Article
Virology
Neda Hosseini, Zabihollah Shoja, Sarang Younesi, Nazanin-Zahra Shafiei-Jandaghi, Somayeh Jalilvand
Summary: The study found that lineage A of HPV 31 was predominant in Iran, while lineage B of HPV 45 was also dominant among Iranian women. Further research with larger sample sizes is needed to evaluate the pathogenicity risk of HPV 31 or HPV 45 lineages/sublineages in the development of cervical cancer among Iranian women.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Oncology
Jennifer Margaret Roberts, Dorothy A. Machalek, Bethan C. Butler, Joanne Crescini, Suzanne M. Garland, Annabelle Farnsworth
Summary: In Australia's HPV-based cervical screening program, the risk of histological high-grade abnormality decreased with age in women with oncogenic HPV. This study followed HPV16/18 positive women aged 55 years and over for up to 3 years to determine the proportion with histological high-grade abnormality and its correlation with liquid-based cytology result and prior screening history. The results showed that age, screening history, and cytology result are important factors to consider in managing screen-detected abnormalities in HPV-based cervical screening programs.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Oncology
Biyuan Xing, Jianfeng Guo, Yuhan Sheng, Gang Wu, Yingchao Zhao
Summary: HPV-negative cervical cancers, predominantly adenocarcinomas, pose challenges in diagnosis and management due to unclear etiology and possible false negative results. It is important to pay greater attention to these cases as they are often diagnosed at advanced stages with poor prognoses.
FRONTIERS IN ONCOLOGY
(2021)
Article
Virology
Fernanda L. S. G. Santos, Maria C. V. Invencao, Edilaine D. Araujo, Gerlane S. Barros, Marcus V. A. Batista
Summary: This study evaluated the effectiveness of three different PCR-based strategies for HPV detection and genotyping from cervical samples. The results showed that different primer design strategies influenced the sensitivity and specificity of detecting different HPV types. EntroA primers were able to detect HPV in more samples compared to MY09/MY11, while multiplex PCR had higher sensitivity despite targeting a limited number of HPV types.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Public, Environmental & Occupational Health
Yaojuan He, Wenting Chen, Zhiliang Guo, Danni Yi, Chunfang Cai, Ying Shi, Yanfen Long, Kun Shi
Summary: This study evaluated the performance of Cobas HPV test in cervical cancer screening, comparing it with HC2 test. The results showed a positive rate of 9.53% for Cobas HPV, with a 90% concordance rate between Cobas HPV and HC2. Age was found to have a non-linear relationship with HPV positivity and typing rates, and Cobas HPV test had higher sensitivity in detecting high-grade cervical neoplasia compared to LBC test.
EPIDEMIOLOGY AND INFECTION
(2021)
Article
Oncology
Marc Arbyn, Philip E. Castle, Mark Schiffman, Nicolas Wentzensen, Brandy Heckman-Stoddard, Vikrant V. Sahasrabuddhe
Summary: This study conducted a meta-analysis to compare the test agreement and concordance between HPV testing in self-collected and clinician-collected samples. The overall agreement was found to be 88.7%, with higher agreement observed for target amplification-based DNA assays.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Health Care Sciences & Services
Frithjof Sy, Astrid Berner-Rodoreda, Takelech Asnake, Misrak Getnet, Wondwossen Amogne, Hermann Bussmann, Helen Abera, Till Barnighausen, Andreas Deckert
Summary: Health decision-makers in Ethiopia are willing to use computer-aided predictions to support cervical cancer interventions, with a particular interest in identifying local HPV hotspots.
NPJ DIGITAL MEDICINE
(2023)
Article
Oncology
Yulong Zhang, Haibo Li, Xiaowen Li, Zhelong Li, Qianru You, Huan Yi, Yanzhao Su, Xiangqin Zheng, Yusha Chen, Jiancui Chen
Summary: Abnormal vessel patterns are specific signs in patients with early cervical abnormality and cervical cancer (CC) by colposcopy. This study found that HPV 16 and 33 are the most dangerous HPV genotypes correlated with abnormal vascular patterns, and co-infection of HPV 16 and 33 increases the risk of abnormal vascular patterns.
FRONTIERS IN ONCOLOGY
(2023)
Article
Immunology
Yongji Yan, Hongfeng Zhang, Chunfan Jiang, Xin Ma, Xueying Zhou, Xun Tian, Yuping Song, Xu Chen, Liyao Yu, Rui Li, Hongwei Chen, Xin Wang, Ting Liu, Zhaohui He, Hongzhao Li
Summary: The study found that HPV infection may contribute to bladder cancer in both men and women, with HPV18, HPV33, HPV16, and HPV39 genotypes potentially representing the predominant oncogenic risk types for bladder carcinogenesis.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Virology
Teboho Amelia Tiiti, Tebogo Loraine Mashishi, Varsetile Varster Nkwinika, Ina Benoy, Selokela Gloria Selabe, Johannes Bogers, Ramokone Lisbeth Lebelo
Summary: This study in South Africa compared the positivity of HPV in healthcare worker-collected and self-collected samples, finding high concordance in HPV DNA detection between the two methods but differences in HPV mRNA detection. The study suggests that self-sampling using an applicator tampon may be considered as a primary screening tool for cervical cancer prevention.
Article
Immunology
Nelli T. Suominen, Tiina H. Luukkaala, Claudie Laprise, Marjut A. Haataja, Seija E. Grenman, Stina M. Syrjaenen, Karolina Louvanto
Summary: This study aimed to determine whether vertical human papillomavirus (HPV) transmission occurs from parents to their offspring before or during birth. The study included 321 mothers, 134 fathers, and their 321 newborn offspring. The results showed statistically significant genotype-specific HPV concordance between mother-newborn and father-newborn pairs, suggestive for vertical HPV transmission, but transmission from the father to the newborn remains uncertain.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Medicine, Research & Experimental
Fabiola Hernandez-Rosas, Erika Orozco-Hernandez, Liliana Maza-Sanchez, Pamela Citlalli Salgado-Garcia, Enrique Navarro-Vidal, Mercedes Piedad de Leon-Bautista
Summary: The study found a high prevalence of HPV infection in Mexican women, with risk factors such as lifetime sexual partners and smoking. Common HPV genotypes in healthy women included 6, 31, and HR-HPV was associated with a low frequency of cytological abnormalities and CIN1-3 occurrences.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Review
Oncology
Hiroshi Yoshida, Kouya Shiraishi, Tomoyasu Kato
Summary: Although cervical cancer is primarily caused by HPV infection, some cases test negative for HPV. True HPV-negative cancers are more common in certain adenocarcinoma subtypes, and have different pathological progression and pathogenesis compared to HPV-associated cervical cancers.
Article
Medicine, Research & Experimental
Alice Avian, Nicolo Clemente, Elisabetta Mauro, Erica Isidoro, Michela Di Napoli, Sandra Dudine, Anna Del Fabro, Stefano Morini, Tiziana Perin, Fabiola Giudici, Tamara Cammisuli, Nicola Foschi, Marco Mocenigo, Michele Montrone, Chiara Modena, Martina Polenghi, Luca Puzzi, Vjekoslav Tomaic, Giulio Valenti, Riccardo Sola, Shivani Zanolla, Enea Vogrig, Elisabetta Riva, Silvia Angeletti, Massimo Ciccozzi, Santina Castriciano, Maria Pachetti, Matteo Petti, Sandro Centonze, Daniela Gerin, Lawrence Banks, Bruna Marini, Vincenzo Canzonieri, Francesco Sopracordevole, Fabrizio Zanconati, Rudy Ippodrino
Summary: According to the study, HPV Selfy, a full-genotyping HPV DNA test, meets the criteria for primary cervical cancer screening described in international guidelines and shows good performance on both clinician-collected and self-collected samples.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Biochemical Research Methods
Habtamu Biazin
Summary: This study evaluated the concordance of Anyplex (TM) II HPV HR with other HPV assays in cervical cancer screening and found that it has high clinical sensitivity for CIN2+ and CIN3+, comparable to the currently most widely used HPV test. The results suggest that Anyplex T II is clinically validated for primary cervical cancer screening and triage in referral population settings.
JOURNAL OF VIROLOGICAL METHODS
(2022)