Review
Biochemistry & Molecular Biology
Madison Trujillo, Anupreet Kharbanda, Christa Corley, Pilar Simmons, Antino R. Allen
Summary: Breast cancer has become the most prevalent type of cancer, with chemotherapy treatments carrying substantial side effects, while tocotrienols are considered to have the potential to be an anti-cancer agent. Further research is needed to support clinical trials.
Article
Biochemistry & Molecular Biology
Sarita Garg, Tarun K. Garg, Stephen Y. Wise, Oluseyi O. Fatanmi, Isabelle R. Miousse, Alena V. Savenka, Alexei G. Basnakian, Vijay K. Singh, Martin Hauer-Jensen
Summary: This study evaluated the effects of the vitamin E analog gamma-tocotrienol (GT3) on GI recovery in nonhuman primates (NHPs) after total-body irradiation. The results showed that GT3 promoted the survival and proliferation of intestinal stem cells, reduced cell apoptosis, and had a radioprotective function. Therefore, GT3 has the potential to be used as a prophylactic medical countermeasure for radiation-induced GI injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sang-gyu Lee, Teja Muralidhar Kalidindi, Hanzhi Lou, Kishore Gangangari, Blesida Punzalan, Ariana Bitton, Casey J. Lee, Hebert A. Vargas, Soobin Park, Lisa Bodei, Michael G. Kharas, Vijay K. Singh, Naga Vara Kishore Pillarsetty, Steven M. Larson
Summary: A novel radioprotector drug, GT3-Nano, shows promising efficacy in mitigating bone marrow radiation damage during targeted radionuclide therapy in mice. GT3-Nano demonstrates significant radioprotection effects and facilitates rapid recovery of hematopoietic components in mice.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Stephen A. Shrum, Ujwani Nukala, Shivangi Shrimali, Edith Nathalie Pineda, Kimberly J. Krager, Shraddha Thakkar, Darin E. Jones, Rupak Pathak, Philip J. Breen, Nukhet Aykin-Burns, Cesar M. Compadre
Summary: Tocotrienols have powerful multi-organ radioprotective effects, involving antioxidant and other signaling effects.
Article
Multidisciplinary Sciences
Vidya P. Kumar, Gregory P. Holmes-Hampton, Shukla Biswas, Sasha Stone, Neel Kamal Sharma, Bernadette Hritzo, Mary Guilfoyle, Gary Eichenbaum, Chandan Guha, Sanchita P. Ghosh
Summary: This study evaluated the efficacy of a PEGylated thrombopoietin mimetic peptide, JNJ-26366821, in treating Acute Radiation Syndrome (ARS). The findings suggest that JNJ-26366821 can mitigate mortality and thrombocytopenia associated with ARS, and promote the growth of bone marrow cells and megakaryocytes. Single administration of doses ranging from 0.3 to 1 mg/kg increased survival by 30-90% and remained effective for up to 6 months after irradiation. These results support the potential use of JNJ-26366821 as a medical countermeasure in the event of a nuclear radiation incident.
SCIENTIFIC REPORTS
(2022)
Article
Physics, Multidisciplinary
Miguel C. Sequeira, Jean-Gabriel Mattei, Henrique Vazquez, Flyura Djurabekova, Kai Nordlund, Isabelle Monnet, Pablo Mota-Santiago, Patrick Kluth, Clara Grygiel, Shuo Zhang, Eduardo Alves, Katharina Lorenz
Summary: This study demonstrates that recrystallization induced by swift heavy ions is the key mechanism behind the observed resistance in GaN. Atomistic simulations predict and reveal the significant reduction in expected damage levels, with excellent agreement between simulation and experiment. The developed modeling scheme is expected to improve the design and test of future radiation-resistant GaN-based devices.
COMMUNICATIONS PHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Sarita Garg, Tarun K. Garg, Isabelle R. Miousse, Stephen Y. Wise, Oluseyi O. Fatanmi, Alena Savenka, Alexei G. Basnakian, Vijay K. Singh, Martin Hauer-Jensen
Summary: Exposure to high doses of radiation can cause gastrointestinal injury, and there are currently no effective therapies available for mitigating this damage. Gamma-tocotrienol (GT3) is being investigated as a potential radioprotector, but its effectiveness in accelerating gastrointestinal recovery has not been well-studied. This study examined the effects of GT3 in nonhuman primates exposed to partial-body irradiation and found that it had some protective effects in reducing intestinal injury and promoting cell proliferation, although its impact on citrulline levels was minimal.
Article
Ophthalmology
Daniel Pawliczek, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis, Jochen Graw, Claudia Dalke
Summary: The study demonstrated that exposure to low doses of ionising radiation can lead to significant vision impairment in mice, with visual acuity decreasing by as much as 50% due to retinal atrophy and inner cortical cataracts. These findings contribute to our understanding of the potential risks of ionising radiation for human foeti at similar stages of eye development.
EXPERIMENTAL EYE RESEARCH
(2021)
Review
Cell Biology
Ren Jie Tuieng, Sarah H. Cartmell, Cliona C. Kirwan, Michael J. Sherratt
Summary: Exposure to ionising and non-ionising radiation can impact human health, particularly through damage to extracellular matrix proteins, but the exact consequences of this type of radiation exposure on tissue function and structure remain poorly defined compared to the well-characterised impact on cell biology.
Article
Radiology, Nuclear Medicine & Medical Imaging
Steve Ebdon-Jackson, Guy Frija
Summary: This discussion paper addresses the issues and challenges associated with justification of medical exposures using ionising radiation for individual patient diagnostic imaging procedures, and discusses approaches intended to improve justification.
INSIGHTS INTO IMAGING
(2021)
Article
Nanoscience & Nanotechnology
Zhenchao Tao, Jingguo Wang, Haitao Wu, Jiaru Hu, Lu Li, Yuhang Zhou, Qi Zheng, Lisha Zha, Zhengbao Zha
Summary: In response to diffuse ionizing radiation damage, molybdenum-based polyoxometalate nanoclusters (MoPOM NCs) were developed as a non-toxic radioprotectant with impressive free radical scavenging capacities. The Mo-POM NCs exhibited effective shielding capacity by alleviating ionizing radiation-induced DNA damage and disruption of the hematopoietic system. Moreover, the small-sized Mo-POM NCs can be easily eliminated from the body through renal-urinary and hepato-enteral excretory systems.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Plant Sciences
Bimal Prasad Jit, Subhaswaraj Pattnaik, Rakesh Arya, Rutumbara Dash, Saubhagya Subhadarsini Sahoo, Biswajita Pradhan, Prajna Paramita Bhuyan, Pradyota Kumar Behera, Mrutyunjay Jena, Ashok Sharma, Paban Kumar Agrawala, Rajendra Kumar Behera
Summary: This review discusses the potential role of plant-derived chemical compounds in radioprotection, highlighting their importance in the treatment of radiation-induced injury. Further research and clinical trials are needed to explore their therapeutic potential.
Article
Radiology, Nuclear Medicine & Medical Imaging
Michael Rowan, Catherine Wilkinson, Mandy Lewis, Aisling Ni Shuilleabhain, Lee O'Hora, Paddy Gilligan, Geraldine O'Reilly
Summary: The management of pregnant or potentially pregnant patients undergoing medical imaging procedures involving ionising radiation has been a challenge for healthcare providers in Ireland. An expert group developed a policy template to address the issues and recommendations for improvement. Survey results showed high uptake and satisfaction with the template, and a reduction in the use of the clinical waiver system.
EUROPEAN RADIOLOGY
(2022)
Article
Chemistry, Medicinal
Henri Baudhuin, Julie Cousaert, Philippe Vanwolleghem, Geert Raes, Vicky Caveliers, Marleen Keyaerts, Tony Lahoutte, Catarina Xavier
Summary: The study investigates the issue of radiolysis during labeling with high activities of Ga-68, and found that a combination of ethanol and ascorbic acid is successful in preventing radiolysis. This combination is able to maintain the stability of the tracer without affecting its radiochemical purity.
Article
Multidisciplinary Sciences
Jinhuang Shen, Xinhua Ma, Yubin He, Yanjun Wang, Tianhua Zhong, Yonghong Zhang
Summary: This study found that Melianodiol (MN) can activate the Nrf-2 signaling pathway and inhibit the JAK/STAT, iNOS/eNOS, and NF-kappa B signaling cascades, enhance intestinal barrier function, and effectively reduce the LPS-mediated inflammatory response in mouse macrophages and DSS-induced intestinal injury in UC.
Article
Biochemistry & Molecular Biology
Grace A. Ledet, Shukla Biswas, Vidya P. Kumar, Richard A. Graves, Demaurian M. Mitchner, Taylor M. Parker, Levon A. Bostanian, Sanchita P. Ghosh, Tarun K. Mandal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Biology
Vijay K. Singh, Shilpa Kulkarni, Oluseyi O. Fatanmi, Stephen Y. Wise, Victoria L. Newman, Patricia L. P. Romaine, Howard Hendrickson, Jatinder Gulani, Sanchita P. Ghosh, K. Sree Kumar, Martin Hauer-Jensen
RADIATION RESEARCH
(2016)
Article
Biology
Sanchita P. Ghosh, Rupak Pathak, Parameet Kumar, Shukla Biswas, Sharmistha Bhattacharyya, Vidya P. Kumar, Martin Hauer-Jensen, Roopa Biswas
RADIATION RESEARCH
(2016)
Review
Oncology
Smrithi S. Menon, Medha Uppal, Subeena Randhawa, Mehar S. Cheema, Nima Aghdam, Rachel L. Usala, Sanchita P. Ghosh, Amrita K. Cheema, Anatoly Dritschilo
FRONTIERS IN ONCOLOGY
(2016)
Article
Biology
Merriline Satyamitra, Vidya P. Kumar, Shukla Biswas, Lynnette Cary, Leonora Dickson, Srinivasan Venkataraman, Sanchita P. Ghosh
RADIATION RESEARCH
(2017)
Article
Environmental Sciences
Vidya P. Kumar, Shukla Biswas, Neel K. Sharma, Sasha Stone, Christine M. Fam, George N. Cox, Sanchita P. Ghosh
Article
Biology
Amrita K. Cheema, Stephanie D. Byrum, Neel Kamal Sharma, Tatiana Altadill, Vidya P. Kumar, Shukla Biswas, Brian M. Balgley, Martin Hauer-Jensen, Alan J. Tackett, Sanchita P. Ghosh
RADIATION RESEARCH
(2018)
Article
Medicine, General & Internal
Rupak Pathak, Vidya Prasanna Kumar, Martin Hauer-Jensen, Sanchita Purohit Ghosh
Article
Multidisciplinary Sciences
Merriline Satyamitra, Lynnette Cary, Dylan Dunn, Gregory P. Holmes-Hampton, Lawrence J. Thomas, Sanchita P. Ghosh
SCIENTIFIC REPORTS
(2020)
Article
Geriatrics & Gerontology
Neel K. Sharma, Sasha Stone, Vidya P. Kumar, Shukla Biswas, Saeed Y. Aghdam, Gregory P. Holmes-Hampton, Christine M. Fam, George N. Cox, Sanchita P. Ghosh
FRONTIERS IN AGING NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
Nabarun Chakraborty, Aarti Gautam, Gregory P. Holmes-Hampton, Vidya P. Kumar, Shukla Biswas, Raina Kumar, Dana Hamad, George Dimitrov, Ayodele O. Olabisi, Rasha Hammamieh, Sanchita P. Ghosh
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Neel K. Sharma, Gregory P. Holmes-Hampton, Vidya P. Kumar, Shukla Biswas, Kefale Wuddie, Sasha Stone, Zemenu Aschenake, William L. Wilkins, Christine M. Fam, George N. Cox, Sanchita P. Ghosh
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Saeed Y. Aghdam, Doreswamy Kenchegowda, Neel K. Sharma, Gregory P. Holmes-Hampton, Betre Legesse, Maria Moroni, Sanchita P. Ghosh
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Medicine, Research & Experimental
Dharmendra Kumar Soni, Vidya P. Kumar, Shukla Biswas, Gregory P. Holmes-Hampton, Sharmistha Bhattacharyya, Lawrence J. Thomas, Roopa Biswas, Sanchita P. Ghosh
Summary: CDX-301, as a radioprophylactic drug, can prevent radiation-induced dysregulation of microRNA and other cellular functions, inhibit the activation of the HOTAIR regulatory pathway, and restore the expression of genes associated with radiation, thus providing protection.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Biochemistry & Molecular Biology
Sarita Garg, Ratan Sadhukhan, Sudip Banerjee, Alena Savenka, Alexei G. Basnakian, Victoria McHargue, Junru Wang, Snehalata A. Pawar, Sanchita P. Ghosh, Jerry Ware, Martin Hauer-Jensen, Rupak Pathak