Article
Oncology
Basic Original Report Pule Wang, Marissa Gilbert, Henry W. Lim, Chauncey McHargue, Ben J. Friedman, Jesse J. Veenstra, Farzan Siddiqui
Summary: The purpose of this study was to investigate the treatment outcomes of single-fraction radiation therapy for CTCL. The results showed that single-fraction radiation therapy had a high rate of complete response and durable responses in the affected sites.
PRACTICAL RADIATION ONCOLOGY
(2023)
Article
Medicine, General & Internal
Sang Hee Youn, Sun Young Lee
Summary: The treatment for advanced-stage CTCL remains challenging due to the rarity of the disease. High-dose 3-dimensional conformal radiation therapy can be effective for curative purposes with tolerable toxicities.
Article
Health Care Sciences & Services
Christopher McLaughlin, Mark A. Russell
Summary: This article presents a case of a 100-year-old woman with advanced dementia and inoperable cSCC who was successfully treated with single-fraction palliative radiotherapy. The patient achieved a complete response with no residual tumor and experienced no persistent side effects, demonstrating the effectiveness and tolerability of this treatment option in elderly patients.
ANNALS OF PALLIATIVE MEDICINE
(2022)
Article
Multidisciplinary Sciences
Christine L. Jones, Andrea Degasperi, Vieri Grandi, Tauanne D. Amarante, Tracey J. Mitchell, Serena Nik-Zainal, Sean J. Whittaker
Summary: This study identified different mutational signatures and associated recurrent gene mutations in various subtypes of T-cell non-Hodgkin's lymphomas. UV radiation was found to have a strong correlation with cutaneous T-cell lymphoma. This finding highlights the importance of understanding the pathogenesis of the disease.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Xiangjun Liu, Shanzhao Jin, Simeng Hu, Ruoyan Li, Haihao Pan, Yi Liu, Pan Lai, Deshu Xu, Jingru Sun, Ziyang Liu, Yumei Gao, Yifan Zhao, Fengjie Liu, Yu Xiao, Yingyi Li, Yujie Wen, Zhuojing Chen, Bufang Xu, Yuchieh Lin, Menglong Ran, Qianxi Li, Shuxia Yang, Hang Li, Ping Tu, Muzlifah Haniffa, Sarah A. Teichmann, Fan Bai, Yang Wang
Summary: Cutaneous T cell lymphoma (CTCL) is a heterogeneous group of non-Hodgkin lymphoma characterized by clonal malignant T cells. This study analyzed CTCL patient samples using single-cell RNA-seq, TCR and whole-exome sequencing, revealing the molecular profiles of malignant T cells and their association with the microenvironment and clinical outcomes.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Shuichi Nakai, Eiji Kiyohara, Rei Watanabe
Summary: CTCL is a heterogeneous group of non-Hodgkin lymphoma, mainly including MF and SS, with malignant cells possibly originating from different T cell phenotypes. The pathogenesis and therapeutic strategies for CTCL remain unclear due to the similar characteristics between malignant cells and anti-tumor T cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Till Tobias Boehlen, Jean-Francois Germond, Jean Bourhis, Marie-Catherine Vozenin, Esat Mahmut Ozsahin, Francois Bochud, Claude Bailat, Raphael Moeckli
Summary: This study evaluated the magnitude of normal tissue sparing provided by the FLASH effect and parameterized its relationship with dose. The results showed that the magnitude of tissue sparing decreases as the dose increases and is dependent on the irradiated tissue.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Dermatology
Cosimo Di Raimondo, Sara Vaccarini, Andrea Nunzi, Vito Rapisarda, Annagiulia Zizzari, Federico Meconi, Alessandro Monopoli, Maria Grazia Narducci, Enrico Scala, Luca Bianchi, Cristiano Tesei, Maria Cantonetti
Summary: The aim of this retrospective study was to assess the efficacy of a lower dosage of gemcitabine in treating cutaneous T cell lymphomas (CTCL). The study found that the schedule of 1000 mg every 15 days had the highest efficacy and lowest toxicity profile. Gemcitabine at a lower dose showed durable response in advanced-stage and refractory CTCL patients.
DERMATOLOGIC THERAPY
(2022)
Article
Dermatology
Christoph Blazejak, Rene Stranzenbach, Janika Gosman, Thilo Gambichler, Ulrike Wehkamp, Sarja Stendel, Claus-Detlev Klemke, Marion Wobser, Joanna Olk, Jan P. Nicolay, Maria Weyermann, Rudolf Stadler, Chalid Assaf
Summary: This retrospective study on 64 CTCL and BPDCN patients treated with low-dose gemcitabine found that the treatment showed a comparable overall response rate and progression-free survival to standard dose therapy, but with fewer adverse events.
Article
Oncology
Michael T. Milano, Jimm Grimm, Scott G. Soltys, Ellen Yorke, Vitali Moiseenko, Wolfgang A. Tome, Arjun Sahgal, Jinyu Xue, Lijun Ma, Timothy D. Solberg, John P. Kirkpatrick, Louis S. Constine, John C. Flickinger, Lawrence B. Marks, Issam El Naqa
Summary: This study analyzed dosimetric and clinical predictors of radiation-induced optic nerve/chiasm neuropathy after single-fraction stereotactic radiosurgery or hypofractionated radiosurgery. The results showed that the maximum point dose to the optic apparatus was related to RION risk, providing insight into NTCP risks.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Tina Petrogiannis-Haliotis, Kevin Pehr, David Roberge, Ryan N. Rys, Yury Monczak, Gizelle Popradi, Lissa Ajjamada, Naciba Benlimame, Christiane Querfeld, Nathalie Johnson, Hans Knecht
Summary: We present a case of CD4+ small/medium-sized pleomorphic lymphoma with extensive lesions in the legs. Immunohistochemistry and flow cytometry analysis showed distinct CD4+ and CD8+ T-cell populations with no CD4/CD8 co-expression. TCR gene rearrangement studies confirmed the neoplastic population to be of T-cytotoxic cell lineage, representing a previously undescribed type of CTCL.
Review
Oncology
Eirini Kalliara, Emma Belfrage, Urban Gullberg, Kristina Drott, Sara Ek
Summary: While most CTCL patients are diagnosed with early-stage disease, a significant number will progress unexpectedly to advanced-stage disease. Deciphering the biological events behind disease aggressiveness is crucial for identifying high-risk patients and designing personalized treatment strategies. By utilizing advanced single-cell transcriptomics tools, a comprehensive analysis of immune and malignant T-cell populations can be conducted, leading to the development of novel biomarkers and personalized treatments for CTCL patients.
Article
Dermatology
Sara Peru, Martina Prochazkova-Carlotti, Floriane Cherrier, Joanne Velazquez, Elodie Richard, Yamina Idrissi, David Cappellen, Lamia Azzi-Martin, Anne Pham-Ledard, Marie Beylot-Barry, Jean-Philippe Merlio, Sandrine Poglio
Summary: Cutaneous T-cell lymphoma (CTCL) is characterized by abnormal infiltration of T lymphocytes in the skin. In this study, the researchers found that the expression of cutaneous lymphocyte antigen (CLA) in CTCL cells is crucial for their migration and survival. The use of a CLA antibody significantly reduced the migration and survival of CTCL cells both in vitro and in vivo. These findings suggest that inhibiting CLA could be a potential therapeutic strategy for CTCL patients.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Oncology
Lin Lin, Nathanael Kane, Naoko Kobayashi, Evelyn A. Kono, Joyce M. Yamashiro, Nicholas G. Nickols, Robert E. Reiter
Summary: In prostate cancer models, high-dose radiotherapy induced an early increase of MDSCs, followed by a transient rise of functionally active CD8 TILs. However, systemic depletion of MDSCs did not enhance the antitumor efficacy of high-dose radiotherapy due to compensatory Treg-mediated immune suppression, suggesting that targeting both MDSCs and Tregs may be necessary to enhance radiotherapy-induced antitumor immunity.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Till Kaemmerer, Pia-Charlotte Stadler, Leonie Helene Frommherz, Anne Guertler, Lars Einar French, Markus Reinholz
Summary: This study analyzed the treatment of 35 patients with MF and SS CTCL using alitretinoin between 2015 and 2020, showing that nearly two thirds of the patients responded positively or had stable disease, with minimal side effects. This suggests that alitretinoin may be a potential alternative for less advanced CTCLs due to its effectiveness and low cost compared to bexarotene.
Article
Dermatology
Murad Alam, Sarah A. Ibrahim, Bianca Y. Kang, Arianna F. Yanes, Bharat B. Mittal, Daniel I. Schlessinger, David Zloty, Emily Poon, Erica H. Lee, Joseph F. Sobanko, Naomi Lawrence, Ramona Behshad, Ian A. Maher
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2022)
Article
Dermatology
K. A. Reynolds, D. Schlessinger, A. F. Yanes, V Godinez-Puig, B. R. Chen, A. O. Kurta, J. K. Cotseones, S. G. Chiren, S. Iyengar, S. A. Ibrahim, B. Y. Kang, B. Worley, R. Behshad, D. M. DeHoratius, P. Denes, A. M. Drucker, L. M. Dzubow, J. R. Etzkorn, C. A. Harwood, J. Y. S. Kim, N. Lawrence, E. H. Lee, G. S. Lissner, A. A. Marghoob, A. Guminiski, R. N. Matin, A. R. Mattox, B. B. Mittal, J. R. Thomas, X. A. Zhou, D. Zloty, B. G. M. Hughes, M. K. Nottage, A. C. Green, A. A. E. Testori, G. Argenziano, C. Longo, I Zalaudek, C. Lebbe, J. Malvehy, P. Saiag, S. S. Cernea, J. Schmitt, J. J. Kirkham, E. Poon, J. F. Sobanko, T. Cartee, I. A. Maher, M. Alam
Summary: Inconsistency in reported outcomes in clinical studies of cSCC complicates comparison of treatment effectiveness. A core outcome set was developed through systematic literature review and stakeholder interviews, with a final set of seven outcomes identified through Delphi exercises involving physicians, patients, and international experts. These core outcomes aim to improve comparability of trial results and reduce selective reporting bias.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Arkajyoti Roy, Reisa Widjaja, Min Wang, Dan Cutright, Mahesh Gopalakrishnan, Bharat B. Mittal
Summary: A multivariate quality control tool is developed in this study to model plan quality measures with correlations and patient-specific risk factors, reducing false alarms and being able to detect unusual plans. It incorporates risk-adjustment models, Hotelling's T-2 statistic, and principal component analysis to account for non-normality in DVH points and correlations among OAR DVH points.
Article
Environmental Sciences
Indra J. Das, John A. Kalapurakal, Jonathan B. Strauss, Brian R. Zawislak, Mahesh Gopalakrishnan, Amishi Bajaj, Bharat B. Mittal
Summary: This study presented a comprehensive response to the challenges posed by COVID-19, evaluating the adaptability and resilience of radiation oncology departments in response to the pandemic.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Dermatology
N. A. Trum, J. Zain, X. U. Martinez, V Parekh, M. Afkhami, F. Abdulla, K. R. Carson, S. T. Rosen, C. L. Bennett, C. Querfeld
Summary: MAR incidence is higher in CTCL patients than previously reported. Diagnosis and treatment of MAR should be emphasized to improve outcomes.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Joseph J. Foy, Serpil K. Dogan, Poonam Yadav, Bharat B. Mittal, Indra J. Das
Summary: This study investigated the feasibility of transferring patients between unmatched machines for 3D conformal radiation therapy (3DCRT) and volumetric modulated arc therapy (VMAT) treatments. Results showed that there were small differences in dose between the two machines, allowing for the transfer of a significant number of treatment fractions without exceeding a +/- 5% change in the prescribed dose.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2022)
Review
Oncology
Nour Kibbi, Joshua L. Owen, Brandon Worley, Jake X. Wang, Vishnu Harikumar, Malia B. Downing, Sumaira Z. Aasi, Phyu P. Aung, Christopher A. Barker, Diana Bolotin, Jeremy S. Bordeaux, Todd Cartee, Sunandana Chandra, Nancy L. Cho, Jennifer N. Choi, Kee Yang Chung, William A. Cliby, Oliver Dorigo, Daniel B. Eisen, Yasuhiro Fujisawa, Nicholas Golda, Thorvardur R. Halfdanarson, Christos Iavazzo, Shang I. Brian Jiang, Jean Kanitakis, Ashraf Khan, John Y. S. Kim, Timothy M. Kuzel, Naomi Lawrence, Mario M. Leitao, Allan B. MacLean, Ian A. Maher, Bharat B. Mittal, Kishwer S. Nehal, David M. Ozog, Curtis A. Pettaway, Jeffrey S. Ross, Anthony M. Rossi, Sabah Servaes, Michael J. Solomon, Valencia D. Thomas, Maria Tolia, Bryan B. Voelzke, Abigail Waldman, Michael K. Wong, Youwen Zhou, Nobuo Arai, Alexandria Brackett, Sarah A. Ibrahim, Bianca Y. Kang, Emily Poon, Murad Alam
Summary: Extramammary Paget disease is a frequently recurring malignant neoplasm that requires multiple skin biopsies for diagnosis, with surgical resection preferred for intraepidermal and invasive disease. Non-surgical treatments like radiotherapy and medications are options for unresectable cases, with a recommendation for close follow-up for at least 5 years.
Article
Biotechnology & Applied Microbiology
Li Du, Wei Liu, Flavia Pichiorri, Steven T. Rosen
Summary: This study identified SUMOylation as a potential mechanism regulating lenalidomide resistance in multiple myeloma. Inhibition of SUMOylation can enhance sensitivity to lenalidomide by downregulating IRF4 expression.
CANCER GENE THERAPY
(2023)
Article
Dermatology
Zhen Han, Renee J. Estephan, Xiwei Wu, Chingyu Su, Yate-Ching Yuan, Hanjun Qin, Sung Hee Kil, Corey Morales, Daniel Schmolze, James F. Sanchez, Lei Tian, Jianhua Yu, Marcin Kortylewski, Steven T. Rosen, Christiane Querfeld
Summary: Cutaneous T cell lymphoma (CTCL) is a malignant tumor characterized by chronic inflammation. This study found that miR-155-5p, miR-130b-3p, and miR-21-3p positively correlated with immune checkpoint gene expression in CTCL and were enriched in the IL-6/Jak/signal transducer and activator of transcription signaling pathway.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Dermatology
Daniel Schlessinger, Kelly A. Reynolds, McKenzie A. Dirr, Sarah A. Ibrahim, Arianna F. Yanes, Jake M. Lazaroff, Victoria Godinez-Puig, Brian R. Chen, Anastasia O. Kurta, Jill K. Cotseones, Sarah G. Chiren, Karina C. Furlan, Sanjana Iyengar, Ramona Behshad, Danielle M. DeHoratius, Pablo Denes, Aaron M. Drucker, Leonard M. Dzubow, Jeremy R. Etzkorn, Catherine A. Harwood, John Y. S. Kim, Naomi Lawrence, Erica H. Lee, Gary S. Lissner, Ashfaq A. Marghoob, Rubeta N. Matin, Adam R. Mattox, Bharat B. Mittal, J. Regan Thomas, Xiaolong Alan Zhou, David Zloty, Jochen Schmitt, Jamie J. Kirkham, April W. Armstrong, Nicole Basset-Seguin, Elizabeth M. Billingsley, Jeremy S. Bordeaux, Jerry Brewer, Marc Brown, Mariah Brown, Scott A. B. Collins, Maria Concetta Fargnoli, Sergio Jobim De Azevedo, Reinhard Dummer, Alexander Eggermont, Glenn D. Goldman, Merete Haedersdal, Elizabeth K. Hale, Allison Hanlon, Kelly L. Harms, Conway C. Huang, Eva A. Hurst, Gino K. In, Nicole Kelleners-Smeets, Meenal Kheterpal, Barry Leshin, Michel Mcdonald, Stanley J. Miller, Alexander Miller, Eliot N. Mostow, Myrto Trakatelli, Kishwer S. Nehal, Desiree Ratner, Howard Rogers, Kavita Y. Sarin, Seaver L. Soon, Thomas Stasko, Paul A. Storrs, Luca Tagliaferri, Allison T. Vidimos, Sandra L. Wong, Siegrid S. Yu, Iris Zalaudek, Nathalie C. Zeitouni, John A. Zitelli, Emily Poon, Joseph F. Sobanko, Todd Cartee, Ian A. Maher, Murad Alam
Summary: This study aims to identify a recommended minimum set of core outcomes for clinical trials of basal cell carcinoma. Through a patient and professional Delphi process, a final core set of 5 agreed-upon outcomes, including complete response, persistent or serious adverse events, recurrence-free survival, quality of life, and patient satisfaction (including cosmetic outcome), were determined.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Oncology
Jimmy J. Caudell, Maura L. Gillison, Ellie Maghami, Sharon Spencer, David G. Pfister, Douglas Adkins, Andrew C. Birkeland, David M. Brizel, Paul M. Busse, Anthony J. Cmelak, A. Dimitrios Colevas, David W. Eisele, Thomas Galloway, Jessica L. Geiger, Robert Haddad, Wesley L. Hicks, Ying J. Hitchcock, Antonio Jimeno, Debra Leizman, Loren K. Mell, Bharat B. Mittal, Harlan A. Pinto, James W. Rocco, Cristina P. Rodriguez, Panayiotis S. Savvides, David Schwartz, Jatin P. Shah, David Sher, Maie St John, Randal S. Weber, Gregory Weinstein, Frank Worden, Justine Yang Bruce, Sue S. Yom, Weining Zhen, Jennifer L. Burns, Susan D. Darlow
Summary: The NCCN Guidelines for Head and Neck Cancers provide clinical treatment guidance for tumors in the oral cavity, pharynx, larynx, and paranasal sinuses, as well as occult primary cancer, salivary gland cancer, and mucosal melanoma. The treatment recommendations are based on the specific site of disease, stage, and pathological findings, and are continuously updated with new research data.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2022)
Article
Medicine, General & Internal
Laila A. Gharzai, Benjamin S. Rosen, Bharat Mittal, Michelle L. Mierzwa, Poonam Yadav
Summary: This article provides an overview of the current use of MR-guided radiotherapy (MRgRT) for head/neck squamous cell carcinomas (HNSCCs), as well as the challenges and developing research areas associated with its use.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biotechnology & Applied Microbiology
Thuy Phan, Xu Hannah Zhang, Steven Rosen, Laleh G. Melstrom
Summary: Gastrointestinal cancers are a major cause of cancer-related morbidity and mortality worldwide. The p38 signaling pathway, particularly p38 gamma, plays a crucial role in cancer development and metastasis. This article provides an overview of p38 and p38 gamma in gastrointestinal cancers, as well as discusses the potential of targeting p38 gamma as a therapy.
CANCER GENE THERAPY
(2023)
Article
Dermatology
Zhen Han, Xiwei Wu, Hanjun Qin, Yate-Ching Yuan, Jasmine Zain, D. Lynne Smith, Oleg E. Akilov, Steven T. Rosen, Mingye Feng, Christiane Querfeld
Summary: This study investigated the effects of CD47 and PD-L1 immune checkpoint blockades on cutaneous T-cell lymphoma (CTCL). The results showed that dual targeting of CD47 and PD-L1 enhanced immune activity and suppressed tumor growth.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Review
Pharmacology & Pharmacy
Melissa Cheng, Jasmine Zain, Steven T. Rosen, Christiane Querfeld
Summary: This review discusses the recent advancements in biological and novel therapeutics for the management of CTCL. Mogamulizumab and brentuximab vedotin have been approved for CTCL treatment, providing valuable options for patients. Other therapies such as immune checkpoint inhibitors, miRNA inhibitors, and peptide inhibitors show promising results in clinical trials. However, further studies are needed to determine the long-term effectiveness of these treatments.
EXPERT OPINION ON EMERGING DRUGS
(2022)