Article
Biology
Cristina Faccani, Gianluca Rotta, Francesca Clemente, Maya Fedeli, Danilo Abbati, Francesco Manfredi, Alessia Potenza, Achille Anselmo, Federica Pedica, Guido Fiorentini, Chiara Villa, Maria P. Protti, Claudio Doglioni, Luca Aldrighetti, Chiara Bonini, Giulia Casorati, Paolo Dellabona, Claudia de Lalla
Summary: This study describes a workflow for high-dimensional flow cytometry analysis of T cells infiltrating liver metastatic tumor lesions. By optimizing the flow cytometer settings, establishing a multi-color antibody panel, and accurately tuning the dissociation of samples, the phenotypic complexity of T cells infiltrating the tumor lesions was effectively captured. This study provides a robust tool for analyzing complex T cell populations and can be adapted to characterize other relevant pathological tissues.
LIFE SCIENCE ALLIANCE
(2022)
Article
Urology & Nephrology
Tilman Schmidt, Jonas Luebbe, Christoph Kilian, Jan-Hendrik Riedel, Sonja Hiekmann, Nariaki Asada, Pauline Ginsberg, Lennart Robben, Ning Song, Anna Kaffke, Anett Peters, Alina Borchers, Richard A. Flavell, Nicola Gagliani, Penelope Pelzcar, Samuel Huber, Tobias B. Huber, Jan-Eric Turner, Hans-Joachim Paust, Christian F. Krebs, Ulf Panzer
Summary: CD4(+) IL-17A-producing TH17 cells play a crucial role in autoimmune and chronic inflammatory diseases of the kidney, skin, and gut. The IL-17RA/IL-17RC complex is highly expressed in these cells and controls the TH17 response, potentially offering new insights for more efficient treatment strategies.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Gastroenterology & Hepatology
Benjamin G. Wiggins, Laura J. Pallett, Xiaoyan Li, Scott P. Davies, Oliver E. Amin, Upkar S. Gill, Stephanie Kucykowicz, Arzoo M. Patel, Konstantinos Aliazis, Yuxin S. Liu, Gary M. Reynolds, Brian R. Davidson, Amir Gander, Tu Vinh Luong, Gideon M. Hirschfield, Patrick T. F. Kennedy, Yuehua Huang, Mala K. Maini, Zania Stamataki
Summary: This study found that high and intermediate CD69 expressions marked human hepatic CD4(+) T-RM and a novel functionally distinct recirculating population, both shaped by the liver microenvironment to achieve diverse immunosurveillance.
Article
Cell & Tissue Engineering
Xueer Xu, Cheng Zu, Mingming Zhang, Pingnan Xiao, Ruimin Hong, Jingjing Feng, Huijun Xu, Jiazhen Cui, Jian Yu, Jimin Shi, Guoqing Wei, Alex H. Chang, He Huang, Yongxian Hu
Summary: This study reported on a patient with refractory hepatosplenic & gamma;& delta; T-cell lymphoma who achieved complete remission and maintained it after receiving HLA fully-mismatched sibling-derived CD7 CAR-T therapy followed by haploidentical hematopoietic stem cell transplantation. This is the first case of its kind, highlighting the potential of CAR-T therapy and haploidentical HSCT in treating relapsed/refractory T-cell lymphoma.
CELL TRANSPLANTATION
(2023)
Article
Oncology
Rebecca Baur, Franziska Karl, Romy Boettcher-Loschinski, Andrej Stoll, Simon Voelkl, Andreas Giessl, Cindy Flamann, Heiko Bruns, Ursula Schloetzer-Schrehardt, Martin Boettcher, Denis M. Schewe, Thomas Fischer, Regina Jitschin, Andreas Mackensen, Dimitrios Mougiakakos
Summary: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only curative treatment option for certain hematological malignancies. However, allo-HSCT can also lead to graft-versus-host disease (GvHD) and disease relapse. Recent studies have found that extracellular vesicles (EVs) expressing PD-L1 can suppress T-cell responses and contribute to GvHD and disease relapse in allo-HSCT patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Immunology
Peng Zhang, Yuwen Su, Siying Li, Hui Chen, Ruifang Wu, Haijing Wu
Summary: This paper reviews the different subtypes of T lymphocytes and their functions in psoriasis, as well as provides an overview of targeted therapies for treating psoriasis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Christoph S. N. Klose, Henrique Veiga-Fernandes
Summary: Neuroimmune interactions are crucial for tissue defense, organ homeostasis, and organismal physiology. Neuronal and immune cell subsets can colocalize in tissues, forming neuroimmune cell units that drive coordinated responses to signals. Recent studies show how these interactions maximize sensing of environmental aggressions and modulate immune function in health and disease.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Martin J. Lett, Hema Mehta, Adrian Keogh, Tina Jaeger, Maxime Jacquet, Kate Powell, Marie-Anne Meier, Isabel Fofana, Hassan Melhem, Juerg Vosbeck, Gieri Cathomas, Andres Heigl, Markus H. Heim, Emanuel Burri, Kirsten D. Mertz, Jan Hendrik Niess, Otto Kollmar, Christoph J. Zech, Robert Ivanek, Urs Duthaler, Paul Klenerman, Deborah Stroka, Magdalena Filipowicz Sinnreich
Summary: This study reveals the significant roles of liver cells in the activation and antigen metabolism of MAIT cells. The presence of MAIT cell stimulatory antigens in the serum may contribute to the development of liver diseases.
Article
Oncology
Audrey Moatti, Anais Debesset, Caroline Pilon, Asma Beldi-Ferchiou, Mathieu Leclerc, Rabah Redjoul, Frederic Charlotte, Nhu Hanh To, Adeline Bak, Yazid Belkacemi, Benoit Laurent Salomon, Fadi Issa, David Michonneau, Sebastien Maury, Jose Laurent Cohen, Allan Thiolat
Summary: This study reveals the potential of targeting TNFR2 to enhance anti-tumor responses and treat relapse of blood malignancies. The researchers also found that TNFR2 is over-expressed in Tregs from healthy donors and patients with leukemia relapse or GVHD. These findings provide new perspectives for the development of immunotherapies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Djordje Atanackovic, Robert J. Kreitman, Jeffrey Cohen, Nancy M. Hardy, Destiny Omili, Thierry Iraguha, Peter D. Burbelo, Etse Gebru, Xiaoxuan Fan, John Baddley, Tim Luetkens, Saurabh Dahiya, Aaron P. Rapoport
Summary: A patient with B cell lymphoma developed vaccine-induced anti-SARS-CoV-2 antibodies after receiving the fifth and sixth doses of a COVID-19 mRNA vaccine, indicating the potential for T cells to enhance protective immunity in patients with B cell lymphoma. Despite severe treatment-induced suppression of the humoral immune system, the patient was able to mount strong virus-specific CD4(+) and CD8(+) responses, even targeting the Omicron variant of the SARS-CoV-2 virus. These findings have implications for COVID-19 vaccination strategies and antitumor vaccines in immunosuppressed cancer patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Oncology
Stephanie L. Goff, David N. Danforth
Summary: The review highlights the presence and important roles of immune cells in both normal breast tissue and breast carcinoma, with an emphasis on the increased immune cell infiltrates during breast cancer progression. Different subtypes of immune cells within and around tumors present potential targets for immunotherapy strategies.
CLINICAL BREAST CANCER
(2021)
Review
Oncology
Grace H. Attrill, Peter M. Ferguson, Umaimainthan Palendira, Georgina V. Long, James S. Wilmott, Richard A. Scolyer
Summary: The field of tumor immunology has advanced rapidly in the past decade, leading to effective immunotherapies for patients with advanced cancers. Understanding immune cell function in the tumor immune microenvironment (TIME) is crucial for elucidating the complex interactions between tumors and the immune system. This knowledge can contribute to improved treatment strategies and outcomes for cancer patients.
PIGMENT CELL & MELANOMA RESEARCH
(2021)
Article
Immunology
Emma Lorenzen, Vanessa Contreras, Anja W. Olsen, Peter Andersen, Delphine Desjardins, Ida Rosenkrands, Helene Baek Juel, Benoit Delache, Sebastien Langlois, Constance Delaugerre, Christophe Joubert, Nathalie Dereuddre-Bosquet, Cecile Bebear, Bertille De Barbeyrac, Arabella Touati, Paul F. McKay, Robin J. Shattock, Roger Le Grand, Frank Follmann, Jes Dietrich
Summary: This study evaluated different immunization strategies in a nonhuman primate model and found that immunization with the CTH522 protein vaccine can rapidly induce a strong specific immune response, while DNA and vector vaccines can also establish cell-mediated immunity. The DNA vaccine boosted with CAF01-adjuvanted CTH522 showed the fastest clearance of infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Gastroenterology & Hepatology
Niklas K. Bjorkstrom
Summary: This review provides a comprehensive overview of the emerging knowledge on immunobiology of the biliary tract system, with a specific emphasis on the role of distinct immune cells in biliary disorders.
JOURNAL OF HEPATOLOGY
(2022)
Article
Oncology
Margaret Veitch, Kimberly Beaumont, Rebecca Pouwer, Hui Yi Chew, Ian H. Frazer, H. Peter Soyer, Scott Campbell, Brian W. Dymock, Andrew Harvey, Terrie-Anne Cock, James W. Wells
Summary: This study aimed to identify a compound capable of re-establishing antitumor T-cell control in the skin despite the presence of tacrolimus.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)