Review
Nanoscience & Nanotechnology
Vignesh Kumar, Sairam Yadavilli, Raghuraman Kannan
Summary: Non-small cell lung cancer (NSCLC) is a major cause of cancer-related deaths worldwide, with treatment focusing on targeting oncogenes, but the efficacy is often limited by drug resistance. Development of more effective treatment strategies is crucial.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Peng Liu, Tian Xie, Xinyue Wu, Gongshe Han, Sita D. Gupta, Zike Zhang, Jian Yue, Feitong Dong, Kenneth Gable, Somashekarappa Niranjanakumari, Wanyuan Li, Lin Wang, Wenchen Liu, Ruifeng Yao, Edgar B. Cahoon, Teresa M. Dunn, Xin Gong
Summary: This study reveals the structure of the serine palmitoyltransferase (SPT) complex and its interaction with ORM/ORMDL proteins. ORM1 acts as a negative regulator of SPT by binding to a small molecule derived from steroid degradation, thereby controlling lipid synthesis and homeostasis. This has implications for plant responses to microbial attacks.
Article
Multidisciplinary Sciences
Tian Xie, Peng Liu, Xinyue Wu, Feitong Dong, Zike Zhang, Jian Yue, Usha Mahawar, Faheem Farooq, Hisham Vohra, Qi Fang, Wenchen Liu, Binks W. Wattenberg, Xin Gong
Summary: The researchers elucidated the molecular mechanism of ceramide sensing by the SPT-ORMDL complex, which is tightly regulated by cellular sphingolipid levels. They found that the ORM/ORMDL family proteins can bind to specific sites of the serine palmitoyltransferase (SPT) complex after modifying cellular sphingolipids, leading to the inhibition of its activity. Furthermore, they discovered that mutations in the SPTLC1 subunit in childhood amyotrophic lateral sclerosis (ALS) patients impair ceramide sensing.
NATURE COMMUNICATIONS
(2023)
Article
Genetics & Heredity
B. Molloy, E. R. Jones, N. D. Linhares, P. G. Buckley, T. R. Leahy, B. Lynch, I. Knerr, M. D. King, K. M. Gorman
Summary: A UPD screen using WGS data identified large runs of homozygosity and deleterious homozygous variants in rare disorder cohorts. The prevalence of UPiD in these cohorts was higher compared to the general population, emphasizing its importance for family planning and cascade testing.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Jun Yuan, Qianqian Ju, Jun Zhu, Yun Jiang, Xuechao Yang, Xiaoyu Liu, Jinyu Ma, Cheng Sun, Jiahai Shi
Summary: RASSF9 is upregulated in non-small cell lung cancer and promotes tumor cell proliferation by targeting the MEK/ERK axis. Therefore, RASSF9 may be a potential druggable target for treating NSCLC.
CELL DEATH DISCOVERY
(2021)
Article
Chemistry, Multidisciplinary
Hong Yu, Yi Li, Ruirui Zhang, Mengchen Shen, Yuting Zhu, Qiang Zhang, Huiliang Liu, Dong Han, Xiaoli Shi, Jiao Zhang
Summary: In this study, a novel delivery system based on silica nanoparticles successfully enhanced the expression of miR-24 in cardiomyocytes, leading to the inhibition of apoptosis by suppressing the pro-apoptotic gene Bim. In vivo experiments further demonstrated that this delivery system also significantly improved ventricular remodeling and cardiac function post-coronary artery ligation.
NANOSCALE ADVANCES
(2021)
Article
Pharmacology & Pharmacy
Jungang Zhao, Haojie Lin, Lusheng Wang, Keke Guo, Rongrong Jing, Xuenan Li, Yu Chen, Zhenlin Hu, Shuang Gao, Nuo Xu
Summary: The study demonstrates that by inhibiting the genes FGF5 and FGF18, the hair follicle cycle can be effectively regulated to prolong the anagen phase or promote hair follicles to enter the anagen phase. Cholesterol-modified siRNA shows better expression inhibition effects both in vitro and in vivo. Intradermal injection of cholesterol-modified siRNA can effectively intervene in the hair follicle cycle, while topical application of cream also has similar inhibitory effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hui Hu, Xiao-Wei Zhang, Lin Li, Ming-Ning Hu, Wen-Qian Hu, Jing-Ying Zhang, Xiao-Kang Miao, Wen-Le Yang, Ling-Yun Mou
Summary: Non-small cell lung cancer (NSCLC) is the most common cancer in the world, and Gefitinib has been shown to be effective in treating NSCLC. However, innate and acquired resistance present challenges in therapy. Inhibition of autophagy is considered a promising strategy to overcome resistance.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Mathematics, Interdisciplinary Applications
Yao Li, Haiming Long, Jiajun Ouyang
Summary: Research shows that improving digital financial inclusion can promote household consumption, but it may have a negative impact on the consumption levels of neighboring areas. Policymakers need to balance regional disparities and consider the overall development of digital financial inclusion when formulating policies to promote consumption. Furthermore, the effect of digital financial inclusion on rural households is more significant.
Article
Biochemistry & Molecular Biology
Jing Mao, Zhuchi Zhang, Yongde Chen, Tao Wu, Viktor Fersht, Yan Jin, Jing Meng, Min Zhang
Summary: Sea cucumber peptide (SCP) has shown inhibitory effects on proliferation and invasion of lung cancer cells, as well as reducing tumor growth and increasing survival time in mice. The mechanism of action may involve the regulation of miR-378a-5p and TUSC2 to suppress tumor growth. This study provides a basis for further development of SCP as an anti-tumor nutritional supplement and explores the molecular mechanism of food-derived active peptides in anti-tumor applications.
Article
Medicine, Research & Experimental
Maria L. Ibba, Giuseppe Ciccone, Deborah Rotoli, Gabriele Coppola, Alfonso Fiorelli, Silvia Catuogno, Carla L. Esposito
Summary: The identification of new effective therapeutic options for non-small-cell lung cancer (NSCLC) is crucial. Recent studies indicate that cancer-associated fibroblasts (CAFs) play a significant role in tumor progression, making the development of strategies to inhibit the interaction between CAFs and cancer cells a promising approach for anti-cancer drug development.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Chemistry, Multidisciplinary
Casper F. T. Van der Ven, Mark W. Tibbitt, Joao Conde, Alain van Mil, Jesper Hjortnaes, Pieter A. Doevendans, Joost P. G. Sluijter, Elena Aikawa, Robert S. Langer
Summary: The study developed a drug delivery platform using gold nanoparticles and polymer nanoparticles hydrogel to improve miRNA delivery efficiency. The results demonstrated that AuNP-miRNAs could be linearly released with functionality in vitro, leading to a decrease in Luciferase reporter activity in HEK293 cells and successful tracking in a 3D bioprinted CAVD model. In the mouse model, AuNP-miRNAs mainly cleared via the liver and kidneys, showing potential for in vivo applications.
Article
Oncology
Li Sun, Yi-Jia Guo, Jun Song, Yan-Ru Wang, Shu-Ling Zhang, Le-Tian Huang, Jian-Zhu Zhao, Wei Jing, Cheng-Bo Han, Jie-Tao Ma
Summary: The neoadjuvant EGFR-TKI therapy shows feasibility in treating patients with resectable or potentially resectable EGFR-mutant NSCLC, with satisfactory surgical outcomes and low toxicity. Further phase III clinical trials are needed to confirm these findings and explore the feasibility of a more effective EGFR-TKI combination neoadjuvant therapy.
FRONTIERS IN ONCOLOGY
(2021)
Review
Multidisciplinary Sciences
Oriana Perez, Tatyana Garza, Olivia Hindera, Alicia Beltran, Salma M. Musaad, Tracey Dibbs, Anu Singh, Shria Chug, Amy Sisson, Anil Kumar Vadathya, Tom Baranowski, Teresia M. O'Connor
Summary: This study aims to systematically review validated measurement tools for screen media use that have been compared to an objective gold standard tool. The results showed that self or parent report of screen media use had lower correlations with the gold standard compared to technology-based measures and video observation. However, further research is needed to develop practical and objective measures of diverse types of screen media use to better understand their impact on the development and health of children and adults.
Article
Oncology
Manuel C. Scheidmann, Francesc Castro-Giner, Karin Strittmatter, Ilona Krol, Aino Paasinen-Sohns, Ramona Scherrer, Cinzia Donato, Sofia Gkountela, Barbara M. Szczerba, Zoi Diamantopoulou, Simone Muenst, Tatjana Vlajnic, Leo Kunz, Marcus Vetter, Christoph Rochlitz, Verdon Taylor, Claudio Giachino, Timm Schroeder, Randall J. Platt, Nicola Aceto
Summary: This study identified specific genetic dependencies for each step of the metastatic process in breast cancer using a newly derived CTC xenograft model and a loss-of-function CRISPR screen. The findings provide insights into the biology of metastasis and potential targeted treatment approaches for metastatic breast cancer.
Article
Pathology
Kirill A. Lyapichev, Sergio Pina-Oviedo, L. Jeffrey Medeiros, Mark G. Evans, Hui Liu, Alonso R. Miranda, Kelly K. Hunt, Mark W. Clemens, John M. Stewart, Mitual B. Amin, Andres E. Quesada, Siaw Ming Chai, Arianna Di Napoli, Arthy Yoga, Sanat K. Dave, Ignacio I. Wistuba, Yun Wu, Carlos E. Bueso-Ramos, Ellen J. Schlette, Maria C. Ferrufino-Schmidt, Sanam Loghavi, Joseph D. Khoury, Ken H. Young, Roberto N. Miranda
Article
Oncology
Xiao-Peng Tian, Dan Xie, Wei-Juan Huang, Shu-Yun Ma, Liang Wang, Yan-Hui Liu, Xi Zhang, Hui-Qiang Huang, Tong-Yu Lin, Hui-Lan Rao, Mei Li, Fang Liu, Fen Zhang, Li-Ye Zhong, Li Liang, Xiao-Liang Lan, Juan Li, Bing Liao, Zhi-Hua Li, Qiong-Lan Tang, Qiong Liang, Chun-Kui Shao, Qiong-Li Zhai, Run-Fen Cheng, Qi Sun, Kun Ru, Xia Gu, Xi-Na Lin, Kun Yi, Yue-Rong Shuang, Xiao-Dong Chen, Wei Dong, Wei Sang, Cai Sun, Hui Liu, Zhi-Gang Zhu, Jun Rao, Qiao-Nan Guo, Ying Zhou, Xiang-Ling Meng, Yong Zhu, Chang-Lu Hu, Yi-Rong Jiang, Ying Zhang, Hong-Yi Gao, Wen-Jun He, Zhong-Jun Xia, Xue-Yi Pan, Hai Lan, Guo-Wei Li, Lu Liu, Hui-Zheng Bao, Li-Yan Song, Tie-Bang Kang, Qing-Qing Cai
Editorial Material
Hematology
Hui Liu, Yi Miao, Alessandra Ferrajoli, Guilin Tang, Timothy McDonnell, L. Jeffrey Medeiros, Shimin Hu
AMERICAN JOURNAL OF HEMATOLOGY
(2020)
Article
Oncology
Xiao-Peng Tian, Ning Su, Liang Wang, Wei-Juan Huang, Yan-Hui Liu, Xi Zhang, Hui-Qiang Huang, Tong-Yu Lin, Shu-Yun Ma, Hui-Lan Rao, Mei Li, Fang Liu, Fen Zhang, Li-Ye Zhong, Li Liang, Xiao-Liang Lan, Juan Li, Bing Liao, Zhi-Hua Li, Qiong-Lan Tang, Qiong Liang, Chun-Kui Shao, Qiong-Li Zhai, Run-Fen Cheng, Qi Sun, Kun Ru, Xia Gu, Xi-Na Lin, Kun Yi, Yue-Rong Shuang, Xiao-Dong Chen, Wei Dong, Cai Sun, Wei Sang, Hui Liu, Zhi-Gang Zhu, Jun Rao, Qiao-Nan Guo, Ying Zhou, Xiang-Ling Meng, Yong Zhu, Chang-Lu Hu, Yi-Rong Jiang, Ying Zhang, Hong-Yi Gao, Wen-Jun He, Zhong-Jun Xia, Xue-Yi Pan, Lan Hai, Guo-Wei Li, Li-Yan Song, Tie-Bang Kang, Dan Xie, Qing-Qing Cai
CLINICAL CANCER RESEARCH
(2020)
Article
Cell Biology
Hui Liu, Cheng Chen, Dongshen Ma, Yubing Li, Qianqian Yin, Qing Li, Chenxi Xiang
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Oncology
Hui Liu, Chenxi Xiang, Mei Wu, Shimin Hu
FRONTIERS IN ONCOLOGY
(2020)
Article
Oncology
Wei Sang, Ming Shi, Jingjing Yang, Jiang Cao, Linyan Xu, Dongmei Yan, Meixue Yao, Hui Liu, Weidong Li, Bing Zhang, Kemeng Sun, Xuguang Song, Cai Sun, Jun Jiao, Yuanyuan Qin, Tingting Sang, Yuanyuan Ma, Mei Wu, Xiang Gao, Hai Cheng, Zhiling Yan, Depeng Li, Haiying Sun, Feng Zhu, Ying Wang, Lingyu Zeng, Zhenyu Li, Junnian Zheng, Kailin Xu
Article
Pathology
Xiao Huang, Qingqing Ding, Hua Guo, Yun Gong, Jun Zhao, Min Zhao, Dawen Sui, Yun Wu, Hui Chen, Hui Liu, Jinxia Zhang, Erika Resetkova, Stacy L. Moulder, Wei-Lien Wang, Lei Huo
Summary: The study compared the concordance of three PD-L1 assays in TNBC, finding that 28-8 and 22C3 had higher positive rates and good agreement in scoring methods, while SP142 showed lower concordance with the other assays. When using SP142 as a reference, optimal agreement was achieved by selecting specific cutoff values for IC, TC, and TCIC/CPS.
Article
Oncology
Zhihong Hu, Zenggang Pan, Weina Chen, Yang Shi, Wei Wang, Ji Yuan, Endi Wang, Shanxiang Zhang, Habibe Kurt, Brenda Mai, Xiaohui Zhang, Hui Liu, Adan A. Rios, Hilary Y. Ma, Nghia D. Nguyen, L. Jeffrey Medeiros, Shimin Hu
Summary: Primary effusion lymphoma (PEL) is a rare large B-cell lymphoma associated with HHV8 infection, presenting mainly as effusion with occasional extracavitary mass. Clinicopathological features of PEL are associated with disease type and HIV status, and the prognosis is poor regardless of presentation or HIV status.
Editorial Material
Hematology
Hui Liu, Shimin Hu
Article
Cell Biology
Hui Liu, Zijun Y. Xu-Monette, Guilin Tang, Wei Wang, Young Kim, Ji Yuan, Yu Li, Weina Chen, Yanping Li, George Y. Fedoriw, Feng Zhu, Xiaosheng Fang, Catherine Luedke, L. Jeffrey Medeiros, Ken H. Young, Shimin Hu
Summary: This study identified 16 cases of EBV+ DHL/THL, with half presenting high-grade/Burkitt-like morphology and the other half diffuse large B cell lymphoma morphology. Using Hans' algorithm, 13 cases were classified as germinal centre B cell and 3 as non-GCB. Most cases showed EBV latency Type I, with a median of 80% positive cells for EBV-encoded small RNAs.
Article
Oncology
Hua Guo, Qingqing Ding, Yun Gong, Michael Z. Gilcrease, Min Zhao, Jun Zhao, Dawen Sui, Yun Wu, Hui Chen, Hui Liu, Jinxia Zhang, Erika Resetkova, Stacy L. Moulder, Wei-Lien Wang, Lei Huo
BREAST CANCER RESEARCH
(2020)
Article
Medicine, Research & Experimental
Jun Ye, Mei Lin, Chuanmeng Zhang, Xiaowei Zhu, Sumeng Li, Hui Liu, Jianfeng Yin, Hong Yu, Kuichun Zhu
BIOMEDICAL REPORTS
(2020)
Meeting Abstract
Medicine, Research & Experimental
Hui Liu, Chenxi Xiang, Dongshen Ma
LABORATORY INVESTIGATION
(2020)
Meeting Abstract
Pathology
Hui Liu, Chenxi Xiang, Dongshen Ma