Article
Nutrition & Dietetics
Giuseppe Riezzo, Laura Prospero, Antonella Orlando, Michele Linsalata, Benedetta D'Attoma, Antonia Ignazzi, Gianluigi Giannelli, Francesco Russo
Summary: Most female IBS patients experience abdominal bloating rather than abdominal pain and diarrhea. A diet based on Tritordeum grain can effectively reduce bloating and improve the psychological profile of female IBS-D patients. The study found no correlation between bloating intensity and waist circumference.
Article
Gastroenterology & Hepatology
Xiu-Cai Fang, Wen-Juan Fan, Douglas D. Drossman, Shao-Mei Han, Mei-Yun Ke
Summary: This study compared bowel symptoms and psychosocial features in IBS patients diagnosed with Rome III criteria with abdominal discomfort, abdominal pain, and pain & discomfort. The results showed that IBS patients with abdominal discomfort have similar bowel symptoms and psychosocial features to those with abdominal pain.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Nutrition & Dietetics
Robin Spiller
Summary: IBS is strongly influenced by diet, but identifying specific food intolerances is difficult due to the complexities of diet. Rapidly fermented carbohydrates and gut-specific mast cell activation may cause symptoms in IBS patients. More research is needed to fully understand the mechanisms of food intolerances and improve personalized medicine approaches to diet in IBS.
Article
Gastroenterology & Hepatology
Heidi M. Staudacher, Sophie Mahoney, Kim Canale, Rachelle S. Opie, Amy Loughman, Daniel So, Lauren Beswick, Chris Hair, Felice N. Jacka
Summary: A Mediterranean diet is feasible and effective in improving gastrointestinal and psychological symptoms in patients with IBS.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Neurosciences
Toshinori Yoshioka, Misaki Ohashi, Kenjiro Matsumoto, Tomoki Omata, Takumi Hamano, Mayuna Yamazaki, Sayaka Kimiki, Kotaro Okano, Riho Kobayashi, Daisuke Yamada, Noriyasu Hada, Shinichi Kato, Akiyoshi Saitoh
Summary: Increasing evidence suggests a connection between emotional states and intestinal conditions in brain-gut interactions. This study focused on a validated animal model of stress-induced psychiatric disorders (cVSDS model mice) and found that these mice exhibited symptoms similar to irritable bowel syndrome (IBS), including changes in intestinal motility and increased visceral pain. These symptoms persisted for a month after the stress session. Additionally, a traditional Chinese medicine used for the treatment of IBS normalized the intestinal motility changes in the model mice.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Qiang-Song Wang, Yi-Lun Wang, Wen-Yan Zhang, Kuang-Dai Li, Xiong-Fei Luo, Yuan-Lu Cui
Summary: IBS, especially IBS-D, affects approximately 9-20% of the global population, with traditional treatments often causing side effects. Natural medicines, such as puerarin, have gained attention for their beneficial effects in recent years. Puerarin has been found to reverse IBS-D symptoms by regulating gut microbiota and various physiological processes.
Article
Cell Biology
Karem Awad, Christian Barmeyer, Christian Bojarski, Oliver Nagel, In-Fah M. Lee, Michal R. Schweiger, Joerg-Dieter Schulzke, Roland Buecker
Summary: This study investigated the pathophysiological mechanisms of diarrhea, constipation, and antigen uptake in mixed-type irritable bowel syndrome (IBS-M). The findings showed that in IBS-M, chloride secretion was reduced and antigen permeability was increased, which contributed to a low-grade inflammation in the colon mucosa.
Article
Gastroenterology & Hepatology
Takanori Yoshimoto, Tadayuki Oshima, Xinyi Huang, Toshihiko Tomita, Hirokazu Fukui, Hiroto Miwa
Summary: In patients with irritable bowel syndrome (IBS), an increase in duodenal mast cells and intraepithelial lymphocytes (IELs) was observed, with a positive correlation between the number of duodenal and ileal IELs and the frequency of diarrhea. Further studies are needed to clarify the pathophysiological functions associated with micro-inflammation in IBS, as this study was strictly observational.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Nutrition & Dietetics
Laura Prospero, Giuseppe Riezzo, Michele Linsalata, Antonella Orlando, Benedetta D'Attoma, Francesco Russo
Summary: The study shows that a diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (LFD) improves both gastrointestinal symptoms and the psychological profile of patients with irritable bowel syndrome with diarrhea (IBS-D). The LFD also enhances intestinal barrier function and reduces inflammation levels.
Article
Gastroenterology & Hepatology
Claire L. Jansson-Knodell, Mattie White, Carolyn Lockett, Huiping Xu, Andrea Shin
Summary: The type of food intolerance is associated with irritable bowel syndrome (IBS), anxiety, depression, and decreased health-related quality of life, often leading to food elimination. Adults with lactose and lactose plus food intolerance have higher rates of IBS, increased psychological symptoms, and poorer quality of life.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Vivek C. Goodoory, Antonina Mikocka-Walus, Yan Yiannakou, Lesley A. Houghton, Christopher J. Black, Alexander C. Ford
Summary: The prognosis of individuals with Rome IV-defined IBS worsens according to incremental increases in psychological comorbidity. This finding has significant implications for clinical practice and research.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Gastroenterology & Hepatology
Iam van Thiel, W. J. de Jonge, R. M. van den Wijngaard
Summary: Although the gut microbiota consists of bacteria, viruses, and fungi, most studies on the microbiota-gut-brain axis in IBS have primarily focused on bacteria due to their higher presence. However, recent research on the intestinal mycobiome in inflammatory bowel disease suggests that the low numbers of fungi and viruses may still have relevance. This review discusses the current IBS mycobiome data and how these findings could relate to previous observations in IBS, as well as identifies questions for future research.
Article
Gastroenterology & Hepatology
Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Giulia Cacciari, Francesca Falangone, Anna Kagramanova, Dmitry Bordin, Vasile Drug, Egidia Miftode, Pietro Fusaroli, Salem Youssef Mohamed, Chiara Ricci, Massimo Bellini, Mohammed Masudur Rahman, Luigi Melcarne, Javier Santos, Beatriz Lobo, Serhat Bor, Suna Yapali, Deniz Akyol, Ferdane Pirincci Sapmaz, Yonca Yilmaz Urun, Tugce Eskazan, Altay Celebi, Huseyin Kacmaz, Berat Ebik, Hatice Cilem Binicier, Mehmet Sait Bugdayci, Munkhtsetseg Banzragch Yagci, Husnu Pullukcu, Berrin Yalinbas Kaya, Ali Tureyen, Ibrahim Hatemi, Elif Sitre Koc, Goktug Sirin, Ali Riza Caliskan, Goksel Bengi, Esra Ergun Alis, Snezana Lukic, Meri Trajkovska, Keren Hod, Dan Dumitrascu, Antonello Pietrangelo, Elena Corradini, Magnus Simren, Jessica Sjoelund, Navkiran Tornkvist, Uday C. Ghoshal, Olga Kolokolnikova, Antonio Colecchia, Jordi Serra, Giovanni Maconi, Roberto De Giorgio, Silvio Danese, Piero Portincasa, Antonio Di Sabatino, Marcello Maggio, Elena Philippou, Yeong Yeh Lee, Daniele Salvi, Alessandro Venturi, Claudio Borghi, Marco Zoli, Paolo Gionchetti, Pierluigi Viale, Vincenzo Stanghellini, Giovanni Barbara
Summary: This study aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction among hospitalized patients with SARS-CoV-2 infection. The results showed that patients with COVID-19 had higher rates of gastrointestinal symptoms on hospital admission and lower rates of constipation and hard stools at 12 months post-infection compared to the control group. Additionally, the rate of irritable bowel syndrome was significantly higher in patients with COVID-19 than in controls.
Article
Gastroenterology & Hepatology
Tom Holvoet, Marie Joossens, Jorge F. Vazquez-Castellanos, Evelien Christiaens, Lander Heyerick, Jerina Boelens, Bruno Verhasselt, Hans van Vlierberghe, Martine De Vos, Jeroen Raes, Danny De Looze
Summary: Fecal microbiota transplantation (FMT) therapy has shown promising efficacy in treating patients with treatment-resistant Irritable Bowel Syndrome (IBS), particularly in relieving predominant bloating symptoms. The treatment response was associated with higher microbiome diversity in stool samples before FMT administration, suggesting a potential biomarker for patient selection.
Article
Gastroenterology & Hepatology
Pr. Benoit Coffin, Henri Duboc
Summary: Persistent abdominal pain is a challenging condition often misdiagnosed as functional disorders. This article provides an update on less well-known causes of abdominal pain and their diagnosis and management.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)