Article
Fisheries
Xiaojing Li, Ruichen Bai, Yichen Bai, Xu Shi, Yuhong Yang, Shiwen Xu
Summary: Acetochlor exposure triggers apoptosis and autophagy in fish hepatocytes, which are mediated by ROS-mediated PPAR/RXR inhibition. Understanding the toxicological mechanism of acetochlor is important for the development of antidotes.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Integrative & Complementary Medicine
Chih-Chia Chang, Kun-Ling Tsai, Hui-Ching Cheng, Wan-Ching Chou, Yu-Ting Huang, Pei-Ling Hsieh, Shin-Da Lee
Summary: Mangiferin (MGN) has the potential to alleviate cardiac hypertrophy. By suppressing the MAPK signaling and NF-kappa Bp65/iNOS axis, MGN can attenuate cell size, expression of hypertrophy markers, and oxidative stress in cardiomyocytes.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Biology
Qi Zhang, Danyang Li, Xue Dong, Xiaowen Zhang, Junwu Liu, Lili Peng, Bo Meng, Qi Hua, Xinyu Pei, Lu Zhao, Xiaoxi Hu, Yang Zhang, Zhenwei Pan, Yanjie Lu, Baofeng Yang
Summary: The study showed that in diabetic cardiomyopathy, lncDACH1 aggravates the disease by promoting mitochondrial oxidative stress and cell apoptosis, leading to increased ubiquitination-mediated SIRT3 degradation. Inhibition of lncDACH1 may represent a novel therapeutic strategy for the intervention of diabetic cardiomyopathy.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Neurosciences
Halil Duzova, Mustafa Naziroglu, Bilal Cig, Perihan Gurbuz, Ayse Nur Akatli
Summary: The study revealed that Noopept has protective effects against diabetes-induced neuropathic pain and hippocampal oxidative neurotoxicity, possibly due to its potent antioxidant properties.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tongyu Zhang, Minghai Zhang
Summary: This study investigated the possible mechanism of NL-1 after subarachnoid hemorrhage (SAH) in rats. The results showed that NL-1 could improve neurological behavior, increase mitophagy, and reduce oxidative stress and apoptosis. However, liensinine may inhibit the treatment effect of NL-1.
NEUROCHEMICAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Nathalie Esser, Stephen M. Mongovin, Jacqueline Parilla, Breanne M. Barrow, Thomas O. Mundinger, Brendy S. Fountaine, Megan J. Larmore, Joseph J. Castillo, Rehana Akter, Rebecca L. Hull, Sakeneh Zraika
Summary: The neprilysin inhibitor sacubitril improves glycemic status in a mouse model of reduced insulin secretion. Sacubitril enhances insulin secretion in response to intravenous glucose, but not oral glucose. The increased glucose-mediated insulin secretion is dependent on GLP-1 receptor.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Pharmacology & Pharmacy
Nazi Song, Hongjiao Xu, Jiahua Liu, Qian Zhao, Hui Chen, Zhibin Yan, Runling Yang, Zhiteng Luo, Qi Liu, Jianmei Ouyang, Shuohan Wu, Suijia Luo, Shuyin Ye, Runfeng Lin, Xi Sun, Junqiu Xie, Tian Lan, Zhongdao Wu, Rui Wang, Xianxing Jiang
Summary: TB001, a dual GLP-1R/GCGR agonist, shows remarkable potency, selectivity, extended half-life and low toxicity in retarding the progression of liver fibrosis. It attenuates liver injury, collagen accumulation, and activation of hepatic stellate cells. It also inhibits proinflammatory pathways and hepatocyte apoptosis. The knock-down results suggest that GCGR plays an important role in ameliorating CCl4-induced hepatic fibrosis. TB001 has shown promise as a therapeutic candidate for the treatment of multiple causes of hepatic fibrosis.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Environmental Sciences
Cao Zhaohui, Tang Cifei, Huang Di, Zeng Weijia, Han Cairui, Li Zecong, Hu Xiaobo
Summary: In this study, it was found that cadmium exposure induced cell death in HepG2 cells via a ROS-mediated PERK-CHOP-related apoptotic signaling pathway, providing a novel insight into the mechanisms of cadmium-induced hepatotoxicity. Inhibitors targeting oxidative stress and ER stress might be potential strategies for preventing or treating this disorder.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Cell Biology
Cheng Li, Xiao Miao, Shudong Wang, Yucheng Liu, Jian Sun, Quan Liu, Lu Cai, Yonggang Wang
Summary: The study demonstrates that Elabela treatment has profound protective effects against diabetes-induced cardiac oxidative stress, inflammation, fibrosis, and apoptosis, potentially through SIRT3-mediated pathways. This suggests that Elabela may have cardioprotective effects in diabetic models.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Toxicology
Chen Zhang, Qinghua Dan, Song Lai, Yutong Zhang, Erer Gao, Haiyan Luo, Liping Yang, Xiaobo Gao, Cailing Lu
Summary: This study investigated the role of Rab10 in doxorubicin (DOX)-induced cardiotoxicity. The results showed that cardiac-specific overexpression of Rab10 alleviated cardiac dysfunction and mitochondrial damage caused by DOX treatment. Rab10 also inhibited apoptosis and oxidative stress in cardiomyocytes. Furthermore, Rab10 inhibited the cleavage of Mst1, a serine-threonine kinase, mediated by DOX treatment.
TOXICOLOGY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Xiangxu Wei, Miao Zhong, Song Wang, Lexun Li, Zi-Long Song, Junmin Zhang, Jianqiang Xu, Jianguo Fang
Summary: The study synthesized 72 disulfides and identified two compounds with significant antitumor activity against HeLa cells. Kinetic studies showed one of the disulfides had faster inhibition of Trx compared to the other. These findings suggest potential for the development of anticancer candidates with Trx inhibition.
BIOORGANIC CHEMISTRY
(2021)
Article
Oncology
Ya Feng, Tianjiao Li, Yin Li, Zhoujun Lin, Xiao Han, Xiaolin Pei, Yupeng Zhang, Fei Li, Juan Yang, Di Shao, Chenggang Li
Summary: This study identifies a novel redox-dependent mechanism in the pathogenesis of LAM and suggests that Glrx may potentially be a beneficial strategy for the treatment of LAM or other TSC-related diseases.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Swaimanti Sarkar, Ankur Das, Ankan Mitra, Songita Ghosh, Sreya Chattopadhyay, Debasish Bandyopadhyay
Summary: This study found that adrenaline-copper complex can cause damage to cardiomyocytes, while melatonin can protect them. The results indicate that melatonin exerts cardioprotective effects through multiple mechanisms, including reducing oxidative stress, regulating inflammation, and inhibiting cell apoptosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Gaiying Luo, Rui Wang, Hui Zhou, Xiaoling Liu
Summary: ALDOA protects cardiomyocytes from H/R-induced oxidative stress through the VEGF/Notch 1/Jagged 1 axis, potentially serving as a therapeutic target for the treatment of myocardial infarction in the future.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Cell Biology
Ziqi Cheng, Dongsheng Guo, Aynisahan Ruzi, Tingcai Pan, Kai You, Yan Chen, Xinping Huang, Jiaye Zhang, Fan Yang, Lizhi Niu, Kecheng Xu, Yin-Xiong Li
Summary: This study utilized patient-origin iPSCs to model multiple phenotypes of MEN1, revealing an association between increased insulin-positive cells in MEN1-iPSC derived cells and elevated expression of various factors and signaling pathways, and suggesting GLP-1R as a potential therapeutic target for MEN1-related hyperinsulinemia.
Article
Cardiac & Cardiovascular Systems
Chayodom Maneechote, Sasiwan Kerdphoo, Thidarat Jaiwongkam, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Chronic inhibition of mitochondrial fission and promotion of fusion have cardioprotective effects in pre-diabetic rats with cardiac ischemia-reperfusion injury, by relieving cardiac mitochondrial dysfunction and dynamic alterations, and reducing myocardial infarction, thereby improving cardiac function.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Pathology
Wichida Kaorop, Chayodom Maneechote, Sirinart Kumfu, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Obesity is a common health problem worldwide, and mitochondrial dysfunction is suggested to be a potential mechanism for its progression. Recent studies have shown that mitochondrial-derived peptides (MDPs) have the potential to improve metabolic function and treat obesity-associated diabetes and heart pathologies. This review comprehensively summarizes the roles of MDPs in metabolic pathways and their use in treating adverse effects of obesity based on evidence from in vitro, in vivo, and clinical studies.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Review
Pharmacology & Pharmacy
Panat Yanpiset, Chayodom Maneechote, Sirawit Sriwichaiin, Natthaphat Siri-Angkul, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Cardiomyocyte death plays a major role in the development of myocardial infarction and myocardial ischemia/reperfusion injury. Pyroptosis, a regulated programmed cell death pathway, has been shown to be involved in these conditions. Activation of gasdermin D (GSDMD) through the canonical or non-canonical pathways is an important step in pyroptosis. Inhibition of GSDMD provides cardioprotection against myocardial infarction and myocardial ischemia/reperfusion injury.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Dentistry, Oral Surgery & Medicine
Savitri Vaseenon, Tanida Srisuwan, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: This study aimed to investigate the effects of lipopolysaccharides (LPS), hydrogen peroxide (H2O2), and their combination on various indicators of human dental pulpal cells. The results showed that H2O2 and the combined agents equally decreased cell proliferation. LPS, H2O2, and the combination decreased mineralization and differentiation while increasing inflammation and apoptosis. Surprisingly, LPS and the combined agents also increased expression of SOD2 and caused an imbalance in mitochondrial dynamics.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Toxicology
Chanisa Thonusin, Wichwara Nawara, Thawatchai Khuanjing, Nanthip Prathumsup, Apiwan Arinno, Benjamin Ongnok, Busarin Arunsak, Sirawit Sriwichaiin, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: This study investigated the changes in blood and cardiac metabolome levels following treatment with doxorubicin and trastuzumab, and their association with cardiac dysfunction and injury. The study found that there were distinct patterns of metabolome alterations between the two treatment groups, and that the constituents of the blood metabolome may serve as non-invasive biomarkers for assessing the severity and prognosis of heart failure induced by these drugs.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Weiwei Zhu, Minxiu Wang, Leiming Jin, Bin Yang, Bin Bai, Rumbidzai Natasha Mutsinze, Wei Zuo, Nipon Chattipakorn, Joo Young Huh, Guang Liang, Yi Wang
Summary: This study discovered a natural compound, licochalcone A, with anti-inflammatory activity. It was found to directly bind to the protein MD2, which regulates the LPS inflammatory signaling pathway, and blocked both TRIF- and MYD88-dependent pathways. In vivo experiments showed that licochalcone A treatment alleviated acute lung injury (ALI) in mice by reducing immunocyte infiltration and suppressing TLR4 pathway activation and inflammatory cytokine production.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Chanon Piamsiri, Chayodom Maneechote, Kewarin Jinawong, Busarin Arunsak, Titikorn Chunchai, Wichwara Nawara, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Myocardial infarction (MI) is a leading cause of death worldwide, and oxidative stress, inflammation, and mitochondrial dysfunction are recognized as possible mechanisms in the development of MI. Different types of programmed cell death (PCDs), including apoptosis, necroptosis, ferroptosis, and pyroptosis, have been associated with different phases of ischemic injury following MI. However, it is still unknown which types of PCDs play the most dominant role in post-MI.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Kwannapas Saengsin, Rekwan Sittiwangkul, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Cardiovascular disease is the leading cause of death globally. Molecular hydrogen, which can be administered through various methods, has shown antioxidant, anti-inflammatory, and anti-apoptotic effects, providing protection for the heart.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Cell Biology
Prit Kusirisin, Nattayaporn Apaijai, Kajohnsak Noppakun, Srun Kuanprasert, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Contrast-induced acute kidney injury (CI-AKI) is a common type of acute kidney injury in hospitalized patients. However, diagnosing CI-AKI using serum creatinine may not be early enough. This study aimed to investigate the role of circulating mitochondrial dysfunction as a potential early biomarker for detecting CI-AKI. Twenty patients with chronic kidney disease (CKD) undergoing percutaneous coronary intervention (PCI) were included. Blood and urine samples were collected at different time points after PCI to measure neutrophil gelatinase-associated lipocalin (NGAL) levels and assess oxidative stress, inflammation, mitochondrial function, dynamics, and cell death. The results showed that 40% of patients developed AKI, and plasma NGAL levels increased after 24 hours of receiving contrast media. Cellular and mitochondrial oxidative stress, dysfunction, and decreased fusion occurred 6 hours after contrast media exposure. The subgroup with AKI had higher necroptosis cells and TNF-alpha mRNA expression compared to the subgroup without AKI. In conclusion, circulating mitochondrial dysfunction could serve as an early predictive biomarker for CI-AKI in CKD patients receiving contrast media. These findings provide insights for the development of novel strategies to prevent CI-AKI based on its pathophysiology.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Endocrinology & Metabolism
Chanisa Thonusin, Wichwara Nawara, Apiwan Arinno, Thawatchai Khuanjing, Nanthip Prathumsup, Benjamin Ongnok, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Using mass spectrometry-based targeted metabolomics, this study aimed to investigate the patterns of cardiac metabolic reprogramming and energetics in doxorubicin-induced heart failure, as well as the potential effects of melatonin on these processes. The results showed that co-treatment with melatonin could restore cardiac function, glucose and ketone body utilization, and adenosine triphosphate production, while also increasing cardiac fatty acid oxidation, branched-chain amino acid catabolism, and anaplerosis. These findings highlight the potential efficacy of melatonin in cardiac metabolic reprogramming and energetics, suggesting it as an adjunctive treatment for doxorubicin-induced heart failure.
JOURNAL OF PINEAL RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Chayodom Maneechote, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Doxorubicin is an effective chemotherapy drug, but its cardiotoxicity limits its effectiveness. Recent research has shown that excessive mitochondrial fission and impaired fusion contribute to this cardiotoxicity. However, using inhibitors of mitochondrial fission or promoters of fusion can protect the heart against the toxicity of doxorubicin.
Review
Environmental Sciences
Wanitcha Gumtorntip, Nuntana Kasitanon, Worawit Louthrenoo, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: This review summarizes and discusses the association between air pollutants and the development or aggravation of rheumatoid arthritis (RA). The findings suggest that air pollutants can stimulate immunological processes and inflammatory mediators and autoantibodies productions. Furthermore, air pollutants can induce and aggravate RA disease activity. However, discrepancies in the results highlight the need for future studies to elucidate these mechanisms and identify reliable biomarkers for individual susceptibility and disease activity assessment.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biochemistry & Molecular Biology
Thawatchai Khuanjing, Chayodom Maneechote, Benjamin Ongnok, Nanthip Prathumsap, Apiwan Arinno, Titikorn Chunchai, Busarin Arunsak, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: This study found that donepezil protects against trastuzumab-induced cardiotoxicity by reducing mitochondrial dysfunction, oxidative stress, inflammation, and cardiomyocyte death, leading to improved left ventricular function through activation of muscarinic acetylcholine receptors. This provides a new intervention strategy for treating trastuzumab-induced cardiotoxicity.
MOLECULAR MEDICINE
(2023)
Review
Surgery
Kittitorn Supphapipat, Prangmalee Leurcharusmee, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: Air pollution has negative effects on human health, especially for organ transplant patients receiving immunosuppressive treatment. Clinical investigations have shown that air pollution is associated with organ rejection and various diseases.
CLINICAL TRANSPLANTATION
(2023)
Article
Orthopedics
Prangmalee Leurcharusmee, Passakorn Sawaddiruk, Yodying Punjasawadwong, Nantawit Sugandhavesa, Kasisin Klunklin, Siam Tongprasert, Patraporn Sitilertpisan, Nattayaporn Apaijai, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: The study found that ischemic preconditioning (IPC) can protect muscle strength after total knee arthroplasty (TKA) by enhancing mitochondrial fusion proteins and preventing I/R injury. Additionally, IPC significantly increased the expression of Mfn2 and Opa1 proteins, positively impacting postoperative muscle recovery.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)