期刊
MOLECULAR ECOLOGY
卷 24, 期 20, 页码 5145-5157出版社
WILEY
DOI: 10.1111/mec.13382
关键词
adaptive introgression; Anopheles; epistasis; hybridization; insecticide resistance; kdr; malaria vector; P450
资金
- NIH S10 Instrumentation Grants [S10RR029668, S10RR027303]
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health [R21AI117174, D43TW007390, R01AI078183, T32AI074550]
In certain cases, a species may have access to important genetic variation present in a related species via adaptive introgression. These novel alleles may interact with their new genetic background, resulting in unexpected phenotypes. In this study, we describe a selective sweep on standing variation on the X chromosome in the mosquito Anopheles coluzzii, a principal malaria vector in West Africa. This event may have been influenced by the recent adaptive introgression of the insecticide resistance gene known as kdr from the sister species Anopheles gambiae. Individuals carrying both kdr and a nearly fixed X-linked haplotype, encompassing at least four genes including the P450 gene CYP9K1 and the cuticular protein CPR125, have rapidly increased in relative frequency. In parallel, a reproductively isolated insecticide-susceptible A.gambiae population (Bamako form) has been driven to local extinction, likely due to strong selection from increased insecticide-treated bed net usage.
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