Article
Biochemistry & Molecular Biology
Javier Conde, Marlene Schwarzfischer, Egle Katkeviciute, Janine Hafliger, Anna Niechcial, Nathalie Brillant, Roberto Manzini, Katharina Babler, Kirstin Atrott, Silvia Lang, Michael Scharl
Summary: This study investigated the interaction between the food additive TiO2 and the IBD risk gene Ptpn2 in the development of intestinal inflammation. Results showed that TiO2 exacerbated intestinal inflammation in Ptpn2 deficient mice by impacting the differentiation of intestinal macrophages. Furthermore, TiO2 was found to induce the secretion of IL-1 beta and suppress the expression of IL-10 in macrophages through different signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Analytical
He-Song Wang, Xiao-Fan Zhang, Han Dong, Qian Chen, Xiao-Qun Cao, Shi-Li Shen
Summary: Ulcerative colitis is a common inflammatory disease related to hypoxia in the colon microenvironment. Researchers have developed a new probe for detecting overexpressed nitroreductase (NTR) and conducting in vivo hypoxia imaging.
ANALYTICA CHIMICA ACTA
(2022)
Article
Engineering, Biomedical
Yannan Chen, Wentao Su, Shanshan Tie, Weina Cui, Xiaoting Yu, Lijuan Zhang, Zheng Hua, Mingqian Tan
Summary: A new kind of sequence-targeted astaxanthin nanoparticles was developed for the treatment of ulcerative colitis (UC). The nanoparticles demonstrated excellent macrophages and mitochondria targeting ability, and significantly alleviated inflammation. Additionally, they also improved the composition of gut microbiota and the production of short chain fatty acid.
Article
Biochemistry & Molecular Biology
Ning Zhang, Yifei Lu, Yong Huang, Qing Zhang, Jianglin Tan, Jianxiang Zhang, Mengyun Yao, Gaoxing Luo
Summary: In this study, a novel fluorescent probe SNP-1 was developed for real-time and high selectivity detection of HSNO. SNP-1 exhibited strong fluorescence, low detection limit, and a broad linear detection range. The probe successfully visualized changes in HSNO levels in two disease models and showed a good correlation with disease activity index. Hence, SNP-1 can serve as a promising fluorescent probe for precise detection of HSNO in various biological systems.
Article
Pharmacology & Pharmacy
Ming Wu, Hongrui Ping, Kun Wang, Hui Ding, Meng Zhang, Ziqiong Yang, Qian Du
Summary: Oral delivery of anti-inflammatory drugs is a promising strategy for treating ulcerative colitis, but achieving specific drug delivery to colon tissues and target cells is challenging. In this study, macrophages-targeted liposome-loaded pectin-chitosan hydrogels were developed for effective UC treatment through oral administration.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Gastroenterology & Hepatology
Lujain Maasfeh, Anetta Hartlova, Stefan Isaksson, Johanna Sundin, Georgios Mavroudis, Otto Savolainen, Hans Strid, Lena Ohman, Maria K. Magnusson
Summary: Fecal luminal factors from healthy donors can down-regulate signaling pathways in macrophages and influence their function, while those from UC patients in remission have a weaker effect on macrophages. Metabolomic analysis revealed differential fecal metabolite composition between healthy individuals and UC patients in remission. This suggests that UC patients in remission may lack the necessary signals to condition macrophages towards a hyporesponsive and tolerogenic phenotype, making them vulnerable to relapse.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Yanru Ma, Xinyu Zhang, Baoqin Xuan, Danjie Li, Nan Yin, Lijun Ning, Yi-Lu Zhou, Yuqing Yan, Tianying Tong, Xiaoqiang Zhu, Xiaowen Huang, Muni Hu, Zhenhua Wang, Zhe Cui, Huabin Li, Jiqiu Wang, Jing-Yuan Fang, Ruixin Liu, Haoyan Chen, Jie Hong
Summary: FTO downregulation promotes UC by decreasing CerS6 expression, resulting in increased S1P accumulation in IECs and exacerbating colitis via m6A-dependent mechanisms. UC patients with lower FTO expression may have a better response to vedolizumab treatment.
Article
Immunology
Jinke Huang, Fengyun Wang, Xudong Tang
Summary: This study reveals the close relationship between ulcerative colitis (UC) and atherosclerosis (AS) and uncovers the key pathological mechanisms underlying their co-occurrence. By analyzing differentially expressed genes (DEGs) and biological functions, 59 shared DEGs related to immunity and inflammation were identified. The protein tyrosine phosphatase, receptor type C (PTPRC) was found to be the key gene for the comorbidity of UC and AS, with its upregulation correlated to immune and inflammatory pathways.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Wei Yu, Yijia Zhang, Cai Kang, Yang Zheng, Xincheng Liu, Zhenghao Liang, Jing Yan
Summary: Ulcerative colitis is an inflammatory bowel disease that mainly occurs in the colon. The use of the Chang-Yan-Ning formula has been found to alleviate the development and progression of colitis by maintaining immune responses and microbiota homeostasis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Kaoru Takabayashi, Shinya Sugimoto, Kosaku Nanki, Yusuke Yoshimatsu, Hiroki Kiyohara, Yohei Mikami, Tomohisa Sujino, Motohiko Kato, Naoki Hosoe, Masayuki Shimoda, Naohisa Yahagi, Haruhiko Ogata, Yasushi Iwao, Takanori Kanai
Summary: This study aimed to describe the main diagnostic patterns for ulcerative colitis-associated neoplasia (UCAN), including lateral extension surrounding flat lesions. Through dye chromoendoscopy (DCE) imaging analysis, it was found that lesions with small round or mesh structures were more likely to have high-grade dysplasia or carcinoma. Therefore, when these characteristic mucosal patterns are found in DCE, the possibility of UCAN should be considered.
DIGESTIVE ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Ding-Jia-Cheng Jia, Qi-Wen Wang, Ying-Ying Hu, Jia-Min He, Qi-Wei Ge, Ya-Dong Qi, Lu-Yi Chen, Ying Zhang, Li-Na Fan, Yi-Feng Lin, Yong Sun, Yao Jiang, Lan Wang, Yan-Fei Fang, Hui-Qin He, Xiong-E Pi, Wei Liu, Shu-Jie Chen, Liang-Jing Wang
Summary: This study identified Lactobacillus johnsonii as a potential anti-inflammatory bacterium that can alleviate ulcerative colitis by increasing the proportion of intestinal macrophages and the secretion of Il-10. The activation of CD206(+) macrophages(IL-10) by L. johnsonii was mediated through the TLR1/2-STAT3 pathway. Clinically, there was a positive correlation between the abundance of L. johnsonii and the expression level of MRC1, IL10 and TLR1/2 in UC tissues.
Article
Pharmacology & Pharmacy
Jing Yan, Wei Yu, Chang Lu, Chen Liu, Guoliang Wang, Lu Jiang, Zizheng Jiang, Zheng Qin
Summary: In a murine model of experimental colitis, GCZX capsule alleviated pathological symptoms induced by DSS, such as rectal bleeding, decreased levels of albumin and interleukin-17, reduced CXCL1 levels, and shorter colon length. Network pharmacology analysis revealed that GCZX-target genes were involved in pathogen-induced infections, inflammatory pathways, and neoplastic processes.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Lijiang Ji, Qiong Zhou, Jinke Huang, Dongxue Lu
Summary: This study evaluated the research trends and hotspots regarding macrophages in ulcerative colitis (UC) using bibliometric analysis. The analysis showed a continuous increase in publications on macrophages in UC, with China and the USA as the major contributors. The emerging research hotspots included macrophage polarization, gut microbiota, and NLRP3 inflammasome.
Article
Gastroenterology & Hepatology
Le Liu, Liping Liang, Chenghai Yang, Youlian Zhou, Ye Chen
Summary: The study demonstrated that Fusobacterium nucleatum-derived extracellular vesicles induce epithelial cell death and gut barrier disruption in ulcerative colitis, potentially through the activation of receptor-interacting protein kinase 1 (RIPK1). These findings provide insights for further investigation of the disease.
Article
Multidisciplinary Sciences
Kai Xiong, Jia Deng, Tinghui Yue, Wenting Hu, Xinglin Zeng, Tao Yang, Tianbao Xiao
Summary: This study aimed to investigate the anti-inflammatory and immune-modulatory roles of berberine (BBR) in ulcerative colitis (UC) treatment, and to explore the underlying mechanisms. The results showed that BBR suppressed M1 macrophages while promoting M2 macrophages, which contributed to its anti-inflammatory and immune-modulating activities.
Article
Biochemical Research Methods
Jyoti Roy, Miranda Kaake, Madduri Sriniyasarao, Philip S. Low
BIOCONJUGATE CHEMISTRY
(2018)
Article
Medicine, Research & Experimental
Isaac S. Marks, Spencer S. Gardeen, Sarah J. Kurdziel, Sonia T. Nicolaou, J. Evan Woods, Sumith A. Kularatne, Philip S. Low
MOLECULAR PHARMACEUTICS
(2018)
Article
Medicine, Research & Experimental
Sakkarapalayam M. Mahalingam, Fernando Dip, Marco Castillo, Mayank Roy, Steven D. Wexner, Raul J. Rosenthal, Philip S. Low
MOLECULAR PHARMACEUTICS
(2018)
Article
Biochemical Research Methods
Sakkarapalayam M. Mahalingam, Haiyan Chu, Xin Liu, Christopher P. Leamon, Philip S. Low
BIOCONJUGATE CHEMISTRY
(2018)
Article
Biochemical Research Methods
Mingding Wang, Soie Park, Yoonhee Nam, Jeffery Nielsen, Stewart A. Low, Madduri Srinivasarao, Philip S. Low
BIOCONJUGATE CHEMISTRY
(2018)
Article
Chemistry, Medicinal
Sakkarapalayam M. Mahalingam, Sumith A. Kularatne, Carrie H. Myers, Pravin Gagare, Mohammad Norshi, Xin Liu, Sunil Singhal, Philip S. Low
JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Chemistry, Multidisciplinary
Jeffery J. Nielsen, Stewart A. Low, Neal T. Ramseier, Rahul Hadap, Nicholas A. Young, Mingding Wang, Philip S. Low
Summary: The study aimed to improve bone fracture management by continuously applying bone anabolic agents to the fracture surface. Short oligopeptides of acidic amino acids were found to significantly increase localization of peptide payload to bone fractures, offering a promising strategy for enhancing fracture healing.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemistry & Molecular Biology
Ioannis Tsamesidis, Karine Reybier, Giuseppe Marchetti, Maria Carmina Pau, Patrizia Virdis, Claudio Fozza, Francoise Nepveu, Philip S. Low, Francesco Michelangelo Turrini, Antonella Pantaleo
Article
Biochemical Research Methods
Xin Liu, Weichuan Luo, Boning Zhang, Yong Gu Lee, Imrul Shahriar, Madduri Srinivasarao, Philip S. Low
Summary: In this study, a modified influenza virus neuraminidase inhibitor, zanamivir, was utilized for diagnostic, imaging, and therapeutic purposes in influenza virus infections. Different conjugates like the zanamivir-conjugated rhodamine dye and zanamivir99 mTc radioimaging conjugate were designed for visual monitoring of virus-infected cells. Moreover, targeted cytotoxic drugs and CAR T cells were developed specifically for viral neuraminidase-expressing cells, showing potential for improved treatment of influenza virus infections.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Sakkarapalayam M. Mahalingam, Karson S. Putt, Madduri Srinivasarao, Philip S. Low
Summary: The inadvertent severing of a ureter during colorectal surgeries is a common issue, leading to the development of new near-infrared dyes to help surgeons identify ureter location. The new PEGylated UreterGlow derivatives show promising optical and biodistribution characteristics, making them good candidates for translation into the clinic.
Article
Chemistry, Multidisciplinary
John Victor Napoleon, Boning Zhang, Qian Luo, Madduri Srinivasarao, Philip S. Low
Summary: Administering a CAR-targeted TLR7 agonist can reverse CAR T cell exhaustion and successfully treat solid tumors.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Oncology
Qian Luo, John Napoleon, Xin Liu, Boning Zhang, Suilan Zheng, Philip S. Low
Summary: This study describes a strategy to reverse CAR T-cell exhaustion by using a universal anti-fluorescein CAR that engages multiple cancer cell clones and acts as a drug-internalizing receptor. By attaching a Toll-like receptor 7 agonist to the anti-fluorescein CAR, they downregulate exhaustion markers and reactivate exhausted CAR-T cells, leading to regression of solid tumors.
MOLECULAR CANCER RESEARCH
(2022)
Article
Engineering, Biomedical
Yun Chang, Gyuhyung Jin, Weichuan Luo, Qian Luo, Juhyung Jung, Sydney N. Hummel, Sandra Torregrosa-Allen, Bennett D. Elzey, Philip S. Low, Xiaojun Lance Lian, Xiaoping Bao
Summary: Adoptive CAR-engineered NK cells have potential for cancer treatment, but limited immunological memory and donor cell availability hinder their applications. We evaluated different CAR constructs to enhance NK cell proliferation and anti-tumor cytotoxicity. We genetically engineered hPSCs with optimized CARs and differentiated them into dual CAR-NK cells. The memory-like hPSC-NK cells showed enhanced anti-tumor activity through antigen-dependent activation of signaling pathways. Our modular hPSC CAR-NK engineering platform is a realistic strategy for off-the-shelf CAR-NK cells with immunological memory-like phenotype for targeted immunotherapy.
BIOACTIVE MATERIALS
(2023)
Article
Immunology
Huynh Dinh Chien, Antonella Pantaleo, Kristina R. Kesely, Panae Noomuna, Karson S. Putt, Tran Anh Tuan, Philip S. Low, Francesco M. Turrini
Summary: The coadministration of imatinib with standard of care (SOC) in uncomplicated P. falciparum malaria patients led to a faster decline in parasite density and fever, without any delayed parasite clearance. The improvements were most significant in patients with the highest parasite density, where serious complications and death are most common.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Xin Liu, Boning Zhang, Yingcai Wang, Hanan S. Haymour, Fenghua Zhang, Le-cun Xu, Madduri Srinivasarao, Philip S. Low
NATURE COMMUNICATIONS
(2020)