Article
Medicine, Research & Experimental
Fabiola Lili Sarmiento-Salinas, Andrea Perez-Gonzalez, Adilene Acosta-Casique, Adrian Ix-Ballote, Alfonso Diaz, Samuel Trevino, Nora Hilda Rosas-Murrieta, Lourdes Millan-Perez-Pena, Paola Maycotte
Summary: Cancer is a major global cause of death, with the role of reactive oxygen species (ROS) in cancer development and progression being extensively studied. However, conflicting evidence exists regarding the specific impact of ROS on cancer, which may vary depending on the type of cancer and stage of tumorigenesis. Recent research has focused on exploring the diverse aspects of ROS interaction with cancer at different stages of cancer progression.
Article
Chemistry, Multidisciplinary
Naeun Park, Kyoung Sub Kim, Kun Na
Summary: This study presents an approach for manipulating paracrine factors and signaling pathways in adipose-derived stem cells to achieve effective tumor immunotherapy. The method involves precise control of reactive oxygen species concentration and regulation of specific signaling pathways to induce the secretion of inflammatory cytokines and inhibit the secretion of cell growth factors. When injected into a tumor animal model, the modified stem cells autonomously target and accumulate at the tumor site, generating anti-inflammatory factors and reducing angiogenesis growth factors upon laser irradiation, leading to effective melanoma and pancreatic tumor treatment in mice. This technology holds significant promise for the treatment of various diseases.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Biochemistry & Molecular Biology
Alessio Biagioni, Sara Peri, Giampaolo Versienti, Claudia Fiorillo, Matteo Becatti, Lucia Magnelli, Laura Papucci
Summary: Blood vessels are crucial for cancer cells to survive and spread in the body, and the formation of abnormal vessel networks is closely related to patients' prognosis. It is urgent to find new pharmaceutical solutions to control and normalize the formation of these networks.
Article
Biochemistry & Molecular Biology
Chou-Yuan Ko, Po-Chang Shih, Po-Wei Huang, Yi-Hsin Lee, Yen-Fu Chen, Ming-Hong Tai, Chi-Hao Liu, Zhi-Hong Wen, Hsiao-Mei Kuo
Summary: Sinularin was found to effectively inhibit the growth of hepatocellular carcinoma SK-HEP-1 cells at a concentration of 10 μM, inducing DNA fragmentation and apoptosis, as well as affecting cell migration and colony formation. Additionally, it altered the expression levels of various proteins related to cell signaling and metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Qian Liu, Shanshan Zhao, Fanguang Meng, Hankang Wang, Liwei Sun, Guijie Li, Feng Gao, Feng Chen
Summary: The combination of EPI and CPT can inhibit Nrf2 expression and show a more effective suppression of tumor growth. Down-regulation of Nrf2 is beneficial in reducing invasion, metastasis, and angiogenesis in hepatoma.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Shanshan Gou, Lu Qiu, Qiufang Yang, Peng Li, Xiaowen Zhou, Yixuan Sun, Xiuman Zhou, Wenshan Zhao, Wenjie Zhai, Guodong Li, Yahong Wu, Yonggang Ren, Yuanming Qi, Yiguo Zhang, Yanfeng Gao
Summary: Metformin induces ROS accumulation by inhibiting the expression of the core antioxidant transcription factor NFE2L1, which can be reversed by high glucose. The inhibitory effect of metformin on NFE2L1 is AMPK-independent, and NFE2L1 may play a crucial role in regulating the AMPK signaling pathway.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Review
Engineering, Biomedical
Xiaohua Zheng, Yilan Jin, Xiao Liu, Tianqing Liu, Weiqi Wang, Haijun Yu
Summary: Reactive species-based cancer therapies have gained significant attention for their simplicity, controllability, and efficacy. Utilizing nanomaterials for photo-controlled generation of highly reactive radical species is a promising approach for cancer treatment, showing potential synergistic effects with other therapeutic modalities.
BIOACTIVE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Jianfeng Guo, Zhuo Yu, Dandan Sun, Yifang Zou, Yun Liu, Leaf Huang
Summary: This study demonstrates the concept of successful FOLFOX-associated CRC and HCC therapies through the combination of two nano delivery systems. Further optimization in dosing and timing has the potential to enhance the clinical efficacy of this combination strategy.
Article
Oncology
Jie Du, Fan Jiang, Shen-Sheng Xu, Zi-Feng Huang, Li-Li Chen, Li Li
Summary: Tephrosin exhibits potent anticancer activity against pancreatic cancer cells by suppressing cell viability and promoting apoptosis through increased ROS production and DNA damage. Additionally, it demonstrates strong antitumor activity with low toxicity in a mouse model.
Review
Physiology
Wenqi Zhao, Peizhen Zhuang, Yixi Chen, Yi Wu, Mintao Zhong, Yongzhi Lun
Summary: Reactive oxygen species (ROS) produced by cellular metabolism play a crucial role in regulating various functions in both normal and cancerous cells. ROS, at different concentrations, can have either positive or negative effects on tumor development. Certain levels of ROS can activate growth-promoting signals, enhance tumor cell proliferation and invasion, and cause damage to biomacromolecules. However, ROS can also enhance stress response.
PHYSIOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Fang-Yuan Liu, Guo Nan Yin, Jiyeon Ock, Fitri Rahma Fridayana, Lashkari Niloofar, Yan Huang, Minh Nhat Vo, Jun-Kyu Suh, Soon-Sun Hong, Ju-Hee Kang, Ji-Kan Ryu
Summary: Severe vascular and nerve damage from diabetes leads to erectile dysfunction and poor response to oral phosphodiesterase 5 inhibitors. The study showed that administration of Ago2 can effectively improve penile erection in diabetic mice by enhancing cavernous endothelial cell angiogenesis and survival. Ago2 administration reduces reactive oxygen species production and improves signaling pathways, leading to improved cellular functions and erectile function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yu Jin Lee, Sang Yeol Lee
Summary: Maclurin, a natural compound extracted from white mulberry and purple mangosteen, demonstrates anticancer effects on human osteosarcoma cells by inducing prooxidative apoptosis and inhibiting cell migration. It modulates key signaling pathways related to cancer metastasis and shows potential as a candidate molecule for anti-osteosarcoma treatment.
Review
Immunology
Defa Huang, Dingyu Rao, Qing Jin, Mi Lai, Jiali Zhang, Zhonghong Lai, Haibin Shen, Tianyu Zhong
Summary: Hepatocellular carcinoma (HCC) is a common liver cancer with a poor prognosis. CD147, a glycoprotein, plays a crucial role in HCC invasion, metastasis, and angiogenesis. This review discusses the molecular structure of CD147 and its potential as a diagnostic and therapeutic target for HCC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Renkai Li, Chengwen Zheng, Polly Ho-Ting Shiu, Panthakarn Rangsinth, Wen Wang, Yiu-Wa Kwan, Emily Sze-Wan Wong, Yanbo Zhang, Jingjing Li, George Pak-Heng Leung
Summary: Despite various therapeutic approaches, developing novel and more effective methods for colorectal cancer treatment is crucial due to its high fatality rate. The recent study explored the anticancer effects of GAR E, a bioactive xanthone found in mangosteen, and identified the involvement of the ROS/JNK signaling pathway in its mechanism of action. The experiments demonstrated that GAR E inhibited colony formation and wound healing in cancer cells, triggered ROS production, induced mitochondrial dysfunction and apoptosis, and caused cell cycle arrest. In vivo experiments also confirmed the antitumor effect of GAR E in a xenograft mouse model. These findings suggest that GAR E could be a potential chemotherapeutic agent for colorectal cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Environmental Sciences
Yong Jun Choi, Jongsung Lee, Sang Hoon Ha, Han Ki Lee, Heui Min Lim, Seon-Hak Yu, Chang Min Lee, Myeong Jin Nam, Yung-Hun Yang, Kyungmoon Park, Youn Soo Choi, Kyu Yun Jang, See-Hyoung Park
Summary: 6,8-Diprenylorobol inhibits proliferation of LoVo and HCT15 colon cancer cells in a dose- and time-dependent manner. It activates p53 and generates ROS, leading to decreased cell viability and increased apoptotic cell portion.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Surgery
Fei Wang, Sheng Liu, Le Qiu, Ben Ma, Jian Wang, Yong-Jie Wang, April Peszel, Xu-Lin Chen
ANNALS OF PLASTIC SURGERY
(2015)
Article
Oncology
Fei Wang, Wei Zhang, Chao Wang, Xu Fang, Hao Cheng, Sheng Liu, Xu-Lin Chen
Article
Critical Care Medicine
Shi-Ji Li, Hao Cheng, Xu Fang, Jian-Yang Xu, Fei Wang, Sheng Liu, Xu-Lin Chen, Xiong-Wen Lv
Article
Dermatology
Fei Wang, Xu-Lin Chen, Xun Liang
ACTA DERMATOVENEROLOGICA CROATICA
(2012)
Article
Critical Care Medicine
Fei Wang, Xu-Lin Chen, Yong-Jie Wang, Xia-Ying Chen, Feng Guo, Ye-Xiang Sun
JOURNAL OF BURN CARE & RESEARCH
(2007)