Article
Oncology
Christopher Nutting, Laura Finneran, Justin Roe, Mark A. Sydenham, Matthew Beasley, Shree Bhide, Cheng Boon, Audrey Cook, Emma De Winton, Marie Emson, Bernadette Foran, Robert Frogley, Imran Petkar, Laura Pettit, Keith Rooney, Tom Roques, Devraj Srinivasan, Justine Tyler, DARS Trialist Grp
Summary: The study found that dysphagia-optimised intensity-modulated radiotherapy (DO-IMRT) improved swallowing function and reduced radiation dose-related damage in patients with oropharyngeal and hypopharyngeal cancers. Therefore, DO-IMRT should be considered as a new standard treatment for patients receiving radiotherapy for pharyngeal cancers.
Article
Oncology
Amro M. Abdelrahman, Ajit H. Goenka, Roberto Alva-Ruiz, Jennifer A. Yonkus, Jennifer L. Leiting, Rondell P. Graham, Kenneth W. Merrell, Cornelius A. Thiels, Christopher L. Hallemeier, Susanne G. Warner, Michael G. Haddock, Travis E. Grotz, Nguyen H. Tran, Rory L. Smoot, Wen Wee Ma, Sean P. Cleary, Robert R. McWilliams, David M. Nagorney, Thorvardur R. Halfdanarson, Michael L. Kendrick, Mark J. Truty
Summary: Among patients with post-NAT resected BR/LA PDAC, FDG-PET highly predicts pathologic response and survival, superior to biochemical responses alone. Given the poor ability of anatomic imaging or biochemical markers to assess NAT responses in these patients, FDG-PET is a preoperative metric of NAT efficacy, thereby allowing potential therapeutic alterations and surgical treatment decisions. We suggest that FDG-PET should be an adjunct and recommended modality during the NAT phase of care for these patients.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2022)
Review
Oncology
Elizabeth J. Buss, Lisa A. Kachnic, David P. Horowitz
Summary: This review summarizes the expanding role of radiotherapy in the management of locally advanced, unresectable pancreatic cancer. Higher, ablative doses of radiation and advancements in technology have been shown to improve patient survival rates.
SEMINARS IN ONCOLOGY
(2021)
Article
Oncology
You-Ping Liu, Yi-Hui Wen, Jun Tang, Yi Wei, Rui You, Xiao-Lin Zhu, Jian Li, Lin Chen, Li Ling, Ning Zhang, Xiong Zou, Yi-Jun Hua, You-Mou Chen, Lei Chen, Li-Xia Lu, Ming-Yuan Chen, Wei-Ping Wen
Summary: Surgery significantly improved overall survival compared with IMRT in patients with resectable locally recurrent NPC. ENPG could be considered as the standard treatment option for this patient population, although long-term follow-up is needed to further determine the efficacy and toxicity of this strategy.
Article
Surgery
Smita Sihag, Tamar Nobel, Meier Hsu, Kay See Tan, Rebecca Carr, Yelena Y. Janjigian, Laura H. Tang, Abraham J. Wu, Matthew J. Bott, James M. Isbell, Manjit S. Bains, David R. Jones, Daniela Molena
Summary: The study aimed to determine the optimal extent of lymphadenectomy in patients with locally advanced esophageal adenocarcinoma treated with neoadjuvant chemoradiotherapy followed by esophagectomy. The results showed that removing 20 to 25 lymph nodes improved the survival rate of patients.
Article
Oncology
Colin S. Hill, Lauren M. Rosati, Chen Hu, Wei Fu, Shuchi Sehgal, Amy Hacker-Prietz, Christopher L. Wolfgang, Matthew J. Weiss, Richard A. Burkhart, Ralph H. Hruban, Ana De Jesus-Acosta, Dung T. Le, Lei Zheng, Daniel A. Laheru, Jin He, Amol K. Narang, Joseph M. Herman
Summary: Despite having more advanced disease, the nCT-SBRT cohort was still more likely to undergo an R0 resection and experienced similar survival outcomes compared with the nCT alone cohort.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Shuai Li, Yangzi Zhang, Yang Yu, Xianggao Zhu, Jianhao Geng, Huajing Teng, Zhilong Wang, Tingting Sun, Lin Wang, Hongzhi Wang, Yongheng Li, Aiwen Wu, Yong Cai, Weihu Wang
Summary: The study aimed to analyze the optimal radiotherapy dose for clinically positive LPLN from LARC. Results showed a significantly lower 2-year LPLN regrowth rate in the SIB-IMRT group compared to the non-SIB-IMRT group, especially for patients with LPLN measuring >= 8mm in the short axis or >= 10mm in the long axis.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Mathilde Weisz Ejlsmark, Tine Schytte, Uffe Bernchou, Rana Bahij, Britta Weber, Michael Bau Mortensen, Per Pfeiffer
Summary: Pancreatic cancer is a leading cause of cancer-related death worldwide, and the management of locally advanced or metastatic disease is difficult due to limited treatment options. While systemic chemotherapy is commonly used, the role of radiotherapy in treatment remains unclear. This review explores the available data on radiotherapy, chemoradiation, and stereotactic body radiation therapy for locally advanced pancreatic cancer. The included studies showed conflicting results and high heterogeneity, highlighting the need for further research to improve outcomes and define the role of radiation therapy in pancreatic cancer.
Article
Oncology
Hideyuki Harada, Shota Omori, Keita Mori, Masahiro Konno, Haruyasu Murakami, Toshiyuki Imagumbai, Haruyuki Fukuda, Kiyoshi Nakamatsu, Tomoki Kimura, Hiroaki Tanabe, Hideki Fujita, Hitoshi Tatebe, Kazunori Fujitaka, Yasumasa Nishimura
Summary: This study evaluated the feasibility of IMRT for patients with locally advanced NSCLC. The treatment completion rate was 77.3%, with 20 out of 22 patients completing IMRT.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Edouard Auclin, Lysiane Marthey, Raef Abdallah, Leo Mas, Eric Francois, Angelique Saint, Antonio Sa Cunha, Angelique Vienot, Thierry Lecomte, Vincent Hautefeuille, Christelle de la Fouchardiere, Matthieu Sarabi, Feryel Ksontini, Julien Forestier, Romain Coriat, Emmanuelle Fabiano, Florence Leroy, Nicolas Williet, Jean-Baptiste Bachet, David Tougeron, Julien Taieb
Summary: FOLFIRINOX shows promising efficacy with manageable toxicity in treating locally advanced or borderline resectable pancreatic adenocarcinoma. Surgical resection rates are low but significantly impact overall survival for patients.
BRITISH JOURNAL OF CANCER
(2021)
Article
Gastroenterology & Hepatology
John Reynolds, Shaun R. Preston, Brian O'Neill, Maeve A. Lowery, Lene Baeksgaard, Thomas Crosby, Moya Cunningham, Sinead Cuffe, Gareth Griffiths, Imelda Parker, Signe Lenora Risumlund, Rajarshi Roy, Stephen Falk, George B. Hanna, Frederick R. Bartlett, Alberto Alvarez-Iglesias, Michael P. Achiam, Magnus Nilsson, Guillaume Piessen, Narayanasamy Ravi, Dermot O'Toole, Ciaran Johnston, Raymond S. Mcdermott, Richard C. Turkington, Shajahan Wahed, Sharmila Sothi, Hugo Ford, Martin S. Wadley, Derek Power
Summary: The study compares trimodality therapy and perioperative chemotherapy for adenocarcinoma of the oesophagus and oesophagogastric junction, showing similar 3-year survival rates and outcomes in terms of surgery and quality of life.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Xiu-Yun Lu, Xi Guo, Qi Zhang, Yi-Jie Qiu, Dan Zuo, Sheng Chen, Xiao-Fan Tian, Yu-Hong Zhou, Yi Dong, Wen-Ping Wang
Summary: This study aimed to evaluate the value of DCE-US and quantitative parameters in early prediction of tumor response to CRT in LAPC patients. The results showed that DCE-US could be a potential non-invasive imaging method for early follow-up of response in LAPC patients treated by CRT.
Article
Multidisciplinary Sciences
Tzu-Hui Pao, Ying-Yuan Chen, Wei-Lun Chang, Jeffrey Shu-Ming Chang, Nai-Jung Chiang, Chia-Ying Lin, Wu-Wei Lai, Yau-Lin Tseng, Yi-Ting Yen, Ta-Jung Chung, Forn-Chia Lin
Summary: The study found that T4 and esophageal stenosis at baseline were independent risk factors for esophageal fistula in ESCC patients treated with definitive CCRT with IMRT. Patients who received repair or stenting for esophageal perforation appeared to have a trend towards improved survival.
Article
Surgery
E. L. Vos, R. A. Carr, M. Hsu, M. Nakauchi, T. Nobel, A. Russo, A. Barbetta, K. S. Tan, L. Tang, D. Ilson, G. Y. Ku, A. J. Wu, Y. Y. Janjigian, S. S. Yoon, M. S. Bains, D. R. Jones, D. Coit, D. Molena, V. E. Strong
Summary: In patients undergoing surgical resection for locally advanced adenocarcinoma of the gastro-oesophageal junction, there was no significant difference in overall survival and disease-free survival between those who had neoadjuvant chemoradiation compared with chemotherapy.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Cell Biology
Kaixuan Yang, Wenji Xie, Xiangbin Zhang, Yu Wang, Arthur Shou, Qiang Wang, Jiangfang Tian, Jiangping Yang, Guangjun Li
Summary: This study aimed to predict late radiation xerostomia and successfully developed a predictive model, which can effectively improve patients' quality of life.