Article
Biochemistry & Molecular Biology
Srivatsan Raghavan, Peter S. Winter, Andrew W. Navia, Hannah L. Williams, Alan DenAdel, Kristen E. Lowder, Jennyfer Galvez-Reyes, Radha L. Kalekar, Nolawit Mulugeta, Kevin S. Kapner, Manisha S. Raghavan, Ashir A. Borah, Nuo Liu, Sara A. Vayrynen, Andressa Dias Costa, Raymond W. S. Ng, Junning Wang, Emma K. Hill, Dorisanne Y. Ragon, Lauren K. Brais, Alex M. Jaeger, Liam F. Spurr, Yvonne Y. Li, Andrew D. Cherniack, Matthew A. Booker, Elizabeth F. Cohen, Michael Y. Tolstorukov, Isaac Wakiro, Asaf Rotem, Bruce E. Johnson, James M. McFarland, Ewa T. Sicinska, Tyler E. Jacks, Ryan J. Sullivan, Geoffrey Shapiro, Thomas E. Clancy, Kimberly Perez, Douglas A. Rubinson, Kimmie Ng, James M. Cleary, Lorin Crawford, Scott R. Manalis, Jonathan A. Nowak, Brian M. Wolpin, William C. Hahn, Andrew J. Aguirre, Alex K. Shalek
Summary: Prognostically relevant RNA expression states exist in pancreatic ductal adenocarcinoma (PDAC), with strong culture-specific biases in cancer cell transcriptional state representation and non-genetic modulation of cell state strongly influencing drug responses. This study provides a framework for aligning cell states across in vivo and ex vivo settings, identifying drivers of transcriptional plasticity, and manipulating cell state to target associated vulnerabilities.
Article
Biology
Peter K. Kim, Christopher J. Halbrook, Samuel A. Kerk, Megan Radyk, Stephanie Wisner, Daniel M. Kremer, Peter Sajjakulnukit, Anthony Andren, Sean W. Hou, Ayush Trivedi, Galloway Thurston, Abhinav Anand, Liang Yan, Lucia Salamanca-Cardona, Samuel D. Welling, Li Zhang, Matthew R. Pratt, Kayvan R. Keshari, Haoqiang Ying, Costas A. Lyssiotis
Summary: The rewired metabolism in pancreatic ductal adenocarcinomas is sustained by cancer cells scavenging nutrients from the tumor microenvironment to maintain glycosylation precursor pools. Hyaluronic acid, a carbohydrate polymer in pancreatic tumors, can refuel the hexosamine biosynthetic pathway beyond its structural and signaling roles, providing energy for PDA metabolism.
Article
Cell Biology
Young Mi Kim, Sung-Hwa Ko, Yong-Il Shin, Yeonye Kim, Taehyung Kim, Jaehoon Jung, Sang-Yull Lee, Nam Gyun Kim, Kyoung-Jun Park, Ji Hyeon Ryu
Summary: The study demonstrated that blue LED irradiation suppressed pancreatic cancer cell and tumor growth by regulating the AKT/mTOR signaling pathway, while also increasing the expression of apoptosis-related proteins. These findings suggest that blue LEDs could be utilized as a nonpharmacological treatment for pancreatic cancer.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Pietro Carotenuto, Francesco Amato, Andrea Lampis, Colin Rae, Somaieh Hedayat, Maria C. Previdi, Domenico Zito, Maya Raj, Vincenza Guzzardo, Francesco Sclafani, Andrea Lanese, Claudia Parisi, Caterina Vicentini, Ian Said-Huntingford, Jens C. Hahne, Albert Hallsworth, Vladimir Kirkin, Kate Young, Ruwaida Begum, Andrew Wotherspoon, Kyriakos Kouvelakis, Sergio Xavier Azevedo, Vasiliki Michalarea, Rosie Upstill-Goddard, Sheela Rao, David Watkins, Naureen Starling, Anguraj Sadanandam, David K. Chang, Andrew Biankin, Nigel B. Jamieson, Aldo Scarpa, David Cunningham, Ian Chau, Paul Workman, Matteo Fassan, Nicola Valeri, Chiara Braconi
Summary: The study reveals that MIR1307 microRNA is elevated in a subset of human pancreatic cancers, and inhibiting this microRNA increases sensitivity of cells to treatment. Chemotherapy-induced apoptosis and DNA damage accumulation are higher in PDAC cells lacking MIR1307, while re-expression of MIR1307 rescues these effects.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Tomoaki Hirashima, Hideaki Karasawa, Takashi Aizawa, Takashi Suzuki, Akihiro Yamamura, Hideyuki Suzuki, Taiki Kajiwara, Hiroaki Musha, Ryo Funayama, Matsuyuki Shirota, Shinobu Ohnuma, Keiko Nakayama, Michiaki Unno
Summary: The study reveals that cancer-associated fibroblasts with increased expression of Wnt5a play a crucial role in the progression of colorectal cancer, and may serve as a target for anti-cancer therapies.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Xiuhui Shi, Min Wang, Yuqing Zhang, Xingjun Guo, Mingyang Liu, Zhijun Zhou, Yan Zhao, Ruizhi He, Yang Gao, Yuhui Liu, Shutao Pan, Min Zhou, Chunle Zhao, Taoyuan Yin, Xu Li, Hebin Wang, Jingxuan Yang, Feng Zhu, Min Li, Renyi Qin
Summary: High expression levels of alpha-SMA and hypoxia markers are associated with poor prognosis in pancreatic cancer patients. Mechanistically, hypoxia induces HGF expression and secretion in PSC via HIF-1 alpha, which then activates Met and suppresses pancreatic cancer cell sensitivity to EGFR inhibitors. The combination of EGFR inhibitor and Met inhibitor shows promise for pancreatic cancer treatment based on the demonstrated signaling axis between PSC and cancer cells.
Article
Biotechnology & Applied Microbiology
Yuanhua Lu, Jie Ma, Jian Lin, Yafei Tian, Yongjun Ma, Wei Wang, Jialin Li, Hugang Zhang, Ping Jiao
Summary: A new peptide KK-64 was designed in this study, showing strong cytotoxicity against liver cancer cells. The pcTERT-kk-64 plasmid demonstrated tumor targeting property and significant inhibition of liver cancer cell viability.
Article
Integrative & Complementary Medicine
Juan-ni Zeng, Jin-yu Tan, Li Mo
Summary: This study investigated the therapeutic effect of naringin on colorectal cancer (CRC) and the related mechanism. The results showed that naringin could inhibit cell proliferation and promote apoptosis of CRC cells, as well as suppress cell migration. In vivo experiments also demonstrated its inhibitory effect on tumor growth with good bio-compatibility.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Oncology
Tao Wang, Ping Chen, Ruochen Dong, Scott Weir, Michael Baltezor, Frank J. Schoenen, Qi Chen
Summary: The novel compound C150 was found to inhibit epithelial-to-mesenchymal transition (EMT) in pancreatic cancer cells, leading to reduced migration and proliferation. In animal models, C150 demonstrated promising anti-tumor effects by inhibiting tumor growth and metastasis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Simon Schworer, Francesco V. Cimino, Manon Ros, Kaloyan M. Tsanov, Charles Ng, Scott W. Lowe, Carlos Carmona-Fontaine, Craig B. Thompson
Summary: Cancer-associated fibroblasts (CAF) in pancreatic ductal adenocarcinoma (PDAC) exhibit heterogeneity, with myofi-broblastic CAFs (myCAF) and inflammatory CAFs (iCAF) having opposing roles. In vivo, iCAFs show a hypoxic gene expression profile and are enriched in hypoxic regions of PDAC tumors, while myCAFs are excluded from these areas. Hypoxia induces an inflammatory gene expression signature in fibroblasts and synergizes with cancer cell-derived cytokines to promote the iCAF phenotype. HIF1a stabilization is sufficient to induce the iCAF phenotype and promote PDAC tumor growth.
Article
Cell Biology
Dan Wang, Jianfei Chen, Bohan Li, Qingling Jiang, Ling Liu, Ziyi Xia, Qiusheng Zheng, Minjing Li, Defang Li
Summary: Emerging evidence suggests that lncRNA-Gm31932 is significantly decreased in ATRA and PB-4-induced mouse melanoma B16 cells. Silencing lncRNA-Gm31932 inhibits cell proliferation, induces cell cycle arrest and differentiation, and affects the expression of cell cycle-related proteins through the miR-344d-3-5p/Prc1 (and Nuf2) axis.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Zikun Ma, Xiangdong Li, Yize Mao, Chen Wei, Zhuoli Huang, Guibo Li, Jianhua Yin, Xiaoyu Liang, Zhuowei Liu
Summary: In this study, a subset of cancer-associated fibroblasts (CAFs) characterized by overexpression of the urea transporter SLC14A1 was identified in bladder cancer patients. These CAFs were induced by interferon signaling and conferred stemness to bladder cancer cells through the WNT5A paracrine pathway. Inhibiting the formation of SLC14A1(+) CAFs sensitized tumor cells to chemotherapy. Importantly, bladder cancer patients with a high proportion of intratumoral SLC14A1(+) CAFs had a poor outcome and a worse response rate to neoadjuvant chemotherapy or immunotherapy.
Article
Oncology
Raphaela Schwappacher, Walburga Dieterich, Dejan Reljic, Christian Pilarsky, Debabrata Mukhopadhyay, David K. Chang, Andrew Biankin, Juergen Siebler, Hans J. Herrmann, Markus F. Neurath, Yurdagul Zopf
Summary: Exercise-induced cytokines in serum from advanced-stage pancreatic cancer patients inhibit cancer cell growth and migration, and induce cancer cell death. This study provides new insights into the cancer-protective function of exercise in pancreatic cancer and supports the use of sport therapies for cancer patients.
Article
Biotechnology & Applied Microbiology
Keying Liu, Biyun Xue, Guiqin Bai, Wentao Zhang
Summary: The study demonstrates that elevated DGKZ expression in cervical cancer tissues and downregulation of DGKZ inhibit cell proliferation, promote apoptosis, and induce cell cycle arrest. Moreover, in a nude mouse model, knockdown of DGKZ suppresses tumor growth. Functional analysis indicates that DGKZ may play a role in cell proliferation and tumor growth through autophagy or mitophagy pathways. PathScan analysis reveals inhibition of PI3K-AKT and TAK1-NF-kappa B signaling pathways in DGKZ-silenced cells.
Article
Multidisciplinary Sciences
Hari Prasad Gandikota, S. Abirami, M. Sunil Kumar
Summary: This study explores the design of a deep learning-based technique for pancreatic cancer segmentation and classification, aiming to improve the diagnostic performance of pancreatic cancer. By utilizing the W-Net segmentation approach, the GhostNet feature extractor, the deep echo state network model, and hyperparameter tuning, this technique achieves significant classification results in CT scans.