期刊
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
卷 32, 期 5, 页码 344-352出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0031-1271679
关键词
senile osteoporosis; histomorphometry; ageing; lifelong physical activity; osteocytes
资金
- FCT [PTDC/DES/103047/2008, PTDC/DES/104567/2008]
- Fundação para a Ciência e a Tecnologia [PTDC/DES/103047/2008, PTDC/DES/104567/2008] Funding Source: FCT
The aim of the present study was to analyze the lifelong differences of femur structure in sedentary and physically active animal models. Thirty male C57BL/6 mice, 2 months old, were either: i) housed in cages with running wheel (AA; n = 10), ii) housed in cages without running wheel (AS; n = 10), iii) or sacrificed without intervention (Y; n = 10). AA and AS animals were sacrificed after 23 months of housing. Right femur structure was analyzed in all animals by histomorphometry. Significant differences in several microarchitectural parameters of cancellous and cortical bone were identified between Y mice and both groups of aged mice, as well as between AA and AS groups. Lifelong physically active mice had significantly higher cancellous bone surface (Cn.BS) and trabecular number (Tb.N) and decreased trabecular separation (Tb.Sp) at both epiphyses when compared to AS animals. No differences were observed between Y and AA groups regarding osteocyte number (N.Ot) despite its significant reduction in AS animals, suggesting that age alone was not a cause for decreases in N.Ot. Our results suggest that the reduced bone quality observed in the elderly is not only a consequence of age but also of lack of physical activity since sedentary behaviour significantly aggravated the degenerative age-related bone differences.
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