期刊
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
卷 85, 期 9, 页码 715-728出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09553000903072470
关键词
Linear energy transfer (LET); relative biological effectiveness (RBE)
资金
- National Institute of Radiological Sciences-Heavy-ion Medical Accelerator in Chiba (NIRS-HIMAC)
Purpose: Radiotherapy using charged and/or high-linear energy transfer (LET) particles has a long history, starting with proton beams up to now carbon-ions. Radiation quality of particle beams is different from conventional photons, and therefore the biological effects of high-LET irradiation have attracted scientific interests of many scientists in basic and clinical fields. A brief history of particle radiotherapy in the past half-century is followed by the reviewed biological effectiveness of high-LET charged particles. Results: The latter includes 54 papers presenting 506 RBE (relative biological effectiveness) values for carbon ions and a total of 290 RBE values for other ions identified from 48 papers. By setting a selection window of LET up to 100 keV/m, we fitted a linear regression line to an LET-RBE relation. The resulting slope of the regression line had a dimension of m/keV, and showed different steepness for different cells/tissues and endpoints as well. The steepest regression was found for chromosome aberration of human malignant melanoma while the shallowest was for apoptosis of rodent cells/tissue. Both tumour and normal tissue showed relatively shallower slopes than colony formation. Conclusions: In general, there is a large variation of slope values, but the majority (25 out of 29 values) of data was smaller than 0.05m/keV.
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