Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaofeng Jiang, Hengyu Zhao, Oliver Lester Saldanha, Sven Nebelung, Christiane Kuhl, Iakovos Amygdalos, Sven Arke Lang, Xiaojian Wu, Xiaochun Meng, Daniel Truhn, Jakob Nikolas Kather, Jia Ke
Summary: A deep learning model based on preoperative MRI scans was developed and validated to predict survival in patients with rectal cancer.
Article
Multidisciplinary Sciences
David Paul Peschel, Mathias Duesberg, Jan C. Peeken, Jan Christian Kaiser, Kai Joachim Borm, Katharina Sommer, Stephanie E. Combs, Stefan Muench
Summary: This dosimetric study evaluated the extent of incidental nodal irradiation in patients with esophageal squamous cell carcinoma undergoing definitive chemoradiotherapy. The results showed that volumetric-modulated arc therapy was associated with significantly lower doses to regional lymph node areas compared to three-dimensional conformal radiotherapy.
SCIENTIFIC REPORTS
(2022)
Article
Surgery
R. E. Clifford, D. Harji, L. Poynter, R. Jackson, R. Adams, N. S. Fearnhead, D. Vimalachandran
Summary: The high mortality rate in rectal cancer patients with COVID-19 has prompted the adoption of alternative treatment strategies. The ReCaP study aims to study these variations and associated outcomes.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Medicine, General & Internal
Xu Guan, Ran Wei, Runkun Yang, Zhao Lu, Enrui Liu, Zhixun Zhao, Haipeng Chen, Ming Yang, Zheng Liu, Zheng Jiang, Xishan Wang
Summary: Radiotherapy for rectal cancer is associated with an increased risk of developing cancer of the uterine corpus and ovarian cancer, leading to lower survival rates. Special attention should be given to reducing the occurrence of radiotherapy-associated SGMNs and improving prognosis.
Article
Medicine, General & Internal
Deborah Schrag, Qian Shi, Martin R. Weiser, Marc J. Gollub, Leonard B. Saltz, Benjamin L. Musher, Joel Goldberg, Tareq Al Baghdadi, Karyn A. Goodman, Robert R. McWilliams, Jeffrey M. Farma, Thomas J. George, Hagen F. Kennecke, Ardaman Shergill, Michael Montemurro, Garth D. Nelson, Brian Colgrove, Vallerie Gordon, Alan P. Venook, Eileen M. O'Reilly, Jeffrey A. Meyerhardt, Amylou C. Dueck, Ethan Basch, George J. Chang, Harvey J. Mamon
Summary: Preoperative FOLFOX chemotherapy is as effective as preoperative chemoradiotherapy for locally advanced rectal cancer eligible for sphincter-sparing surgery.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Oncology
Wei-Wei Xiao, Min Li, Zhi-Wei Guo, Rong Zhang, Shao-Yan Xi, Xiang-Guo Zhang, Yong Li, De-Qing Wu, Yu-Feng Ren, Xiao-Lin Pang, Xiang-Bo Wan, Kun Li, Chun-Lian Zhou, Xiang-Ming Zhai, Zhi-Kun Liang, Qiao-Xuan Wang, Zhi-Fan Zeng, Hui-Zhong Zhang, Xue-Xi Yang, Ying-Song Wu, Ming Li, Yuan-Hong Gao
Summary: The PGS-LARC model is a reliable predictive tool for pCR in LARC patients, showing superior predictive performance compared to clinical factors. For patients with clinical complete response (cCR), the positive prediction value is 94.7%.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Editorial Material
Medicine, General & Internal
Hanna K. Sanoff
Summary: The cure rate for nonmetastatic rectal cancer has been improving over the years, with surgery, radiation therapy, and chemotherapy being the routine treatment. Recent studies have shown that adding multiagent chemotherapy to radiation therapy before proctectomy can significantly increase the 3-year disease-free survival rate. However, this treatment approach also comes with severe long-term sequelae.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Oncology
Hagen F. Kennecke, Henry T. Bahnson, Bruce Lin, Colin O'Rourke, Jennifer Kaplan, Huong Pham, Andrew Suen, Vlad V. Simianu
Summary: This study analyzed the changes in treatment patterns of rectal cancer patients and their association with pathological stage and survival rate, showing a shift towards preoperative chemotherapy/radiation therapy (C/RT) and lower pathological stage was associated with improved overall survival in stage 2/3 rectal cancers.
Article
Oncology
Chavelli M. Kensen, Tomas M. Janssen, Anja Betgen, Lisa Wiersema, Femke P. Peters, Peter Remeijer, Corrie A. M. Marijnen, Uulke A. van der Heide
Summary: This study investigates the potential benefit of intrafraction motion monitoring and a second adaptation in rectal cancer patients undergoing online adaptive MRI-guided radiotherapy. The results suggest that performing a second adaptation when motion exceeds 1mm and 4mm for CTVmeso and GTV(prim) respectively could result in a 30-50% reduction in PTV margins, with limited reduction in dose to the bowel.
RADIATION ONCOLOGY
(2022)
Article
Oncology
Peter S. N. van Rossum, Celia Juan-Cruz, Barbara Stam, Maddalena M. G. Rossi, Steven H. Lin, Azadeh Abravan, Jose S. A. Belderbos, Jan-Jakob Sonke
Summary: The study aimed to externally validate lymphopenia prediction models developed at The Christie and MD Anderson Cancer Center in patients with stage III NSCLC. The results showed that the PTV-based MDACC model demonstrated superior performance in predicting severe RIL compared to the dosimetry-based Christie model.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Vedang Murthy, Ketaki Adsul, Priyamvada Maitre, Aarushi Singla, Pallavi Singh, Gitanjali Panigrahi, Vysakh Raveendran, Reena Phurailatpam
Summary: This study compared the urinary and gastrointestinal adverse effects in patients with prostate cancer treated with extreme hypofractionated stereotactic radiation therapy with or without inclusion of pelvic nodal regions. The results showed that overall, WP-SBRT was associated with significantly higher rates of acute gastrointestinal toxic effects and late urinary adverse effects compared with PO-SBRT.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Victor Duque-Santana, Fernando Lopez-Campos, Margarita Martin-Martin, Mireia Valero, Juan Zafra-Martin, Felipe Counago, Sonsoles Sancho
Summary: In patients with locally advanced rectal adenocarcinoma, NLR and PLR can be considered as prognostic factors for DFS after nCRT.
Article
Surgery
Stefi Nordkamp, Eva L. K. Voogt, Desley M. G. van Zoggel, Anna Martling, Torbjorn Holm, Gabriella Jansson Palmer, Chikako Suzuki, Joost Nederend, Miranda Kusters, Jacobus W. A. Burger, Harm J. T. Rutten, Henrik Iversen
Summary: No standard of care has been defined in the treatment of locally recurrent rectal cancer due to its heterogeneous nature, low incidence, and varied treatment options. This study compared data from two tertiary hospitals and found that aiming for wide resection margins increased the R0 resection rate and local re-recurrence-free survival. Neoadjuvant full-course chemoradiotherapy improved survival, while reirradiation showed no benefit.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Multidisciplinary Sciences
Saori Tatsuno, Hiroshi Doi, Wataru Okada, Eri Inoue, Kiyoshi Nakamatsu, Masao Tanooka, Masahiro Tanaka, Yasumasa Nishimura
Summary: The risk factors for severe radiation pneumonitis (RP) in patients with lung cancer who undergo rotating gantry intensity-modulated radiation therapy (IMRT) using volumetric modulated arc therapy (VMAT) or helical tomotherapy (HT) are poorly understood. This retrospective study included 52 patients who received rotating gantry IMRT for locally advanced lung cancer. In multivariate analysis, lung V5 >= 40% was associated with grade >= 2 RP, and past medical history of pneumonectomy and total lung volume <= 3260 cc were independently associated with grade >= 3 RP.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Aswin George Abraham, Nawaid Usmani, Brad Warkentin, JoAnn Thai, Jihyun Yun, Sunita Ghosh, Winson Cheung, Yuan Xu, Tirath Nijjar, Diane Severin, Keith Tankel, Alysa Fairchild, Kurian Joseph
Summary: This study aimed to identify dosimetric parameters predicting late small bowel toxicity after neoadjuvant long course chemoradiation for rectal cancer. Results showed a significant dose-volume relationship between the volume of small bowel receiving 30 Gy and late grade >= 3 small bowel toxicity. Restricting the volume of small bowel receiving at least 30 Gy to <200 cm(3) is a useful guideline to minimize 5 year grade >= 3 late small bowel toxicity to <5%.
PRACTICAL RADIATION ONCOLOGY
(2021)