Article
Pharmacology & Pharmacy
Rehab S. Abdelrahman, Ghada S. El-Tanbouly
Summary: Protocatechuic acid has protective effects on thioacetamide-induced liver/brain injury by reducing oxidative stress, inflammation, autophagy, and apoptosis, which contribute to its hepatoprotective and neuroprotective potentials.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Immunology
Ya Dong, Fei Han, Yue Su, Bei Sun, Wei Zhao, Congqing Pan
Summary: Cigarette smoke exposure is the major cause of chronic obstructive pulmonary disease (COPD) and cigarette smoke extract (CSE) induces the increase of reactive oxygen species (ROS), mitochondrial dynamics disorder, and apoptosis. High uric acid (HUA) aggravates the effects of CSE by decreasing the expression of antioxidant enzyme-peroxiredoxin-2 (PRDX2). Overexpression of PRDX2 inhibits the effects of HUA, while knockdown of PRDX2 promotes the effects of HUA on cellular ROS levels, mitochondrial dynamics disorder, and apoptosis in MLE-12 cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Qian Ren, Sibei Tao, Fan Guo, Bo Wang, Letian Yang, Liang Ma, Ping Fu
Summary: Fisetin can regulate the expression of urate transporters, reduce uric acid levels, alleviate renal inflammation, prevent kidney fibrosis, and protect against hyperuricemic nephropathy.
Article
Neurosciences
Qiaolifan Aerqin, Sha-Sha Jia, Xue-Ning Shen, Quan Li, Ke-Liang Chen, Ya-Nan Ou, Yu-Yuan Huang, Qiang Dong, Shu-Fen Chen, Jin-Tai Yu
Summary: This study found that decreased levels of serum UA were correlated with Alzheimer's disease, Parkinson's disease, progressive supranuclear palsy, frontotemporal dementia, and dementia with Lewy bodies. Additionally, serum UA levels were positively correlated with cognitive levels in all patients.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Multidisciplinary Sciences
Ryota Sato, Keitaro Akita, Takenori Ikoma, Keisuke Iguchi, Takayo Murase, Takashi Nakamura, Seigo Akari, Satoshi Mogi, Yoshihisa Naruse, Hayato Ohtani, Yuichiro Maekawa
Summary: This study compared the changes in plasma XOR (pXOR) activity in patients undergoing percutaneous coronary intervention (PCI) and coronary angiography (CAG). The study found that there was a significant decrease in pXOR activity after PCI, with a correlation between in-hospital adverse events and the percentage reduction in pXOR activity. No significant changes were observed in pXOR activity in patients undergoing CAG.
Article
Nutrition & Dietetics
Corrado Pelaia, Daniele Pastori, Giuseppe Armentaro, Sofia Miceli, Velia Cassano, Keti Barbara, Giulia Pelaia, Maria Perticone, Raffaele Maio, Pasquale Pignatelli, Francesco Violi, Francesco Perticone, Giorgio Sesti, Angela Sciacqua
Summary: This study demonstrates a significant decline in renal function over time in COPD patients, with uric acid (UA) and diabetes identified as the two strongest predictors.
Article
Biochemistry & Molecular Biology
Masaru Matsuoka, Junko Yamaguchi, Kosaku Kinoshita
Summary: This study aimed to investigate the relationship between blood levels of uric acid (UA), xanthine dehydrogenase (XDH), and 8-hydroxy-2-deoxyguanosine (8-OHdG) in sepsis patients. The results showed that UA and XDH levels were correlated with the severity of sepsis and poor outcomes. Elevated XDH levels were associated with reduced survival rates. The findings suggest that increased oxidative stress in sepsis can be counteracted by elevated UA levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Pablo Muriel, Pedro Lopez-Sanchez, Erika Ramos-Tovar
Summary: Chronic diseases, particularly metabolic syndrome and non-alcoholic fatty liver disease (NAFLD), are major health challenges globally, with fructose overconsumption playing a significant role in their development. Fructose-induced inflammation, fibrosis, and oncogenic signaling pathways contribute to the progression of NAFLD, leading to serious liver complications such as NASH and ultimately liver cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
W. A. Saka, R. E. Akhigbe, A. O. Abidoye, O. S. Dare, A. O. Adekunle
Summary: The study showed that Dichlorvos induced hepatic and renal damage, accompanied by redox dyshomeostasis. L-arginine was found to reverse the damage and improve organ structure, suggesting a potential therapeutic role against Dichlorvos-induced toxicity.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Pengqiang Ma, Menghui Zhao, Yue Li, Guanqian Zhang, Yuxia Ma, Youlan Shi, Peihui Su, Rongxia Chen, Zhen-gang Tang, Yan Zhang, Bing Liu, Qiong Zhang, Xiang Liu, Feifeng Li
Summary: This study demonstrates that uric acid can ameliorate oxidative stress caused by myocardial ischemia by activating the Nrf2 pathway and inducing downstream antioxidant factors. This finding contributes to the understanding of the protective effects of uric acid in heart disease.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Biology
Marko Kumric, Josip A. Borovac, Tina Ticinovic Kurir, Josko Bozic
Summary: Heart failure is a major global health problem with increasing prevalence, requiring further research to improve outcomes and reduce healthcare costs. Uric acid serves as a significant prognostic factor in both acute and chronic HF, and is being explored as a potential therapeutic target in the pathogenesis of the condition.
Article
Nutrition & Dietetics
Juliana Farias de Novaes, Mariana De Santis Filgueiras, Lara Gomes Suhett, Mariane Alves Silva, Fernanda Martins de Albuquerque, Rafaela Mara Silva Fonseca, Maria do Carmo Gouveia Peluzio
Summary: The aim of this study was to evaluate the association of serum uric acid with adiposity, adipokines, and anti-and oxidative markers in Brazilian children. We compared the distributions of adiposity, adipokines, and anti-and oxidative markers by serum uric acid categories using linear regression. The results showed a positive association between serum uric acid and adiposity, adipokines, and antioxidative status.
Article
Environmental Sciences
Barakat M. ALRashdi, Hassan A. Elgebaly, Mousa O. Germoush, Moath M. Qarmush, Mona S. Azab, Reem S. Alruhaimi, Ahmad F. Ahmeda, Mohammad H. Abukhalil, Emadeldin M. Kamel, Hany H. Arab, Mohammed A. Alzoghaibi, Mohammed F. Alotaibi, Ayman M. Mahmoud
Summary: This study investigated the effects of Monolluma quadrangula extract (MQE) on hyperuricemic rats and found that MQE exhibited renoprotective properties by inhibiting xanthine oxidase activity, reducing oxidative stress and inflammation, and modulating urate transporters.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Medicine, Research & Experimental
Luana Heimfarth, Marilia Matos Rezende, Erik Willyame Menezes Pereira, Fabiolla Rocha Santos Passos, Brenda Souza Monteiro, Tiffany Karoline Barroso Santos, Natalia Teles Lima, Isana Carla Leal Souza, Ricardo Luiz Cavalcanti de Albuquerque Junior, Pollyana de Souza Siqueira Lima, Adriano Antunes de Souza Araujo, Lucindo Jose Quintans Junior, Bonglee Kim, Henrique D. M. Coutinho, Jullyana de Souza Siqueira Quintans
Summary: Inflammatory arthritis is a common chronic inflammatory disease, and oral administration of BIS and β CD/BIS can significantly alleviate its symptoms, with the cyclodextrin inclusion complex also improving the pharmacological profile of the drug.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Cardiac & Cardiovascular Systems
Yawen Deng, Fei Liu, Xiaolei Yang, Yunlong Xia
Summary: Hyperuricemia is identified as an independent risk factor for atrial fibrillation, with various studies demonstrating its role in the pathogenesis of AF through oxidative stress, inflammation, fibrosis, apoptosis, and immunity at different uric acid concentrations.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)