期刊
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
卷 17, 期 1, 页码 16-21出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1066896908315813
关键词
activator protein-4 (AP-4); VEGF; MMP-9; colorectal cancer; metastasis; apoptosis
The aim Of this Study is to investigate the expression of AP-4, VEGF, and MMP-9 genes in human colorectal cancer. The expression pattern of activator protein-4 in 160 colorectal cancer compared with 32 colorectal adenomas and 32 normal colorectal tissues is demonstrated by tissue microarray-immunohistochemistry, and real-time reverse transcriptase-polymerase chain reaction. Apoptosis status using terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling by comparing activator protein-4 positive versus activator protein-4 negative colorectal cancer is also assessed. The messenger RNA levels of vascular endothelial growth factor and matrix metalloproteinase-9 expression in activator protein-4 positive and negative colorectal cancer were measured using real-time reverse transcriptase-polymerase chain reaction. The activator protein-4 expression in normal colorectal tissue, adenoma, and adenocarcinoma were 4 of 32, 8 of 32, and 78 of 160, respectively. It is shown that the activator protein-4 expression was significantly correlated with the progression of colorectal cancer (P <.01) and differentiation and lymph node metastasis (P <.0.1). Our results also presented that the activator protein-4 expression was associated with the expression of matrix metalloproteinase-9 and vascular endothelial growth factor in the advanced colorectal cancer.
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