期刊
INTERNATIONAL JOURNAL OF STD & AIDS
卷 23, 期 8, 页码 603-605出版社
ROYAL SOC MEDICINE PRESS LTD
DOI: 10.1258/ijsa.2012.011305
关键词
HIV; AIDS; progressive multifocal leukoencephalopathy; PML; IRIS; mefloquine
资金
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) for Program of Japan Initiative for Global Research Network on Infectious Diseases
- Global COE Program (Center of Education and Research for Advanced Genome-Based Medicine - for personalized medicine and the control of worldwide infectious diseases) of MEXT
- Ministry of Health, Labor, and Welfare of Japan
- Ministry of Health, Labor and Welfare, Japan [H24-AIDS-002]
A 33-year-old man who developed progressive multifocal leukoencephalopathy (PML) with HIV infection is reported. The patient exhibited rapid decline in neurological status after initiation of antiretroviral therapy (ART), which was attributed to the PML-immune re-constitution inflammatory syndrome. Following the administration of mefloquine in combination with ART, the patient's neurological status improved substantially. This case suggests that further investigation of the use of mefloquine might be warranted for treatment of PML in HIV-infected patients.
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