Article
Oncology
Joo Ho Lee, Keun-Yong Eom, Ji Hoon Phi, Chul-Kee Park, Seung Ki Kim, Byung-Kyu Cho, Tae Min Kim, Dae Seog Heo, Kyung Taek Hong, Jung Yoon Choi, Hyoung Jin Kang, Hee Young Shin, Seung Hong Choi, Soon Tae Lee, Sung Hye Park, Kyu-Chang Wang, Il Han Kim
Summary: The study indicated that reducing the radiation dose in the extended field is crucial for decreasing late toxicities. For patients with complete response, upfront chemotherapy may help minimize radiation dose to 30 Gy. Prospective trials focusing on de-intensification of extended field radiation therapy are needed.
CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Douglas H. Brand, Sarah C. Bruningk, Anna Wilkins, Olivia Naismith, Annie Gao, Isabel Syndikus, David P. Dearnaley, Nicholas van As, Emma Hall, Sarah Gulliford, Alison C. Tree, CHHiP Trial Management Grp
Summary: This study provides estimates of the a/0 ratio for human genitourinary toxicity endpoints derived from a hypofractionation trial. The results showed that the symptoms of dysuria and hematuria were less severe when EQD2 correction was considered, and the a/0 ratio was lower, indicating that the therapeutic gain of hypofractionation may be lower than expected.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Oncology
Laila Koenig, Cornelia Jaekel, Nikolaus von Knebel Doeberitz, Meinhard Kieser, Fabian Eberle, Marc Muenter, Juergen Debus, Klaus Herfarth
Summary: The GRIPS trial aims to assess whether proton beam radiotherapy can reduce toxicity for glioblastoma patients during and in the first months after treatment.
RADIATION ONCOLOGY
(2021)
Article
Oncology
Juliet E. van Hoorn, Max Dahele, Johannes M. A. Daniels
Summary: This study analyzed patient characteristics and clinical outcomes of 70 patients with central airway toxicity after high-dose radiotherapy, proposing a classification system based on bronchoscopic findings. The main patterns of airway toxicity identified were luminal stenosis and vascular changes, with potential prognostic value in predicting radiation damage severity. Prospective data is needed to confirm these findings.
Article
Multidisciplinary Sciences
Junichi Fukada, Kyohei Fukata, Naoyoshi Koike, Ryuichi Kota, Naoyuki Shigematsu
Summary: This study investigated the incidence of pericardial effusion in patients with oesophageal cancer undergoing definitive chemoradiotherapy based on the mean heart dose. The results showed that mean heart dose was a significant predictor for pericardial effusion, and the NTCP model based on MHD was comparable to the LKB model in predicting PCE. The NTCP model may provide clinically useful parameters for predicting PCE.
SCIENTIFIC REPORTS
(2021)
Review
Biology
Miruna Florina Stefan, Catalin Gabriel Herghelegiu, Stefania Lucia Magda
Summary: The number of patients diagnosed with breast cancer and cardiovascular disease is increasing, and radiotherapy still plays a key role in breast cancer treatment. Cardiotoxicity is a significant side effect of radiotherapy, which can result in various cardiovascular diseases, with atherosclerosis being the most common. The management of these patients requires an interdisciplinary team to achieve maximum therapeutic effect and minimize cardiovascular toxicity. This review will summarize the current incidence, risk factors, mechanisms, and follow-up of radiotherapy-induced cardiovascular toxicity.
Article
Oncology
Brian De, Marcus A. Florez, Ethan B. Ludmir, Moshe H. Maor, Susan L. McGovern, Mary Frances McAleer, David R. Grosshans, Eric L. Chang, Anita Mahajan, Arnold C. Paulino
Summary: This study reviewed the records of 84 patients who received spinal radiation therapy using electrons between 1983 and 2014. The results showed that long-term follow-up revealed musculoskeletal toxic effects and decreased height, while pulmonary and cardiac toxic effects were rare.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Oncology
Jannet C. Beukema, Crystal de Groot, John T. M. Plukker, Rozemarijn Vliegenthart, Johannes A. Langendijk, Peter van Luijk, Joost P. van Melle, Niek H. J. Prakken, Christina T. Muijs
Summary: This study aimed to compare the potential cardiac dysfunction between esophageal cancer patients who received neoadjuvant chemoradiation and those who underwent surgery alone. The study found an increased rate of myocardial fibrosis, atrial fibrillation, and conduction changes in patients treated with neoadjuvant chemoradiation. The findings indicate a greater impact on quality of life for this patient group.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Maarten C. C. M. Hulshof, Elisabeth D. Geijsen, Tom Rozema, Vera Oppedijk, Jeroen Buijsen, Karen J. Neelis, Joost J. M. E. Nuyttens, Maurice J. C. van der Sangen, Paul M. Jeene, Jannie G. Reinders, Mark I. van Berge Henegouwen, Adriana Thano, Jeanin E. van Hooft, Hanneke W. M. van Laarhoven, Ate van der Gaast
Summary: In definitive chemoradiation for esophageal cancer, escalating radiation dose up to 61.6 Gy to the primary tumor did not significantly improve local tumor control compared to 50.4 Gy. The absence of a dose-effect was observed in both adenocarcinoma and squamous cell carcinoma.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Ying Wang, Wan-Min Qiang, Jia-Qian Li, Ao-Mei Shen, Xiao-Cen Chen, Xiao-Fang Li, Bao-Zhong Zhang, Juan Xie, Rong Yan, Xiang-Hua Li, Zhao-Li Zhang, Cui-Ling Wang, Lai-You Li
Summary: This study compared the short-term efficacy and radiotoxicity of morning radiotherapy and evening radiotherapy in patients with cervical cancer. The results showed similar total effective response rates between the two groups, but significant differences in the incidence of bone marrow suppression and intestinal reaction. Patients in the morning radiotherapy group had higher symptom scores and lower quality of life compared to the evening radiotherapy group.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Jessika Contreras, Amar Srivastava, Pamela Samson, Todd DeWees, Ramaswamy Govindan, Maria Q. Baggstrom, Daniel Morgensztern, Michael Roach, Shahed N. Badiyan, Jeffrey Bradley, Saiama Waqar, Clifford Robinson
Summary: The study aimed to evaluate the maximum tolerated dose of hypofractionated proton beam radiation therapy with concurrent weekly carboplatin/paclitaxel in patients with stage II-III non-small cell lung cancer. The results showed that the treatment was acutely well tolerated, with high rates of locoregional control and overall survival. Late serious adverse events were noted in some patients outside of the dose-escalation window.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Sophie R. de Mol van Otterloo, John P. Christodouleas, Erwin L. A. Blezer, Hafid Akhiat, Kevin Brown, Ananya Choudhury, Dave Eggert, Beth A. Erickson, Lois A. Daamen, Corinne Faivre-Finn, Clifton D. Fuller, Joel Goldwein, Shaista Hafeez, Emma Hall, Kevin J. Harrington, Uulke A. van der Heide, Robert A. Huddart, Martijn P. W. Intven, Anna M. Kirby, Susan Lalondrelle, Claire McCann, Bruce D. Minsky, Stella Mook, Marlies E. Nowee, Uwe Oelfke, Kristina Orrling, Marielle E. P. Philippens, Arjun Sahgal, Christopher J. Schultz, Robbert J. H. A. Tersteeg, Rob H. N. Tijssen, Alison C. Tree, Baukelien van Triest, Chia-Lin Tseng, William A. Hall, Helena M. Verkooijen
Summary: This study reports the initial experience within the MOMENTUM Study, a prospective international registry of the MRLinac Consortium. The high-field MR-Linac treatments showed diverse patterns of care, good patient tolerability of daily high-field MRI, and encouraging acute radiation toxicity experience in the first 21 months of the study.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Matthew P. Deek, Missak Haigentz, Salma K. Jabbour
Summary: The article summarizes the Oncology Grand Rounds series, which aims to provide clinical context to original reports published in the Journal. It includes a case presentation, description of diagnostic and management challenges, literature review, and suggested management approaches. The goal is to help readers understand how to apply key study results to their own clinical practice.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Ragu Ratnakumaran, Victoria Hinder, Douglas Brand, John Staffurth, Emma Hall, Nicholas van As, Alison Tree
Summary: This study examines the association between short- and long-term bowel and urinary side-effects in prostate radiotherapy using modern techniques. Results show that patients with short-term side-effects are at higher risk of developing long-term side-effects, even after adjusting for various factors. Monitoring and early treatment for patients with significant short-term side-effects are recommended.
Article
Oncology
Ugo de Paula, Rolando Maria D'Angelillo, Angela Damiana Andrulli, Giuseppina Apicella, Cristina Caruso, Christian Ghini, Sara Gomellini, Elisabetta Ponti, Marco Pompei, Aurelia Caccavari, Alessandra Petrocchi, Leopoldo Costarelli, Marco Giordano, Massimo La Pinta, Emanuele Zarba Meli, Maria Mauri, Mauro Minelli, Rosalinda Rossi, Paola Scavina, Laura Broglia, Tatiana Ponzani, Andrea Loreti, Lucio Fortunato
Summary: Long-term outcomes of APBI-tomotherapy in invasive breast cancer patients were reported in this phase 2 trial. The study showed excellent results with low rates of adverse events and good cosmetic outcomes. Even patients deemed cautionary or unsuitable for APBI by ASTRO criteria had a low rate of IBTR recurrence.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Medicine, Research & Experimental
Abdallah S. R. Mohamed, Blaine D. Smith, Joshua B. Smith, Parag Sevak, Jessica S. Malek, Aasheesh Kanwar, Theodora Browne, G. Brandon Gunn, Adam S. Garden, Steven J. Frank, William H. Morrison, Jack Phan, Mark Zafereo, Heath Skinner, Stephen Y. Lai, Katherine A. Hutcheson, Jan S. Lewin, Amy E. Hessel, Apurva A. Thekdi, Randal S. Weber, Clifton D. Fuller, David I. Rosenthal
Article
Oncology
G. Brandon Gunn, Tito R. Mendoza, Adam S. Garden, Xin Shelley Wang, Qiuling Shi, William H. Morrison, Steven J. Frank, Jack Phan, Clifton D. Fuller, Mark S. Chambers, Ehab Y. Hanna, Charles Lu, David Rosenthal, Charles S. Cleeland
SUPPORTIVE CARE IN CANCER
(2020)
Article
Oncology
Shane Mesko, He Wang, Samuel Tung, Congjun Wang, Dario Pasalic, Bhavana V. Chapman, Amy C. Moreno, Jay P. Reddy, Adam S. Garden, David I. Rosenthal, G. Brandon Gunn, Steven J. Frank, Clifton D. Fuller, William Morrison, Jack Phan
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2020)
Article
Oncology
Alexander F. Bagley, Rong Ye, Adam S. Garden, Gary Brandon Gunn, David I. Rosenthal, Clifton David Fuller, William H. Morrison, Jack Phan, Erich M. Sturgis, Renata Ferrarotto, Richard Wu, Amy Y. Liu, Steven J. Frank
RADIOTHERAPY AND ONCOLOGY
(2020)
Article
Oncology
Sweet Ping Ng, Temitayo Ajayi, Andrew J. Schaefer, Courtney Pollard, Houda Bahig, Adam S. Garden, David I. Rosenthal, G. Brandon Gunn, Steven J. Frank, Jack Phan, William H. Morrison, Jason M. Johnson, Abdallah S. R. Mohamed, Erich M. Sturgis, Clifton D. Fuller
Article
Otorhinolaryngology
Dario Pasalic, Sonia L. Betancourt-Cuellar, Nicolette Taku, Ethan B. Ludmir, Yi Lu, Pamela K. Allen, Chad Tang, Mara B. Antonoff, Clifton D. Fuller, David Rosenthal, William H. Morrison, Jack Phan, Adam S. Garden, James W. Welsh, Joe Y. Chang, Zhongxing Liao, Jeremy J. Erasmus, Quynh-Nhu Nguyen
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2020)
Article
Otorhinolaryngology
Houda Bahig, Sweet P. Ng, Courtney Pollard, Theresa P. Nguyen, Gary B. Gunn, David I. Rosenthal, Clifton D. Fuller, Steven J. Frank, Adam S. Garden, Jay P. Reddy, William H. Morrison, Renata Ferrarotto, Ehab Y. Hanna, Franco DeMonte, Shirley Y. Su, Jack Phan
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2020)
Article
Otorhinolaryngology
Adam S. Garden, Mona Kamal, Abdallah S. R. Mohamed, Steven J. Frank, Jan S. Lewin, Stephen Y. Lai, William H. Morrison, Jack Phan, Renata Ferrarotto, David I. Rosenthal, Katherine A. Hutcheson, Clifton D. Fuller, Gary B. Gunn
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2020)
Article
Oncology
David J. Thomson, David Palma, Matthias Guckenberger, Panagiotis Balermpas, Jonathan J. Beitler, Pierre Blanchard, David Brizel, Wilfred Budach, Jimmy Caudell, June Corry, Renzo Corvo, Mererid Evans, Adam S. Garden, Jordi Giralt, Vincent Gregoire, Paul M. Harari, Kevin Harrington, Ying J. Hitchcock, Jorgen Johansen, Johannes Kaanders, Shlomo Koyfman, J. A. Langendijk, Quynh-Thu Le, Nancy Lee, Danielle Margalit, Michelle Mierzwa, Sandro Porceddu, Yoke Lim Soong, Ying Sun, Juliette Thariat, John Waldron, Sue S. Yom
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2020)
Article
Oncology
Sweet Ping Ng, Houda Bahig, Amit Jethanandani, Courtney Pollard, Joel Berends, Erich M. Sturgis, Faye M. Johnson, Baher Elgohari, Hesham Elhalawani, David Rosenthal, Heath D. Skinner, G. Brandon Gunn, Jack Phan, Steven J. Frank, Abdallah S. R. Mohamed, Clifton D. Fuller, Adam S. Garden
RADIOTHERAPY AND ONCOLOGY
(2020)
Article
Oncology
Mohamed Zaid, Eugene J. Koay, Nimit Bajaj, Ryan Mathew, Lianchun Xiao, Anshuman Agrawal, Pearl Fernandes, Hannah Burrows, Millicent A. Roach, Christopher T. Wilke, Caroline Chung, Clifton D. Fuller, Jack Phan, G. Brandon Gunn, William H. Morrison, Adam S. Garden, Steven J. Frank, David Rosenthal, Michael Andersen, Adegbenga Otun, Mark S. Chambers
Article
Oncology
Stephen R. Grant, Katherine A. Hutcheson, Rong Ye, Adam S. Garden, William H. Morrison, David Rosenthal, G. Brandon Gunn, C. David Fuller, Jack Phan, Jay P. Reddy, Amy C. Moreno, Jan S. Lewin, Erich M. Sturgis, Renata Ferrarotto, Steven J. Frank
RADIOTHERAPY AND ONCOLOGY
(2020)
Article
Oncology
Sonja Stieb, Abdallah S. R. Mohamed, Tanaya S. Deshpande, Jared Harp, Benjamin Greiner, Adam S. Garden, Ryan P. Goepfert, Richard Cardoso, Renata Ferrarotto, Jack Phan, Jay P. Reddy, William H. Morrison, David Rosenthal, Steven J. Frank, C. David Fuller, G. Brandon Gunn
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2020)
Article
Psychology, Clinical
E. H. Shinn, K. Jensen, J. McLaughlin, A. S. Garden, B. M. Fellman, Li Liang, S. K. Peterson
INTERNET INTERVENTIONS-THE APPLICATION OF INFORMATION TECHNOLOGY IN MENTAL AND BEHAVIOURAL HEALTH
(2019)
Article
Oncology
Sweet Ping Ng, Carlos E. Cardenas, Hesham Elhalawani, Courtney Pollard, Baher Elgohari, Penny Fang, Mohamed Meheissen, Nandita Guha-Thakurta, Houda Bahig, Jason M. Johnson, Mona Kamal, Adam S. Garden, Jay P. Reddy, Shirley Y. Su, Renata Ferrarotto, Steven J. Frank, G. Brandon Gunn, Amy C. Moreno, David Rosenthal, Clifton D. Fuller, Jack Phan
PHYSICS & IMAGING IN RADIATION ONCOLOGY
(2020)