Article
Oncology
Yi-Jun Hua, Yan-Feng Ou-Yang, Xiong Zou, Le Xia, Dong-Hua Luo, Ming-Yuan Chen
Summary: Radiotherapy is crucial for nasopharyngeal carcinoma patients, with a typical treatment duration of six to six and a half weeks. Prolonged radiotherapy duration is associated with higher risk of distant metastasis and death, highlighting the importance of avoiding prolonged treatment to improve outcomes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Shao-Bo Liang, Lu-Si Chen, Hai-Yang Chen, Xing-Li Yang, Dong-Hui Wang, Chun-Yan Cui, Chuan-Bo Xie, Li-Zhi Liu, Xiang-Ying Xu
Summary: The study evaluated the impact of prevertebral space involvement (PSI) and tumor extension on prognosis in nasopharyngeal carcinoma patients. Results show that PSI is an independent predictor of poor prognosis, with BPMI patients having lower survival rates than PMI patients, and NPC with PSI should be classified as T4 stage.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Otorhinolaryngology
Jing-Jin Weng, Jia-Zhang Wei, Min Li, Le-Ping Ning, Fei Liu, Yun-Zhong Wei, Wei-Ming Xiong, Ben-Jian Zhang, Jin-Long Lu, He Jiang, Qiu-Tian Lu, Shen-Hong Qu
Summary: This study aimed to investigate the effect of hypothyroidism and thyroxine replacement therapy on the prognosis of nasopharyngeal carcinoma (NPC) patients. The results showed that patients with hypothyroidism had better survival rates. Hypothyroidism was identified as a positive independent prognostic factor. Thyroxine replacement therapy did not negatively affect the survival rates of these patients.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Otorhinolaryngology
Dan Bao, Yanfeng Zhao, Zhou Liu, Haijun Xu, Ya Zhang, Meng Yuan, Lin Li, Meng Lin, Xinming Zhao, Dehong Luo
Summary: This study developed a model based on MRI radiomics and clinical features to predict radiation-induced temporal lobe injury (RTLI) in patients with nasopharyngeal carcinoma (NPC). The clinical-radiomics model and radiomics signature both showed excellent performance in predicting RTLI in patients with NPC.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Oncology
Fen Xue, Xiaoshuang Niu, Chaosu Hu, Xiayun He
Summary: This study aimed to determine the long-term risk of second primary lung adenocarcinoma (SPLAC) in nasopharyngeal cancer (NPC) patients after intensity-modulated radiotherapy (IMRT). The results showed that the incidence of SPLAC in NPC patients after IMRT was similar to that of the normal population, and most cases were detected in early stages during follow-up, with good surgical efficacy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Guanzhu Shen, Yinglin Peng, Jian Li, Haijun Wu, Guangshun Zhang, Chong Zhao, Xiaowu Deng
Summary: This study evaluated the incidence of hypothyroidism in patients with nasopharyngeal carcinoma after IMRT, finding that 34.8% of patients developed hypothyroidism 12 months after radiotherapy. The average thyroid dose and thyroid volume were identified as key factors affecting hypothyroidism, with an NTCP model constructed based on these factors showing good fit.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Xiao-Tang Xiao, Yi-Shan Wu, Yu-Pei Chen, Xu Liu, Rui Guo, Ling-Long Tang, Jun Ma, Wen-Fei Li
Summary: This study analyzed the patterns of lymph node failure and prognosis in patients with regional recurrent nasopharyngeal carcinoma (rNPC) alone after primary intensity-modulated radiotherapy (IMRT). The results showed that in-field failure was the main pattern of regional recurrence, while out-field failure mainly occurred in the parotid gland and level Ib. Patients with regional rNPC alone had a good prognosis after salvage treatment.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xue-Song Sun, Zhi-Wen Xiao, Sai-Lan Liu, Rui Sun, Dong-Hua Luo, Qiu-Yan Chen, Hai-Qiang Mai
Summary: This study developed and validated a nomogram model to predict the overall survival of patients with nasopharyngeal carcinoma without distant metastasis. The model incorporates clinical characteristics, serum biomarkers, and the presence of nasopharyngeal necrosis.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Ruiping Zhai, Yingchen Lyu, Mengshan Ni, Fangfang Kong, Chengrun Du, Chaosu Hu, Hongmei Ying
Summary: The study aims to identify factors predicting the risk of hypothyroidism in nasopharyngeal carcinoma patients after intensity-modulated radiotherapy (IMRT). The findings suggest that younger age, female gender, and small thyroid volume are the most important factors predicting hypothyroidism risk. Thyroid volume Vt40 is a key parameter in predicting the risk of hypothyroidism after IMRT in nasopharyngeal carcinoma patients.
RADIATION ONCOLOGY
(2022)
Article
Oncology
Ping Zhou, Juan Zhou, Chen-Lu Lian, Yi-Feng Yu, Rui Zhou, Qin Lin, San-Gang Wu
Summary: This study found that positive post-IMRT EBV DNA is associated with poor prognosis in patients with nasopharyngeal carcinoma.
Article
Oncology
Qiaojuan Guo, Nan Xiao, Hanchuan Xu, Jingfeng Zong, Youping Xiao, Tianzhu Lu, Yun Xu, Bingyi Wang, Bijuan Chen, Jianji Pan, Shaojun Lin
Summary: This study investigated the feasibility of level Ib sparing in selected nasopharyngeal carcinoma patients during intensity-modulated radiation therapy based on the International Guideline. The results showed that level Ib-sparing IMRT is safe and feasible for patients who meet certain criteria.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Lin Chen, Jing Li, Kunpeng Li, Jiang Hu, Qingjie Li, Chenglong Huang, Gaoyuan Wang, Na Liu, Linglong Tang
Summary: This study analyzed the probability of hearing impairment after radiotherapy for nasopharyngeal carcinoma and developed a predictive model, providing dose limitation suggestions to improve patients' quality of life.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Otorhinolaryngology
Xixi Liu, Bian Wu, Jing Huang, You Qin, Zhanjie Zhang, Liangliang Shi, Xiaohua Hong, Qian Ding, Gang Peng, Kunyu Yang
Summary: This study aims to identify tumor factors associated with in-field failure in patients with nasopharyngeal carcinoma (NPC) receiving intensity-modulated radiotherapy (IMRT). The results showed that in-field failure was the major pattern of recurrence in NPC patients. Large tumor volume, nonkeratinizing differentiated carcinoma, and cervical nodal necrosis were independent tumor factors associated with in-field failure.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Review
Otorhinolaryngology
Yongyuan Xue, Guoping Li, Tao Xie, Hongyang Xu, Tianrui Xu, Zhengfei Li, Lixiu Zhu, Xin Li, Zhiyao Li, Wei Xiong
Summary: This study systematically reviewed the significance of concurrent chemoradiotherapy for stage II nasopharyngeal cancer. The results showed that in the era of intensity-modulated radiotherapy, concurrent chemoradiotherapy and radiotherapy alone have the same survival benefits and concurrent chemoradiotherapy increases acute hematological toxicity. Subgroup analysis showed that for people with N1 nasopharyngeal cancer at risk of distant metastases, concurrent chemoradiotherapy and radiotherapy alone also had equal survival benefits.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Health Care Sciences & Services
Ronald Wihal Oei, Yingchen Lyu, Lulu Ye, Fangfang Kong, Chengrun Du, Ruiping Zhai, Tingting Xu, Chunying Shen, Xiayun He, Lin Kong, Chaosu Hu, Hongmei Ying
Summary: This study compared the performance of the Cox proportional hazards model (CPH) with the conditional survival forest (CSF) and DeepSurv, two state-of-the-art machine learning algorithms, for disease progression prediction in nasopharyngeal carcinoma (NPC), with DeepSurv achieving the best performance.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Fei Peng, Yongjun Men, Yingfeng Tu, Yongming Chen, Daniela A. Wilson
ADVANCED FUNCTIONAL MATERIALS
(2018)
Article
Engineering, Biomedical
Huaan Li, Hong Liu, Tianqi Nie, Yi Chen, Zhiyong Wang, Huahua Huang, Lixin Liu, Yongming Chen
Article
Engineering, Biomedical
Xilong Wu, Yundi Wu, Zhiyong Wang, Lixin Liu, Chengxin Sun, Yongming Chen, Chun Wang
ADVANCED HEALTHCARE MATERIALS
(2018)
Article
Engineering, Biomedical
Houkuan Tian, Zhiyu He, Chengxin Sun, Chengbiao Yang, Pengfei Zhao, Lixin Liu, Kam W. Leong, Hai-Quan Mao, Zhijia Liu, Yongming Chen
ADVANCED HEALTHCARE MATERIALS
(2018)
Article
Biochemistry & Molecular Biology
Lilong Sun, Zhijia Liu, Houkuan Tian, Zhicheng Le, Lixin Liu, Kam W. Leong, Hai-Quan Mao, Yongming Chen
Article
Chemistry, Physical
Boyuan Chen, Zhitao Hu, Haoqi Li, Zhiyong Li, Qiong Li, Yongming Chen
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2019)
Review
Oncology
Run-Cong Nie, Fo-Ping Chen, Shu-Qiang Yuan, Ying-Shan Luo, Shi Chen, Yong-Ming Chen, Xiao-Jiang Chen, Ying-Bo Chen, Yuan-Fang Li, Zhi-Wei Zhou
EUROPEAN JOURNAL OF CANCER
(2019)
Article
Polymer Science
Jing Wang, Yan Lu, Yongming Chen
Article
Oncology
Shao-Bo Liang, Ning Zhang, Dan-Ming Chen, Xing-Li Yang, Bin-Hong Chen, Hai Zhao, Rui-Liang Lu, Yong Chen, Li-Wu Fu
RADIOTHERAPY AND ONCOLOGY
(2019)
Article
Engineering, Biomedical
Zhipeng Zeng, Cong Dong, Pengfei Zhao, Zhijia Liu, Lixin Liu, Hai-Quan Mao, Kam W. Leong, Xiaohu Gao, Yongming Chen
ADVANCED HEALTHCARE MATERIALS
(2019)
Article
Oncology
Ruiwan Chen, Yu Zhou, Yujie Yuan, Qun Zhang, Shasha He, Yong Chen, Yufeng Ren
FRONTIERS IN ONCOLOGY
(2019)
Article
Polymer Science
Yongwei Wu, Zhitao Hu, Huahua Huang, Yongming Chen
Article
Oncology
Jing Guo, Yongming Chen, Zhimin Liu, Yuanxiang Guan, Wei Wang, Xiaowei Sun, Wei Li, Dazhi Xu
Article
Polymer Science
Houbo Zhou, Christopher M. Plummer, Huaan Li, Huahua Huang, Pengfei Ma, Le Li, Lixin Liu, Yongming Chen
Article
Polymer Science
Lue Xiang, Wen Zhu, Mei-lin Long, Ke Zhang, Yong-ming Chen
ACTA POLYMERICA SINICA
(2018)