Article
Oncology
Omar J. Mohammed, Maria Estevez Cebrero, Omar Ahmad, Andrew Peet, Richard G. Grundy, Anbarasu Lourdusamy
Summary: This study aims to comprehensively characterize medulloblastoma in teenagers and young adults (TYA) using genomic technologies. The findings show that TYA medulloblastoma consists of heterogeneous molecular subgroups with distinct characteristics. A gene signature-based score stratifies TYA patients into low- and high-risk groups and is significantly associated with outcomes. Understanding the TYA-specific biology may impact future treatment approaches.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hui Zheng, Jinning Li, Huanhuan Liu, Gui Ting, Qiufeng Yin, Rui Li, Ming Liu, Yuzhen Zhang, Shaofeng Duan, Yuhua Li, Dengbin Wang
Summary: This study aimed to evaluate the value of an MRI radiomics signature in stratifying the risk of pediatric MB and compared it with clinical-MRI features. The integrated model, combining radiomics signature, clinical, and conventional MRI features, showed the best performance in evaluating the overall survival of children with MB.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Oncology
Bree R. Eaton, Grace W. Fong, Lisa M. Ingerski, Margaret B. Pulsifer, Subir Goyal, Chao Zhang, Elizabeth A. Weyman, Natia Esiashvili, James L. Klosky, Tobey J. MacDonald, David H. Ebb, Shannon M. MacDonald, Nancy J. Tarbell, Torunn Yock
Summary: Proton therapy may reduce cognitive deficits after radiotherapy among brain tumor survivors, with patients treated with proton therapy showing higher intelligence quotient scores compared to those treated with photon radiation. Comprehensive prospective studies are needed to further evaluate the neurocognitive advantages of proton therapy.
Article
Multidisciplinary Sciences
Xiaojing Wang, Anne-Marie Langevin, Peter J. Houghton, Siyuan Zheng
Summary: This study investigates the clinical and genomic disparities between adolescents and young adults (AYA) and older adults in cancer patients. It reveals significant differences in clinical presentation and genetic characteristics between AYA and older adult tumors. AYA tumors tend to have lower mutation burden and less genomic instability, but show overrepresentation of certain mutations across multiple cancer types.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Sujith Baliga, Sara Gallotto, Benjamin Bajaj, Jaqueline Lewy, Elizabeth Weyman, Miranda Lawell, Beow Y. Yeap, David E. Ebb, Mary Huang, Paul Caruso, Alisa Perry, Robin M. Jones, Shannon M. MacDonald, Nancy J. Tarbell, Torunn Yock
Summary: This study shows that proton radiotherapy is effective in treating pediatric medulloblastoma, with disease outcomes comparable to traditional photon therapy. The incidence of secondary malignancies and brainstem injury is low in this cohort with long-term follow-up.
Review
Oncology
Aditi Bagchi, Sandeep K. Dhanda, Paige Dunphy, Edgar Sioson, Giles W. Robinson
Summary: The treatment of medulloblastoma in infants and young children is challenging, as traditional therapies like craniospinal irradiation can cause significant harm to young patients. However, recent advancements in molecular diagnostics have allowed for better assessment of treatment response and risk stratification, leading to the selection of more effective and less toxic therapies.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2023)
Article
Oncology
Craig Erker, Martin Mynarek, Simon Bailey, Claire M. Mazewski, Lorena Baroni, Maura Massimino, Juliette Hukin, Dolly Aguilera, Andrea M. Cappellano, Vijay Ramaswamy, Alvaro Lassaletta, Sebastien Perreault, Cassie N. Kline, Revathi Rajagopal, George Michaiel, Michal Zapotocky, Vicente Santa-Maria Lopez, Andres Morales La Madrid, Chantel Cacciotti, Eric S. Sandler, Lindsey M. Hoffman, Darren Klawinski, Sara Khan, Ralph Salloum, Anna L. Hoppmann, Valerie Larouche, Kathleen Dorris, Helen Toledano, Stephen W. Gilheeney, Mohamed S. Abdelbaki, Beverly Wilson, Derek S. Tsang, Jeffrey Knipstein, Michal Yalon Oren, Shafqat Shah, Jeffrey C. Murray, Kevin F. Ginn, Zhihong J. Wang, Gudrun Fleischhack, Denise Obrecht, Svenja Tonn, Virginia L. Harrod, Kara Matheson, Bruce Crooks, Douglas R. Strother, Kenneth J. Cohen, Jordan R. Hansford, Sabine Mueller, Ashley Margol, Amar Gajjar, Girish Dhall, Jonathan L. Finlay, Paul A. Northcott, Stefan Rutkowski, Steven C. Clifford, Giles Robinson, Eric Bouffet, Lucie Lafay-Cousin
Summary: The purpose of this study was to assess salvage strategies and prognostic features of patients with infant and young childhood medulloblastoma (iMB) who relapse after craniospinal irradiation (CSI)-sparing therapy. The results showed that the 3-year postrelapse survival rate for patients treated with curative intent was 52.4%. Salvage radiotherapy and chemotherapy might be beneficial for a subset of patients. Therefore, CSI-sparing therapy can be effective in a substantial proportion of relapsed iMB patients.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Lucie Lafay-Cousin, Lorena Baroni, Vijay Ramaswamy, Eric Bouffet
Summary: Therapeutic strategies for young children with medulloblastoma are evolving, including high-dose chemotherapy with stem cell rescue and intraventricular chemotherapy. Studies on different molecular subgroups show excellent survival rates for sonic hedgehog medulloblastoma patients, while those with high-risk features may require innovative therapies.
PEDIATRIC BLOOD & CANCER
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jungheum Cho, Youngjune Kim, Seungjae Lee, Hooney Daniel Min, Yousun Ko, Choong Guen Chee, Hae Young Kim, Ji Hoon Park, Kyoung Ho Lee
Summary: This study compares the visualization of the appendix on 2-mSv CT and conventional-dose CT in adolescents and young adults, and analyzes the undesirable clinical and diagnostic outcomes that follow appendix nonvisualization. The results show that appendix visualization is poorer in the 2-mSv CT group, but the undesirable outcomes following appendix nonvisualization in this group are rare.
KOREAN JOURNAL OF RADIOLOGY
(2022)
Review
Oncology
Atsushi Makimoto
Summary: Due to their rarity, there is limited understanding of rhabdomyosarcomas (RMS) in adolescents and young adults (AYA), resulting in poor treatment outcomes. This review aims to integrate new developments with existing evidence to explore factors and potential solutions in RMS in AYA.
Article
Radiology, Nuclear Medicine & Medical Imaging
Summary: The recent survey on European radiology departments showed a mixed picture in terms of compliance with BSSD requirements, with both improvement and deterioration observed compared to the 2018 survey. Higher levels of skipping responses were also observed in 2021, possibly due to the impact of the COVID-19 pandemic.
INSIGHTS INTO IMAGING
(2021)
Article
Social Sciences, Interdisciplinary
Francisco Simoes, Jale Tosun, Antonella Rocca
Summary: This study investigates the impact of individual, parental, and social factors on young adults' job-finding intentions. The findings show that individual factors are the most decisive, while social factors and country-level factors also play a role. The study reflects on the importance of education as a means of improving professional aspirations and providing adequate services to help young people through the school-to-work transition.
SOCIAL INDICATORS RESEARCH
(2022)
Article
Medicine, General & Internal
Peng Du, Xionggang Yang, Li Shen, Jiawei Chen, Xiao Liu, Xuefan Wu, Aihong Cao, Daoying Geng
Summary: This study aimed to identify critical factors associated with progression-free survival (PFS) and overall survival (OS) in adult patients with high-grade glioma (HGG) who received standard treatment, and to establish a novel graphical nomogram and online dynamic nomogram. Factors including age, extent of resection (EOR), IDH mutation, and edema index (EI) were found to be associated with PFS and OS. Additionally, patients with IDH and TERT promoter co-mutations had longer PFS and OS. Nomogram models were developed based on these factors to assist in clinical management and treatment strategies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Green & Sustainable Science & Technology
Agnieszka Sompolska-Rzechula, Agnieszka Kurdys-Kujawska
Summary: Young adults in Europe are finding it increasingly difficult to leave their hometowns, resulting in a growing number of them living with their parents. The phenomenon of nesting varies across European countries, with a particular intensity among the unemployed and those without permanent employment.
Article
Respiratory System
Anne-Elie Carsin, Judith Garcia-Aymerich, Simone Accordini, Shyamali Dharmage, Benedicte Leynaert, Marti de las Heras, Lidia Casas, Seraina Caviezel, Pascal Demoly, Bertil Forsberg, Thorarinn Gislason, Angelo Guido Corsico, Christer Janson, Rain Jogi, Jesus Martinez-Moratalla, Dennis Nowak, Leopoldo Palacios Gomez, Isabelle Pin, Nicole Probst-Hensch, Chantal Raherison-Semjen, Giulia Squillacioti, Cecilie Svanes, Kjell Toren, Isabel Urrutia, Ismael Huerta, Josep Maria Anto, Debbie Jarvis, Stefano Guerra
Summary: This study aimed to describe the characteristics and risk factors of restrictive and obstructive spirometric patterns occurring before 40 years (young onset) and between 40 and 61 years (mid-adult onset). Data from the European Community Respiratory Health Survey (ECRHS) were used, and longitudinal assessments of forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were conducted.
Article
Oncology
Ugo Pastorino, Emanuela Palmerini, Luca Porcu, Roberto Luksch, Paolo Scanagatta, Cristina Meazza, Giovanni Leuzzi, Maura Massimino, Piero Picci
Summary: This study analyzed the clinical benefit and potential cure rate of repeated lung metastasectomy in a pediatric population. The results showed that repeated lung metastasectomy can achieve a permanent cure when offered to properly selected patients with metastases from osteosarcoma.
Article
Oncology
Elisabetta Schiavello, Veronica Biassoni, Giovanna Gattuso, Marta Podda, Stefano Chiaravalli, Francesco Barretta, Manila Antonelli, Loris De Cecco, Emilia Pecori, Lorenza Gandola, Maura Massimino
Summary: This is a small series of homogeneously-treated DMG patients with H3K27M mutation. The treatment approach is similar to DIPG and the results obtained are comparable with those of DIPG patients. Therefore, these DMG patients should be included in registries and protocols of DIPG.
Article
Oncology
Patrizia Gasparini, Michela Casanova, Giovanni Centonze, Cristina Borzi, Luca Bergamaschi, Paola Collini, Adele Testi, Stefano Chiaravalli, Maura Massimino, Gabriella Sozzi, Andrea Ferrari, Massimo Moro
Summary: This study established a series of pediatric RMS patient derived xenografts (PDXs) that closely mirrored the characteristics of the primary tumors. The grafting rate was higher for patients with worse prognosis. These PDX models serve as important tools for identifying potential treatments and developing personalized therapies.
Letter
Oncology
Matteo Silva, Stefano Rizzo, Alice Patriccioli, Giovanna Sironi, Carlo Alfredo Clerici, Maura Massimino, Andrea Ferrari
Article
Oncology
Cristina Meazza, Sironi Giovanna, Olga Nigro, Giovanna Gattuso, Barretta Francesco, Marta Podda, Roberto Luksch, Veronica Biassoni, Elisabetta Schiavello, Andrea Ferrari, Filippo Spreafico, Michela Casanova, Stefano Chiaravalli, Nadia Puma, Luca Bergamaschi, Virginia Livellara, Morosi Carlo, Antonina Parafioriti, Primo Daolio, Stefano Bastoni, Sabina Vennarini, Emilia Pecori, Ombretta Alessandro, Paola Collini, Maura Massimino, Monica Terenziani
Summary: This study examines the clinical characteristics and outcomes of patients with secondary osteosarcoma (SOS). The results show that the survival rates after SOS are lower than in patients with primary osteosarcoma but not negligible. Therefore, the best choice of treatment for such patients should be discussed at a referral center in terms of their chances of cure and quality of life.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Craig Erker, Martin Mynarek, Simon Bailey, Claire M. Mazewski, Lorena Baroni, Maura Massimino, Juliette Hukin, Dolly Aguilera, Andrea M. Cappellano, Vijay Ramaswamy, Alvaro Lassaletta, Sebastien Perreault, Cassie N. Kline, Revathi Rajagopal, George Michaiel, Michal Zapotocky, Vicente Santa-Maria Lopez, Andres Morales La Madrid, Chantel Cacciotti, Eric S. Sandler, Lindsey M. Hoffman, Darren Klawinski, Sara Khan, Ralph Salloum, Anna L. Hoppmann, Valerie Larouche, Kathleen Dorris, Helen Toledano, Stephen W. Gilheeney, Mohamed S. Abdelbaki, Beverly Wilson, Derek S. Tsang, Jeffrey Knipstein, Michal Yalon Oren, Shafqat Shah, Jeffrey C. Murray, Kevin F. Ginn, Zhihong J. Wang, Gudrun Fleischhack, Denise Obrecht, Svenja Tonn, Virginia L. Harrod, Kara Matheson, Bruce Crooks, Douglas R. Strother, Kenneth J. Cohen, Jordan R. Hansford, Sabine Mueller, Ashley Margol, Amar Gajjar, Girish Dhall, Jonathan L. Finlay, Paul A. Northcott, Stefan Rutkowski, Steven C. Clifford, Giles Robinson, Eric Bouffet, Lucie Lafay-Cousin
Summary: The purpose of this study was to assess salvage strategies and prognostic features of patients with infant and young childhood medulloblastoma (iMB) who relapse after craniospinal irradiation (CSI)-sparing therapy. The results showed that the 3-year postrelapse survival rate for patients treated with curative intent was 52.4%. Salvage radiotherapy and chemotherapy might be beneficial for a subset of patients. Therefore, CSI-sparing therapy can be effective in a substantial proportion of relapsed iMB patients.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Sophie Thomas, Leanne Embry, Karin Walsh, Kim Bull, Richard Grundy, Colin Kennedy, Jurgen Lemiere, Pablo Hernaiz Driever, Jennifer Limond, Mathilde Chevignard, Kristina Hardy
Summary: The importance of measuring quality of survival in paediatric oncology trials is recognized. However, capturing neuropsychological outcomes and other aspects of quality of survival in large or multinational trials is challenging. We provide examples of protocols designed to address this challenge in recent clinical trials in the USA and Europe, discussing their strengths, challenges, and opportunities for transatlantic collaboration.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Danielle Awounou, Brigitte Lacour, Emmanuel Desandes, Sandra Guissou, Nathalie Cassoux, Francois Doz, Christelle Dufour, Veronique Minard-Colin, Gudrun Schleiermacher, Sophie Taque, Arnauld Verschuur, Jacqueline Clavel, Stephanie Goujon
Summary: This study aimed to investigate seasonal variations in the incidence rates of embryonal tumors by the month of birth and diagnosis. The findings showed a seasonal variation in the incidence rates of retinoblastoma and rhabdomyosarcoma by the month of diagnosis. These results may be due to delayed consultation during the summer months, but the potential role of seasonally varying environmental exposures cannot be ruled out.
Article
Oncology
Lucas Moreno, Steven G. DuBois, Julia Glade Bender, Audrey Mauguen, Nick Bird, Vickie Buenger, Michela Casanova, Francois Doz, Elizabeth Fox, Lia Gore, Douglas S. Hawkins, Shai Izraeli, David T. W. Jones, Pamela R. Kearns, Jan J. Molenaar, Karsten Nysom, Stefan Pfister, Gregory Reaman, Malcolm Smith, Brenda Weigel, Gilles Vassal, Christian Michel Zwaan, Xavier Paoletti, Alexia Iasonos, Andrew D. J. Pearson
Summary: There is a growing need to evaluate innovative drugs for childhood cancer using combination strategies. Combinations of anticancer therapies should be developed on the basis of mechanism of action and robust preclinical evaluation. An optimized, agreed approach to the design and evaluation of early-phase pediatric combination trials will accelerate drug development and benefit all stakeholders.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Andrea Ferrari, Matteo Silva, Alice Patriccioli, Stefano Signoroni, Carlo Alfredo Clerici, Maura Massimino
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Francesca Minnai, Sara Noci, Nunzia Mangano, Loris De Cecco, Cristina Meazza, Monica Terenziani, Maura Massimino, Francesca Colombo
Summary: In this exome-wide association study, gene sets significantly associated with neutropenia and hepatotoxicity induced by methotrexate were identified in pediatric osteosarcoma patients. However, further validation and functional characterization of these associations are needed in larger series, emphasizing the importance of investigating variants along the whole genome to identify potential pharmacogenes.
PEDIATRIC BLOOD & CANCER
(2023)
Letter
Oncology
Matteo Silva, Massimo Guglielmi, Carlo Alfredo Clerici, Maura Massimino, Andrea Ferrari
Editorial Material
Oncology
Marta G. Podda, Cristina Meazza, Giovanna Gattuso, Giovanna Sironi, Olga Nigro, Luca Bergamaschi, Veronica Biassoni, Michela Casanova, Stefano Chiaravalli, Andrea Ferrari, Roberto Luksch, Nadia Puma, Elisabetta Schiavello, Filippo Spreafico, Paolo Grampa, Siranoush Manoukian, Sabina Vennarini, Paola Collini, Primo A. Daolio, Massimiliano Gennaro, Marco Guzzo, Carlo Morosi, Davide Biasoni, Maura Massimino, Monica Terenziani
Summary: Each year, around 35,000 children and adolescents in Europe are diagnosed with cancer. Survival rates have increased to 80% in most European countries, thanks to chemotherapy, radiotherapy, and surgery. However, cancer survivors in childhood and adolescence face the risk of developing chronic health conditions and even second malignant neoplasms later in life. It is crucial to discuss potential problems early on and provide specialized care for these survivors.
Article
Pediatrics
Olga Nigro, Cristina Meazza, Elisabetta Schiavello, Veronica Biassoni, Nadia Puma, Luca Bergamaschi, Giovanna Gattuso, Giovanna Sironi, Virginia Livellara, Gabriele Papagni, Maura Massimino
Summary: This study investigated the occurrence of acute kidney injury in patients with concurrent SARS-CoV-2 infection during high-dose methotrexate (HDMTX) treatment. The results showed that all three patients who were infected with SARS-CoV-2 during HDMTX treatment developed acute kidney injury. Therefore, the researchers suggested that COVID-19 could be one of the causes of kidney failure in these patients.
Article
Oncology
Mathieu Chicard, Yasmine Iddir, Julien Masliah Planchon, Valerie Combaret, Valery Attignon, Alexandra Saint-Charles, Didier Frappaz, Cecile Faure-Conter, Kevin Beccaria, Pascale Varlet, Birgit Geoerger, Sylvain Baulande, Gaelle Pierron, Yassine Bouchoucha, Francois Doz, Olivier Delattre, Joshua J. Waterfall, Franck Bourdeaut, Gudrun Schleiermacher
Summary: We demonstrated that cell-free DNA extracted from CSF can be used for whole exome sequencing in pediatric embryonal brain tumors, with informative results in 83% of samples. Clonal heterogeneity was identified in most cases compared to primary tumor tissue sequencing. Nucleosome footprinting at transcription start sites of genes of interest enabled the inference of gene expression. These findings pave the way for the use of CSF cfDNA in molecular diagnosis and disease monitoring.