Review
Biochemistry & Molecular Biology
Erik Martinez-Hackert, Anders Sundan, Toril Holien
Summary: The TGF-beta family is a group of structurally related, multifunctional growth factors crucially involved in the development, regulation, and maintenance of animal tissues. These ligands exhibit promiscuity and compete with each other for binding to receptors, possibly allowing cells to process multiple ligand inputs for subtle, distinctive, or adaptive responses and developmental plasticity. This concept of ligand competition may be fundamentally tied to human physiology, disease, and therapy.
CYTOKINE & GROWTH FACTOR REVIEWS
(2021)
Article
Endocrinology & Metabolism
Zhenzong Tan, Wang Huang, Peng Yu
Summary: ARID2 is downregulated in colon cancer, and its overexpression suppresses cell proliferation, invasion, migration, and EMT in colon cancer by inactivating the TGF-ss 1/Smad pathway.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Oncology
Noam Cohen, Dhanashree Mundhe, Sarah K. Deasy, Omer Adler, Nour Ershaid, Tamar Shami, Oshrat Levi-Galibov, Rina Wassermann, Ruth Scherz-Shouval, Neta Erez
Summary: Metastatic cancer is difficult to cure and is the main cause of cancer-related deaths. In this study, the researchers found that cancer-associated fibroblasts play a crucial role in creating a favorable microenvironment for metastasis by mediating inflammation. They also discovered that a protein called Activin A is secreted from breast tumors and promotes fibrosis in the lung, which enhances metastasis. This new mechanism could potentially be targeted for therapeutic intervention to inhibit metastatic relapse.
Article
Oncology
Yuxuan Li, Pan Wang, Dongmei Ye, Xue Bai, Xuemei Zeng, Qiang Zhao, Zhiwei Zhang
Summary: This study investigated the expression of IGHG1 in gastric cancer and its effects on the proliferation, migration, invasion, and EMT of gastric cancer SGC7901 cells. High expression of IGHG1 was found in gastric cancer tissues, promoting cell proliferation, migration, and invasion. Low expression of IGHG1 reduced EMT-related protein expression and induced EMT in SGC7901 cells through the TGF-beta/SMAD3 signaling pathway.
Article
Biology
Erich J. Goebel, Luisina Ongaro, Emily C. Kappes, Kylie Vestal, Elitza Belcheva, Roselyne Castonguay, Ravindra Kumar, Daniel J. Bernard, Thomas B. Thompson, Roger J. Davis
Summary: ActC and ActAC are active ligands with distinct signaling receptor and antagonist profiles, activating SMAD2/3-dependent signaling via the receptor activin receptor-like kinase 7 (ALK7), and exhibiting a similar response to ActB in mature murine adipocytes.
Article
Biochemistry & Molecular Biology
Yanfen Lian, Dongxiao Jiang, Jiangtao Sun
Summary: The study found that miR-33a-5p expression is significantly decreased in PDAC tissues and cell lines, and its downregulation is significantly associated with TNM staging and lymph node metastasis. Overexpression of miR-33a-5p inhibits cell proliferation, migration, and invasion in SW1990 and PANC-1 cells, while knockdown of miR-33a-5p promotes these processes in BxPC-3 and ASPC-1 cells. Additionally, RAP2A was identified as a direct target of miR-33a-5p in PDAC cells, and its overexpression reversed the suppressive effects of miR-33a-5p in SW1990 and PANC-1 cells.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2021)
Article
Oncology
Xing Huang, Feng Zhao, Quan Wu, Zitong Wang, Haiyue Ren, Qiqi Zhang, Zhe Wang, Jin Xu
Summary: For patients with pancreatic cancer, KIF2C is abnormally expressed and affects the prognosis. KIF2C promotes the proliferation, invasion, and metastasis of pancreatic cancer. The overexpression of KIF2C has potential therapeutic implications for pancreatic ductal adenocarcinoma (PDAC).
Article
Orthopedics
Nathalie G. M. Thielen, Arjan P. M. van Caam, Henk M. V. Beuningen, Elly L. Vitters, Martijn H. J. van den Bosch, Marije I. Koenders, Fons A. J. van de Loo, Esmeralda N. Blaney Davidson, Peter M. van der Kraan
Summary: The study aimed to block TGF-beta-induced SMAD1/5/9 signaling in primary human OA chondrocytes while maintaining functional SMAD2/3 signaling. The results demonstrated that using a low dose of SB-505124 inhibited SMAD1/5/9 phosphorylation and the expression of ID1 and ID3, while maintaining SMAD2/3 phosphorylation and the induction of JUNB and SERPINE1. In addition, TGF-beta regulated hypertrophic and dedifferentiation markers in OA chondrocytes, and blocking only the SMAD1/5/9 pathway showed stronger inhibition on TGF-beta-induced RUNX2 compared to blocking both SMAD pathways.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Biochemistry & Molecular Biology
Senem Aykul, Jordan Maust, Vijayalakshmi Thamilselvan, Monique Floer, Erik Martinez-Hackert
Summary: The study revealed the significant regulatory role of TGF-beta family growth factors and inhibitors in adipocyte development, with SMAD1/5/8 signaling playing a crucial role in 3T3-L1 adipogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Tao Tian, Xiangyang Fu, Liangliang Hu, Xiaofeng Yang, Peng Sun, Fengfeng Sun
Summary: The study confirmed that FAST1 is up-regulated in RC tissues and cell lines, and its overexpression indicates a poor prognosis for RC patients. Overexpressing FAST1 promoted RC cell viability, proliferation, migration, invasion, and EMT, while repressing apoptosis. Mechanistically, FAST1 regulates RC progression through activation of the TGF-beta/Smad signaling pathway.
ONCOTARGETS AND THERAPY
(2021)
Article
Medicine, General & Internal
Han Ping Cheng, Chiu-Jung Huang, Ming-Long Tsai, Hooi Tin Ong, Soon Keng Cheong, Kong Bung Choo, Shih-Hwa Chiou
Summary: The study reveals that miR-362 regulates cell migration and invasion by targeting SMAD4 and E-cadherin expression to suppress metastasis, with knockdown of miR-362 leading to decreased motility and invasion. Knockdown of miR-362 inhibits metastasis in cancer mouse models with similar results observed in in vitro studies.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Oncology
Yi Hu, Zhenmei Li, Lanlan Gong, Zhe Song
Summary: This study found that beta-Asarone can inhibit the proliferation and induce apoptosis in esophageal squamous cell carcinoma (ESCC). Additionally, beta-Asarone also suppresses epithelial-mesenchymal transition (EMT) and invasive abilities in ESCC. The study also discovered that beta-Asarone inhibits TGF-beta/Smad signaling activation to suppress invasive properties in ESCC.
Article
Oncology
Guang-Yu Lian, Qing-Ming Wang, Thomas Shiu-Kwong Mak, Xiao-Ru Huang, Xue-Qing Yu, Hui-Yao Lan
Summary: The combined therapy with Asiatic acid and Naringenin effectively suppressed tumor invasion and metastasis by targeting TGF-beta/Smad-dependent MMP2 transcription. This approach retrieved the balance between Smad3 and Smad7 signaling in the tumor microenvironment.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Article
Immunology
Xue-Feng Li, Cigdem Selli, Han-Lin Zhou, Jian Cao, Shuiqing Wu, Ruo-Yu Ma, Ye Lu, Cheng-Bin Zhang, Bijie Xun, Alyson D. Lam, Xiao-Cong Pang, Anu Fernando, Zeda Zhang, Asier Unciti-Broceta, Neil O. Carragher, Prakash Ramachandran, Neil C. Henderson, Ling-Ling Sun, Hai-Yan Hu, Gui-Bo Li, Charles Sawyers, Bin-Zhi Qian
Summary: This study identified macrophages as the major component of the metastatic microenvironment in bone-metastatic prostate cancer. Macrophages were found to play a critical role in enzalutamide resistance through the induction of a wound-healing-like response and activation of the cytokine activin A- fibronectin-integrin alpha 5-tyrosine kinase Src signaling cascade. Depletion of macrophages or inhibition of Src significantly inhibited resistant growth, suggesting a potential therapeutic approach for treating metastatic prostate cancer.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Zhiwen Yang, Xinlin Wu, Junjie Shen, A. Gudamu, Yongxiang Ma, Zishu Zhang, Mingxing Hou
Summary: In this study, the effects of ginsenoside Rh1 on gastric cancer cells were investigated. It was found that ginsenoside Rh1 inhibited cell proliferation and invasion, and promoted apoptosis. Mechanistically, ginsenoside Rh1 reduced the levels of TGF-β and phosphorylated Smad2/3.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Cedric Carl, Anne Flindt, Julian Hartmann, Markus Dahlke, Dirk Rades, Juergen Dunst, Hendrik Lehnert, Frank Gieseler, Hendrik Ungefroren
CELLULAR AND MOLECULAR LIFE SCIENCES
(2016)
Review
Biochemistry & Molecular Biology
Hendrik Ungefroren, David Witte, Bernhard H. Rauch, Utz Settmacher, Hendrik Lehnert, Frank Gieseler, Roland Kaufmann
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Biochemistry & Molecular Biology
Hendrik Ungefroren, David Witte, Christian Fiedler, Thomas Gaedeken, Roland Kaufmann, Hendrik Lehnert, Frank Gieseler, Bernhard H. Rauch
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Pharmacology & Pharmacy
Hendrik Ungefroren, David Witte, Koichiro Mihara, Bernhard H. Rauch, Petra Henklein, Olaf Joehren, Shirin Bonni, Utz Settmacher, Hendrik Lehnert, Morley D. Hollenberg, Roland Kaufmann, Frank Gieseler
MOLECULAR PHARMACOLOGY
(2017)
Editorial Material
Oncology
Frank Gieseler, Lynn Gaertner, Elske Thaden, Werner Theobald
Article
Cell Biology
Frank Gieseler, Corinna Plattfaut, Tabea Quecke, Annika Freund, Hendrik Ungefroren, Fanny Ender
CELL BIOLOGY INTERNATIONAL
(2018)
Article
Oncology
Hendrik Ungefroren, Hannah Otterbein, Christian Fiedler, Koichiro Mihara, Morley D. Hollenberg, Frank Gieseler, Hendrik Lehnert, David Witte
Article
Oncology
Fanny Ender, Annika Freund, Tabea Quecke, Corinna Steidel, Piet Zamzow, Nikolas von Bubnoff, Frank Gieseler
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Fanny Ender, Piet Zamzow, Nikolas von Bubnoff, Frank Gieseler
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Editorial Material
Biochemistry & Molecular Biology
Frank Gieseler, Fanny Ender
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Multidisciplinary Sciences
Lucy Kappes, Ruba L. Amer, Sabine Sommerlatte, Ghada Bashir, Corinna Plattfaut, Frank Gieseler, Timo Gemoll, Hauke Busch, Abeer Altahrawi, Ashraf Al-Sbiei, Shoja M. Haneefa, Kholoud Arafat, Lena F. Schimke, Nadia El Khawanky, Kai Schulze-Forster, Harald Heidecke, Anja Kerstein-Staehle, Gabriele Marschner, Silke Pitann, Hans D. Ochs, Antje Mueller, Samir Attoub, Maria J. Fernandez-Cabezudo, Gabriela Riemekasten, Basel K. al-Ramadi, Otavio Cabral-Marques
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Corinna Steidel, Fanny Ender, Achim Rody, Nikolas von Bubnoff, Frank Gieseler
Summary: This study discusses the potential causal role of tissue factor-bearing extracellular vesicles (TF+ EVs) released from tumor cells in the pathological coagulation status of ovarian cancer patients. Results show that EVs derived from ascites of ovarian cancer patients have significantly high TF activities and are associated with a high rate of VTE, suggesting a potential role in prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Andreas Heidenreich, Susanne Elsner, Frank Woerler, Joachim Huebner, Christina Schuees, Christoph Rehmann-Sutter, Alexander Katalinic, Frank Gieseler
Summary: This study explores physicians' perspectives on the roles and involvement of family caregivers in consultations and therapy decision-making for elderly cancer patients in Germany. The findings indicate that although physicians recognize the importance of family caregivers in providing information, supporting the patient, and contributing to the treatment decision, they rarely involve them closely in consultations.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
Andreas Heidenreich, Rabea Fuchshofen, Susanne Elsner, Frank Gieseler, Alexander Katalinic, Joachim Huebner
Summary: This study investigates the factors associated with deviations from guideline recommendations in elderly breast cancer patients. The findings indicate that patients aged 70 and older are more likely to deviate from guideline recommendations, while patients aged 50-69 who prioritize quality of life in treatment decision-making are also more likely to deviate. In older patients, higher age and pre-existing depression are associated with an increased chance of receiving guideline-discordant care.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Frank Gieseler, Andreas Heidenreich, Jacqueline Schubert, Fabian Frielitz, Christoph Rehmann-Sutter, Frank Woerler, Christina Schuees, Joachim Huebner, Susanne Elsner, Katarina Block, Achim Rody, Nikolas von Bubnoff, Tobias Keck, Monika Steimann, Gero Endsin, Alexander Katalinic
Summary: This study explored the relationships between cancer patients and their family caregivers using reconstructive methodology, revealing the potential influence of caregivers on treatment decisions. However, the actual involvement of caregivers in patient-physician consultations was found to be relatively low in practice.
HEALTH SCIENCE REPORTS
(2021)