Article
Oncology
Naoyuki Kanayama, Toshiki Ikawa, Shingo Ohira, Takero Hirata, Masahiro Morimoto, Kazuhiko Ogawa, Teruki Teshima, Koji Konishi
Summary: This study demonstrates that a significant reduction in brain metastases volume at 6 months post-SRT can predict local control. The dose of 80% of the gross tumor volume (GTV) D80 in the LQ model: alpha/beta = 20 may be a predictive factor for volume reduction.
Article
Oncology
Binwei Lin, Dan Huang, Huan Du, Jinjia Fan, Yu Zhang, Gang Feng, Feng Gao, Xiao Bo Du
Summary: This study compared the efficacy of whole-brain radiation therapy (WBRT) with simultaneous integrated boost (SIB) to WBRT followed by stereotactic radiosurgery (SRS) in lung cancer patients with brain metastasis. The results showed that WBRT + SIB provided a longer intracranial progression-free survival and lower incidence of progression outside the radiation field compared to WBRT + SRS, indicating better local control for brain metastasis. However, there was no significant difference in overall survival and toxicity between the two treatment groups.
FRONTIERS IN ONCOLOGY
(2021)
Article
Clinical Neurology
Diana A. Roth O'Brien, Sydney M. Kaye, Phillip J. Poppas, Sean S. Mahase, Anjile An, Paul J. Christos, Benjamin Liechty, David Pisapia, Rohan Ramakrishna, A. G. Wernicke, Jonathan P. S. Knisely, Susan C. Pannullo, Theodore H. Schwartz
Summary: This study evaluated the real-world local recurrence of all brain metastasis patients referred for adjuvant stereotactic radiosurgery (SRS) and identified predictors of SRS timing. The timing of SRS was found to be associated with local recurrence rate and LRFS, with receiving SRS within 4 weeks postoperatively potentially reducing the recurrence rate.
JOURNAL OF NEUROSURGERY
(2021)
Article
Oncology
Xiaotao Dong, Kunlun Wang, Hui Yang, Yan Li, Yanqi Hou, Jiali Chang, Ling Yuan
Summary: A retrospective review compared the efficacy of SRS and WBRT+SIB in NSCLC-BM patients, and found that WBRT+SIB may have better intracranial local control than SRS in the context of systemic drug therapy.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Francois Lucia, Ruben Touati, Nicolae Crainic, Gurvan Dissaux, Olivier Pradier, Vincent Bourbonne, Ulrike Schick
Summary: Approximately 30% of cancer patients will develop brain metastases, leading to local recurrence post intracranial stereotactic radiotherapy. Advances in cancer treatments have increased overall survival, but also local failures (LF) after SRS/SRT. Second courses of SRS or SRT may be used to treat LF, with factors affecting efficacy including histology, tumor size, and prior treatments. Prospective studies with more patients are needed to determine the best management of brain metastases recurrence.
Article
Oncology
Chan-Wei Liu, Huai-Che Yang, Chi-Lu Chiang, Chia-I. Shen, Hsiu-Mei Wu, Yung-Hung Luo, Yong-Sin Hu, Chung-Jung Lin, Wen-Yuh Chung, Cheng-Ying Shiau, Wan-Yuo Guo, David Hung-Chi Pan, Cheng-Chia Lee
Summary: This study compared the incidence of leukoencephalopathy in patients with brain metastases who received WBRT plus SRS versus those who received SRS only, and found that SRS is safe for reducing the development of leukoencephalopathy. Patient age and total tumor volume were identified as important factors in assessing the development of leukoencephalopathy. Even at a higher integral dose (> 2 J), the addition of SRS did not increase the incidence of leukoencephalopathy.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Biology
Leonie Johannwerner, Elisa M. Werner, Oliver Blanck, Stefan Janssen, Florian Cremers, Nathan Y. Yu, Dirk Rades
Summary: Based on the study, a maximum biologically effective dose (BED) of 45 Gy(12) is recommended for stereotactic radiosurgery (SRS) of brain metastases measuring 21-30 mm. However, for de novo lesions without prior brain irradiation, the tolerable BED may be higher than 45 Gy(12). This study investigated the occurrence of radiation necrosis (RN) after single-fraction SRS or fractionated stereotactic radiotherapy (FSRT) with a BED greater than 49 Gy(12) for radiotherapy-naive brain metastases. The results showed that FSRT with BED > 49 Gy(12) had a lower risk of RN for metastases larger than 20 mm and appeared to be safer than SRS for such lesions.
Article
Oncology
Alejandro Bugarini, Evan Meekins, Joshua Salazar, Andrea L. Berger, Michel Lacroix, Edward A. Monaco III, Andrew R. Conger, Anand Mahadevan
Summary: Neoadjuvant stereotactic radiosurgery (SRS) may reduce the incidence of radionecrosis (RN) and decrease radiation to normal tissue in patients with cerebral metastatic disease. A retrospective analysis of 47 brain metastases patients showed that neoadjuvant SRS was associated with reduced radiotherapy doses, improved conformality profile, and decreased radiation to normal tissue, supporting its use in the treatment of brain metastases.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Mateusz Jacek Spalek, Tomasz Mandat
Summary: Brain metastases are common in patients with breast cancer, with treatment options including surgery and radiotherapy. However, some patients may still experience intracranial progression despite local treatment. The choice of optimal treatment methods should take into consideration various factors such as patient performance status, cancer burden, toxicity, and previous therapies.
Article
Medicine, General & Internal
Jung Hyun Park, Byung Se Choi, Jung Ho Han, Chae-Yong Kim, Jungheum Cho, Yun Jung Bae, Leonard Sunwoo, Jae Hyoung Kim
Summary: Texture analysis on pre-treatment MRI of lung cancer patients with brain metastases may play a role in predicting the response to SRS. The primary tumor histology of small cell lung cancer (SCLC) and the texture feature RLN are associated with local PFS.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Clinical Neurology
Mandara M. Harikar, Tejas Venkataram, Paolo Palmisciano, Gianluca Scalia, Matias Baldoncini, Salvatore Massimiliano Cardali, Giuseppe E. Umana, Gianluca Ferini
Summary: This study compared the efficacy of fractionated stereotactic radiotherapy (FSRT) with staged stereotactic radiosurgery (SSRS) in patients with brain metastases larger than 2 cm. The results showed that both treatment modalities were comparable, but FSRT was associated with lower 12-month overall survival and higher rate of salvage radiotherapy. Further research is needed to support these findings.
WORLD NEUROSURGERY
(2023)
Article
Oncology
Christine Park, Evan D. Buckley, Amanda E. D. Van Swearingen, Will Giles, James E. E. Herndon II, John P. Kirkpatrick, Carey K. Anders, Scott R. Floyd
Summary: Patients with HER2+ breast cancer brain metastasis who receive multiple HER2-directed therapies during stereotactic radiosurgery (SRS) may be at higher risk of radiation necrosis (RN). It is recommended that, if HER2-directed therapy is medically necessary within the eight-week window around SRS administration, patients should receive a single agent.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Tian-Qi Du, Xiang Li, Wei-Si Zhong, Jian-Dong Tian, Yu-Xia Zhao, Dan Liu
Summary: For patients with brain metastasis of lung cancer, SIB-IMRT may be associated with a more favorable prognosis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Review
Oncology
Mario Levis, Alessio Gastino, Greta De Giorgi, Cristina Mantovani, Paolo Bironzo, Luca Mangherini, Alessia Andrea Ricci, Umberto Ricardi, Paola Cassoni, Luca Bertero
Summary: In the era of precision medicine, the management of brain metastases (BMs) in lung cancer patients is rapidly evolving. Advances in radiotherapy techniques, along with new systemic target therapies, are changing the therapeutic landscape in this clinical setting. The role of the tumor microenvironment in influencing treatment response is also being recognized, leading to the identification of potential prognostic and predictive biomarkers. This review provides an overview of current trends in BM treatment and discusses future perspectives based on integrated translational approaches.
Review
Surgery
Hao Deng, Botao Xiong, Yuan Gao, Yang Wu, Wei Wang
Summary: This systematic review and meta-analysis evaluated the effect of combining radiosurgery and immune checkpoint inhibitors in the treatment of brain metastasis. The results showed that combination therapy significantly improved overall survival, local control, and distant brain control compared to radiosurgery alone, but the effect varied for different pathological types.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Clinical Neurology
Stephen T. Magill, Young M. Lee, Roberto R. Rubio, Minh P. Nguyen, Carl B. Heilman, Michael W. McDermott
Summary: This study presented the technical nuances developed by two senior skull base surgeons for retrosigmoid craniectomy with reconstruction, including anatomic dissections, surgical video, and outcomes. The revised technique for retrosigmoid craniectomy with reconstruction was shown to have acceptable results.
JOURNAL OF NEUROLOGICAL SURGERY PART B-SKULL BASE
(2022)
Article
Clinical Neurology
Jonathan Giurintano, Michael W. McDermott, Ivan H. El-Sayed
Summary: This study reviewed the outcomes of nine patients with advanced anterior cranial base malignancies treated by the University of California - San Francisco minimally invasive skull base service from 2011 to 2017. Each patient underwent reconstruction of the anterior cranial base defect using a vascularized pericranial flap obtained through bicoronal incision and tunneled anteriorly to the nasal cavity through a frontoethmoidal incision.
JOURNAL OF NEUROLOGICAL SURGERY PART B-SKULL BASE
(2022)
Article
Clinical Neurology
Jennifer Vermilion, Erika F. Augustine, Heather R. Adams, Amy Vierhile, Alyssa T. Collins, Michael P. McDermott, Thomas G. O'Connor, Roger Kurlan, Edwin van Wijngaarden, Jonathan W. Mink
Summary: The study found no significant differences in risky behaviors between youth with TS and control youth, but ADHD was more common in youth with TS, and those who were bullied in school had higher ADHD symptom severity scores.
PEDIATRIC NEUROLOGY
(2022)
Article
Veterinary Sciences
Michael P. McDermott, Malcolm A. Cobb, Iain J. Robbe, Rachel S. Dean
Summary: This study aimed to analyze the frequency and types of dialogue directed to animals by veterinary surgeons in routine companion animal consultations. The results showed that pet-directed speech was present in all consultations, with codes such as 'praise,' 'small talk,' and 'explanation' being the most common.
Article
Clinical Neurology
Daniel D. Cummins, Ramin A. Morshed, Miguel M. Chavez, Lauro N. Avalos, Vivek Sudhakar, Jason E. Chung, Aaron Gallagher, Satvir Saggi, Mariza Daras, Steve Braunstein, Philip Theodosopoulos, Michael W. McDermott, Manish K. Aghi
Summary: Salvage surgery may be effective in controlling brain metastases after previous stereotactic radiosurgery (SRS), especially when combined with adjuvant therapies such as brachytherapy and repeat SRS. Presence of extracranial malignancy is associated with shorter survival.
WORLD NEUROSURGERY
(2022)
Article
Health Care Sciences & Services
Chris K. Kim, Ji Whae Choi, Zhicheng Jiao, Dongcui Wang, Jing Wu, Thomas Y. Yi, Kasey C. Halsey, Feyisope Eweje, Thi My Linh Tran, Chang Liu, Robin Wang, John Sollee, Celina Hsieh, Ken Chang, Fang-Xue Yang, Ritambhara Singh, Jie-Lin Ou, Raymond Y. Huang, Cai Feng, Michael D. Feldman, Tao Liu, Ji Sheng Gong, Shaolei Lu, Carsten Eickhoff, Xue Feng, Ihab Kamel, Ronnie Sebro, Michael K. Atalay, Terrance Healey, Yong Fan, Wei-Hua Liao, Jianxin Wang, Harrison X. Bai
Summary: The study developed a diagnostic model for the detection and evaluation of COVID-19 pneumonia, integrating it into an automated triage pipeline. By collecting a large number of chest X-rays and related data, the study demonstrated the value of the pipeline through assessing the model's generalizability and comparing it with traditional radiologist interpretation.
NPJ DIGITAL MEDICINE
(2022)
Correction
Gastroenterology & Hepatology
Jamison Seabury, Jennifer Weinstein, Spencer Rosero, Anika Varma, Ellen Wagner, Christine Zizzi, Nuran Dilek, Michael McDermott, Aaron Kaat, Lawrence Saubermann, Larissa Temple, Scott Rogoff, Chad Heatwole
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Editorial Material
Medicine, General & Internal
Mary M. McDermott
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Cell Biology
Flora Magnotti, Daria Chirita, Sarah Dalmon, Amandine Martin, Pauline Bronnec, Jeremy Sousa, Olivier Helynck, Wonyong Lee, Daniel L. Kastner, Jae Jin Chae, Michael F. McDermott, Alexandre Belot, Michel Popoff, Pascal Seve, Sophie Georgin-Lavialle, Helene Munier-Lehmann, Tu Anh Tran, Ellen De Langhe, Carine Wouters, Yvan Jamilloux, Thomas Henry
Summary: This study identifies an unconventional activation mechanism of the pyrin inflammasome and explains the impact of endogenous steroid catabolites on autoinflammation, providing an explanation for steroid fever after steroid injection.
Article
Oncology
Sana Abbasi, Helia Rivand, Fatemeh Eshaghi, Mohammad Amin Moosavi, Saeid Amanpour, Michael F. Mcdermott, Marveh Rahmati
Summary: This study aimed to sensitize colorectal cancer cells to chemotherapy by targeting the IRE1a/XBP1 pathway. The results showed that the IRE1a inhibitor 4 mu 8C inhibited CRC cell growth and enhanced the cytotoxicity of 5-FU. In vivo experiments demonstrated that 4 mu 8C inhibited tumor growth and significantly enhanced drug responses when combined with 5-FU.
Letter
Hematology
Adam Al-Hakim, Alyssa Cull, Joanna Topping, Fatima Nadat, Joanna Milek, Razan F. Alhefzi, Michael F. McDermott, Roger Owen, Catherine Cargo, James G. Poulter, David G. Kent, Sinisa Savic, ImmunAID Consortium
Article
Clinical Neurology
Maria R. H. Castro, Stephen T. Magill, Ramin A. Morshed, Jacob S. Young, Steve E. Braunstein, Michael W. McDermott, Edward F. Chang
Summary: Most patients with facial sensory symptoms caused by meningiomas or vestibular schwannomas (VSs) experienced improvement after tumor resection. Surgery led to immediate and sustained improvement in pain and paresthesias, whereas numbness was slower to improve. Patients with smaller tumors and complete decompression of the trigeminal nerve were more likely to experience improvement in facial pain.
JOURNAL OF NEUROSURGERY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Jamison Seabury, Jennifer Weinstein, Spencer Rosero, Anika Varma, Ellen Wagner, Christine Zizzi, Nuran Dilek, Michael McDermott, Aaron Kaat, Lawrence Saubermann, Larissa Temple, Scott Rogoff, Chad Heatwole, Zach Rose
Review
Clinical Neurology
Ramin A. Morshed, Nicole T. Jiam, Elaina J. Wang, Stephen T. Magill, Renata M. Knoll, Elliott D. Kozin, Philip Theodosopoulos, Steven W. Cheung, Jeffrey D. Sharon, Michael W. McDermott
Summary: This study found that posterior fossa meningiomas involving the endolymphatic sac can cause Meniere's syndrome. Early recognition and microsurgical excision of these tumors are crucial for relieving most symptoms and stabilizing hearing loss.
JOURNAL OF NEUROSURGERY
(2022)
Article
Clinical Neurology
Zachary A. Seymour, Jason W. Chan, Michael W. McDermott, Inga Grills, Hong Ye, Hideyuki Kano, Craig A. Lehocky, Rachel C. Jacobs, L. Dade Lunsford, Tomas Chytka, Roman Liscak, Cheng-Chia Lee, Huai-Che Yang, Dale Ding, Jason P. Sheehan, Caleb E. Feliciano, Rafael Rodriguez-Mercado, Veronica L. Chiang, Judith A. Hess, Samuel Sommaruga, Brendan McShane, John Y. K. Lee, Lucas T. Vasas, Anthony M. Kaufmann, Penny K. Sneed
Summary: The study is a multicentered retrospective review of 257 patients treated with volume-staged stereotactic radiosurgery (VS-SRS) for arteriovenous malformations (AVMs). The results showed that size remains the dominant predictor of toxicity following SRS, but overall rates of symptomatic adverse radiation effects (AREs) were lower than anticipated, suggesting dissociation of dose and size through volume staging. Further techniques need to be assessed to optimize outcomes.
JOURNAL OF NEUROSURGERY
(2022)