Review
Oncology
Raphael Bodensohn, Sebastian H. Maier, Claus Belka, Giuseppe Minniti, Maximilian Niyazi
Summary: In the past year, there have been improvements in cancer treatment, especially for cancers that have spread throughout the body. However, treating tumors that spread to the brain, causing brain metastases, is still a challenge. Local treatments like stereotactic radiosurgery are important for addressing brain metastases.
Article
Oncology
Valeria Faccenda, Denis Panizza, Valerio Pisoni, Sara Trivellato, Martina Camilla Daniotti, Sofia Paola Bianchi, Elena De Ponti, Stefano Arcangeli
Summary: This study investigated the efficacy of linac-based SRS/fSRS treatments using the single-isocenter coplanar FFF-VMAT technique for single and multiple BM. Analysis of patient cases showed that for single BM patients, GTV D95% was rarely reduced by more than 5%, while reductions of PTV D95% greater than 1% only occurred in 11 cases (29%). For multiple BM patients, dose deficits of >5% and >1% were observed in 2 GTV (2%) and 34 PTV (37%), respectively.
Article
Oncology
Yucel Saglam
Summary: The study found that compared to Volumetric Modulated Arc Therapy (VMAT), Weight Optimized Dynamic Conformal Arc (WO-DCA) therapy has higher delivery efficiency and better plan quality for the treatment of very small brain metastases.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2023)
Article
Oncology
Takaya Yamamoto, Yu Katagiri, Yoko Tsukita, Haruo Matsushita, Rei Umezawa, Yoshiyuki Katsuta, Noriyuki Kadoya, Noriyoshi Takahashi, Yu Suzuki, Kazuya Takeda, Keita Kishida, So Omata, Eisaku Miyauchi, Ryota Saito, Keiichi Jingu
Summary: This study evaluated the efficacy of a risk-adapted strategy of SRS for lung cancer, and the results showed a low rate of 3-year local recurrence and tolerable toxicity.
Article
Oncology
F. Deodato, D. Pezzulla, S. Cilla, M. Ferro, R. Giannini, C. Romano, M. Boccardi, M. Buwenge, V. Valentini, A. G. Morganti, G. Macchia
Summary: This study reports the final results of a dose-escalation study of VMAT-SRS boost in patients with spine metastases. The study found that a 12 Gy dose of SRS boost after 25 Gy to the affected and adjacent vertebrae resulted in excellent local control and survival rates without significant toxicity.
Article
Oncology
Naoyuki Kanayama, Toshiki Ikawa, Shingo Ohira, Takero Hirata, Masahiro Morimoto, Kazuhiko Ogawa, Teruki Teshima, Koji Konishi
Summary: This study demonstrates that a significant reduction in brain metastases volume at 6 months post-SRT can predict local control. The dose of 80% of the gross tumor volume (GTV) D80 in the LQ model: alpha/beta = 20 may be a predictive factor for volume reduction.
Article
Oncology
Jiuling Shen, Zhitao Dai, Jing Yu, Qingqing Yuan, Kailian Kang, Cheng Chen, Hui Liu, Conghua Xie, Xiaoyong Wang
Summary: The aim of this study was to investigate the impact of collimator angle optimization in single-isocenter coplanar volumetric modulated arc therapy (VMAT) stereotactic radiosurgery (SRS) for multiple metastases. The results showed that the novel algorithm of sub-arc collimator angle optimization (SACAO) could improve the dosimetric quality and treatment delivery efficiency, leading to better conformity index (CI), homogeneity index (HI), and gradient index (GI) for the targets, as well as improved sparing of organs at risk (OARs). Furthermore, the SACAO method also increased treatment efficiency in terms of field size and monitoring units (MUs).
FRONTIERS IN ONCOLOGY
(2022)
Article
Biology
Daichi Torizuka, Megumi Uto, Keiichi Takehana, Takashi Mizowaki
Summary: Comparing DCAT, CoVMAT, and NcVMAT plans in the treatment of single brain metastasis, it was found that NcVMAT significantly improved target conformity and reduced doses to normal brain tissue.
JOURNAL OF RADIATION RESEARCH
(2021)
Article
Oncology
Richard A. Popple, Matthew H. Brown, Evan M. Thomas, Christopher D. Willey, Rex A. Cardan, Elizabeth L. Covington, Kristen O. Riley, James M. Markert, Markus Bredel, John B. Fiveash
Summary: Properly planned single isocenter VMAT radiosurgery plans exhibit high quality and efficiency. The study compared manual planning with a new automated platform, HyperArc, and found that HyperArc produced high-quality plans with lower Paddick gradient index and mean brain doses, as well as shorter treatment times.
PRACTICAL RADIATION ONCOLOGY
(2021)
Article
Clinical Neurology
Carolina Benjamin, Jason Gurewitz, Aya Nakamura, Monica Mureb, Reed Mullen, Donato Pacione, Joshua Silverman, Douglas Kondziolka
Summary: This study investigates the efficacy of corticosteroid therapy followed by stereotactic radiosurgery (SRS) in managing patients with large brain metastases (LBM) not compromised by mass effect. The results show that this treatment approach is safe and efficient in reducing tumor volume and improving patient outcomes.
ACTA NEUROCHIRURGICA
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yusuke Tsuruta, Mitsuhiro Nakamura, Manabu Nakata, Hideaki Hirashima, Dejun Zhou, Megumi Uto, Keiichi Takehana, Takahiro Fujimoto, Takashi Mizowaki
Summary: This study evaluated the displacement of gross tumor volume (GTV) positions in fractionated stereotactic radiotherapy (f-SRT) with single isocenter volumetric modulated arc therapy (SI-VMAT) for multiple brain metastases. The study found no significant difference in GTV dose distribution, despite GTVs being far from the isocenter, likely due to the reduction of intrafractional residual setup errors to a clinically acceptable level.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2022)
Article
Oncology
Pauline Roussille, Marie Auvray, Damien Vansteene, Thierry Lecomte, Eugenie Rigault, Marianne Maillet, Christophe Locher, Marie Dior, Vincent Hautefeuille, Pascal Artru, May Mabro, Yann Touchefeu, Lysiane Marthey, Valerie Moulin, Samy Louafi, Cedric Lecaille, Romain Chautard, Astrid Lievre, Aziz Zaanan, Jaafar Bennouna, Antoine Berger, Sheik Emambux, Violaine Randrian, David Tougeron
Summary: This study evaluated prognostic factors of brain metastases from colorectal cancer and found that ECOG performance status, number of brain metastases, and number of chemotherapy lines are the most relevant factors in the management of patients with this condition.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Dominik Oft, Manuel Alexander Schmidt, Thomas Weissmann, Johannes Roesch, Veit Mengling, Siti Masitho, Christoph Bert, Sebastian Lettmaier, Benjamin Frey, Luitpold Valentin Distel, Rainer Fietkau, Florian Putz
Summary: There is insufficient understanding of the natural course of volumetric regression in brain metastases after stereotactic radiotherapy (SRT) and optimal volumetric criteria for the assessment of response and progression in radiotherapy clinical trials for brain metastases are currently unknown. Volumetric regression post-SRT does not occur at a constant rate but is most pronounced in the first 6 weeks to 3 months. A cutoff of >= 20% regression for the volumetric definition of response at 3 months post-SRT was predictive for subsequent control whereas the currently proposed definition of >= 65% was not.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Raees Tonse, Martin C. Tom, Minesh P. Mehta, Manmeet S. Ahluwalia, Rupesh Kotecha
Summary: In modern times, brain metastasis requires multi-modal management and interdisciplinary care. Traditionally, treatment strategies have focused on local treatments alone due to limited efficacy of cytotoxic chemotherapy. However, with the availability of molecular-based therapies with central nervous system penetration, individualized selection of tailored systemic therapies can now be used alongside local treatments. Moreover, the introduction of immune checkpoint inhibitors has further revolutionized the management of brain metastasis patients.
Article
Oncology
Yingjie Xu, Junjie Miao, Qingfeng Liu, Peng Huang, Pan Ma, Xinyuan Chen, Kuo Men, Jianping Xiao, Jianrong Dai
Summary: The longitudinal grouping method can decrease unnecessary exposure and reduces the low-dose range in normal brain tissue.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Stephen Harrow, David A. Palma, Robert Olson, Stewart Gaede, Alexander V. Louie, Cornelis Haasbeek, Liam Mulroy, Michael Lock, George B. Rodrigues, Brian P. Yaremko, Devin Schellenberg, Belal Ahmad, Sashendra Senthi, Anand Swaminath, Neil Kopek, Mitchell Liu, Roel Schlijper, Glenn S. Bauman, Joanna Laba, X. Melody Qu, Andrew Warner, Suresh Senan
Summary: This study evaluates the effect of ablative therapies in patients with oligometastases over a long-term randomized period. The results indicate that Stereotactic Ablative Radiotherapy (SABR) can significantly improve overall survival and progression-free survival without new major toxicity signals during extended follow-up.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Matthew Van Oirschot, Alanah Bergman, Wilko F. A. R. Verbakel, Lucy Ward, Isabelle Gagne, Vicky Huang, Nick Chng, Peter Houston, Kerry Symes, Christopher G. Thomas, Parminder Basran, David Bowes, Stephen Harrow, Robert Olson, Suresh Senan, Andrew Warner, David A. Palma, Stewart Gaede
Summary: This study assessed the association between target coverage compromise and patient outcomes in SABR treatment for oligometastases. The results showed that for some lesions, a reduction in dose or target coverage was necessary to meet organ at risk constraints. However, target coverage was not significantly associated with survival outcomes or lesional control.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
David R. Spigel, Corinne Faivre-Finn, Jhanelle E. Gray, David Vicente, David Planchard, Luis Paz-Ares, Johan F. Vansteenkiste, Marina C. Garassino, Rina Hui, Xavier Quantin, Andreas Rimner, Yi-Long Wu, Mustafa Ozguroglu, Ki H. Lee, Terufumi Kato, Maike de Wit, Takayasu Kurata, Martin Reck, Byoung C. Cho, Suresh Senan, Jarushka Naidoo, Helen Mann, Michael Newton, Piruntha Thiyagarajah, Scott J. Antonia
Summary: The study examined the efficacy of consolidation durvalumab in patients with non-small-cell lung cancer, showing significant improvements in overall survival and progression-free survival, with manageable safety. The 5-year follow-up data continued to demonstrate the positive effects of durvalumab on survival and disease progression.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Editorial Material
Oncology
Anand Swaminath, Timothy Ritter, Alexander V. Louie, David A. Palma, Matthias Guckenberger, Suresh Senan, Andrea Bezjak, Drew Moghanaki
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Florien W. Boele, Patricia W. M. den Otter, Jaap C. Reijneveld, Philip C. de Witt Hamer, Hinke F. van Thuijl, Linda M. C. Lorenz, Pieter Wesseling, Frank J. Lagerwaard, Martin J. B. Taphoorn, Mathilde C. M. Kouwenhoven, Tom J. Snijders, Linda Douw, Martin Klein
Summary: HRQOL and NCF do not appear greatly impacted during long-term survivorship in LGG, but depressive symptoms and fatigue are persistent.
Article
Radiology, Nuclear Medicine & Medical Imaging
Koen J. Nelissen, Eva Versteijne, Suresh Senan, Daan Hoffmans, Ben J. Slotman, Wilko F. A. R. Verbakel
Summary: A workflow involving preplanning on diagnostic CT imaging and online plan adaption using cone-beam CT scan was developed for single-visit radiotherapy. The study showed that this workflow can meet clinical goals and outperform initial treatment plans based on daily CT scan.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Moritz Rabe, Miguel A. Palacios, John van Sornsen R. de Koste, Chukwuka Eze, Martin Hillbrand, Claus Belka, Guillaume Landry, Suresh Senan, Christopher Kurz
Summary: This study compared the accumulated doses of MRgRT, non-adaptive IMPT, and online adaptive IMPT for central lung tumors, with a focus on the bronchial tree dose. The results showed that non-adaptive and online adaptive proton therapy achieved significant dose sparing for organs in close proximity to central lung tumors compared to MRgRT. Online adaptive IMPT achieved significantly lower doses to the bronchial tree compared to MRgRT.
Article
Oncology
Koen J. Nelissen, Eva Versteijne, Suresh Senan, Barbara Rijksen, Marjan Admiraal, Jorrit Visser, Sarah Barink, Amy L. de la Fuente, Daan Hoffmans, Ben J. Slotman, Wilko F. A. R. Verbakel
Summary: We developed a rapid palliative radiotherapy workflow using diagnostic imaging for pre-planning and on-couch target and plan adaptation based on a synthetic CT obtained from CBCT. The adapted treatment plans showed significant improvements in target coverage compared to the original plans. Most patients were satisfied with the workflow. The average treatment time, including consultation and on-couch adaptive treatment, was 85 minutes.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Puneeth Iyengar, Sean All, Mark F. Berry, Thomas P. Boike, Lisa Brad fi Eld, Anne -Marie C. Dingemans, Jill Feldman, Daniel R. Gomez, Paul J. Hesketh, Salma K. Jabbour, Melenda Jeter, Mirjana Josipovic, Yolande Lievens, Fiona Mcdonald, Bradford A. Perez, Umberto Ricardi, Enrico Ruffini, Dirk De Ruysscher, Hina Saeed, Bryan J. Schneider, Suresh Senan, Joachim Widder, Matthias Guckenberger
Summary: This guideline aims to review the use of local therapy in the management of extracranial oligometastatic non-small cell lung cancer (NSCLC) and provide recommendations. Currently, data is limited, but with increasing evidence supporting the use of local therapy in NSCLC, this guideline attempts to provide recommendations based on the quality of available data.
PRACTICAL RADIATION ONCOLOGY
(2023)
Article
Oncology
Miguel A. Palacios, Georgi Gerganov, Paul Cobussen, Shyama U. Tetar, Tobias Finazzi, Berend J. Slotman, Suresh Senan, Cornelis J. A. Haasbeek, Iwan Kawrakow
Summary: This study evaluated the accuracy of automatic tumor segmentation in MR-guided radiotherapy (MRgRT) by comparing it to manual delineations performed by experienced observers. The results showed a high level of agreement between automatic segmentation and manual delineation.
PHYSICS & IMAGING IN RADIATION ONCOLOGY
(2023)
Article
Oncology
Hilal Tekatli, Miguel A. Palacios, Famke L. Schneiders, Cornelis J. A. Haasbeek, Ben J. Slotman, Frank J. Lagerwaard, Suresh Senan
Summary: This study investigated the long-term clinical outcomes of MR-guided SF-SABR on a 0.35 T linac for lung tumors. The results showed that SF-SABR, using automatic beam gating during breath-holds, achieved good tumor control and low toxicity.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Famke L. Schneiders, Claire van Vliet, Nicolas Giraud, Anna M. E. Bruynzeel, Ben J. Slotman, Miguel A. Palacios, Suresh Senan
Summary: This study retrospectively reviewed the outcomes of MR-guided adrenal SABR and found that this approach is well tolerated and achieves high local control rates. Further research using deformable dose accumulation is needed to better understand the dose-response relationship.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2023)
Article
Oncology
Miguel A. Palacios, Sonja Verheijen, Famke L. Schneiders, Omar Bohoudi, Berend J. Slotman, Frank J. Lagerwaard, Suresh Senan
Summary: The study investigated the clinical feasibility, patient satisfaction, and delivery accuracy of single-fraction MR-guided SABR in a single day. All 10 patients completed the one-stop-shop procedure in a single day and reported satisfaction with the process. The accuracy of SABR delivery was high with little impact of system-latency.
PHYSICS & IMAGING IN RADIATION ONCOLOGY
(2022)