Article
Oncology
Yilin Cao, Vishwa S. Parekh, Emerson Lee, Xuguang Chen, Kristin J. Redmond, Jay J. Pillai, Luke Peng, Michael A. Jacobs, Lawrence R. Kleinberg
Summary: We propose a new framework called tumor connectomics, which combines complex graph theory and multiparametric radiomics, to distinguish radiation necrosis (RN) from true progression (TP) in brain metastases. Our method utilizes MRI-based features, clinical and treatment factors, and machine-learning techniques to achieve accurate classification. The combined features of connectomics and radiomics achieved high sensitivity, specificity, and AUC values in distinguishing TP from RN.
Article
Oncology
Francesco Cicone, Luciano Carideo, Claudia Scaringi, Andrea Romano, Marcelo Mamede, Annalisa Papa, Anna Tofani, Giuseppe Lucio Cascini, Alessandro Bozzao, Francesco Scopinaro, Giuseppe Minniti
Summary: In this study, the long-term metabolic evolution of radiation necrosis (RN) in brain metastases patients following stereotactic radiosurgery (SRS) was characterized using sequential PET/CT imaging with F-DOPA. It was found that F-DOPA uptake parameters increased over time in lesions with local progression (LP) while remaining stable in RN lesions. F-DOPA PET showed high diagnostic accuracy for assessing the long-term evolution of brain metastases following SRS.
Review
Oncology
Francois Lucia, Ruben Touati, Nicolae Crainic, Gurvan Dissaux, Olivier Pradier, Vincent Bourbonne, Ulrike Schick
Summary: Approximately 30% of cancer patients will develop brain metastases, leading to local recurrence post intracranial stereotactic radiotherapy. Advances in cancer treatments have increased overall survival, but also local failures (LF) after SRS/SRT. Second courses of SRS or SRT may be used to treat LF, with factors affecting efficacy including histology, tumor size, and prior treatments. Prospective studies with more patients are needed to determine the best management of brain metastases recurrence.
Article
Oncology
J. A. Crouzen, A. L. Petoukhova, M. L. D. Broekman, M. Fiocco, U. J. Fisscher, J. H. Franssen, C. G. M. Gadellaa-van Hooijdonk, M. Kerkhof, M. Kiderlen, M. E. Mast, C. M. van Rij, R. Nandoe Tewarie, M. A. E. van de Sande, P. P. G. van der Toorn, R. Vlasman, M. J. Vos, N. C. M. G. van der Voort van Zyp, R. G. J. Wiggenraad, L. M. Wiltink, J. D. Zindler
Summary: A multicenter prospective randomized study aims to compare the incidence of adverse local events in patients with brain metastases using fractionated stereotactic radiosurgery (fSRS) versus stereotactic radiosurgery (SRS) in one or three fractions. The study aims to reduce the risk of radionecrosis and improve the effectiveness of brain metastases treatment.
Article
Oncology
Alejandro Bugarini, Evan Meekins, Joshua Salazar, Andrea L. Berger, Michel Lacroix, Edward A. Monaco III, Andrew R. Conger, Anand Mahadevan
Summary: Neoadjuvant stereotactic radiosurgery (SRS) may reduce the incidence of radionecrosis (RN) and decrease radiation to normal tissue in patients with cerebral metastatic disease. A retrospective analysis of 47 brain metastases patients showed that neoadjuvant SRS was associated with reduced radiotherapy doses, improved conformality profile, and decreased radiation to normal tissue, supporting its use in the treatment of brain metastases.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Oncology
Tyler Gutschenritter, Vyshak A. Venur, Stephanie E. Combs, Balamurugan Vellayappan, Anoop P. Patel, Matthew Foote, Kristin J. Redmond, Tony J. C. Wang, Arjun Sahgal, Samuel T. Chao, John H. Suh, Eric L. Chang, Richard G. Ellenbogen, Simon S. Lo
Summary: This article discusses the use of novel treatment techniques such as hypofractionated stereotactic radiotherapy (HSRT) and pre-operative SRS for large brain metastases, which can improve local control rates and reduce the occurrence of LMD and RN.
Article
Oncology
Fabio Y. Moraes, Alireza Mansouri, Archya Dasgupta, Matthew Ramotar, Natalya Kosyak, Jessica Weiss, Normand Laperriere, Barbara-Ann Millar, Alejandro Berlin, Tatiana Conrad, Monique van Prooijen, Robert Heaton, Catherine Coolens, Jeff Winter, Mark Bernstein, Gelareh Zadeh, Paul Kongkham, Mark Doherty, David B. Shultz
Summary: Patients with EGFR-mutated non-small cell lung cancer are at particularly high risk of developing brain metastases. In this study, we evaluated the response and toxicity of EGFR-mutated and EGFR-wild-type brain metastases treated with radiosurgery. The results showed excellent rates of response and toxicity following radiosurgery in EGFR-mutated compared to EGFR-wild-type NSCLC, suggesting a favourable risk benefit ratio in EGFR-mutated brain metastases.
Article
Clinical Neurology
Raj Singh, Greg Bowden, David Mathieu, Haley K. Perlow, Joshua D. Palmer, Shahed Elhamdani, Matthew Shepard, Yun Liang, Ahmed M. Nabeel, Wael A. Reda, Sameh R. Tawadros, Khaled Abdelkarim, Amr M. N. El-Shehaby, Reem M. Emad, Ahmed Hesham Elazzazi, Ronald E. Warnick, Yair M. Gozal, Megan Daly, Brendan McShane, Marcel Addis-Jackson, Gokul Karthikeyan, Sian Smith, Piero Picozzi, Andrea Franzini, Tehila Kaisman-Elbaz, Huai-che Yang, Zhishuo Wei, Andrew Legarreta, Judith Hess, Kelsey Templeton, Stylianos Pikis, Georgios Mantziaris, Gabriela Simonova, Roman Liscak, Selcuk Peker, Yavuz Samanci, Veronica Chiang, Ajay Niranjan, Charles R. Kersh, Cheng-Chia Lee, Daniel M. Trifiletti, L. Dade Lunsford, Jason P. Sheehan
Summary: Limited data is available regarding outcomes for GI primaries patients with brain metastases treated with SRS. This study aimed to examine the clinical outcomes of SRS for patients with brain metastases from GI primaries and evaluate potential prognostic factors. SRS resulted in comparable LC with common primaries. Age and KPS were associated with both LC and OS, and planning target volume and extracranial metastases were correlated with LC and OS, respectively. These factors should be considered in selecting GI cancer patients for SRS.
Article
Oncology
Marta Scorsetti, Pierina Navarria, Luca Cozzi, Elena Clerici, Luisa Bellu, Davide Franceschini, Antonio Marco Marzo, Ciro Franzese, Valter Torri, Giacomo Reggiori, Francesca Lobefalo, Luca Raspagliesi, Luca Attuati, Federico Pessina, Andrea Franzini, Piero Picozzi, Stefano Tomatis
Summary: This study compared two radiosurgery modalities for treating brain metastases from solid tumors and found no significant differences in survival rate and local control between the two methods.
RADIATION ONCOLOGY
(2023)
Article
Clinical Neurology
Yunqi Yang, Aihua Niu, Zhiming Zheng, Yingchao Liu, Qiang Wang, Yang Ming, Yi Zhang
Summary: This study investigated the perfusion condition of preliminary hyperperfusion and hypoperfusion brain metastases when they recur, as well as the performance of quantitative DSC-PWI in distinguishing between the two types of metastases. The results showed that qCBV is feasible to differentiate radionecrosis and recurrence in both groups.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Lauren Andring, Bryan Squires, Zachary Seymour, Daniel Fahim, Jeffrey Jacob, Hong Ye, Kimberly Marvin, Inga Grills
Summary: This study assessed the rates of radionecrosis (RN) in patients receiving immunotherapy (IT) and stereotactic radiosurgery (SRS) for brain metastases. The results showed that patients who received IT and SRS had acceptably low rates of RN. The timing of IT did not predict for RN. Further investigation is needed to determine the risk of RN with combined SRS and IT.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2023)
Article
Oncology
Justin Leu, Meredith Akerman, Christopher Mendez, Jonathan W. Lischalk, Todd Carpenter, David Ebling, Jonathan A. Haas, Matthew Witten, Marissa Barbaro, Paul Duic, Lee Tessler, Michael C. Repka
Summary: This study found that stereotactic radiosurgery with concurrent immunotherapy can reduce the risk of local failure in the treatment of primary brain metastases. However, the time interval between diagnosis and treatment does not affect the incidence of radionecrosis or regional failure. Increased MRI maximum axial dimension and a history of previous whole brain radiation therapy are associated with an increased risk of radionecrosis.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Luca Nicosia, Piera Navarria, Valentina Pinzi, Martina Giraffa, Ivana Russo, Paolo Tini, Niccolo Giaj-Levra, Filippo Alongi, Giuseppe Minniti
Summary: This study evaluated the efficacy and toxicity of linear accelerator-based stereotactic radiosurgery and hypofractionated stereotactic radiotherapy in patients with brainstem metastases. The results showed that this treatment approach provided excellent local control with low toxicity and no detrimental effects on overall survival. Concurrent targeted therapy may be associated with longer survival.
RADIATION ONCOLOGY
(2022)
Article
Medicine, General & Internal
Evan D. Bander, Tarek Y. El Ahmadieh, Justin Chen, Anne S. Reiner, Samantha Brown, Alexandra M. Giantini-Larsen, Robert J. Young, Kathryn Beal, Brandon S. Imber, Luke R. G. Pike, Cameron W. Brennan, Viviane Tabar, Katherine S. Panageas, Nelson S. Moss
Summary: This study aimed to evaluate the optimal timing for adjuvant SRS following surgical resection of brain metastases. The findings suggest that performing adjuvant SRS within 22 to 30 days postoperatively can achieve a balanced approach that minimizes the risks associated with local failure and adverse radiation effects.
Article
Medicine, Research & Experimental
Benoit Calderon, Lea Vazquez, Mohammed Belkacemi, Nicolas Pourel
Summary: This study aimed to identify predictive factors of radionecrosis related to stereotactic radiotherapy (SRT) for brain metastasis. Age at treatment initiation and tumor location were found to be correlated with radionecrosis, which could be helpful in adjusting radiation therapy.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Richard Blake Ross, Shlomo A. Koyfman, Chandana A. Reddy, Narcissa Houston, Jessica L. Geiger, Neil M. Woody, Nikhil P. Joshi, John F. Greskovich, Brian B. Burkey, Joseph Scharpf, Eric D. Lamarre, Brandon Prendes, Robert R. Lorenz, David J. Adelstein, Matthew C. Ward
Article
Oncology
Neil M. Woody, Matthew D. Greer, Chandana A. Reddy, Gregory M. M. Videtic, Samuel T. Chao, Erin S. Murphy, John H. Suh, Liliana Angelov, Gene H. Barnett, Michael A. Vogelbaum, Kevin L. Stephans
CLINICAL LUNG CANCER
(2018)
Article
Oncology
Kevin L. Stephans, Neil M. Woody, Chandana A. Reddy, Matthew Varley, Anthony Magnelli, Tingliang Zhuang, Peng Qi, Gregory M. M. Videtic
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2018)
Article
Oncology
Jimmy J. Caudell, Matthew C. Ward, Nadeem Riaz, Sara J. Zakem, Musaddiq J. Awan, Neal E. Dunlap, Derek Isrow, Comron Hassanzadeh, John A. Vargo, Dwight E. Heron, Samuel Marcrom, Drexell H. Boggs, Chandana A. Reddy, Joshua Dault, James A. Bonner, Kristin A. Higgins, Jonathan J. Beitler, Shlomo A. Koyfman, Mitchell Machtay, Min Yao, Andy M. Trotti, Farzan Siddiqui, Nancy Y. Lee
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2018)
Article
Oncology
John A. Vargo, Matthew C. Ward, Jimmy J. Caudell, Nadeem Riaz, Neal E. Dunlap, Derek Isrow, Sara J. Zakem, Joshua Dault, Musaddiq J. Awan, Kristin A. Higgins, Comron Hassanadeh, Jonathan J. Beitler, Chandana A. Reddy, Samuel Marcrom, Drexell H. Boggs, James A. Bonner, Min Yao, Mitchell Machtay, Farzan Siddiqui, Andy M. Trotti, Nancy Y. Lee, Shlomo A. Koyfman, Robert L. Ferris, Dwight E. Heron
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2018)
Article
Oncology
Matthew C. Ward, Nadeem Riaz, Jimmy J. Caudell, Neal E. Dunlap, Derek Isrow, Sara J. Zakem, Joshua Dault, Musaddiq J. Awan, John A. Vargo, Dwight E. Heron, Kristin A. Higgins, Jonathan J. Beitler, Samuel Marcrom, Drexell H. Boggs, Comron Hassanzadeh, Chandana A. Reddy, James A. Bonner, Min Yao, Mitchell Machtay, Farzan Siddiqui, Andy M. Trotti, Nancy Y. Lee, Shlomo A. Koyfman
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2018)
Article
Oncology
Kiri A. Sandler, Ryan R. Cook, Jay P. Ciezki, Ashley E. Ross, Mark M. Pomerantz, Paul L. Nguyen, Talha Shaikh, Phuoc T. Tran, Richard G. Stock, Gregory S. Merrick, D. Jeffrey Demanes, Daniel E. Spratt, Eyad I. Abu-Isa, Trude B. Wedde, Wolfgang Lilleby, Daniel J. Krauss, Grace K. Shaw, Ridwan Alam, Chandana A. Reddy, Daniel Y. Song, Eric A. Klein, Andrew J. Stephenson, Jeffrey J. Tosoian, John V. Hegde, Sun Mi Yoo, Ryan Fiano, Anthony V. D'Amico, Nicholas G. Nickols, William J. Aronson, Ahmad Sadeghi, Stephen C. Greco, Curtiland Deville, Todd McNutt, Theodore L. DeWeese, Robert E. Reiter, Jonathan W. Said, Michael L. Steinberg, Eric M. Horwitz, Patrick A. Kupelian, Christopher R. King, Amar U. Kishan
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tingliang Zhuang, Neil M. Woody, Han Liu, Sheen Cherian, Chandana A. Reddy, Peng Qi, Anthony Magnelli, Toufik Djemil, Kevin L. Stephans, Ping Xia, Gregory M. M. Videtic
JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY
(2018)
Article
Oncology
Ehsan H. Balagamwala, Jacob A. Miller, Chandana A. Reddy, Lilyana Angelov, John H. Suh, Muhammad B. Tariq, Erin S. Murphy, Kailin Yang, Toufik Djemil, Anthony Magnelli, Alireza M. Mohammadi, Sherry Soeder, Samuel T. Chao
JOURNAL OF NEURO-ONCOLOGY
(2018)
Article
Oncology
Vamsi Varra, Neil M. Woody, Chandana Reddy, Nikhil P. Joshi, Jessica Geiger, David J. Adelstein, Brian B. Burkey, Joseph Scharpf, Brandon Prendes, Eric D. Lamarre, Robert Lorenz, Brian Gastman, Bindu Manyam, Shlomo A. Koyfman
ANTICANCER RESEARCH
(2018)
Article
Oncology
Steven C. Oh, Muhammad B. Tariq, Chandana A. Reddy, Jay P. Ciezki, Kevin L. Stephans, Rahul D. Tendulkar
CLINICAL GENITOURINARY CANCER
(2019)
Article
Oncology
Ibrahim Abu-Gheida, Chandana A. Reddy, Rupesh Kotecha, Michael A. Weller, Chirag Shah, Patrick A. Kupelian, Omar Mian, Jay P. Ciezki, Kevin L. Stephans, Rahul D. Tendulkar
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2019)
Article
Oncology
Sarah M. C. Sittenfeld, Aditya Juloori, Chandana A. Reddy, Kevin L. Stephans, Gregory M. M. Videtic
Summary: The study assessed the safety and efficacy of SBRT as salvage treatment for local recurrence after surgical resection of non-small-cell lung cancer. The results showed high rates of local control and minimal toxicity, similar to definitive SBRT treatment for non-small-cell lung cancer.
CLINICAL LUNG CANCER
(2021)
Article
Oncology
Howard Yu-hao Liu, Laura Tam, Neil M. Woody, Jimmy Caudell, Chandana A. Reddy, Ahmed Ghanem, Matthew Schymick, Nikhil Joshi, Jessica Geiger, Eric Lamarre, Brian Burkey, David Adelstein, Neal Dunlap, Farzan Siddiqui, Shlomo Koyfman, Sandro Virgilio Porceddu
Summary: A study of 176 patients showed that observing the clinically node negative contralateral neck in small lateralized oral cavity squamous cell carcinoma (OCC) can be an appropriate management approach in well selected patients. However, caution should be applied when deeply invasive tumors are upstaged to T3 on the 8th edition AJCC staging.
Article
Oncology
Senthilkumar Gandhidasan, Chandana A. Reddy, Neil M. Woody, Kevin L. Stephans, Molly Freeman, Gregory M. M. Videtic
ADVANCES IN RADIATION ONCOLOGY
(2020)