Article
Oncology
Robert W. Mutter, Sharmila Giri, Briant F. Fruth, Nicholas B. Remmes, Judy C. Boughey, Christin A. Harless, Kathryn J. Ruddy, Lisa A. Mcgee, Arslan Afzal, Robert W. Gao, Dean A. Shumway, Tamara Z. Vern-Gross, Hector R. Villarraga, Stephanie L. Kenison, Yixiu Kang, William W. Wong, Bradley J. Stish, Kenneth W. Merrell, Elizabeth S. Yan, Sean S. Park, Kimberly S. Corbin, Carlos E. Vargas
Summary: This study compared conventional fractionation and hypofractionation in postmastectomy radiotherapy for breast cancer patients. After a median follow-up of 39.3 months, non-inferiority of hypofractionation could not be established. However, hypofractionated proton PMRT appears to be worth further study in patients with and without immediate reconstruction.
Article
Oncology
Jessika Contreras, Amar Srivastava, Pamela Samson, Todd DeWees, Ramaswamy Govindan, Maria Q. Baggstrom, Daniel Morgensztern, Michael Roach, Shahed N. Badiyan, Jeffrey Bradley, Saiama Waqar, Clifford Robinson
Summary: The study aimed to evaluate the maximum tolerated dose of hypofractionated proton beam radiation therapy with concurrent weekly carboplatin/paclitaxel in patients with stage II-III non-small cell lung cancer. The results showed that the treatment was acutely well tolerated, with high rates of locoregional control and overall survival. Late serious adverse events were noted in some patients outside of the dose-escalation window.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Jing Yang, Shu-Nan Qi, Hui Fang, Yong-Wen Song, Jing Jin, Yue-Ping Liu, Wei-Hu Wang, Yong Yang, Yu Tang, Hua Ren, Bo Chen, Ning-Ning Lu, Yuan Tang, Ning Li, Hao Jing, Shu-Lian Wang, Ye-Xiong Li
Summary: The study concluded that postmastectomy hypofractionated radiation therapy (HFRT) is a cost-effective option compared to conventional fractionated radiation therapy (CFRT) for high-risk breast cancer patients, especially from the perspective of Chinese payers. It showed that HFRT had a higher probability of cost-effectiveness in China and was dominant over CFRT in France and the USA. Sensitivity analysis indicated that overall survival after radiotherapy was the most critical parameter influencing the cost-effectiveness of the treatments.
Article
Oncology
Randal H. Henderson, Curtis M. Bryant, R. Charles Nichols, William M. Mendenhall, Bradford S. Hoppe, Zhong Su, Christopher G. Morris, Nancy P. Mendenhall
Summary: This study reports the 5- and 7-year outcomes of image-guided moderately accelerated hypofractionated proton therapy for prostate cancer patients. The results demonstrate high treatment efficacy, minimal toxicity, and excellent patient-reported outcomes in this cohort.
Article
Oncology
Jie Liu, Qingxi Yu, Xin Shelley Wang, Qiuling Shi, Jun Wang, Fan Wang, Simeng Ren, Jiayue Jin, Baojin Han, Wenzheng Zhang, Xueyao Su, Shuanghu Yuan, Hongsheng Lin
Summary: This study demonstrated the effectiveness of compound Kushen injection (CKI) in reducing the incidence of grade ≥2 radiation induced lung injury (RILI) and symptom burden, improving the quality of life in patients with lung cancer.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2023)
Article
Oncology
Chuanxu Luo, Xiaorong Zhong, Ting Luo, Hong Zheng
Summary: In older patients with T1-2N1 breast cancer, there was no association found between PMRT and BCM in patients who received chemotherapy, while the benefit of PMRT was limited to those who did not receive chemotherapy.
Article
Otorhinolaryngology
Alexandra N. de Leo, Roi Dagan, Christopher G. Morris, Adam L. Holtzman, Kathryn E. Hitchcock, Curtis M. Bryant, Robert J. Amdur, William M. Mendenhall
Summary: This study assessed the outcomes of radiotherapy in patients with T2 and select T3 glottic SCC. The addition of concurrent platinum-based chemotherapy to radiotherapy appeared to be safe and worthy of further investigation in patients with impaired cord mobility.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Oncology
Elton Trigo Teixeira Leite, Clarissa Cerchi Angotti Ramos, Victor Augusto Bertotti Ribeiro, Bernardo Peres Salvajoli, William Carlos Nahas, Joao Victor Salvajoli, Fabio Ynoe Moraes
Summary: This study evaluated the safety and feasibility of postoperative hypofractionated radiation therapy to the prostate bed. The results showed acceptable genitourinary and gastrointestinal toxicity profiles in the short to medium term, but further long-term follow-up and large-scale randomized trials are still necessary.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Rui Zhou, Bo Qiu, Mai Xiong, Yimei Liu, Kangqiang Peng, Yifeng Luo, Daquan Wang, Fangjie Liu, Naibin Chen, Jinyu Guo, Jun Zhang, Xiaoyan Huang, Yuming Rong, Hui Liu
Summary: This study aimed to investigate the safety and efficacy of hypofractionated radiation therapy combined with concurrent chemotherapy in patients with unresectable locally advanced non-small cell lung cancer. The results showed that this treatment regimen could provide satisfactory local control and survival outcomes, with moderate radiation-induced toxicity.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Multidisciplinary Sciences
Yipeng He, Sijia Chen, Xiang Gao, Lirong Fu, Zheng Kang, Jun Liu, Liwan Shi, Yimin Li
Summary: This study found that in postmastectomy radiotherapy for breast cancer, using a 5 mm bolus in volumetric modulated arc therapy (VMAT) provides better target coverage and organ-at-risk sparing compared to a 10 mm bolus.
Article
Multidisciplinary Sciences
Dongxiao Zhang, Danni Zhong, Jiang Ouyang, Jian He, Yuchen Qi, Wei Chen, Xingcai Zhang, Wei Tao, Min Zhou
Summary: In this study, researchers have successfully developed an oral delivery system using Spirulina platensis as a microcarrier to protect the whole small intestine from radiation-induced injury during radiotherapy. The system accumulates the drug effectively and provides superior radioprotection compared to free drug and enteric capsules, preventing radiation-induced intestinal injury without affecting tumor regression. It also has benefits on gut microbiota homeostasis and long-term safety.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Ping Wen, Taifang Wang, Yueling Zhou, Yue Yu, Chunli Wu
Summary: The combination of clinical and surgical therapies with adjuvant radiotherapy like brachytherapy is currently the consensus for treating keloids, but there is no uniform scheme for radiotherapy. A specific treatment regimen of 20 Gy in 5 fractions may be effective, easily accepted, and safe for keloid patients, with factors such as primary keloid, site, and interval from surgery to irradiation significantly related to recurrence.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Ananya Choudhury, Nuria Porta, Emma Hall, Yee Pei Song, Ruth Owen, Ranald MacKay, Catharine M. L. West, Rebecca Lewis, Syed A. Hussain, Nicholas D. James, Robert Huddart, Peter Hoskin
Summary: This study compared two radiotherapy fractionation schedules for locally advanced bladder cancer and found that a hypofractionated schedule of 55 Gy in 20 fractions is non-inferior to 64 Gy in 32 fractions in terms of invasive locoregional control and late toxicity, and is actually superior in terms of invasive locoregional control.
Article
Oncology
Waqar Haque, Anukriti Singh, Vivek Verma, Mary R. Schwartz, Neil Chevli, Sandra Hatch, Monica Desai, E. Brian Butler, Candy Arentz, Andrew Farach, Bin S. Teh
Summary: The study examined the utility of post-mastectomy radiotherapy in women with advanced primary and/or nodal disease, showing potential benefits for this higher risk group. However, it could not exclude differences in recurrence-free survival between groups.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Haley K. Perlow, Rahul N. Prasad, Mike Yang, Brett Klamer, Jennifer Matsui, Livia Marrazzo, Beatrice Detti, Marta Scorsetti, Elena Clerici, Andrea Arnett, Sasha Beyer, Mario Ammirati, Arnab Chakravarti, Raju R. Raval, Paul D. Brown, Pierina Navarria, Silvia Scoccianti, John C. Grecula, Joshua D. Palmer
Summary: The study explored the use of accelerated hypofractionated radiation in treating patients with GBM, particularly elderly or frail patients, and found it to be safe and effective, with good overall survival and progression-free survival outcomes. Concurrent chemotherapy was identified as an independent prognostic factor for improved outcomes.