Article
Environmental Sciences
Tae Hong Kang, Kyung Soo Kang, Sang In Lee
Summary: Research has found that DON can induce apoptosis in intestinal epithelial cells through the FOXO3a-signaling pathway, leading to the translocation of FOXO3a into the nucleus. Inhibiting FOXO3a can alleviate apoptosis and the expression of apoptosis-related genes. Additionally, treatment with an ERK1/2 inhibitor can suppress the translocation of FOXO3a into the nucleus.
Review
Chemistry, Medicinal
Xiaojun Zhang, Lusheng Jiang, Huimin Liu
Summary: Forkhead box protein O1 (FoXO1) is a transcription factor involved in regulating various physiological processes, with dysfunction linked to the pathophysiology of multiple diseases. Different post-translational modifications can dynamically regulate FoXO1 activity and target gene transcription.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Environmental Sciences
Mahdieh Farhoudi Sefidan Jadid, Behrouz Shademan, Reza Chavoshi, Nasrin Seyyedsani, Elnaz Aghaei, Elham Taheri, Pouya Goleij, Saba Hajazimian, Vahidreza Karamad, Javad Behroozi, Mehrdad Nasrollahzadeh Sabet, Alireza Isazadeh, Behzad Baradaran
Summary: The combination of Hyd and Cur, as well as nano-encapsulation therapy, showed more profound apoptotic and anti-proliferative effects on PANC-1 cells compared to free Hyd or Hyd monotherapy.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qinqin Xu, Xiaoling Zhang, Tao Li, Shiying Shao
Summary: This study found that exenatide can restore the Th17/Treg balance in obese diabetic mice by regulating the FoxO1 pathway, thereby improving the progression of diabetes and protecting pancreatic beta-cell function.
MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Lingchen Tao, Xi Chen, Yufei Zheng, Yuqi Wu, Xiasen Jiang, Mengmeng You, Shanshan Li, Fuliang Hu
Summary: The study demonstrated that Chinese propolis has a significant anticancer effect on pancreatic cancer cells Panc-1 by inducing apoptosis, inhibiting cell migration, and activating the Hippo pathway to suppress tumor growth.
Article
Cell Biology
Zhiqi Zhang, Haitao Yu, Wenyan Yao, Na Zhu, Ran Miao, Zhiquan Liu, Xuwei Song, Chunhua Xue, Cheng Cai, Ming Cheng, Ke Lin, Dachuan Qi
Summary: This study reveals that RRP9 plays a critical role in inducing gemcitabine chemoresistance in pancreatic cancer through the activation of the IGF2BP1/AKT signaling pathway.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Oncology
Xiaosi Hu, Shuai Zhou, Haohao Li, Zehui Wu, Ye Wang, Lei Meng, Zhangming Chen, Zhijian Wei, Qing Pang, Aman Xu
Summary: This study found that MND1 is highly expressed in gastric cancer and is associated with resistance to the chemotherapy drug oxaliplatin. Overexpression of MND1 is linked to worse prognosis and advanced pathological characteristics in gastric cancer patients. FOXA1 regulates gastric cancer progression by inhibiting the transcription of MND1. The interaction between MND1 and TKT activates the PI3K/AKT signaling pathway, promoting gastric cancer progression.
CANCER CELL INTERNATIONAL
(2023)
Article
Oncology
Ying Shi, Lili Zhao, Yifei Zhang, Qin Qin, Hongliang Cong, Zhigang Guo
Summary: The study reveals that the mechanism of Hcy-induced cardiac fibrosis involves differentiation, proliferation, and migration of CFs, leading to fibrosis through regulation of the Akt/FoxO3 pathway. Overexpression of FoxO3 can alleviate Hcy-induced dysfunction in CFs.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Fei Li, Weiwei Xie, Yunze Fang, Kunfeng Xie, Wendong Liu, Lina Hou, Wanlong Tan
Summary: HnRNP-F promotes the proliferation of BC cells through the PI3K/AKT pathway and is regulated by phosphorylation of FOXO1.
Article
Cell Biology
Wei Hu, Mingxu Li, Yan Wang, Chengcheng Zhong, Xinxin Si, Xiao Shi, Zhong Wang
Summary: This study comprehensively investigated the function of FOX family members in pancreatic adenocarcinoma (PAAD). The study found that FOXM1, FOXP1, and FOXN3 have prognostic value, and most FOX members are related to immune cell infiltration. These findings provide insights for future research on the FOX family and contribute to the identification of potential prognostic or therapeutic targets.
Article
Gastroenterology & Hepatology
Ting Liu, Xiao-Li Xie, Xue Zhou, Sheng-Xiong Chen, Yi-Jun Wang, Lin-Ping Shi, Shu-Jia Chen, Yong-Juan Wang, Shu-Ling Wang, Jiu-Na Zhang, Shi-Ying Dou, Xiao-Yu Jiang, Ruo-Lin Cui, Hui-Qing Jiang
Summary: YB-1, overexpressed in HCC tissues, enhances sorafenib resistance through the PI3K/Akt pathway. Knockdown of YB-1 can improve the efficacy of sorafenib in vivo. The interaction between YB-1 and key proteins of the PI3K/Akt pathway contributes to sorafenib resistance in HCC.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Endocrinology & Metabolism
Xi-juan Zhao, Kui Wang, Rong Li, Yang Lu, Pan Lu, Pei Fan, Yu-ying Lv, Xin-lin Chen, Hao-zheng Yuan
Summary: This study aimed to investigate the action of simvastatin on cortical neurons exposed to isoflurane and establish the mechanism of this action. It was found that simvastatin pretreatment protected neurons from isoflurane-induced neurotoxicity in vitro, and the phosphoinositide 3-kinase (PI3K)/Akt pathway mediated this effect.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Pharmacology & Pharmacy
Yinan Han, Shengxing Wang, Rurui Xia, Jinhuo Chen, Bangfen Zhou
Summary: The study investigated the role of FOXN3 protein in doxorubicin resistance of urothelial carcinoma. FOXN3 was found to be downregulated in DOX-resistant BLCA tissues and cells. Overexpression of FOXN3 attenuated the resistance and increased cell apoptosis. The study also identified the involvement of the SIRT6/PI3K/AKT/mTOR pathway in the mechanism of action.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
Article
Oncology
Yu Zeng, Haifeng Zhang, Minghui Zhu, Qingfan Pu, Jinhai Li, Xiao Hu
Summary: β-HIVS was found to inhibit the growth and invasion of pancreatic cancer through inducing apoptosis, increasing ROS production, decreasing mitochondrial membrane potential, and suppressing the PI3K/AKT pathways.
FRONTIERS IN ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
Usman Sabir, Hafiz Muhammad Irfan, Alamgeer, Ihtisham Umer, Zahid Rasul Niazi, Hafiz Muhammad Mazhar Asjad
Summary: Literature evidence suggests that natural compounds have the potential to improve obesity-associated non-alcoholic fatty liver disease (NAFLD) by targeting the forkhead box O1 (FOXO1) transcription factor. Certain phytochemicals, such as polyphenols, flavonoids, alkaloids, terpenoids, and anthocyanins, can modulate FOXO1 and its associated signaling pathways, making them potential therapeutic agents for NAFLD and related complications.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)