Article
Medicine, Research & Experimental
Colin Carlock, Yunpeng Bai, Allison Paige-Hood, Qinglin Li, Frederick Nguele Meke, Zhong-Yin Zhang
Summary: Overexpression of PRL2 and reduced PTEN protein are frequently observed in patients with acute myeloid leukemia (AML). Inhibiting PRL2 can prolong animal survival and slow the accumulation of leukemia blasts in the bone marrow niche. This study provides evidence for the viability of PRL2 inhibition as a therapeutic strategy for improving clinical outcomes in AML and other PTEN-deficient cancers.
Article
Cell Biology
Huizhen Wang, Yifan Wang, Xin Wang, Huimi Huang, Jingfu Bao, Wenhui Zhong, Aiqing Li
Summary: PTEN plays a crucial role in renal adaptive repair by upregulating CHMP2A to alleviate cell damage, apoptosis, and renal fibrosis. PTEN overexpression promotes phagosome closure, providing a potential therapeutic target for the transition from AKI to CKD.
CELL DEATH & DISEASE
(2021)
Article
Clinical Neurology
Jiaxu Wang, Meng Li, Jing Zhang, Qing Gao, Zhaoxi Ding, Jinhao Sun
Summary: The aim of this animal study was to investigate the mechanisms underlying the efficacy of paliperidone, an antipsychotic drug approved by the US FDA for the treatment of schizophrenia. The results showed that paliperidone alleviated neuronal damage induced by MK-801 through the PP2A/PTEN pathway.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Aiwen Jiang, Hongyun Guo, Xiaoyu Jiang, Jingli Tao, Wangjun Wu, Honglin Liu
Summary: This study reveals the down-regulation of G6PD during skeletal muscle development and explores its importance in myogenic differentiation. G6PD deficiency may provide a new perspective for the treatment of insulin resistance and type-2 diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Myung Jin Kim, Yun Kyung Cho, Han Na Jung, Eun Hee Kim, Min Jung Lee, Chang Hee Jung, Joong-Yeol Park, Hong-Kyu Kim, Woo Je Lee
Summary: This study evaluated the association between insulin resistance and myosteatosis in a large Asian population. The results showed that higher insulin resistance levels were significantly associated with increased absolute values of total abdominal muscle area, normal-attenuation muscle area, low-attenuation muscle area, and intermuscular adipose tissue. However, the ratios of normal-attenuation muscle area to body mass index and normal-attenuation muscle area to total abdominal muscle area showed a decreasing trend.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Engineering, Mechanical
Nan Liu, Hongli Yang, Shasha Li, Danni Wang, Liangui Yang
Summary: The team constructed a coupling model involving p53-Mdm2 negative feedback loop and p53-PTEN-Mdm2 positive feedback loop, finding that PTEN is crucial for p53 oscillation or bistable switching dynamic behaviors, and the positive feedback loop may enrich the dynamic behaviors of the p53 system.
ACTA MECHANICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Jyotsana Pandey, Kapil Dev, Sourav Chattopadhyay, Sleman Kadan, Tanuj Sharma, Rakesh Maurya, Sabyasachi Sanyal, Mohammad Imran Siddiqi, Hilal Zaid, Akhilesh Kumar Tamrakar
Summary: The study found that beta-sitosterol-3-O-D-glucopyranoside (BSD) isolated from the fruits of Cupressus sempervirens exhibits estrogenic activity, stimulating glucose utilization in skeletal muscle cells through a PI-3K/AKT-dependent mechanism, and enhancing GLUT4 translocation.
Article
Biotechnology & Applied Microbiology
Nianxue Wang, Bin Yang, Jiao Jin, Yu He, Xijun Wu, Yichen Yang, Weijun Zhou, Zhixu He
Summary: This study identified circ_0040823/miR-516b/PTEN as a new therapeutic target for AML, as circ_0040823 inhibited proliferation and induced apoptosis of AML cells by sponging miR-516b, thereby diminishing the regulatory effect of miR-516b on PTEN.
JOURNAL OF GENE MEDICINE
(2022)
Article
Endocrinology & Metabolism
Jacob D. Covert, Brian A. Grice, Matthew G. Thornburg, Manpreet Kaur, Andrew P. Ryan, Lixuan Tackett, Theja Bhamidipati, Natalie D. Stull, Teayoun Kim, Kirk M. Habegger, Donald A. McClain, Joseph T. Brozinick, Jeffrey S. Elmendorf
Summary: A Western-style high-fat diet leads to an accumulation of cholesterol in skeletal muscle plasma membrane, causing insulin resistance. The hexosamine biosynthesis pathway (HBP) and increased Sp1 activity contribute to this cholesterolgenic response. Inhibition of Sp1 activity can prevent cholesterol accumulation and insulin resistance. These findings suggest that targeting HBP/Sp1 activity may be a potential therapy for preventing diet-induced insulin resistance.
MOLECULAR METABOLISM
(2023)
Article
Cell Biology
Fu-Shu Li, Pei-Pei Li, Ling Li, Yan Deng, Ying Hu, Bai-Cheng He
Summary: The inhibitory effects of PTEN on BMP9's osteogenic potential may be partially mediated through decreasing the expression of Wnt10b via the disturbance of interaction between CREB and BMP/Smad signaling.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Zhaolu Wang, Jinjin Yang, Xiaohui Sun, Xi Sun, Gongshe Yang, Xin'e Shi
Summary: Skeletal muscle plays a crucial role in physical activities, metabolism, and energy balance, but its homeostasis is challenged by various factors such as injury, aging, and obesity. Exosomes, a type of extracellular vesicles, have emerged as important mediators in intercellular communication and hold great potential for treating skeletal muscle diseases. This review outlines recent research progress in exosomal isolation, characterization, mechanism of action, and highlights advancements in exosomes derived from different organs and tissues, as well as engineered exosomes, which have the ability to regulate the physiological and pathological development of skeletal muscle. These advancements enhance our understanding of muscle formation and diseases, and the utilization of engineered exosomes as nanocarriers with advanced biomolecule design methodologies offers innovative therapeutic perspectives for muscle diseases.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2023)
Article
Health Care Sciences & Services
Chiao-Yun Lin, Ren-Chin Wu, Lan-Yan Yang, Shih-Ming Jung, Shir-Hwa Ueng, Yun-Hsin Tang, Huei-Jean Huang, Hsiu-Jung Tung, Cheng-Tao Lin, Hsuan-Yu Chen, Angel Chao, Chyong-Huey Lai
Summary: Diagnostic agreement among pathologists for endometrial hyperplasia is poor. This study identified miR-30a-3p, miR-141, miR-200a, miR-200b, and complete PTEN loss as useful tissue biomarkers for predicting endometrial cancer risk in patients with simple or complex hyperplasia without atypia.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jongsoo Mok, Tae Sub Park, Sunhong Kim, Daehoon Kim, Cheol Soo Choi, Joonghoon Park
Summary: The study found that Prokr1 plays an important role in skeletal muscle, improving insulin sensitivity and being a potential therapeutic target for ameliorating insulin resistance in skeletal muscle.
Article
Medicine, Research & Experimental
Soumyalekshmi Nair, Dominic Guanzon, Nanthini Jayabalan, Andrew Lai, Katherin Scholz-Romero, Priyakshi Kalita de Croft, Valeska Ormazabal, Carlos Palma, Emilio Diaz, Elizabeth A. McCarthy, Alexis Shub, Jezid Miranda, Eduard Gratacos, Fatima Crispi, Gregory Duncombe, Martha Lappas, H. David McIntyre, Gregory Rice, Carlos Salomon
Summary: Gestational diabetes mellitus (GDM) poses a significant public health concern, affecting 9-15% of pregnancies worldwide. This study found that EV-associated miRNAs in GDM patients undergo significant changes during gestation and can be effectively used for classification. A set of proteins associated with JAK-STAT signaling in skeletal muscle biopsies from GDM patients was identified, which may be targeted by the miRNA-92a-3p carried by circulating EVs. Overexpression of miRNA-92a-3p was shown to increase insulin sensitivity in primary skeletal muscle cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biology
Marcel A. Vieira-Lara, Marleen B. Dommerholt, Wenxuan Zhang, Maaike Blankestijn, Justina C. Wolters, Fentaw Abegaz, Albert Gerding, Ydwine T. van der Veen, Rachel Thomas, Ronald P. van Os, Dirk-Jan Reijngoud, Johan W. Jonker, Janine K. Kruit, Barbara M. Bakker
Summary: The study revealed that aged mice are more susceptible to insulin resistance when on a high-fat diet. Intramuscular lipid accumulation, particularly C18:0-containing ceramides and diacylglycerols, was induced by the high-fat diet in aged mice. Computational modelling identified CPT1B as a crucial factor influencing the response to the high-fat diet in aged animals.
Article
Oncology
Feng Chen, Yong-hui Xia, Wen-zhen Cao, Wei Shan, Yang Gao, Bo Feng, Difei Wang
Article
Endocrinology & Metabolism
Difei Wang, Huiying Cong, Xiaoli Wang, Yanli Cao, Shoichiro Ikuyama, Bin Fan, Jianqiu Gu
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2018)
Article
Endocrinology & Metabolism
Bingshu Wu, Hongzhi Zheng, Jianqiu Gu, Yan Guo, Yixuan Liu, Yingfang Wang, Feng Chen, Aolin Yang, Jiabei Wang, Hailong Wang, Ying Liu, Difei Wang
JOURNAL OF DIABETES INVESTIGATION
(2019)
Article
Endocrinology & Metabolism
Jian-Qiu Gu, Di-Fei Wang, Xiao-Guang Yan, Wei-Li Zhong, Jin Zhang, Bin Fan, Shoichiro Ikuyama
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2010)
Article
Cardiac & Cardiovascular Systems
Difei Wang, Lei Wang, Jianqiu Gu, Huijing Yang, Nanqi Liu, Yichen Lin, Xiaolin Li, Chen Shao
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2014)
Article
Multidisciplinary Sciences
Jianqiu Gu, Xin Meng, Yan Guo, Lei Wang, Hongzhi Zheng, Yixuan Liu, Bingshu Wu, Difei Wang
SCIENTIFIC REPORTS
(2016)
Article
Medicine, Research & Experimental
Chen Shao, Jianqiu Gu, Xin Meng, Hongzhi Zheng, Difei Wang
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2015)