreceptor terminals consist of low-voltage-activated (T-type) and high-voltage-activated (L-type) channels. The T-type Ca2+ channels are located close to the release machinery and generate self-generated spikes in response to light/dark transitions. These findings expand the functional repertoire of cone photoreceptors and enhance synaptic transmission.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Cell Biology
Claire Y. Allan, Paul R. Fisher
Summary: The study reveals the contribution of mucolipin in chemotactic calcium signaling and suggests that Dictyostelium is a useful model for studying the molecular mechanisms of cytopathogenesis in Mucolipidosis type IV.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Philipp Ruehl, Anna Scotto Rosato, Nicole Urban, Susanne Gerndt, Rachel Tang, Carla Abrahamian, Charlotte Leser, Jiansong Sheng, Archana Jha, Guenter Vollmer, Michael Schaefer, Franz Bracher, Christian Grimm
Summary: The study identified a highly potent and isoform-selective TRPML1 antagonist, EDME, and its analogs, which selectively affect key features of TRPML1 function and act as inhibitors of triple-negative breast cancer cell migration and invasion.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Dillon Jevon, Kylie Deng, Nicole Hallahan, Krish Kumar, Jason Tong, Wan Jun Gan, Clara Tran, Marcela Bilek, Peter Thorn
Summary: The spatial compartmentalisation in pancreatic beta cells is critical in controlling insulin secretion. By using live-cell subcellular imaging methods in mouse organotypic pancreatic slice, this study discovers the essential role of integrins and focal adhesion kinase (FAK) in regulating beta cells.
Article
Biochemistry & Molecular Biology
Yu-Wang Chang, Yong-Cyuan Chen, Chien-Chang Chen
Summary: The Cav3.2 T-type calcium channel plays a crucial role in various pathological conditions, and its calcium channel function is regulated by phosphorylation by multiple kinases. In this study, we used quantitative mass spectrometry to identify the serine/threonine residues on Cav3.2 that are dephosphorylated by calcineurin. We found six dephosphorylated serine residues in different regions of Cav3.2, and observed that calcineurin binds to and dephosphorylates the C-terminus of Cav3.2. Additionally, we discovered that calcineurin can dephosphorylate a previously known CaMKII-phosphorylated site (S1198) and a novel CaMKII-phosphorylated site (S2137) on Cav3.2. These findings provide insights into the regulation of Cav3.2 through both kinase phosphorylation and calcineurin phosphatase dephosphorylation.
Article
Multidisciplinary Sciences
Xitong Liang, Timothy E. Holy, Paul H. Taghert
Summary: The molecular clocks in Drosophila regulate internal and external calcium fluxes, generating two rhythmical patterns in basal calcium levels and fast calcium fluctuations. These rhythms are essential for circadian pacemaker neurons and provide rhythmic outputs to regulate downstream brain activities.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Pharmacology & Pharmacy
Liqiong Ding, Ping Jiang, Xinfeng Xu, Wanzhen Lu, Chan Yang, Lin Li, Pingzheng Zhou, Shuwen Liu
Summary: The study identified T-type calcium channel blockers as potential inhibitors of HSV-2 infection, while L-type calcium channel blockers showed no significant effect. Additionally, benidipine exerted antiviral effects by suppressing viral gene expression in the late stage of infection.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Da-Hye Lee, Chang-Zhu Pei, Jae-Yun Song, Kyung-Ju Lee, Bo-Seong Yun, Kyu-Bum Kwack, Eun-Il Lee, Kwang-Hyun Baek
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2019)
Article
Biochemistry & Molecular Biology
Hyo-Sun Lee, Eunil Lee, Joung-Ho Moon, YunJeong Kim, Heon-Jeong Lee
MOLECULAR & CELLULAR TOXICOLOGY
(2019)
Review
Environmental Sciences
Ka Young Kim, Eunil Lee, Yanghee Kim
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2019)
Article
Health Care Sciences & Services
JeongMan Park, YoungJoon Park, Insong Koh, Nam Keun Kim, Kwang-Hyun Baek, Bo-Seong Yun, Kyung Ju Lee, Jae Yun Song, Eunil Lee, KyuBum Kwack
JOURNAL OF PERSONALIZED MEDICINE
(2020)
Article
Public, Environmental & Occupational Health
Suji Lee, Whanhee Lee, Eunil Lee, Myung Ho Jeong, Seung-Woon Rha, Chong-Jin Kim, Shung Chull Chae, Hyo-Soo Kim, Hyeon-Cheol Gwon, Ho Kim
Summary: This study examined the effect of PM on Asian dust-induced myocardial infarction and found that PM2.5 and PM10 emissions had a significant impact on STEMI patients during Asian dust weather, especially in the < 65-year-old group. Additionally, revision of the Asian dust alarm system is needed to protect vulnerable populations.
Article
Environmental Sciences
You Yeon Choi, Mihyun Yang, Younghyun Lee, Eunil Lee, Young Woo Jin, Ki Moon Seong
Summary: The survey results revealed that respondents generally believed that the national emergency medical plan for radiation accidents was prepared at an above-average level. Inspectors evaluated the emergency medical system for radiation accidents more strictly than licensee workers, especially in terms of radiation medical emergency preparedness and the government's regulatory policy for radiation safety.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Biochemical Research Methods
Eun Jung Koh, So Yeon Yu, Seung Hwan Kim, Seung Jun Kim, Eun-Il Lee, Seung Yong Hwang
Summary: This study assessed the quality of RNA prepared from blood stored at different temperatures and times prior to freezing, as well as the effect of long-term freezing, finding that improper sample handling critically influenced both RNA quality and gene expression patterns.
Article
Obstetrics & Gynecology
Seongmin Kim, Se Hee Lee, Kyung Jin Min, Sanghoon Lee, Jin Hwa Hong, Jae Yun Song, Jae Kwan Lee, Nak Woo Lee, Eunil Lee
Summary: This study, using next-generation sequencing, demonstrates for the first time that vaginal microbiomes in young women with decreased ovarian function are more sensitive to environmental pollutants, especially volatile organic compounds.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Geriatrics & Gerontology
Ji-Won Shin, Eunil Lee, Seungbong Han, Seung-Ah Choe, Ok Hee Jeon
Summary: This study investigated the association between the secretory phenotypes produced by senescent cells and age-related factors in women, particularly chronological and menopausal age. The results showed that certain proteins were positively associated with chronological age, and other proteins were negatively associated with menopausal age and years since menopause. Furthermore, a specific combination of 13 proteins was found to be associated with age and menopausal state. These findings suggest that SASP factors may serve as potential markers for biological aging associated with ovarian senescence.
REJUVENATION RESEARCH
(2022)
Article
Genetics & Heredity
Mari Kim, Gwang-Ic Son, Yun-Ho Cho, Gye-Hyeong Kim, Sung-Eun Yun, Young-Joon Kim, Jongkyeong Chung, Eunil Lee, Joong-Jean Park
Summary: Exposure to dim light at night affects the circadian rhythm and metabolism in Drosophila, leading to decreased levels of branched-chain amino acids and increased expression of enzymes involved in their metabolism. Flies with mutations in the Bcat gene are less vulnerable to starvation stress, and reducing Bcat expression suppresses this vulnerability. Feeding BCAAs to wild-type flies exposed to dim light at night reverses the metabolic vulnerability.
JOURNAL OF NEUROGENETICS
(2023)
Article
Biochemistry & Molecular Biology
Yun Jeong Kim, Eunha Oh, Minhwa Shin, Dae-Hwan Nam, So Young Jeon, Jin Hyuk Yu, Jae Yun Song, Dohsik Minn, Eunil Lee
Summary: The study finds that environmental chemicals, including two phthalate metabolites and mercury, are associated with POI in Korean women. The POI group also has higher consumption of crustaceans and frozen food. Logistic regression analysis suggests that only the metabolite-mono-n-butyl phthalate (MnBP) has a significant difference between the POI and non-POI groups. This indicates that exposure to environmental chemicals may affect the female reproductive system even at low exposure levels.
MOLECULAR & CELLULAR TOXICOLOGY
(2023)
Article
Multidisciplinary Sciences
Yesol Moon, Eunil Lee, Seoeun Lee, Gwang-Ic Son, Hangjin Byeon, Hyang-Ree Shin, Baatar Bolortsetseg
Summary: Recent studies have found that the cortisol awakening response (CAR) is associated with various health risks. This study investigated the factors affecting CAR and found that sleep efficiency and obesity influenced average cortisol levels in the morning (AVE) and the total area under the curve of cortisol levels (AUCg), while factors such as age affected the area under the curve of cortisol levels with respect to increase (AUCi). Furthermore, a marine retreat program was shown to improve CAR levels related to obesity and aging.
Article
Biology
Gwang-ic Son, Eunil Lee, Mari Kim, Seoeun Lee, Yesol Moon, Joonhee Kim
Summary: Human cells are constantly exposed to different stress factors in their physiological environment, and certain mechanical stress has been found to influence cell cycle progression and proliferation. However, the signaling pathways involved in this process are not well understood. In this study, researchers developed a pressure chamber to simulate an elevated barometric pressure environment and investigated its effect on cell proliferation. The results showed that the elevated barometric pressure inhibited cell proliferation by delaying the G2/M phase, which was caused by attenuated cell adhesion and actin cytoskeleton assembly.
ARCHIVES OF BIOLOGICAL SCIENCES
(2023)
Review
Hematology
Beomjun Seo, Jeeyoon Kim, Seungwook Kim, Eunil Lee
Article
Biology
Jung-Ick Byun, Byeong Uk Lee, Yong Seo Koo, Jun-Sang Sunwoo, Jung-Ah Lim, Jangsup Moon, Soon-Tae Lee, Keun-Hwa Jung, Kon Chu, Manho Kim, Jong-Min Lim, Heon-Jeong Lee, Eunil Lee, Sang Kun Lee, Ki-Young Jung
CHRONOBIOLOGY INTERNATIONAL
(2018)