Article
Oncology
Anna Maria Reuss, Dominik Groos, Ali Ghoochani, Michael Buchfelder, Nicolai Savaskan
Summary: The study found that MCT4 is overexpressed in gliomas and is associated with malignant tumor characteristics, including proliferation, survival, migration, invasion, and angiogenesis. MCT4 promotes cell proliferation and survival by regulating cell cycle and cell death mechanisms, enhances cell migration and invasiveness through actin cytoskeleton reorganization, and plays a crucial role in angiogenesis.
JOURNAL OF ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mariya Sabadashka, Dariya Hertsyk, Paulina Strugala-Danak, Anita Dudek, Olena Kanyuka, Alicja Z. Kucharska, Leonid Kaprelyants, Nataliia Sybirna
Summary: The red wine concentrate enriched with natural polyphenolic compounds showed significant hypoglycemic and antioxidant effects in rats with experimental diabetes mellitus. It promoted the recovery of glucose tolerance, normalization of glycated hemoglobin levels, and increased erythrocyte quantity and hemoglobin concentration. The polyphenolic compound concentrate also exhibited anti-radical effects and antioxidant properties in vivo by inhibiting oxidation and increasing the activity of certain enzymes in plasma of diabetic rats.
Article
Chemistry, Multidisciplinary
Irina Balyasnikova, Markella Zannikou, Guankui Wang, Yue Li, Joseph T. Duffy, Rebecca N. Levine, Maggie Seblani, Hanmant Gaikwad, Dmitri Simberg
Summary: The study demonstrates that fluorescent indocarbocyanine lipids (ICLs) formulated in PEGylated lipid nanoparticles (PLN) show highly efficient penetration and accumulation in glioblastoma (GBM). PLN-formulated ICLs exhibit better penetration than liposomal ICLs in vitro and in an intracranial GBM model. They accumulate in different immune and non-immune cells within the tumor, including myeloid-derived suppressor cells, macrophages, regulatory T cells, and tumor-associated microglia. PLN-formulated ICLs also extravasate better than PEGylated liposomal doxorubicin and fluorescent dextran, and accumulate in invasive tumor margins and brain-invading cells.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biology
Wen Ju, Wenyi Lu, Yurong Bao, Tiantian Sun, Seyram Yao Adzraku, Chunling Fu, Kunming Qi, Xi Zhang, Zhenyu Li, Kailin Xu, Jianlin Qiao, Lingyu Zeng
Summary: Clodronate-liposomes show therapeutic effects on leukemia, hemolytic anemia, and thrombocytopenic purpura in mice, but may worsen hematopoietic suppression. Clod-Lip may induce myeloid differentiation to promote hematopoiesis.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Article
Food Science & Technology
Madison Willy Silva Cordeiro, Diego Michel Matochi Mouro, Ingrid Duarte dos Santos, Roger Wagner
Summary: This study investigated the effect of gamma irradiation on the quality characteristics of yacare caiman meat under typical storage conditions. The overall quality characteristics of the irradiated samples were not significantly affected during frozen storage. However, the formation of volatile compounds from lipid oxidation was promoted in samples treated with high doses of irradiation after long-term frozen storage.
Article
Oncology
Shinji Kobuchi, Miyu Kai, Yukako Ito
Summary: Acute kidney injury complicates the dosing strategies of oxaliplatin (L-OHP), and the need for L-OHP dose reduction in patients with renal failure is controversial. The study assessed the impact of AKI on intact L-OHP pharmacokinetics and simulated the relationship between renal function level and intact L-OHP exposure using a population PK model. Population PK modeling and simulation suggested that dose reduction is unnecessary for patients with mild to moderate AKI.
Review
Biochemistry & Molecular Biology
Vasu Peddinti, Biswajit Rout, Tejas Girish Agnihotri, Shyam Sudhakar Gomte, Aakanchha Jain
Summary: Glioma is a severe CNS-specific tumor with poor survival rates, and conventional chemotherapy is limited by low permeability of the BBB and BBTB. Liposomes, especially those modified with active targeting ligands, show promise in delivering chemotherapy drugs to glioma cells. However, there are still limitations and ongoing clinical trials to explore more effective liposomal treatments.
JOURNAL OF LIPOSOME RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Juan Cen, Xiaoying Dai, Han Zhao, Xiaohan Li, Xiaojiao Hu, Jing Wu, Shaofeng Duan
Summary: In this study, a dual targeting liposomal delivery vector loaded with doxorubicin (DOX) was developed to treat glioma. The liposomes demonstrated high drug encapsulation rate and drug-loading capacity, and showed satisfactory biocompatibility and stability. Experimental results showed that the liposomes could effectively cross the BBB and target gliomas, and the mitochondria targeting of SS31 enhances cell uptake. The liposomes also showed good therapeutic effect on nude mice with glioma in situ.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Xue-Liang Liu, Xiao Dong, Si-Cong Yang, Xing Lai, Hai-Jun Liu, Yuhao Gao, Hai-Yi Feng, Mao-Hua Zhu, Yihang Yuan, Qin Lu, Jonathan F. Lovell, Hong-Zhuan Chen, Chao Fang
Summary: Nano-Pt loaded liposomal system enhances photodynamic therapy and chemotherapy in cancer treatment by increasing oxygen supply and releasing nanoparticles for better penetration, leading to inhibited tumor growth and extended survival without toxicity in animal models.
Article
Multidisciplinary Sciences
S. A. Abd El-Azeem, A. M. Alajmi
Summary: Melanin, the brown pigment found in various parts of the body, was studied in terms of its UV absorption spectra and molar absorption coefficients. The absorption spectrum broadened with increasing concentration, while the molar absorption coefficient values increased at low doses and returned to pre-irradiation levels at high doses. These findings suggest that melanin can block adaptive response and eliminate the effects of low-dose radiation.
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
(2023)
Article
Biology
Prabuddho Mukherjee, Kamendra Kumar, Bincy Babu, Jubilee Purkayastha, Sudhir Chandna
Summary: This study identifies alterations in expression levels of RBC membrane associated proteins following gamma-irradiation in rats, suggesting their potential as radiation exposure biomarkers. Through two-dimensional electrophoresis analysis, several differentially expressed proteins were identified, with peroxiredoxin-2 (PRDX2) and 26S proteasome regulatory subunit RPN11 (PSMD14) showing the most significant over-expression. These findings provide important insights for further research on using RBC membrane associated proteins as radiation biomarkers.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Article
Food Science & Technology
Yosra Ben-Fadhel, Behnoush Maherani, Stephane Salmieri, Monique Lacroix
Summary: The study developed food grade liposomes encapsulating citrus extract and essential oil mixtures by optimizing process and composition, showing the preference of liposomes to encapsulate citrus extract. The system was environmentally-friendly and suitable for food applications, with stable nanoliposomes formed under specific conditions.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Oncology
Jaap P. M. Jaspers, Walter Taal, Yvette van Norden, Jaap D. Zindler, Annemarie T. Swaak, Steven J. M. Habraken, Mischa S. Hoogeman, Remi Nout, Martin J. van den Bent, Alejandra Mendez Romero
Summary: This study aimed to characterize and classify new enhancing lesions in patients with IDH mutated grade 2 diffuse glioma treated with photon therapy. The cumulative incidence of pseudoprogression (psPD) increased over time, and the presence of an 1p/19q codeletion was associated with an increased risk of psPD.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Maryam Kateh Shamshiri, Mahmoud Reza Jaafari, Ali Badiee
Summary: The study demonstrated that PEGylated liposomes containing IFN-gamma, LIP-F2, showed significant advantages in tumor treatment, inducing antitumor immune responses and enhancing cargo delivery efficiency.
Article
Chemistry, Inorganic & Nuclear
Sung Yuan Hsu, Maia C. Murphy, Nicole T. Smolensky, Christopher M. Vogels, Andrea A. Lebel, Jason D. Masuda, Luc H. Boudreau, Pier Morin, Stephen A. Westcott
Summary: A series of iminophosphine ligands (1a -g) were prepared by condensation reaction. The corresponding platinum(II) complexes (2a -g) were synthesized. The cytotoxic properties of the platinum complexes against glioma cell lines were examined.
Article
Clinical Neurology
Natasha Ironside, Ching-Jen Chen, Zhiyuan Xu, David Schlesinger, Mary Lee Vance, Gregory K. Hong, Jr John A. Jane, Samir Patel, Shray K. Bindal, Ajay Niranjan, L. Dade Lunsford, Roman Liscak, Thomas Chytka, Jana Jezkova, Omran Saifi, Daniel M. Trifiletti, Assaf Berger, Juan Alzate, Kenneth Bernstein, Douglas Kondziolka, Herwin Speckter, Wenceslao Hernandez, Erwin Lazo, Selcuk Peker, Yavuz Samanci, Brad E. Zacharia, Christine Mau, Rodney E. Wegner, Matthew J. Shepard, David Mathieu, Michel Maillet, Jason P. Sheehan
Summary: This multicenter study investigated the relationship between neuroanatomic structure distances and anterior pituitary function preservation after stereotactic radiosurgery for pituitary adenomas. The study found that a larger distance between the center of the pituitary stalk and the tumor margin isodose was positively associated with anterior pituitary function preservation. This study provides important insights for preserving pituitary function.
Article
Clinical Neurology
Georgios Mantziaris, Stylianos Pikis, Zhiyuan Xu, Reed Mullen, Juan Alzate, Kenneth Bernstein, Douglas Kondziolka, Zhishuo Wei, Ajay Niranjan, L. Dade Lunsford, Roman Liscak, Jaromir May, Cheng-chia Lee, Huai-che Yang, Francois-Louis Coupe, David Mathieu, Kimball Sheehan, Darrah Sheehan, Joshua D. Palmer, Haley K. Perlow, Selcuk Peker, Yavuz Samanci, Jennifer Peterson, Daniel M. Trifiletti, Matthew J. Shepard, Shahed Elhamdani, Rodney E. Wegner, Herwin Speckter, Wenceslao Hernandez, Ronald E. Warnick, Jason Sheehan
Summary: This retrospective study showed that stereotactic radiosurgery (SRS) is an effective treatment option for intraventricular metastases (IVMs), with a comparable local control rate to SRS for parenchymal brain metastases. However, careful follow-up is needed to detect leptomeningeal spread and hydrocephalus in patients with IVMs.
Article
Oncology
Linda M. Liau, Keyoumars Ashkan, Steven Brem, Jian L. Campian, John E. Trusheim, Fabio M. Iwamoto, David D. Tran, George Ansstas, Charles S. Cobbs, Jason A. Heth, Michael E. Salacz, Stacy D'Andre, Robert D. Aiken, Yaron A. Moshel, Joo Y. Nam, Clement P. Pillainayagam, Stephanie A. Wagner, Kevin A. Walter, Rekha Chaudary, Samuel A. Goldlust, Ian Y. Lee, Daniela A. Bota, Heinrich Elinzano, Jai Grewal, Kevin Lillehei, Tom Mikkelsen, Tobias Walbert, Steven Abram, Andrew J. Brenner, Matthew G. Ewend, Simon Khagi, Darren S. Lovick, Jana Portnow, Lyndon Kim, William G. Loudon, Nina L. Martinez, Reid C. Thompson, David E. Avigan, Karen L. Fink, Francois J. Geoffroy, Pierre Giglio, Oleg Gligich, Dietmar Krex, Scott M. Lindhorst, Jose Lutzky, Hans-Jorg Meisel, Minou Nadji-Ohl, Lhagva Sanchin, Andrew Sloan, Lynne P. Taylor, Julian K. Wu, Erin M. Dunbar, Arnold B. Etame, Santosh Kesari, David Mathieu, David E. Piccioni, David S. Baskin, Michel Lacroix, Sven-Axel May, Pamela Z. New, Timothy J. Pluard, Steven A. Toms, Victor Tse, Scott Peak, John L. Villano, James D. Battiste, Paul J. Mulholland, Michael L. Pearlman, Kevin Petrecca, Michael Schulder, Robert M. Prins, Alton L. Boynton, Marnix L. Bosch
Summary: The study shows that adding autologous tumor lysate-loaded dendritic cell vaccine (DCVax L) to standard of care can extend the survival of patients with glioblastoma.
Article
Oncology
Chad G. Rusthoven, Alyse W. Staley, Dexiang Gao, Shoji Yomo, Denise Bernhardt, Narine Wandrey, Rami El Shafie, Anna Kraemer, Oscar Padilla, Veronica Chiang, Andrew M. Faramand, Joshua D. Palmer, Brad E. Zacharia, Rodney E. Wegner, Jona A. Hattangadi-Gluth, Antonin Levy, Kenneth Bernstein, David Mathieu, Daniel N. Cagney, Michael D. Chan, Inga S. Grills, Steve Braunstein, Cheng-Chia Lee, Jason P. Sheehan, Christien Kluwe, Samir Patel, Lia M. Halasz, Nicolaus Andratschke, Christopher P. Deibert, Vivek Verma, Daniel M. Trifiletti, Christopher P. Cifarelli, Juergen Debus, Stephanie E. Combs, Yasunori Sato, Yoshinori Higuchi, Kyoko Aoyagi, Paul D. Brown, Vida Alami, Ajay Niranjan, L. Dade Lunsford, Douglas Kondziolka, D. Ross Camidge, Brian D. Kavanagh, Tyler P. Robin, Toru Serizawa, Masaaki Yamamoto
Summary: By comparing patients with small-cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), this study found that SCLC patients had shorter overall survival (OS) after stereotactic radiosurgery (SRS), but the central nervous system (CNS) progression was similar in patients matched on baseline factors. There were no significant differences in neurological mortality, number of lesions at CNS progression, or leptomeningeal progression between SCLC and NSCLC.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Clinical Neurology
Raj Singh, Greg Bowden, David Mathieu, Haley K. Perlow, Joshua D. Palmer, Shahed Elhamdani, Matthew Shepard, Yun Liang, Ahmed M. Nabeel, Wael A. Reda, Sameh R. Tawadros, Khaled Abdelkarim, Amr M. N. El-Shehaby, Reem M. Emad, Ahmed Hesham Elazzazi, Ronald E. Warnick, Yair M. Gozal, Megan Daly, Brendan McShane, Marcel Addis-Jackson, Gokul Karthikeyan, Sian Smith, Piero Picozzi, Andrea Franzini, Tehila Kaisman-Elbaz, Huai-che Yang, Zhishuo Wei, Andrew Legarreta, Judith Hess, Kelsey Templeton, Stylianos Pikis, Georgios Mantziaris, Gabriela Simonova, Roman Liscak, Selcuk Peker, Yavuz Samanci, Veronica Chiang, Ajay Niranjan, Charles R. Kersh, Cheng-Chia Lee, Daniel M. Trifiletti, L. Dade Lunsford, Jason P. Sheehan
Summary: Limited data is available regarding outcomes for GI primaries patients with brain metastases treated with SRS. This study aimed to examine the clinical outcomes of SRS for patients with brain metastases from GI primaries and evaluate potential prognostic factors. SRS resulted in comparable LC with common primaries. Age and KPS were associated with both LC and OS, and planning target volume and extracranial metastases were correlated with LC and OS, respectively. These factors should be considered in selecting GI cancer patients for SRS.
Article
Clinical Neurology
William Leduc, David Mathieu, Elizabeth Adam, Raphaelle Ferreira, Christian Iorio-Morin
Summary: This study found that SRS is a safe and effective treatment for pain relief in MS-TN. However, the duration of pain relief is significantly shorter compared to a matched control group without MS.
Article
Clinical Neurology
Othman Bin-Alamer, Andrew Faramand, Norah A. Alarifi, Zhishuo Wei, Arka N. Mallela, Victor M. Lu, Ahmed M. Nabeel, Wael A. Reda, Sameh R. Tawadros, Khaled Abdelkarim, Amr M. N. El-Shehaby, Reem M. Emad, Selcuk Peker, Yavuz Samanci, Cheng-chia Lee, Huai-che Yang, Violaine Delabar, David Mathieu, Manjul Tripathi, Kathryn Nicole Kearns, Adomas Bunevicius, Jason P. Sheehan, Tomas Chytka, Roman Liscak, Nuria Martinez Moreno, Roberto Martinez Alvarez, Inga S. Grills, Jacob S. Parzen, Christopher P. Cifarelli, Azeem A. Rehman, Herwin Speckter, Ajay Niranjan, L. Dade Lunsford, Hussam Abou-Al-Shaar
Summary: The aim of this study was to evaluate hearing preservation, tumor control, and radiation-related risks in patients with NF2 after SRS for VS. The results showed that the tumor control rate at 15 years after SRS was 52% and no new radiation-related neoplasm or malignant transformation was found in NF2-related VS patients.
Article
Clinical Neurology
Georgios Mantziaris, Stylianos Pikis, Chloe Dumot, Samantha Dayawansa, Roman Liscak, Jaromir May, Cheng-chia Lee, Huai-che Yang, Nuria Martinez Moreno, Roberto Martinez Alvarez, L. Dade Lunsford, Ajay Niranjan, Zhishuo Wei, Priyanka Srinivasan, Lilly W. W. Tang, Ahmed M. Nabeel, Wael A. Reda, Sameh R. Tawadros, Khaled Abdelkarim, Amr M. N. El-Shehaby, Reem M. Emad, Ahmed Hesham Elazzazi, Selcuk Peker, Yavuz Samanci, Varun Padmanaban, Francis J. Jareczek, James McInerney, Kevin M. Cockroft, David Mathieu, Salman Aldakhil, Juan Diego Alzate, Douglas Kondziolka, Manjul Tripathi, Joshua D. Palmer, Rituraj Upadhyay, Michelle Lin, Gabriel Zada, Cheng Yu, Christopher P. Cifarelli, Daniel T. Cifarelli, Zhiyuan Xu, Jason P. Sheehan
Summary: This study aimed to provide the combined experience of multiple centers to fully define the role of repeat stereotactic radiosurgery (SRS) for patients with cerebral arteriovenous malformation (AVM). The results showed that repeat SRS achieves reasonable obliteration rates with low complication risk. Extending the latency period to 5 years generally increases the rate of favorable patient outcomes and reduces the necessity of a third intervention.
Article
Clinical Neurology
Chloe Dumot, Georgios Mantziaris, Stylianos Pikis, Sam Dayawansa, Zhiyuan Xu, Yavuz Samanci, Gokce D. Ardor, Selcuk Peker, Ahmed M. Nabeel, Wael A. Reda, Sameh R. Tawadros, Khaled Abdel Karim, Amr M. N. El-Shehaby, Reem M. Emad Eldin, Ahmed H. Elazzazi, Nuria Martinez Moreno, Roberto Martinez alvarez, Roman Liscak, Jaromir May, David Mathieu, Jean-Nicolas Tourigny, Manjul Tripathi, Akshay Rajput, Narendra Kumar, Rupinder Kaur, Piero Picozzi, Andrea Franzini, Herwin Speckter, Wenceslao Hernandez, Anderson Brito, Ronald E. Warnick, Juan Alzate, Douglas Kondziolka, Greg N. Bowden, Samir Patel, Jason P. Sheehan
Summary: Stereotactic radiosurgery (SRS) has been proposed as an alternative to resection for epilepsy control in patients with cerebral cavernous malformations (CCM) located in critical areas. This multicentric, retrospective study evaluated seizure control in patients with a solitary CCM and a history of at least one seizure prior to SRS. 47.7% of patients achieved Engel class I at the last follow-up.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Chloe Dumot, Georgios Mantziaris, Sam Dayawansa, Zhiyuan Xu, Stylianos Pikis, Selcuk Peker, Yavuz Samanci, Gokce D. Ardor, Ahmed M. Nabeel, Wael A. Reda, Sameh R. Tawadros, Khaled Abdelkarim, Amr M. N. El-Shehaby, Reem M. Eldin, Ahmed H. Elazzazi, Nuria Martinez Moreno, Roberto Martinez Alvarez, Roman Liscak, Jaromir May, David Mathieu, Jean-Nicolas Tourigny, Manjul Tripathi, Akshay Rajput, Narendra Kumar, Rupinder Kaur, Piero Picozzi, Andrea Franzini, Herwin Speckter, Wenceslao Hernandez, Anderson Brito, Ronald E. Warnick, Juan Alzate, Douglas Kondziolka, Greg N. Bowden, Samir Patel, Jason Sheehan
Summary: This retrospective study evaluated the safety and efficacy of single-session stereotactic radiosurgery (SRS) for haemorrhagic cerebral cavernous malformations (CCMs). The results showed that SRS can reduce the haemorrhage rate in CCMs, but may result in adverse radiation effects and new neurological deficits post-treatment. Therefore, selecting appropriate doses and CCM volumes is crucial.
STROKE AND VASCULAR NEUROLOGY
(2023)
Article
Clinical Neurology
Roman O. Kowalchuk, Ajay Niranjan, Judith Hess, Joseph P. Antonios, Michael Y. Zhang, Steve Braunstein, Richard B. Ross, Stylianos Pikis, Christopher P. Deibert, Cheng-chia Lee, Huai-che Yang, Anne-Marie Langlois, David Mathieu, Selcuk Peker, Yavuz Samanci, Chad G. Rusthoven, Veronica Chiang, Zhishuo Wei, L. Dade Lunsford, Daniel M. Trifiletti, Jason P. Sheehan
Summary: This study evaluated the overall survival and local tumor control in a multiinstitutional cohort of patients with triple-negative breast cancer metastases treated with stereotactic radiosurgery (SRS). The findings suggest that SRS is a safe and efficacious treatment for well-selected patients with triple-negative breast cancer who have a favorable performance status and small-to moderate-volume metastatic lesions.
JOURNAL OF NEUROSURGERY
(2023)
Article
Clinical Neurology
Eric J. Lehrer, Manmeet S. Ahluwalia, Jason Gurewitz, Kenneth Bernstein, Douglas Kondziolka, Ajay Niranjan, Zhishuo Wei, L. Dade Lunsford, Kareem R. Fakhoury, Chad G. Rusthoven, David Mathieu, Claire Trudel, Timothy D. Malouff, Henry Ruiz-Garcia, Phillip Bonney, Lindsay Hwang, Cheng Yu, Gabriel Zada, Samir Patel, Christopher P. Deibert, Piero Picozzi, Andrea Franzini, Luca Attuati, Rahul N. Prasad, Raju R. Raval, Joshua D. Palmer, Cheng-Chia Lee, Huai-Che Yang, Brianna M. Jones, Sheryl Green, Jason P. Sheehan, Daniel M. Trifiletti
Summary: This retrospective multicenter study investigated the predictors of treatment-related imaging changes (TRICs) and their impact on patient survival in the management of brain metastases using immune checkpoint inhibitors (ICIs) and stereotactic radiosurgery (SRS). The results showed that TRICs were associated with improved overall survival, indicating that the presence of TRICs may increase the survival time of patients after treatment with ICIs and SRS.
JOURNAL OF NEUROSURGERY
(2023)
Article
Clinical Neurology
Stylianos Pikis, Georgios Mantziaris, Rithika Kormath Anand, Ahmed M. Nabeel, Darrah Sheehan, Kimball Sheehan, Wael A. Reda, Sameh R. Tawadros, Khaled Abdelkarim, Amr M. N. El-Shehaby, Reem Emad Eldin, Selcuk Peker, Yavuz Samanci, Tehila Kaisman-Elbaz, Herwin Speckter, Wenceslao Hernandez, Julio Isidor, Manjul Tripathi, Renu Madan, Brad E. Zacharia, Lekhaj C. Daggubati, Nuria Martinez Moreno, Roberto Martinez alvarez, Anne-Marie Langlois, David Mathieu, Christopher P. Deibert, Vivek R. Sudhakar, Christopher P. Cifarelli, Denisse Arteaga Icaza, Daniel T. Cifarelli, Zhishuo Wei, Ajay Niranjan, Gene H. Barnett, L. Dade Lunsford, Greg N. Bowden, Jason P. Sheehan
Summary: In this retrospective multicenter study, the authors evaluated the tumor control and patient outcomes of primary, single-session stereotactic radiosurgery (SRS) treatment for Koos grade IV vestibular schwannomas (VSs). The results showed that single-session SRS treatment is a safe and effective method for obtaining tumor control in patients with non-life-threatening or incapacitating symptoms of Koos grade IV VS. A prescription dose of less than 13 Gy is recommended to reduce the incidence of post-SRS facial palsy.
JOURNAL OF NEUROSURGERY
(2023)
Article
Clinical Neurology
Chloe Dumot, Stylianos Pikis, Georgios Mantziaris, Zhiyuan Xu, Sam Dayawansa, Rithika Kormath Anand, Ahmed M. Nabeel, Darrah Sheehan, Kimball Sheehan, Wael A. Reda, Sameh R. Tawadros, Khaled Abdel Karim, Amr M. N. El-Shehaby, Reem M. Emad Eldin, Selcuk Peker, Yavuz Samanci, Tehila Kaisman-Elbaz, Herwin Speckter, Wenceslao Hernandez, Julio Isidor, Manjul Tripathi, Renu Madan, Brad E. Zacharia, Lekhaj C. Daggubati, Nuria Martinez Moreno, Roberto Martinez Alvarez, Anne-Marie Langlois, David Mathieu, Christopher P. Deibert, Vivek R. Sudhakar, Christopher P. Cifarelli, Denisse Arteaga Icaza, Daniel T. Cifarelli, Zhishuo Wei, Ajay Niranjan, Gene H. Barnett, L. Dade Lunsford, Greg N. Bowden, Jason P. Sheehan
Summary: This study aimed to report the clinical and radiological outcomes after single-session stereotactic radiosurgery (SRS) for Koos IV vestibular schwannomas (VS) in patients aged 65 and above. The results showed that SRS had good efficacy in tumor control and cranial nerve function in these patients.
ACTA NEUROCHIRURGICA
(2023)
Article
Oncology
Keiss Douri, Christian Iorio-Morin, Rosalie Mercure-Cyr, Gabrielle Figueiredo, Charles Jean Touchette, Laurence Masson-Cote, David Mathieu
Summary: The current RANO-BM criteria are unreliable for identifying tumor progression in patients with brain metastases treated using stereotactic radiosurgery (SRS). Using absolute diameter differences as thresholds appears to be more effective in this cohort.
