期刊
MOLECULAR IMMUNOLOGY
卷 68, 期 2, 页码 492-496出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2015.07.026
关键词
T cells; Anergy; Exhaustion; mTOR; Metabolism; Tolerance
资金
- Sidney Kimmel Foundation for Cancer Research [SKF-015-039]
- National Institutes of Health, NIAID [R01A1077610, R01AI091481]
Through the direct control of infection or by providing cytokine signals to other cellular players, T cells play a central role in the orchestration of the immune response. However, in many disease states, T cells are rendered dysfunctional, unable to carry out their effector functions. As T cell activation is bioenergetically demanding, some T cell dysfunction can have metabolic underpinnings. In this review, we will discuss how T cells are programmed to fuel their effector response, and how programmed or pathologic changes can disrupt their ability to generate the energy needed to proliferate and carry out their critical functions. (C) 2015 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据