Article
Dentistry, Oral Surgery & Medicine
Naoto Ohkura, Kunihiko Yoshiba, Nagako Yoshiba, Yohei Oda, Naoki Edanami, Hayato Ohshima, Shoji Takenaka, Takashi Okiji, Yuichiro Noiri
Summary: This study investigated the localization of components of the PGE2-transporting pathway in human dental pulp and their relevance to angiogenesis and dentinogenesis. The results showed that EP2/EP4 agonists promoted the generation of endothelial cell filopodia and upregulated the expression of angiogenesis and odontoblast differentiation-related genes.
JOURNAL OF ENDODONTICS
(2023)
Article
Cell Biology
Ruida Hou, Ying Yu, Madison N. Sluter, Lexiao Li, Jiukuan Hao, Jie Fang, Jun Yang, Jianxiong Jiang
Summary: The EP2 receptor was found to be highly correlated with the aggressiveness of neuroblastoma (NB) and acts as the predominant receptor mediating PGE(2)-initiated signaling in NB cells with high-risk factors. Inhibition of EP2 receptor prevents the development and progression of NB, providing a promising strategy to treat this deadly pediatric cancer.
Article
Oncology
Menglu Zhang, Jiaqi Liu, Gang Liu, Zeyu Xing, Ziqi Jia, Jiaxin Li, Wenyan Wang, Jie Wang, Ling Qin, Xin Wang, Xiang Wang
Summary: Breast cancer, the highest incidence of female malignancy, is heavily reliant on neo-vascularization for growth and metastasis, with Vascular Endothelial Growth Factor (VEGF) playing a crucial role. This review focuses on the prognostic value of VEGF in breast cancer, clinical experiences with anti-VEGF therapeutics, and biomarkers for predicting the effectiveness of anti-angiogenic treatment.
Article
Immunology
Ward Vleeshouwers, Koen van den Dries, Sandra de Keijzer, Ben Joosten, Diane S. Lidke, Alessandra Cambi
Summary: This study highlights the modulation of myeloid immune cell function by Prostaglandin E2 (PGE2) through the activation of EP2 and EP4 receptors. EP4 plays a key role in podosome loss in DCs, while both EP2 and EP4 signaling lead to different cAMP production profiles and reciprocal control of signaling pathways. Efficient signaling of both EP2 and EP4 relies on an intact microtubule network, enhancing our understanding of early signaling events in myeloid cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Jiannan Gong, Zihang Feng, Abigail L. Peterson, Jennifer F. Carr, Xuexin Lu, Haifeng Zhao, Xiangming Ji, You-Yang Zhao, Monique E. De Paepe, Phyllis A. Dennery, Hongwei Yao
Summary: The study showed that hyperoxia can exacerbate abnormal endothelial cell proliferation and dysmorphic vascular growth in neonatal mice through the pentose phosphate pathway (PPP), while inhibition of the PPP can reduce these effects.
Article
Physiology
Signe S. Tofteng, Line Nilsson, Amalie K. Mogensen, Rikke Norregaard, Rolf Nuesing, Mikhail Diatchikhine, Lars Lund, Claus Bistrup, Boye L. Jensen, Kirsten Madsen
Summary: COX-2 activity protects against fibrosis and preserves microvasculature in injured kidney. In the study, it was found that fibrosis markers increased significantly in COX-2(-/-) mice and human kidney tissue with obstruction-induced kidney disease. Fibroblasts from COX-2(-/-) kidneys also showed increased matrix synthesis. Additionally, obstructed human kidneys showed increased PGE2-EP2 receptor levels, which could contribute to protection.
Article
Chemistry, Multidisciplinary
Prashant Jain, Chethan D. Shanthamurthy, Shani Leviatan Ben-Arye, Sharon Yehuda, Sharvani S. Nandikol, Hirekodathakallu Thulasiram, Vered Padler-Karavani, Raghavendra Kikkeri
Summary: A potential heparan sulfate (HS) ligand was discovered to target several growth factors using specific HS tetrasaccharide ligands. One tetrasaccharide ligand showed strong binding with the VEGF(165) growth factor, and in vitro experiments demonstrated the therapeutic potential of these synthetic HS ligands by inhibiting vascular endothelial cell proliferation, migration, and angiogenesis in the presence of VEGF(165) and the specific tetrasaccharides.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Yang Liu, Linyu Long, Fanjun Zhang, Xuefeng Hu, Jieyu Zhang, Cheng Hu, Yunbing Wang, Jianguo Xu
Summary: The study introduced a GelMA microneedle platform for sustained and controlled local delivery of AAV-VEGF, which achieved homogeneous distribution and high transfection efficiency in ischemic brains. Results showed that MNs loaded with AAV-VEGF increased VEGF expression in the brain cortex and enhanced functional angiogenesis and neurogenesis.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Pathology
Hadi Chavoshi, Neda Poormolaie, Vahid Vahedian, Hamid Kazemzadeh, Amirabbas Mir, Hamid Reza Nejabati, Javad Behroozi, Alireza Isazadeh, Saba Hajezimian, Mohammad Nouri, Nazila Fathi Maroufi
Summary: Treating breast cancer in its invasive state is challenging due to factors such as invasion and metastasis. The formation of new blood vessels to nourish tumor cells is a cause of treatment failure. In addition to angiogenesis, vascular mimicry (VM) plays an important role in supplying nutrients and oxygen to tumor cells. This review explores the formation of VM and the therapeutic potential of targeting VM in breast cancer treatment.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Multidisciplinary Sciences
Zhiyang Li, Heng Zhang, Yujie Sun, Zhuangzhuang Feng, Bijia Cui, Jingxia Han, Yinan Li, Huijuan Liu, Tao Sun
Summary: Angiogenesis plays a crucial role in embryologic development, growth, and tissue repair, but dysregulation of this process is a hallmark of various pathologies, including cancer. Existing methods for evaluating cell vascular formation are often limited to static analysis, leading to bias. Researchers have developed code scripts to study the dynamic angiogenesis process, allowing for the screening of drugs that can affect various parameters of vascular formation. Animal experiments have confirmed the efficacy of these drugs in inhibiting blood vessel formation, providing a new perspective for angiogenesis research and drug development.
Article
Nanoscience & Nanotechnology
Xiao-yu Dai, Li-jun Ren, Lang Yan, Ji-qian-zhu Zhang, Yi-fan Dong, Tao-lin Qing, Wen-jing Shi, Jin-feng Li, Fang-yuan Gao, Xiao-fang Zhang, Yi-jun Tian, Yu-ping Zhu, Jiang-bo Zhu, Ji-kuai Chen
Summary: This study demonstrated that MWCNTs can affect endothelial cell activity, disrupt tube formation and cell migration ability, subsequently affecting angiogenesis. Furthermore, the VEGF-Akt-eNOS axis plays a crucial role in MWCNT-induced endothelial cell injury.
Article
Peripheral Vascular Disease
Anantha K. Kanugula, Ravi K. Adapala, Anurag Jamaiyar, Nina Lenkey, Brianna D. Guarino, Wolfgang Liedtke, Liya Yin, Sailaja Paruchuri, Charles K. Thodeti
Summary: TRPV4 plays a critical role in tumor growth, angiogenesis, and metastasis, with endothelial TRPV4 being a key modulator of vascular integrity and tumor angiogenesis. Deletion of TRPV4 promotes tumor angiogenesis, growth, and metastasis.
Review
Biochemistry & Molecular Biology
Mannon Geindreau, Francois Ghiringhelli, Melanie Bruchard
Summary: VEGF plays a crucial role in tumor growth by promoting angiogenesis and modulating the immune response. Clinical approval has been given to therapies targeting VEGF for the treatment of various cancers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Raymond K. H. Yip, Joel S. Rimes, Bianca D. Capaldo, Francois Vaillant, Kellie A. Mouchemore, Bhupinder Pal, Yunshun Chen, Elliot Surgenor, Andrew J. Murphy, Robin L. Anderson, Gordon K. Smyth, Geoffrey J. Lindeman, Edwin D. Hawkins, Jane E. Visvader
Summary: The study demonstrates the preferential homing of mouse mammary tumor cells to specific blood vessels within the bone marrow during the metastasis process, with the tumor cells remodeling the local vasculature by producing granulocyte-colony stimulating factor. This hijacking of the host microenvironment by tumor cells leads to the formation of a pro-tumorigenic niche in the bone marrow, highlighting the importance of targeting this metastatic niche to inhibit blood vessel remodeling and reduce bone metastasis burden.
NATURE COMMUNICATIONS
(2021)
Article
Mechanics
Jyotsana Priyadarshani, Prasoon Awasthi, Pratyaksh Karan, Soumen Das, Suman Chakraborty
Summary: This study presents a simulation mimicking tumor angiogenesis microenvironment on-chip, aiming to establish favorable conditions for gradients of vascular endothelial growth factor. The model platform explores different responses of endothelial cells in a micro-confined fluidic environment, showing potential significance for organ-on-a-chip assays, disease modeling, and optimizing anti-angiogenic therapies.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ranran Li, Yana Qi, Meng Han, Baocheng Geng, Guangyu Wang, Mingyong Han
Summary: Microenvironmental changes in the metastatic organs occur before the arrival of metastatic tumor cells. This study evaluated the effectiveness of CT images in quantifying these changes in the premetastatic lung under both laboratory and clinical conditions. Results show that CT is a reliable tool for providing dynamic information on metastatic processes, with increased lung density correlating with inflammation severity and tumor progression.
EUROPEAN RADIOLOGY
(2021)
Article
Oncology
Zengjun Liu, Hongtu Yuan, Mingyong Han
Summary: A novel SS18-POU5F1 fusion gene was reported in soft tissue sarcoma, showing a quick, robust but transient clinical response to radiotherapy, while demonstrating no response to immune checkpoint inhibitor, angiogenesis inhibitor, and chemotherapy. Further research is needed to understand the mechanisms underlying the different tumor responses to radiotherapy and systemic therapy in this type of tumor.
FRONTIERS IN ONCOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Ady Suwardi, FuKe Wang, Kun Xue, Ming-Yong Han, Peili Teo, Pei Wang, Shijie Wang, Ye Liu, Enyi Ye, Zibiao Li, Xian Jun Loh
Summary: Biomaterials research has historically been hindered by long development periods, but the application of machine learning in materials science has greatly accelerated progress. The combination of machine learning with high-throughput theoretical predictions and experiments has shifted the traditional trial and error paradigm to a data-driven paradigm, which is driving the discovery and application of biomaterials.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Physical
Xiang Yao, Huaxiu Geng, Yunzhi Gu, Hongbo Cui, Guijian Guan, Mingyong Han
Summary: A novel heterojunction doping approach has been developed to boost the efficiency of charge carrier collection in perovskite solar cells by depositing Cs-doped VOx and PTAA thin films, observing extensive heterojunction doping at the contact interface, and enhancing the conductivity and energy level alignment in Cs-doped VOx/PTAA HELs, leading to improved V-OC, J(SC), FF, and PCE in PSCs.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Polymer Science
Khin Yin Win, Choon Peng Teng, Si Yin Tee, Guijian Guan, Xian Jun Loh, Ming-Yong Han
Summary: This study presents an innovative approach using silk to encapsulate hydrophilic colorants, creating a palette of lustrous multicolored silk while retaining its unique properties and offering new functionalities. The success of encapsulation depends on colorant structures, silk recrystallization, and their affinity, with phase transfer capabilities and phase distribution coefficients of colorants being crucial evaluation factors. The formulated silk enhances color-encapsulating efficiency and physiochemical stability, reduces cytotoxicity, and provides flexibility for incorporating various materials in cosmetic applications.
Article
Chemistry, Inorganic & Nuclear
Si Yin Tee, Xian Yi Tan, Xizu Wang, Coryl Jing Jun Lee, Khin Yin Win, Xi Ping Ni, Siew Lang Teo, Debbie Hwee Leng Seng, Yuki Tanaka, Ming-Yong Han
Summary: In this study, binary Ag2Se, composite Ag0:Ag2Se, and ternary Cu+:Ag2Se were successfully synthesized through an ambient aqueous-solution-based approach. The controllability over phases and compositions and the feasibility for large-scale production were demonstrated. Cu+ doping significantly improved the thermoelectric properties of n-type Ag2Se, achieving a ZT value of 0.9-1.2 over a temperature range of 300-393 K, which is the highest among wet chemistry methods reported.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Tianze Wu, Ming-Yong Han, Zhichuan J. Xu
Summary: The efficiency of electrocatalytic reactions has been continuously improved by engineering the size of electrocatalysts. Nanosized electrocatalysts with high surface area have been widely used in advanced electrochemical devices. Studying the size effects of electrocatalysts is important for understanding their intrinsic properties and optimizing performance.
Review
Chemistry, Multidisciplinary
Zilong Guo, Guo Yu, Zhiguo Zhang, Yandong Han, Guijian Guan, Wensheng Yang, Ming-Yong Han
Summary: The collective oscillation of free electrons at the nanoscale surface of gold nanostructures is modulated by various factors, including size, shape, phase, composition, assembly, and surroundings. These modulation techniques lead to changes in optical properties, metal-field-enhanced optical signals, luminescence spectral shaping, chiroptical response, and photogenerated hot carriers. The rich optical properties of gold nanostructures have enabled a wide range of applications in nanoscience and nanotechnology, including full-color displays, solar energy harvesting, photochemical reactions, optical sensing, and biomedical imaging.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jiajia Li, Longdi Zhang, Juan Chen, Ruilong Zhang, Zhengjie Liu, Jun Zhao, Bianhua Liu, Ming-yong Han, Guangmei Han, Zhongping Zhang
Summary: This study presents the use of photostable and amphiphilic carbon dots (Phe-CDs) in STED microscopy for imaging subcellular organelles. The Phe-CDs exhibit high brightness and excellent photostability, allowing for the tracking and reconstruction of the ER ultrastructure. Compared to standard microscopy, STED super-resolution imaging provides a clearer visualization of the ER network and its pores. The findings of this study demonstrate the importance of Phe-CDs in advancing the field of STED microscopy.
Article
Engineering, Electrical & Electronic
Yunzhi Gu, Xiang Yao, Huaxiu Geng, Mengying Long, Guijian Guan, Minglie Hu, Mingyong Han
Summary: Metal halides possess the potential for fabricating photothermoelectric detectors due to their unique properties. In this study, a PTE-based detector was successfully fabricated using a lead-free Cs3Cu2I5 nanolayered film. The self-powered detector exhibited light response wavelengths ranging from visible to terahertz. Furthermore, the Cs3Cu2I5 film-based PTE photodetector arrays were successfully applied in flexible imaging. These findings highlight the promise of lead-free Cs3Cu2I5 as a flexible and self-powered ultra-broadband photodetector.
ACS APPLIED ELECTRONIC MATERIALS
(2022)
Article
Engineering, Electrical & Electronic
Huaxiu Geng, Xiang Yao, Xinhao Tu, Zhiyong Wang, Yunzhi Gu, Hongbo Cui, Guijian Guan, Mingyong Han
Summary: The thermal conductivity of Cs3Bi2I9 thin film was found to be lower than that of BiI3 thin film, attributed to stronger phonon scattering. Photothermal detectors using Cs3Bi2I9 showed better performance in response temperature, photocurrent, responsivity, and detectivity compared to those using BiI3. This suggests opportunities for exploring ultra-low thermal conductivity in metal halide perovskites.
ACS APPLIED ELECTRONIC MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Guanqing Yang, Tong Zhu, Dong Wang, Zhengjie Liu, Ruilong Zhang, Guangmei Han, Xiaohe Tian, Bianhua Liu, Ming-Yong Han, Zhongping Zhang
Summary: The developed ratiometric fluorescent probe with a large emission shift allows for accurate measurement of hydrogen peroxide in pyroptosis signaling pathways, demonstrating the critical role of H2O2 as an upstream signaling molecule in regulating pyroptosis within the complex pathways.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Yuki Tanaka, Shiqiang Bai, Xizu Wang, Si Yin Tee, Siew Lay Lim, Lin Ke, Surani B. Dolmanan, Coryl Jing Jun Lee, Poh Chong Lim, Xiang Yao, Jishan Wu, Ming-Yong Han
Summary: This study describes the synthesis and optical and electronic properties of a one-dimensional sulfoxonium-based hybrid metal halide, as well as the development of a method to calculate tolerance factors based on the ionic radii of non-spherical cations from X-ray crystallographic data.
CHEMICAL COMMUNICATIONS
(2021)
Review
Chemistry, Multidisciplinary
Han Yandong, Han Mingyong, Yang Wensheng
Summary: The hydrolysis/condensation of orthosilicate is commonly used for preparing mesoporous silica materials. By adjusting the process in a multiphase interface, different mesoporous nanostructures can be constructed, offering new opportunities for expanding their application fields.
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
(2021)
Review
Engineering, Biomedical
Guijian Guan, Khin Yin Win, Xiang Yao, Wensheng Yang, Ming-Yong Han
Summary: With the wide use of antibiotics leading to antibiotic-resistant bacteria, the emerging photothermal ablation using anisotropic gold nanostructures has gained significant research interest for combating bacterial infections effectively. This review focuses on the thermal treatment of infectious diseases and photothermal therapy via heat generation on NIR-absorbing gold nanostructures, emphasizing the importance of size, shape, and composition for achieving strong plasmonic absorption in the NIR region. Additionally, the innovative photothermal applications of gold nanostructures are comprehensively discussed, along with suggestions for improving photothermal technologies for practical use.
ADVANCED HEALTHCARE MATERIALS
(2021)