Article
Oncology
Laure Kuntz, Clara Le Fevre, Delphine Jarnet, Audrey Keller, Philippe Meyer, Christophe Mazzara, Helene Cebula, Georges Noel, Delphine Antoni
Summary: This retrospective study analyzed the data of patients who received at least two courses of SRT between 2010 and 2020. The results showed that NDFS and OS after SRT were influenced by various factors, including the number of treatments, patient condition, salvage WBRT, and metastasis velocity.
Review
Oncology
Francois Lucia, Ruben Touati, Nicolae Crainic, Gurvan Dissaux, Olivier Pradier, Vincent Bourbonne, Ulrike Schick
Summary: Approximately 30% of cancer patients will develop brain metastases, leading to local recurrence post intracranial stereotactic radiotherapy. Advances in cancer treatments have increased overall survival, but also local failures (LF) after SRS/SRT. Second courses of SRS or SRT may be used to treat LF, with factors affecting efficacy including histology, tumor size, and prior treatments. Prospective studies with more patients are needed to determine the best management of brain metastases recurrence.
Article
Oncology
Felix Ehret, Lucas Mose, Markus Kufeld, Christoph Fuerweger, Paul Windisch, Alfred Haidenberger, Christian Schichor, Joerg-Christian Tonn, Alexander Muacevic
Summary: This study investigated the efficacy and safety of single-session robotic radiosurgery for spinal metastasis recurrences occurring in the same initial location due to advancements in medical technology. The results showed that this treatment modality is safe, time-saving, and effective, with outcomes comparable to reirradiated metastases in boundary areas.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Matthias Guckenberger, Frederick Mantel, Reinhart A. Sweeney, Maria Hawkins, Jose Belderbos, Merina Ahmed, Nicolaus Andratschke, Indira Madani, Michael Flentje
Summary: The study demonstrates that fractionated SBRT is effective in providing long-term pain relief and improved survival rates for patients with painful spinal metastases. Partial pain response was achieved in some patients at 3 months' follow-up and remained stable up to 5 years. Furthermore, fractionated SBRT resulted in long-term improvements in multiple dimensions of the EuroQol 5-Dimension Questionnaire.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
L. Kuntz, C. Le Fevre, D. Jarnet, A. Keller, P. Meyer, A. Thiery, H. Cebula, G. Noel, D. Antoni
Summary: Brain metastases are a major cause of intracranial malignant neoplasms in adults. Multiple factors can predict the prognosis of patients and help determine the treatment approach. This study reviewed the characteristics of patients treated with repeated stereotactic radiotherapy and found that it had minimal impact on the overall condition of patients and showed potential for long-term survival.
RADIATION ONCOLOGY
(2023)
Article
Oncology
Scott G. Soltys, Jimm Grimm, Michael T. Milano, Jinyu Xue, Arjun Sahgal, Ellen Yorke, Yoshiya Yamada, George X. Ding, Allen Li, D. Michael Lovelock, Andrew Jackson, Lijun Ma, Issam El Naqa, Iris C. Gibbs, Lawrence B. Marks, Stanley Benedict
Summary: This study investigated the tumor control probability (TCP) of spinal metastases treated with stereotactic body radiation therapy (SBRT) in different dose and fractionation schemes. The results showed that spinal SBRT with common fractionation schemes yields 2-year estimates of local control of 82% to 96%. Care should be taken interpreting the results due to heterogeneity in tumor control estimates extracted from literature.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Vincent Cassidy, Robert J. Amdur
Summary: This report describes a case of severe esophageal damage from stereotactic body radiation therapy to the T-2 vertebral body, particularly highlighting the increased risk in the upper thoracic or cervical spine. The review of relevant literature provides implications for future research and practice.
PRACTICAL RADIATION ONCOLOGY
(2022)
Article
Oncology
Brian Hrycushko, Paul M. Medin
Summary: This study aimed to evaluate various models for their ability to describe the increase in radiation tolerance of spinal nerves as the irradiated length is reduced. While the Lyman-Kutcher-Burman model, relative seriality, and critical volume model all fit the data well, the mean dose logistic regression model and relative seriality model performed best after penalizing for the number of model parameters. The critical volume model provided the closest match to the rat data when extrapolating to a 0.5-cm dose distribution.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Clinical Neurology
Dukagjin M. Blakaj, Joshua D. Palmer, Khaled Dibs, Alexander Olausson, Eric C. Bourekas, Daniel Boulter, Ahmet S. Ayan, Eric Cochran, William S. Marras, Prasath Mageswaran, Miki Katzir, Vedat O. Yildiz, John Grecula, Andrea Arnett, Raju Raval, Thomas Scharschmidt, James B. Elder, Russell Lonser, Arnab Chakravarti, Ehud Mendel
Summary: Factors associated with local control and progression-free survival for patients receiving postoperative stereotactic spine radiosurgery included time from surgery to radiosurgery, radiotherapy dose, and preoperative embolization.
Article
Oncology
Arjun Sahgal, Joe H. Chang, Lijun Ma, Lawrence B. Marks, Michael T. Milano, Paul Medin, Andrzej Niemierko, Scott G. Soltys, Wolfgang A. Tome, C. Shun Wong, Ellen Yorke, Jimm Grimm, Andrew Jackson
Summary: The study shows that the spinal cord tolerance data for SBRT in different fractions and the factors associated with a lower risk of radiation myelopathy for reirradiation SBRT, such as dose control and time intervals, are important for reducing risks.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
R. Kinj, J. Doyen, J. M. Hannoun-Levi, A. O. Naghavi, M. E. Chand, G. Baudin, J. M. Ferrero, E. Francois, L. Evesque, D. Borchiellini, K. Benezery, P. Y. Bondiau
Summary: This study evaluated the outcomes of SBRT reirradiation for extraosseous recurrences in the pelvis, showing it to be a safe and effective treatment modality. Improved local control was associated with smaller tumour volume and primary prostate location.
Article
Oncology
John A. Vargo, Vitali Moiseenko, Jimm Grimm, Jimmy Caudell, David A. Clump, Ellen Yorke, Jinyu Xue, Yevgeniy Vinogradskiy, Eduardo G. Moros, Panayiotis Mavroidis, Sheena Jain, Issam El Naqa, Lawrence B. Marks, Dwight E. Heron
Summary: This study systematically reviewed the available literature on tumor control probability with SBRT in head and neck cancer patients, finding a dose-response relationship suggesting better local control and possibly improved overall survival with doses of 35 to 45 Gy (in 5 fractions) compared with <30 Gy. It is suggested that SBRT doses equivalent to 5-fraction doses of 40 to 50 Gy are used for retreatment.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Leor Zach, Amir Agami, Orit Furman, Moshe Attia, Zvi Cohen, Iris Ben-Bassat Mizrachi, Guy Tam, Zion Zibly, Ouzi Nissim, Roberto Spiegelmann, Ruth Huna-Baron
Summary: This study retrospectively compared the effects of cFSRT and hSRT regimens on visual function outcomes in AVPM cases treated at Sheba Medical Center. The results suggest that hSRT may be associated with a higher risk of visual acuity and visual field deterioration in AVPM patients, especially in ONSM cases, recommending the use of cFSRT for treatment.
RADIATION ONCOLOGY
(2021)
Review
Oncology
A. Amraee, M. R. Tohidkia, L. Darvish, A. Tarighatnia, N. Robatmili, A. Rahimi, N. Rezaei, F. Ansari, S. H. Teshnizi, A. Aghanejad
Summary: This meta-analysis aimed to determine the safe dose and treatment interval for reirradiation of the spine to reduce or prevent myelopathy and pain control. The results showed that using appropriate doses and treatment intervals can have a significant impact in preventing or reducing the effects of myelopathy and regional control pain in spinal reirradiation.
Article
Radiology, Nuclear Medicine & Medical Imaging
Dario Di Perri, Emmanuel Jouglar, Ellen Blanc, Anne Ducassou, Aymeri Huchet, Celine Vigneron, Alexandre Escande, Sophie Chapet, Julie Leseur, Valerie Bernier, Christian Carrie, Valentine Martin, Line Claude
Summary: The study reported preliminary acute and middle-term toxicity results of hypofractionated stereotactic body radiotherapy (SBRT) in pediatric patients, showing a favorable safety profile of SBRT in young patients. Most toxicities occurred in the reirradiation setting.
BRITISH JOURNAL OF RADIOLOGY
(2021)
Article
Oncology
Percy Lee, Billy W. Loo Jr, Tithi Biswas, George X. Ding, Issam M. El Naqa, Andrew Jackson, Feng-Ming Kong, Tamara LaCouture, Moyed Miften, Timothy Solberg, Wolfgang A. Tome, An Tai, Ellen Yorke, X. Allen Li
Summary: Based on the evaluation of published experiences with SBRT, a steep dose-response relationship exists with high rates of durable local control for early-stage non-small cell lung cancer when physical doses of 43-50 Gy are delivered.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Esther G. C. Troost, Krista C. J. Wink, Erik Roelofs, Charles B. Simone, Sebastian Makocki, Steffen Loeck, Peter van Kollenburg, David Dechambre, Andre W. H. Minken, Judith van der Stoep, Stephen Avery, Nicolas Jansen, Timothy Solberg, Johan Bussink, Dirk de Ruysscher
BRITISH JOURNAL OF RADIOLOGY
(2020)
Article
Oncology
Brian Hrycushko, Albert J. van der Kogel, Lauren Phillips, Michael Folkert, James W. Sayre, Steven Vernino, Nima Hassan-Rezaeian, Ryan D. Foster, Yoshiya Yamada, Robert Timmerman, Paul M. Medin
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2020)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Michael Mills, Tim Solberg, Per Halvorsen
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2020)
Article
Multidisciplinary Sciences
Efstathios D. Gennatas, Jerome H. Friedman, Lyle H. Ungar, Romain Pirracchio, Eric Eaton, Lara G. Reichmann, Yannet Interian, Jose Marcio Luna, Charles B. Simone, Andrew Auerbach, Elier Delgado, Mark J. van der Laan, Timothy D. Solberg, Gilmer Valdes
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
John H. Heinzerling, Carnell J. Hampton, Myra Robinson, Megan Bright, Benjamin J. Moeller, Justin Ruiz, Roshan Prabhu, Stuart H. Burri, Ryan D. Foster
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Miguel Romero, Yannet Interian, Timothy Solberg, Gilmer Valdes
Article
Oncology
Scott G. Soltys, Michael T. Milano, Jinyu Xue, Wolfgang A. Tome, Ellen Yorke, Jason Sheehan, George X. Ding, John P. Kirkpatrick, Lijun Ma, Arjun Sahgal, Timothy Solberg, John Adler, Jimm Grimm, Issam El Naqa
Summary: The study aimed to investigate the tumor control probability of vestibular schwannomas after single-fraction stereotactic radiosurgery (SRS) or hypofractionated SRS over 2 to 5 fractions. Data extraction revealed that with specific doses of SRS treatment, the tumor control probability for vestibular schwannoma patients could exceed 91% within 3 to 5 years. For hypofractionated SRS, it is recommended to use specific doses in fractions for better treatment outcomes.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Mikhail Chetvertkov, James Ira Monroe, Jaskaran Boparai, Timothy D. Solberg, Deanna H. Pafundi, Russell L. Ruo, David J. Gladstone, Fang-Fang Yin, Indrin J. Chetty, Stanley Benedict, David S. Followill, Ying Xiao, Jason W. Sohn
FRONTIERS IN ONCOLOGY
(2020)
Article
Oncology
K. Hasse, J. Scholey, B. P. Ziemer, Y. Natsuaki, O. Morin, T. D. Solberg, E. Hirata, G. Valdes, A. Witztum
Summary: The study aimed to assess the use of machine learning methods and M3D dose calculation software to reduce the number of physical IC dose measurements required for patient-specific quality assurance during the COVID-19 pandemic. Results showed that both methods were able to effectively identify patient plans that required physical dose measurements, leading to a potential reduction in the number of measurements taken.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Megan Bright, Ryan D. Foster, Carnell J. Hampton, Justin Ruiz, Benjamin Moeller
Summary: This study aimed to investigate the error risks associated with using surface-guided deep inspiration breath-hold (SG-DIBH) during breast radiation therapy (RT) and to assess and improve these risks through failure modes and effects analysis (FMEA). The research found that operator error was the most common type of error, which was reduced through policy changes and standardization. The study also showed that abbreviated FMEA training can save time, but there were differences in scores between professions, emphasizing the importance of interdisciplinary collaboration.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2022)
Article
Oncology
Jason W. Chan, Nicole Hohenstein, Colin Carpenter, Adam J. Pattison, Olivier Morin, Gilmer Valdes, Cristina Tolentino Sanchez, Jennifer Perkins, Timothy D. Solberg, Sue S. Yom
Summary: The study aimed to develop a novel AI-guided clinical decision support system to predict radiation doses to subsites of the mandible using diagnostic CT scans before head and neck radiation therapy planning. Results showed that the AI predictions had a high accuracy in the test data set and strong correlation with physician predictions.
ADVANCES IN RADIATION ONCOLOGY
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Timothy D. Solberg
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2022)
Article
Oncology
Ryan D. Foster, Benjamin J. Moeller, Myra Robinson, Megan Bright, Justin L. Ruiz, Carnell J. Hampton, John H. Heinzerling
Summary: This study aimed to investigate the dosimetric consequences of uncorrected intrafraction patient motion detected during frameless linac-based SRS. The results showed that if uncorrected, the patient motion detected by SGRT could result in dose reduction and increased dose to the normal brain.
ADVANCES IN RADIATION ONCOLOGY
(2023)
Article
Oncology
Olivier Morin, Martin Vallieres, Steve Braunstein, Jorge Barrios Ginart, Taman Upadhaya, Henry C. Woodruff, Alex Zwanenburg, Avishek Chatterjee, Javier E. Villanueva-Meyer, Gilmer Valdes, William Chen, Julian C. Hong, Sue S. Yom, Timothy D. Solberg, Steffen Lock, Jan Seuntjens, Catherine Park, Philippe Lambin
Summary: Despite the widespread adoption of electronic health records, most hospitals are not ready for data science research in clinical pipelines. The MEDomics infrastructure developed by the researchers organizes multimodal health data and utilizes artificial intelligence to assess data quality for individual prognosis in oncology. The study demonstrates the prognostic utility of the framework and identifies actionable findings related to mortality among cancer patients.