Article
Oncology
Timothy K. Nguyen, Lee Chin, Arjun Sahgal, Roi Dagan, Wietse Eppinga, Matthias Guckenberger, Jin Ho Kim, Simon S. Lo, Kristin J. Redmond, Shankar Siva, Bradley J. Stish, Rachel Chan, Liam Lawrence, Angus Lau, Chia-Lin Tseng
Summary: This study aims to provide consensus recommendations for clinical target volume (CTV) delineation in stereotactic body radiation therapy (SBRT) for non-spine bone metastases (NSBM). Through the contouring and analysis of international expert contours, consistent contouring recommendations were established, which can provide guidance for treating physicians.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Clinical Neurology
Dukagjin M. Blakaj, Joshua D. Palmer, Khaled Dibs, Alexander Olausson, Eric C. Bourekas, Daniel Boulter, Ahmet S. Ayan, Eric Cochran, William S. Marras, Prasath Mageswaran, Miki Katzir, Vedat O. Yildiz, John Grecula, Andrea Arnett, Raju Raval, Thomas Scharschmidt, James B. Elder, Russell Lonser, Arnab Chakravarti, Ehud Mendel
Summary: Factors associated with local control and progression-free survival for patients receiving postoperative stereotactic spine radiosurgery included time from surgery to radiosurgery, radiotherapy dose, and preoperative embolization.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yongye Chen, Siyuan Qin, Weili Zhao, Qizheng Wang, Ke Liu, Peijin Xin, Huishu Yuan, Hongqing Zhuang, Ning Lang
Summary: This study aimed to develop response prediction models for patients with spinal metastases undergoing stereotactic body radiotherapy (SBRT) by extracting radiomics features from MRI using machine learning algorithms. The results showed that the MRI-based radiomics models have valuable predictive capability for treatment outcomes in these patients.
INSIGHTS INTO IMAGING
(2023)
Article
Oncology
Xuguang Chen, Michael C. LeCompte, Chengcheng Gui, Ellen Huang, Majid A. Khan, Chen Hu, Daniel M. Sciubba, Lawrence R. Kleinberg, Sheng-fu Larry Lo, Kristin J. Redmond
Summary: This study analyzed the impact of target delineation on local control after SBRT for spine metastasis. The results showed that deviations from consensus contouring guidelines led to inferior local control, and adherence to the guidelines was associated with superior local control and fewer marginal misses.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Arjun Sahgal, Joe H. Chang, Lijun Ma, Lawrence B. Marks, Michael T. Milano, Paul Medin, Andrzej Niemierko, Scott G. Soltys, Wolfgang A. Tome, C. Shun Wong, Ellen Yorke, Jimm Grimm, Andrew Jackson
Summary: The study shows that the spinal cord tolerance data for SBRT in different fractions and the factors associated with a lower risk of radiation myelopathy for reirradiation SBRT, such as dose control and time intervals, are important for reducing risks.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Pawel Polanowski, Krzysztof Skladowski, Dorota Ksiezniak-Baran, Aleksandra Grzadziel, Natalia Amrogowicz, Jolanta Mrochem-Kwarciak, Agnieszka Pietruszka, Marek Kentnowski, Katarzyna Polanowska
Summary: The treatment outcomes of head and neck tumours are unsatisfactory, with a high recurrence rate. The use of modern radiosurgery boost techniques may improve treatment results. The boost dose depends on the tumour volume and its proximity to critical organs.
Article
Oncology
Nicolas Martz, Julia Salleron, Frederic Dhermain, Guillaume Vogin, Jean-Francois Daisne, Raphaelle Mouttet-Audouard, Ronan Tanguy, Georges Noel, Matthieu Peyre, Isabelle Lecouillard, Julian Jacob, Justine Attal, Marie Charissoux, Ovidiu Veresezan, Chantal Hanzen, Aymeri Huchet, Igor Latorzeff, Alexandre Coutte, Jerome Doyen, Dinu Stefan, Loic Feuvret, Gabriel C. T. E. Garcia, Philippe Royer
Summary: This study aims to develop delineation guidelines for radiotherapy in meningiomas. It is based on a consensus endorsed by a multidisciplinary group of brain tumor experts. The recommendations are expected to improve the uniformity in target volume definition.
RADIATION ONCOLOGY
(2023)
Article
Oncology
Maximilien Roge, Ahmed Hadj Henni, Yasmine Adda Neggaz, Romain Mallet, Chantal Hanzen, Bernard Dubray, Elyse Colard, David Gensanne, Sebastien Thureau
Summary: The study found that the Brainlab software provides accurate assessment of treatment plans for spine metastases, demonstrating high potential for versatile and reliable clinical applications.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Vincent Cassidy, Robert J. Amdur
Summary: This report describes a case of severe esophageal damage from stereotactic body radiation therapy to the T-2 vertebral body, particularly highlighting the increased risk in the upper thoracic or cervical spine. The review of relevant literature provides implications for future research and practice.
PRACTICAL RADIATION ONCOLOGY
(2022)
Article
Oncology
Laura Burgess, K. Liang Zeng, Sten Myrehaug, Hany Soliman, Chia -Lin Tseng, Jay Detsky, Hanbo Chen, Daniel Moore-Palhares, Christopher D. Witiw, Beibei Zhang, Pejman Maralani, Arjun Sahgal
Summary: Spine SBRT is effective in improving local control and pain response. The use of MRI-based delineation of CTV is crucial, but its applicability to metastases involving the posterior elements alone needs validation. This study aimed to determine the patterns of failure and safety of treating posterior element metastases when excluding the vertebral body from the CTV.
PRACTICAL RADIATION ONCOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Martijn H. van der Ree, Phillip S. Cuculich, Marcel van Herk, Geoffrey D. Hugo, Jippe C. Balt, Matthew Bates, Gordon Ho, Etienne Pruvot, Claudia Herrera-Siklody, Wiert F. Hoeksema, Justin Lee, Michael S. Lloyd, Michiel J. B. Kemme, Frederic Sacher, Romain Tixier, Joost J. C. Verhoeff, Brian V. Balgobind, Clifford G. Robinson, Coen R. N. Rasch, Pieter G. Postema
Summary: The study shows high interobserver variability in the manual delineation of the VT-target and ventricular segments. There is a need for methods and tools to improve variability and allow for future comparison of interventions aiming to reduce observer variation, for STAR but possibly also for catheter ablation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Oncology
Felix Ehret, Markus Kufeld, Christoph Furweger, Alfred Haidenberger, Paul Windisch, Carolin Senger, Melina Kord, Malte Trager, David Kaul, Christian Schichor, Jorg-Christian Tonn, Alexander Muacevic
Summary: The study reports treatment outcomes of spinal ependymomas using robotic radiosurgery (RRS) from two institutions, showing that RRS is a safe and efficient treatment modality for managing primary and secondary spinal ependymal tumors in patients with multiple lesions and local recurrences.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Alejandro Bugarini, Evan Meekins, Joshua Salazar, Andrea L. Berger, Michel Lacroix, Edward A. Monaco III, Andrew R. Conger, Anand Mahadevan
Summary: Neoadjuvant stereotactic radiosurgery (SRS) may reduce the incidence of radionecrosis (RN) and decrease radiation to normal tissue in patients with cerebral metastatic disease. A retrospective analysis of 47 brain metastases patients showed that neoadjuvant SRS was associated with reduced radiotherapy doses, improved conformality profile, and decreased radiation to normal tissue, supporting its use in the treatment of brain metastases.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Alexander D. Sherry, Sean Maroongroge, Brian De, Behrang Amini, Anthony P. Conley, Andrew J. Bishop, Chenyang Wang, Thomas Beckham, Martin Tom, Tina Briere, Jing Li, Debra N. Yeboa, Mary Frances McAleer, Robert North, Claudio E. Tatsui, Laurence D. Rhines, Amol J. Ghia
Summary: This study retrospectively evaluated the long-term local control of patients with chordoma or chondrosarcoma treated with spine stereotactic radiosurgery (SSRS). The results indicate that dose-escalated SSRS is a safe and effective treatment option for achieving durable local control in selected patients with chordoma or chondrosarcoma involving the spine.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Oncology
Alexander D. Sherry, Sean Maroongroge, Brian De, Behrang Amini, Anthony P. Conley, Andrew J. Bishop, Chenyang Wang, Thomas Beckham, Martin Tom, Tina Briere, Jing Li, Debra N. Yeboa, Mary Frances McAleer, Robert North, Claudio E. Tatsui, Laurence D. Rhines, Amol J. Ghia
Summary: This study retrospectively evaluated the long-term local control of patients with chordoma or chondrosarcoma treated with spine stereotactic radiosurgery (SSRS). The results showed that dose-escalated SSRS to 24 Gy in 1 fraction appeared to be a safe and effective treatment for achieving durable local control in this population.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Oncology
Xinglei Shen, Daniel E. Spratt, Stacie B. Dusetzina, Ronald C. Chen
Summary: This study evaluated the variation in commercial insurance coverage and its impact on access to cancer care. The analysis of coverage determinations across the nation revealed wide disparities in policy. The findings highlight the need for more consistent methodology in assessing medical necessity to address the unequal access to cancer procedures based on residence and age.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Oncology
Soumyajit Roy, Yilun Sun, Cristopher J. D. Wallis, Scott C. Morgan, Scott Grimes, Julia Malone, Amar U. Kishan, Dibya Mukherjee, Daniel E. Spratt, Fred Saad, Shawn Malone
Summary: This study developed and validated a multivariable prognostic model to predict overall survival (OS) in metastatic castrate sensitive prostate cancer (mCSPC). The model includes 11 prognostic variables and showed high predictive accuracy on a testing set.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Oncology
Richard L. Cantley, Xiaoming Wang, Zachery R. Reichert, Arul M. Chinnaiyan, Rahul Mannan, Xuhong Cao, Daniel E. Spratt, Ulka N. Vaishampayan, Joshi J. Alumkal, Todd M. Morgan, Ganesh Palapattu, Matthew S. Davenport, Liron Pantanowitz, Rohit Mehra
Summary: Fine needle aspiration (FNA) can be used to diagnose metastatic prostatic cancer (MPC) based on typical cytomorphologic and immunohistochemical (IHC) features, but the diagnosis may be complicated by atypical phenotypes induced by androgen deprivation therapy (ADT). Careful assessment of cytologic and biomarker features can provide important therapeutic and prognostic information in MPC.
CANCER CYTOPATHOLOGY
(2023)
Article
Oncology
Sagar A. Patel, Ting Martin Ma, Jessica K. Wong, Bradley J. Stish, Robert T. Dess, Avinash Pilar, Chandana Reddy, Trude B. Wedde, Wolfgang A. Lilleby, Ryan Fiano, Gregory S. Merrick, Richard G. Stock, D. Jeffrey Demanes, Brian J. Moran, Phuoc T. Tran, Daniel J. Krauss, Eyad I. Abu-Isa, Thomas M. Pisansky, C. Richard Choo, Daniel Y. Song, Stephen Greco, Curtiland Deville, Theodore L. DeWeese, Derya Tilki, Jay P. Ciezki, R. Jeffrey Karnes, Nicholas G. Nickols, Matthew B. Rettig, Felix Y. Feng, Alejandro Berlin, Jonathan D. Tward, Brian J. Davis, Robert E. Reiter, Paul C. Boutros, Tahmineh Romero, Eric M. Horwitz, Rahul D. Tendulkar, Michael L. Steinberg, Daniel E. Spratt, Michael Xiang, Amar U. Kishan
Summary: For very-high-risk prostate cancer patients, the addition of brachytherapy to external beam radiation therapy with androgen deprivation therapy did not significantly improve outcomes compared to radiation therapy alone.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Pathology
Rahul Mannan, Xiaoming Wang, Pushpinder S. Bawa, Yuping Zhang, Stephanie L. Skala, Anya K. Chinnaiyan, Aniket Dagar, Lisha Wang, Sylvia B. Zelenka-Wang, Lisa M. McMurry, Nikita Daniel, Xuhong Cao, Ankur R. Sangoi, Sounak Gupta, Ulka N. Vaishampayan, Khaled S. Hafez, Todd M. Morgan, Daniel E. Spratt, Maria S. Tretiakova, Pedram Argani, Arul M. Chinnaiyan, Saravana M. Dhanasekaran, Rohit Mehra
Summary: LINC01187 is a novel biomarker that enhances the currently used KIT assay and facilitates microscopic analysis in routine surgical pathology practice.
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Oncology
Ting Martin Ma, Yilun Sun, Shawn Malone, Mack Roach III, David Dearnaley, Thomas M. Pisansky, Felix Y. Feng, Howard M. Sandler, Jason A. Efstathiou, Isabel Syndikus, Emma C. Hall, Alison C. Tree, Matthew R. Sydes, Claire Cruickshank, Soumyajit Roy, Michel Bolla, Philippe Maingon, Theo De Reijke, Abdenour Nabid, Nathalie Carrier, Luis Souhami, Almudena Zapatero, Araceli Guerrero, Ana Alvarez, Carmen Gonzalez San-Segundo, Xavier Maldonado, Tahmineh Romero, Michael L. Steinberg, Luca F. Valle, Matthew B. Rettig, Nicholas G. Nickols, Jonathan E. Shoag, Robert E. Reiter, Nicholas G. Zaorsky, Angela Y. Jia, Jorge A. Garcia, Daniel E. Spratt, Amar U. Kishan
Summary: The sequencing of androgen-deprivation therapy (ADT) and radiotherapy (RT) may affect the outcome of prostate cancer depending on the size of the RT field. A study found that the sequencing of ADT has a significant impact on clinical outcomes for men receiving ADT with prostate-only RT (PORT) or whole-pelvis RT (WPRT).
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Paul L. Nguyen, Huei-Chung (Rebecca) Huang, Daniel E. Spratt, Elai Davicioni, Howard M. Sandler, William U. Shipley, Jason A. Efstathiou, Jeffry P. Simko, Alan Pollack, Adam P. Dicker, Mack Roach III, Seth A. Rosenthal, Kenneth L. Zeitzer, Lucas C. Mendez, Alan C. Hartford, William A. Hall, Anand B. Desai, Rachel A. Rabinovitch, Christopher A. Peters, Joseph P. Rodgers, Phuoc Tran, Felix Y. Feng
Summary: The study validates the performance of Decipher genomic classifier (GC) in pretreatment biopsy samples. The GC score is independently associated with distant metastases, prostate cancer-specific mortality, and overall survival, providing valuable prognostic information for personalized decision-making.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Oncology
Phuoc T. Tran, Kathryn Lowe, Hua-Ling Tsai, Daniel Y. Song, Arthur Y. Hung, Jason W. D. Hearn, Steven Miller, James A. Proudfoot, Matthew P. Deek, Ryan Phillips, Tamara Lotan, Channing J. Paller, Catherine H. Marshall, Mark Markowski, Shirl Dipasquale, Samuel Denmeade, Michael Carducci, Mario Eisenberger, Theodore L. DeWeese, Matthew Orton, Curtiland Deville, Elai Davicioni, Stanley L. Liauw, Elisabeth I. Heath, Stephen Greco, Neil B. Desai, Daniel E. Spratt, Felix Feng, Hao Wang, Tomasz M. Beer, Emmanuel S. Antonarakis
Summary: This study aimed to investigate the effect of enzalutamide on freedom from PSA progression in men with recurrent prostate cancer after radical prostatectomy. The results showed that enzalutamide monotherapy for 6 months in combination with salvage radiation therapy delayed PSA progression and was safe for high-risk patients with postoperative recurrence.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Randy A. Vince, Ralph Jiang, Merrick Bank, Jake Quarles, Milan Patel, Yilun Sun, Holly Hartman, Nicholas G. Zaorsky, Angela Jia, Jonathan Shoag, Robert T. Dess, Brandon A. Mahal, Kristian Stensland, Nicholas W. Eyrich, Mariana Seymore, Rebecca Takele, Todd M. Morgan, Matthew Schipper, Daniel E. Spratt
Summary: This meta-analysis demonstrates that the interaction between race and social determinants of health (SDOH) is associated with racial disparities in prostate cancer outcomes. Black patients have higher prostate cancer-specific mortality (PCSM) than White patients in studies with minimal accounting for SDOH, but lower PCSM in studies with greater accounting for SDOH. The findings underscore the importance of considering SDOH variables in research to promote health equity.
Correction
Health Care Sciences & Services
Andre J. Esteva, Jean Feng, Douwe van der Wal, Shih-Cheng Huang, Jeffry Simko, Sandy E. DeVries, Emmalyn Chen, Edward Schaeffer, Todd Morgan, Yilun Sun, Amirata A. Ghorbani, Nikhil Naik, Dhruv G. Nathawani, Richard D. Socher, Jeff L. Michalski, Mack R. Roach III, Thomas G. Pisansky, Jedidiah Monson, Farah A. Naz, James Wallace, Michelle M. Ferguson, Jean-Paul T. Bahary, James E. Zou, Matthew Lungren, Serena Y. Yeung, Ashley Ross, Howard M. Sandler, Phouc T. Tran, Daniel E. Spratt, Stephanie Pugh, Felix Y. Feng, Osama Mohamad
NPJ DIGITAL MEDICINE
(2023)
Article
Oncology
Clayton P. Smith, James A. Proudfoot, Paul C. Boutros, Robert E. Reiter, Luca Valle, Matthew B. Rettig, Nicholas G. Nickols, Felix Y. Feng, Paul L. Nguyen, Himanshu Nagar, Daniel E. Spratt, Gert Attard, Adam Weiner, Joanne B. Weidhaas, Jeremie Calais, T. Martin Ma, Elai Davicioni, Michael Xiang, Amar U. Kishan
Summary: PSMA PET has higher specificity and sensitivity than conventional imaging, and it can predict the risk of distant metastasis in high-risk and very high-risk prostate cancer patients. The risk of upstaging on PSMA PET is significantly correlated with the Decipher genetic score. Further studies are needed to explore the causal pathways between PSMA findings, Decipher scores, extraprostatic disease, and long-term clinical outcomes.
EUROPEAN UROLOGY ONCOLOGY
(2023)
Meeting Abstract
Oncology
Corey Weistuch, Kevin Murgas, Ken Dill, Larry Norton, Joseph Deasy, Allen Tannenbaum
Meeting Abstract
Oncology
Jiening Zhu, Jung Hun Oh, Anish K. Simhal, Rena Elkin, Larry Norton, Joseph O. Deasy, Allen R. Tannenbaum
Meeting Abstract
Oncology
Anish K. Simhal, Kylee H. Maclachlan, Rena Elkin, Jiening Zhu, Saad Z. Usmani, Jonathan J. Keats, Larry Norton, Joseph O. Deasy, Jung Hun Oh, Allen Tannenbaum
Article
Oncology
Z. A. R. Gouw, J. Jeong, A. Rimner, N. Y. Lee, A. Jackson, A. Fu, J-j. Sonke, J. O. Deasy
Summary: This study investigates the effectiveness of non-uniform fractionation schedules in radiotherapy for early-stage non-small cell lung cancer. Through modeling, optimized schedules are proposed to minimize local failures and toxicity risk. The results suggest that non-standard primer shot fractionation can reduce hypoxia-induced radioresistance and improve treatment outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)