期刊
INTERNATIONAL JOURNAL OF STROKE
卷 7, 期 4, 页码 321-329出版社
SAGE PUBLICATIONS LTD
DOI: 10.1111/j.1747-4949.2012.00789.x
关键词
lacunar stroke; mechanisms of progression; predictors of outcome; progressive stroke; treatment
Lacunar stroke is generally considered to have a fair outcome. However 2030% of patients with lacunar stroke worsen neurologically in hours or days after onset, reaching eventually an unexpectedly severe disability status. In the field of acute stroke, progressive lacunar stroke remains an important unresolved practice problem, because as yet no treatment does exist proven to prevent or halt progression. Pathophysiology of progression is yet incompletely understood. Hemodynamic factors, extension of thrombosis, excitotoxicity, and inflammation, have been proposed as possible mechanisms of progression. A few clinical studies also aimed at establishing presentation features that may help identifying patients at risk of deterioration. In this paper, we review hypothesized mechanisms of lacunar stroke progression and possible markers of early deterioration. Moreover, based on putative mechanisms and suggestions from reported evidence, we propose a few treatments that seem worthy to be tested by randomized clinical trials.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据