Article
Oncology
Alexander Heinzel, Daniela Dedic, Norbert Galldiks, Philipp Lohmann, Gabriele Stoffels, Christian P. Filss, Martin Kocher, Filippo Migliorini, Kim N. H. Dillen, Stefanie Geisler, Carina Stegmayr, Antje Willuweit, Michael Sabel, Marion Rapp, Michael J. Eble, Marc Piroth, Hans Clusmann, Daniel Delev, Elena K. Bauer, Garry Ceccon, Veronika Dunkl, Jurij Rosen, Caroline Tscherpel, Jan-Michael Werner, Maximilian I. Ruge, Roland Goldbrunner, Jurgen Hampl, Carolin Weiss Lucas, Ulrich Herrlinger, Gabriele D. Maurer, Joachim P. Steinbach, Joerg Mauler, Wieland A. Worthoff, Bernd N. Neumaier, Christoph Lerche, Gereon R. Fink, Nadim Jon Shah, Felix M. Mottaghy, Karl-Josef Langen
Summary: PET imaging using O-(2-[F-18]fluoroethyl)-L-tyrosine (FET) as a tracer has become essential for diagnosing brain tumors, with increasing demand seen for differentiating tumor progress and treatment-related changes. Referring physicians rate FET PET highly for diagnosing recurrent gliomas and brain metastases.
Article
Chemistry, Medicinal
Chunmei Lu, Xiuting Wang, Qiqi Wang, Lixia Zhang, Jianguo Lin, Ling Qiu
Summary: Legumain is overexpressed in several cancers and serves as an important biomarker for cancer diagnosis. In this study, a novel radioactive tracer [F-18]SF-AAN was designed and synthesized for positron emission tomography (PET) imaging, targeting legumain. The tracer showed specificity in detecting legumain activity in vitro and in vivo, making it a promising tool for the diagnosis of legumain-related diseases.
Article
Oncology
Xiufang Qiu, Haixia Wu, Ting Xu, Shihan Xie, Ziqing You, Yixin Hu, Yinghong Zheng, Zewei Liang, Chaoxiong Huang, Li Yi, Li Li, Jing Liu, Zhaodong Fei, Chuanben Chen
Summary: This study aimed to reassess the clinical significance of standardized uptake values (SUVs) in nasopharyngeal carcinoma (NPC) on F-18-fluorodeoxyglucose (F-18-FDG) positron-emission tomography (PET). The results showed that high SUVs were associated with cancer recurrence, and the SUVmax-NTR ratio was identified as a potential prognostic factor.
Article
Veterinary Sciences
Su-Hyeon Kim, Sungin Lee
Summary: This case report describes the characteristics of 18F-FDG PET-CT imaging in a dog with an abdominal gossypiboma, which has not been reported in the veterinary literature before. A 13-year-old, spayed, female mixed breed dog underwent mastectomy and ovariohysterectomy and was referred for evaluation of metastasis after surgery. F-18-deoxy-2-D-glucose positron emission tomography/computed tomography (18F-FDG PET-CT) was performed and a soft-tissue mass was observed in the abdominal cavity.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Neurosciences
Takashi Nihashi, Keita Sakurai, Takashi Kato, Kaori Iwata, Yasuyuki Kimura, Hiroshi Ikenuma, Akiko Yamaoka, Akinori Takeda, Yutaka Arahata, Yukihiko Washimi, Keisuke Suzuki, Masahiko Bundo, Takashi Sakurai, Nobuyuki Okamura, Kazuhiko Yanai, Kengo Ito, Akinori Nakamura
Summary: Using the F-18-THK5351 tracer, the study investigated the changes in accumulation patterns in individuals along the Alzheimer's disease continuum. The results showed an increase in F-18-THK5351 accumulation with disease progression, suggesting its potential as a tool for visualizing the severity of Alzheimer's disease.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Medicine, Research & Experimental
Yong Huang, Yajing Liu, Chengze Li, Zhongjing Li, Hualong Chen, Lu Zhang, Ying Liang, Zehui Wu
Summary: Glutamine metabolism-related tracer (2S,4S)-4-[F-18]FEBGln has the potential to visualize various tumors through PET imaging, with good tumor retention and contrast. It shows different retention capabilities in different tumor models. The tracer has potential in accurately diagnosing lung cancer and glioma, but cannot accurately determine prostate cancer.
MOLECULAR PHARMACEUTICS
(2023)
Article
Urology & Nephrology
Sarah R. Ottenhof, Rosa S. Djajadiningrat, Michelle W. J. Versleijen, Maarten L. Donswijk, Vincent van der Noort, Oscar R. Brouwer, Niels M. Graafland, Erik Vegt, Simon Horenblas
Summary: FDG-PET/CT has high diagnostic value for staging pelvic lymph nodes and detecting distant metastases in high-risk penile cancer patients. It has high sensitivity and negative predictive value for pelvic lymph node staging, as well as a high positive predictive value for the detection of distant metastases.
EUROPEAN UROLOGY FOCUS
(2022)
Review
Oncology
Maoqing Jiang, Xiaohui Zhang, Yan Chen, Ping Chen, Xiuyu Guo, Lijuan Ma, Qiaoling Gao, Weiqi Mei, Jingfeng Zhang, Jianjun Zheng
Summary: PET/CT with F-18-2-fluoro-2-deoxyglucose (F-18-FDG) is a promising modality for diagnosing and monitoring treatment response and evaluating prognosis in non-small cell lung cancer (NSCLC) patients. Semiquantitative metabolic parameters measured by PET/CT, such as SUVmax, MTV, and TLG, can predict EGFR mutation status, monitor TKI treatment response, and assess outcome in NSCLC patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Nika Guberina, Lukas Kessler, Christoph Pottgen, Maja Guberina, Martin Metzenmacher, Ken Herrmann, Maja Mucha, Christoph Rischpler, Frank Indenkampen, Jens T. Siveke, Jurgen Treckmann, Lale Umutlu, Stefan Kasper, Wolfgang P. Fendler, Martin Stuschke
Summary: This study examined the impact of pretreatment and posttreatment PET/CT imaging on radiation therapy for biliary-tract-carcinomas, pancreatic-ductal-adenocarcinomas, and adenoidcystic-carcinomas. The results showed that pretreatment [Ga-68]FAPI-PET/CT enhanced radiation treatment planning, and the combination of [Ga-68]FAPI and [F-18]FDG imaging improved treatment response assessment.
SCIENTIFIC REPORTS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
R. Gallicchio, A. Nardelli, G. Calice, A. Guarini, G. Guglielmi, G. Storto
Summary: This study evaluated the prognostic significance of combined use of FDG and FLT PET/CT in MM patients, showing that PET/CT can predict patient prognosis and that FDG+; FLT- patients have better EFS compared to other groups.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Oncology
Xiaojun Xu, Xun Sun, Ling Ma, Huangqi Zhang, Wenbin Ji, Xiaotian Xia, Xiaoli Lan
Summary: This study aimed to investigate the feasibility of predicting progression-free survival (PFS) in breast cancer patients using pretreatment F-18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) radiomics signature and clinical parameters. The study found that the integrated clinical-radiomics (ICR) model, which combined clinical parameters and preoperative FDG PET/CT imaging, was able to independently predict PFS in breast cancer patients, and was superior to the clinical model alone and rad-score alone.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xiang Zhang, Falguni Basuli, Zhen-Dan Shi, Swati Shah, Jianfeng Shi, Amelia Mitchell, Jianhao Lai, Zeping Wang, Dima A. Hammoud, Rolf E. Swenson
Summary: In this study, a series of fluorine-18-labeled L-rhamnose derivatives were developed as potential PET tracers for various fungal and bacterial strains. The tracer showed good stability and renal clearance in mice, with minimal tissue and skeletal uptake and a low background signal in healthy mice.
Article
Oncology
Matthew L. Scarpelli, Debbie R. Healey, Shwetal Mehta, C. Chad Quarles
Summary: This study aimed to investigate the association between multiple biological factors and fluciclovine PET uptake in human glioblastoma, and found that fluciclovine PET uptake was significantly correlated with the level of the amino acid transporter ASCT2 in tumor cells, suggesting that fluciclovine PET may be useful for assessing amino acid metabolism in brain tumors.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Haodan Dang, Jinming Zhang, Ruimin Wang, Jiajin Liu, Huaping Fu, Mu Lin, Baixuan Xu
Summary: The decision-tree model of diffusion kurtosis imaging (DKI) and C-11-methionine (C-11-MET) PET shows potential in differentiating radiotherapy (RT) injury from glioblastoma recurrence. The combined model demonstrates the best diagnostic accuracy.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Oncology
Suk-Hyun Lee, Jee-Soo Park, Hyunjeong Kim, Dongwoo Kim, Seung-Hwan Lee, Won-Sik Ham, Woong-Kyu Han, Young-Deuk Choi, Mijin Yun
Summary: The heterogeneous uptake of both F-18 FDG and C-11 methionine on PET/CT in renal cell carcinomas is associated with higher grades of cancer. The metabolic tumour volume on F-18 FDG PET/CT but not C-11 methionine PET/CT is significant in predicting advanced-stage renal cell carcinoma. These metabolic features derived from PET/CT imaging may aid in the development of new drugs targeting glucose and amino acid metabolic pathways.
Article
Neurosciences
Ravichandran Rajkumar, Ezequiel Farrher, Joerg Mauler, Praveen Sripad, Claudia Regio Brambilla, Elena Rota Kops, Juergen Scheins, Juergen Dammers, Christoph Lerche, Karl-Josef Langen, Hans Herzog, Bharat Biswal, N. Jon Shah, Irene Neuner
Summary: This study utilized trimodal PET/MRI/EEG data to explore brain functional states. The results showed a significant positive correlation between microstate C and the DC metric, indicating a functional relationship between different brain regions.
HUMAN BRAIN MAPPING
(2021)
Article
Clinical Neurology
Ann Kristin Schmitz, Ruediger Sorg, Gabriele Stoffels, Oliver M. Grauer, Norbert Galldiks, Hans-Jakob Steiger, Marcel A. Kamp, Karl-Josef Langen, Michael Sabel, Marion Rapp
Summary: This study analyzed the impact of additional F-18-FET PET imaging following dendritic cell vaccination therapy for glioblastoma patients, showing that F-18-FET PET may have an additional impact on monitoring treatment outcome, especially in cases where it indicated treatment related changes that were not detected by MRI.
BRITISH JOURNAL OF NEUROSURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Norbert Galldiks, Diana S. Y. Abdulla, Matthias Scheffler, Fabian Wolpert, Jan-Michael Werner, Martin Huellner, Gabriele Stoffels, Viola Schweinsberg, Max Schlaak, Nicole Kreuzberg, Jennifer Landsberg, Philipp Lohmann, Garry Ceccon, Christian Baues, Maike Trommer, Eren Celik, Maximilian Ruge, Martin Kocher, Simone Marnitz, Gereon R. Fink, Joerg-Christian Tonn, Michael Weller, Karl-Josef Langen, Juergen Wolf, Cornelia Mauch
Summary: The study showed that F-18-FET PET is valuable for treatment monitoring in patients with brain metastasis undergoing ICI or TT, assisting in distinguishing between metastasis relapse and treatment-related changes, and providing valuable information in assessing metabolic responses to ICI or TT.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Eike Steidl, Karl-Josef Langen, Sarah Abu Hmeidan, Nenad Polomac, Christian P. Filss, Norbert Galldiks, Philipp Lohmann, Fee Keil, Katharina Filipski, Felix M. Mottaghy, Nadim Jon Shah, Joachim P. Steinbach, Elke Hattingen, Gabriele D. Maurer
Summary: The retrospective analysis evaluated the diagnostic value of consecutive PWI and [F-18]FET PET, showing that the combination of both methods can improve overall accuracy. Under specific conditions, PWI outperformed [F-18]FET PET for certain tumors. These results emphasize the importance of sequential use of PWI and [F-18]FET PET in clinical diagnosis.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Neurosciences
Anna Weller, Gerard N. Bischof, Philipp Schlueter, Nils Richter, Julian Dronse, Oezguer Onur, Bernd Neumaier, Juraj Kukolja, Karl-Josef Langen, Gereon Fink, Angela Kunoth, Yaping Shao, Thilo van Eimeren, Alexander Drzezga
Summary: The study revealed a reorganization of functional connectome communities in Alzheimer's disease patients, resulting in lower overall efficiency and higher tau pathology burden in nodes tending to leave communities. This suggests a correlation between local tau pathology in AD and fundamental changes in basic organizational principles of the human connectome.
BRAIN CONNECTIVITY
(2021)
Article
Biochemistry & Molecular Biology
Julia Post, Vanessa Kogel, Anja Schaffrath, Philipp Lohmann, N. Jon Shah, Karl-Josef Langen, Dieter Willbold, Antje Willuweit, Janine Kutzsche
Summary: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with neuroinflammation playing a key role in its pathogenesis. A treatment study using RD2RD2 in a transgenic mouse model of ALS showed reduction of astrocytes and microglia activation, rescue of neurons, and slowed disease progression, making RD2RD2 a potential therapeutic candidate against ALS.
Article
Geriatrics & Gerontology
Nils Nellessen, Oezguer A. Onur, Nils Richter, Heidi I. L. Jacobs, Kim N. H. Dillen, Boris von Reutern, Karl J. Langen, Gereon R. Fink, Juraj Kukolja
Summary: In individuals with subjective cognitive decline (SCD), memory complaints are associated with sub-clinical depression and executive functions rather than memory performance. Additionally, memory complaints in SCD are correlated with higher gray matter density in specific brain regions. The study did not find evidence of early neurodegeneration in SCD, but identified sub-clinical depression as a potential underlying factor for subjective cognitive complaints.
NEUROBIOLOGY OF AGING
(2021)
Article
Oncology
Martin Kocher, Christiane Jockwitz, Philipp Lohmann, Gabriele Stoffels, Christian Filss, Felix M. Mottaghy, Maximilian I. Ruge, Carolin Weiss Lucas, Roland Goldbrunner, Nadim J. Shah, Gereon R. Fink, Norbert Galldiks, Karl-Josef Langen, Svenja Caspers
Summary: This study used structural MRI and amino acid PET in conjunction with brain atlases and elastic registration techniques to investigate the impact of treatment-related brain damage on cognitive functioning in well-functioning WHO Grade III/IV glioma patients. The results showed that T2/FLAIR hyperintensities caused by radiation therapy significantly impaired cognitive performance, especially affecting the left hemisphere functional nodes and fiber tracts, which were highly correlated with verbal episodic memory dysfunction.
Article
Biochemistry & Molecular Biology
Julia Post, Anja Schaffrath, Ian Gering, Sonja Hartwig, Stefan Lehr, N. Jon Shah, Karl-Josef Langen, Dieter Willbold, Janine Kutzsche, Antje Willuweit
Summary: The study demonstrates that RD2RD2 has therapeutic potential in SOD1(G93A) mice, significantly improving performance in behavioral and motor coordination tests and slowing the progression of neurodegenerative phenotype. Additionally, treatment of SOD1(G93A) mice leads to a significant reduction in glial cell activation and rescue of neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Letter
Clinical Neurology
Francesco Cicone, Karl-Josef Langen, Giuseppe Minniti
WORLD NEUROSURGERY
(2021)
Article
Biochemistry & Molecular Biology
Luana Cristina Camargo, Dominik Honold, Robert Bauer, N. Jon Shah, Karl-Josef Langen, Dieter Willbold, Janine Kutzsche, Antje Willuweit, Sarah Schemmert
Summary: Research on the Tau-P301L mouse model revealed that male mice exhibit olfactory and motor deficits, increased Tau pathology, while female mice did not show these changes. Both male and female Tau-P301L mice showed phenotypic alterations, as well as cognitive deficits in behavioral tests.
Article
Biochemistry & Molecular Biology
Katharina Wintz, Julia Post, Karl-Josef Langen, Dieter Willbold, Antje Willuweit, Janine Kutzsche
Summary: Amyotrophic lateral sclerosis (ALS) is a deadly disease with no cure, causing complete muscle loss and respiratory arrest. Only three symptomatic drugs have been approved by the FDA so far. RD2RD2, a new drug candidate, has shown the ability to delay symptom onset in mouse models of ALS.
Review
Oncology
Karl-Josef Langen, Norbert Galldiks, Joerg Mauler, Martin Kocher, Christian Peter Filss, Gabriele Stoffels, Claudia Regio Brambilla, Carina Stegmayr, Antje Willuweit, Wieland Alexander Worthoff, Nadim Jon Shah, Christoph Lerche, Felix Manuel Mottaghy, Philipp Lohmann
Summary: Advanced MRI methods and PET using radiolabelled amino acids provide valuable additional information for brain tumour diagnostics. While the hybrid PET/MRI has allowed for the convergence of these methods, simultaneous imaging has limited relevance in clinical neuro-oncology. A multimodal approach that combines PET and MRI shows promising improvement in the diagnosis of cerebral gliomas.
Article
Radiology, Nuclear Medicine & Medical Imaging
Garry Ceccon, Philipp Lohmann, Jan-Michael Werner, Caroline Tscherpel, Veronika Dunkl, Gabriele Stoffels, Jurij Rosen, Marion Rapp, Michael Sabel, Ulrich Herrlinger, Niklas Schaefer, Nadim J. Shah, Gereon R. Fink, Karl-Josef Langen, Norbert Galldiks
Summary: Changes in F-18-FET PET parameters were found to be helpful for early identification of responders to adjuvant TMZ therapy, predicting prolonged progression-free survival (PFS) and overall survival (OS). These changes were independent of other strong prognostic factors, suggesting their potential clinical utility in glioma patients.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Computer Science, Interdisciplinary Applications
Christoph W. Lerche, Timon Radomski, Philipp Lohmann, Liliana Caldeira, Claudia Regio Brambilla, Lutz Tellmann, Juergen Scheins, Elena Rota Kops, Norbert Galldiks, Karl-Josef Langen, Hans Herzog, N. Jon Shah
Summary: A linearized model for dynamic PET scans of F-18-FET TACs was derived and validated in this study, showing high agreement with measured TACs and small parameter uncertainties. The model demonstrated good diagnostic performance in discriminating between IDH wildtype and IDH mutant gliomas in adult patients. Voxel-wise fitting within a short computation time and comparable classification accuracy to linear fits based on average TAC values were achievable.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2021)
