Article
Oncology
Zoe Schmal, Claudia E. Ruebe
Summary: Radiation-induced brain injury significantly affects the neurocognitive functions of brain cancer survivors, especially in pediatric patients. This study investigated the underlying mechanisms of radiation-induced brain injury by analyzing different hippocampal subregions in a mouse model. The findings suggest that region-specific differences in radiosensitivity are primarily determined by the presence of proliferating neuroprogenitors.
Review
Engineering, Biomedical
C. M. Charlie Ma
Summary: Pulsed low dose-rate radiotherapy (PLDR) relies on the hyper-radiosensitivity of tumor cells at small doses and the reduced normal tissue toxicity at low dose rates. PLDR delivers the daily radiation dose in pulses with a 3 minute time interval, showing therapeutic potential for various treatment sites especially for recurrent cancers.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Biology
Paula Bennett, Alicia M. Johnson, Sarah E. Ackerman, Pankaj Chaudhary, Deborah J. Keszenman, Paul F. Wilson
Summary: This study investigates the effects of low-dose exposures of accelerated protons on DNA damage induction, survival, and transformation in human fibroblasts. The results show that DNA double-strand breaks and clustered DNA damages induced by proton irradiation are dependent on dose-rate and linear energy transfer. The cell survival and transformation exhibit a dose-rate effect, which is more significant at SPE-like LDR doses.
RADIATION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Simon Sioen, Oniecha Vanhove, Barbara Vanderstraeten, Carlos De Wagter, Monique Engelbrecht, Charlot Vandevoorde, Evan De Kock, Marc-Jan Van Goethem, Anne Vral, Ans Baeyens
Summary: Proton therapy and photon irradiation were investigated for their effects on DNA damage and repair in hematopoietic stem and progenitor cells (HSPCs). The study found that there were no significant differences in the induction and repair of DNA damage between proton therapy and X-ray irradiation. However, proton irradiation caused more severe chromosomal damage in HSPCs compared to X-rays, indicating possible changes in biological response.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Natalie Y. L. Ngoi, Valerie Heong, Johann Tang, Bok Ai Choo, Nesaretnam Barr Kumarakulasinghe, Diana Lim, Mellisa Low, Siew Eng Lim, Yi Wan Lim, Yiat Horng Leong, Michelle Tseng, Pearl S. Y. Tong, Arunachalam Ilancheran, Jeffrey J. H. Low, Joseph Ng, Yee Liang Thian, Vicky Koh, David S. P. Tan
Summary: The study aimed to determine the recommended dose and efficacy of weekly paclitaxel with low-dose fractionated whole abdominal radiation therapy in platinum-resistant ovarian cancer patients. Encouraging efficacy was observed in heavily pretreated patients with a disease control rate of 66.7%, with four patients achieving durable disease control of >= 12 weeks.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Chemistry, Physical
Ashraf Almahwasi
Summary: Cells have different sensitivity to ionising radiation depending on their phase during the cell cycle. Low doses of radiation can induce various delayed and non-targeted effects, including bystanders and hyper-radiosensitivity. The hyper-activation of DNA repair mechanisms due to excessive induction of DNA double-strand breaks is thought to be responsible for the hyper-radiosensitivity phenomenon. This phenomenon modifies the Linear Quadratic model and is observed at low doses below 1 Gy of radiation.
RADIATION PHYSICS AND CHEMISTRY
(2023)
Review
Oncology
Harald Paganetti
Summary: Radiation therapy causes lymphopenia in patients, and the mechanisms behind this are not completely understood. Research is currently focused on determining the effects of tumor dose conformation, dose fractionation, and selective lymph node irradiation on lymphopenia and immune response. Understanding the impact of radiation on the immune system is crucial for the design and interpretation of clinical trials combining radiation with immune checkpoint inhibitors. The reviewed data suggest that radiation-induced cell death is not the sole factor in radiation-induced lymphopenia.
FRONTIERS IN ONCOLOGY
(2023)
Article
Humanities, Multidisciplinary
Yoshiyuki Oguri, Hitoshi Fukuda, Jun Hasegawa, Naoto Hagura
Summary: This study tested a setup of PIXRF as a low-radiation dose analytical technique for precious cultural heritage samples. The low-dose performance of PIXRF was compared with that of conventional XRF through experimental assessments using test samples. The results suggest that PIXRF potentially offers better performance in terms of radiation dose and limit of detection, despite its degraded multi-elemental analytical capability. If introduced in an existing PIXE facility, PIXRF could be a cost-effective method for low dose measurements of precious samples.
Review
Medicine, General & Internal
Robbie S. Kerr, Nimisha Kumar, Myfanwy J. Williams, Anna Cuthbert, Nasreen Aflaifel, David M. Haas, Andrew D. Weeks
Summary: The study suggests that low-dose oral misoprostol may reduce the likelihood of caesarean sections and lower the risk of uterine hyperstimulation compared to vaginal dinoprostone. However, it may prolong the time to birth, resulting in a decrease in vaginal births within 24 hours.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Biology
Daisuke Ohsawa, Yota Hiroyama, Alisa Kobayashi, Tamon Kusumoto, Hisashi Kitamura, Satoru Hojo, Satoshi Kodaira, Teruaki Konishi
Summary: This study aimed to investigate the effects of ultra-high dose rate FLASH exposure on DNA strand break induction. By comparing the results of conventional dose rate and ultra-high dose rate exposure in plasmid DNA, it was found that FLASH exposure significantly reduced the induction of single strand breaks, but had no significant effect on double strand breaks.
JOURNAL OF RADIATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Orla Howe, Lisa White, Daniel Cullen, Grainne O'Brien, Laura Shields, Jane Bryant, Emma Noone, Shirley Bradshaw, Marie Finn, Mary Dunne, Aoife M. Shannon, John Armstrong, Brendan McClean, Aidan Meade, Christophe Badie, Fiona M. Lyng
Summary: Validation of a new 4-gene signature panel using G2 chromosomal radiosensitivity assay revealed significant differences in radiation response post-exposure, while some prostate cancer donors showed altered response due to Androgen Deprivation Therapy, suggesting intra-individual heterogeneity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Eymeric Le Reun, Adeline Granzotto, Adeline Petre, Larry Bodgi, Guillaume Beldjoudi, Thomas Lacornerie, Veronique Vallet, Audrey Bouchet, Joelle Al-Choboq, Michel Bourguignon, Juliette Thariat, Jean Bourhis, Eric Lartigau, Nicolas Foray
Summary: We demonstrated the occurrence of hypersensitivity to low dose (HRS) phenomenon in both tumor and healthy cells in SBRT modality. The response to SBRT was found to be exacerbated in HRS-positive cells, leading to the appearance of a subset of highly damaged cells that can enhance the treatment efficiency. It is important to determine the HRS status of tumors and healthy tissues to increase SBRT efficiency and reduce the risk of adverse reactions.
Article
Biochemistry & Molecular Biology
John E. Slaven, Matthew Wilkerson, Anthony R. Soltis, W. Bradley Rittase, Dmitry T. Bradfield, Michelle Bylicky, Lynnette Cary, Alena Tsioplaya, Roxane Bouten, Clifton Dalgard, Regina M. Day
Summary: Low dose-rate radiation exposure can lead to Chronic Radiation Syndrome (CRS) and various diseases, including circulatory, digestive, cardiovascular, and neurological diseases, as well as cancer. The response to low dose-rate ionizing radiation is fundamentally different compared to high-dose-rate exposure, with alterations in pathways related to cellular metabolism, extracellular matrix modification, cell adhesion/migration, and regulation of vasoconstriction and inflammation.
Article
Oncology
John D. D. O'Connor, Ian M. M. Overton, Stephen J. J. McMahon
Summary: Radiation therapy is a crucial treatment for cancer, but there has been little progress in adjusting radiation dose based on genetic differences. This study shows that preprocessing greatly affects model predictions and existing gene expression-based models lack evidence for radiation specificity.
Article
Medicine, Research & Experimental
Huanliang Chen, Wenzhi Tu, Yue Lu, Yingzi Zhang, Yiqing Xu, Xuming Chen, Meiling Zhu, Yong Liu
Summary: Radiation therapy offers limited benefits for pancreatic cancer patients due to the immunosuppressive microenvironment. Low-dose X-ray irradiation and focal adhesion kinase inhibitor treatment can reduce hypoxia, increase immune cell infiltration, and improve sensitivity to radiation therapy in pancreatic cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Trisha A. Rettig, Claire Ward, Bailey A. Bye, Michael J. Pecaut, Stephen K. Chapes
Article
Biochemistry & Molecular Biology
Xiao W. Mao, Stephanie Byrum, Nina C. Nishiyama, Michael J. Pecaut, Vijayalakshmi Sridharan, Marjan Boerma, Alan J. Tackett, Dai Shiba, Masaki Shirakawa, Satoru Takahashi, Michael D. Delp
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Biochemistry & Molecular Biology
Xiao Wen Mao, Lawrence B. Sandberg, Daila S. Gridley, E. Clifford Herrmann, Guangyu Zhang, Ravi Raghavan, Roman A. Zubarev, Bo Zhang, Louis S. Stodieck, Virginia L. Ferguson, Ted A. Bateman, Michael J. Pecaut
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Multidisciplinary Sciences
Trisha A. Rettig, Bailey A. Bye, Nina C. Nishiyama, Savannah Hlavacek, Claire Ward, Michael J. Pecaut, Stephen K. Chapes
Article
Multidisciplinary Sciences
Xiao W. Mao, Nina C. Nishiyama, Stephanie D. Byrum, Seta Stanbouly, Tamako Jones, Alyson Drew, Vijayalakshmi Sridharan, Marjan Boerma, Alan J. Tackett, David Zawieja, Jeffrey S. Willey, Michael Delp, Michael J. Pecaut
SCIENTIFIC REPORTS
(2019)
Article
Astronomy & Astrophysics
Trisha A. Rettig, Nina C. Nishiyama, Michael J. Pecaut, Stephen K. Chapes
LIFE SCIENCES IN SPACE RESEARCH
(2019)
Article
Multidisciplinary Sciences
Eliah G. Overbey, Willian Abraham da Silveira, Seta Stanbouly, Nina C. Nishiyama, Gina D. Roque-Torres, Michael J. Pecaut, David Carl Zawieja, Charles Wang, Jeffrey S. Willey, Michael D. Delp, Gary Hardiman, Xiao Wen Mao
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Xiao W. Mao, Nina C. Nishiyama, Stephanie D. Byrum, Seta Stanbouly, Tamako Jones, Jacob Holley, Vijayalakshmi Sridharan, Marjan Boerma, Alan J. Tackett, Jeffrey S. Willey, Michael J. Pecaut, Michael D. Delp
Review
Developmental Biology
Foluwasomi A. Oyefeso, Alysson R. Muotri, Christopher G. Wilson, Michael J. Pecaut
Summary: Oxidative stress is a significant contributor to systemic damage, with implications for various diseases, and can be induced by multiple factors. Studies have shown that oxidative stress contributes to neurodegeneration, and brain organoids have emerged as a promising model to study central nervous system diseases.
DEVELOPMENTAL NEUROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Amber M. Paul, Eliah G. Overbey, Willian A. da Silveira, Nathaniel Szewczyk, Nina C. Nishiyama, Michael J. Pecaut, Sulekha Anand, Jonathan M. Galazka, Xiao Wen Mao
Summary: The study used a ground-based model to simulate spaceflight conditions and found negligible differences in immune differentials but large disparities in red blood cell differentials post-exposure. Analysis of spleen cells revealed expression profiles associated with inflammation and dysregulated immune function persisting to 1-week post-simulated spaceflight. Additionally, specific regulation pathways associated with human blood disease gene orthologs were noted.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Jacob M. Holley, Seta Stanbouly, Michael J. Pecaut, Jeffrey S. Willey, Michael Delp, Xiao Wen Mao
Summary: This study aimed to characterize changes in gene expression profiles associated with neuroinflammation, neuronal function, metabolism, and stress in mouse brain tissue after spaceflight. Results showed that many pathways related to cellular stress, inflammation, apoptosis, and metabolism were significantly altered by the flight conditions. Additionally, the mRNA expression of genes involved in anti-viral signaling, reactive oxygen species generation, and bacterial immune response were significantly downregulated. These findings suggest that altered immune reactions may be closely associated with spaceflight-induced stress responses and can affect neuronal function.
Article
Biochemistry & Molecular Biology
Alicia L. Veliz, Lana Mamoun, Lorelei Hughes, Richard Vega, Bailey Holmes, Andrea Monteon, Jillian Bray, Michael J. Pecaut, Mary Kearns-Jonker
Summary: This study focuses on the transcriptomic changes in the hearts of female C57BL/6J mice flown on the International Space Station (ISS) for 30 days. RNA sequencing revealed that 1147 transcripts were significantly regulated after spaceflight, and the MAPK, PI3K-Akt, and GPCR signaling pathways were predicted to be activated. Transcripts related to cytoskeleton breakdown and organization were upregulated, but no significant change in the expression of extracellular matrix (ECM) components or oxidative stress pathway-associated transcripts occurred. Our findings suggest an absence of cellular senescence and an adaptive response to long-term spaceflight in the cardiovascular transcriptome.
Meeting Abstract
Immunology
Trisha A. Rettig, Nina C. Nishiyama, Michael J. Pecaut, Stephen K. Chapes
JOURNAL OF IMMUNOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Trisha A. Rettig, Michael J. Pecaut, Stephen K. Chapes
Article
Astronomy & Astrophysics
Claire Ward, Trisha A. Rettig, Savannah Hlavacek, Bailey A. Bye, Michael J. Pecaut, Stephen K. Chapes
LIFE SCIENCES IN SPACE RESEARCH
(2018)